ライフサイエンスコーパス: regulation of expression

1 ages that have evolved a tight, hierarchical regulation of expression.

2 ns and/or via changes in temporal or spatial regulation of expression.

3 was complex, suggesting post-transcriptional regulation of expression.

4 tion of IFNlambda4 to determine its role and regulation of expression.

5 e active rather than passive participants in regulation of expression.

6 hich genes might be subject to tRNA-mediated regulation of expression.

7 xpression, whereas low levels resulted in up-regulation of expression.

8 he infection, suggesting an infection-driven regulation of expression.

9 ion machinery to accomplish rigorous spatial regulation of expression.

10 oter, and dramatically altered iron-mediated regulation of expression.

11 II/Gu, its chromosomal localization, and the regulation of expression.

12 posin displayed similar temporal and spatial regulation of expression.

13 undergo thigmomorphogenesis and TCH gene up-regulation of expression.

14 3' of the US3 TATA box are required for down regulation of expression.

15 eam sequence may be involved in quantitative regulation of expression.

16 iana, the members of which show differential regulation of expression.

17 owed unusually rapid decay, indicating tight regulation of expression.

18 2, was previously shown to be essential for regulation of expression.

19 rhesus tissues demonstrated tissue-specific regulation of expression.

20 me that the LINC complex facilitates mechano-regulation of expression across the genome.

21 ervations reveal a crucial role for LTCCs in regulation of expression, activity and stability of aqua

22 genes were found to have at least 3-fold up-regulation of expression after treatment in each cell li

23 Our results indicate some cross-regulation of expression among ABI3, ABI4, and ABI5 and

24 tems have revealed fundamental shifts in the regulation of expression among critical genes in the not

25 Compensatory up-regulation of expression and activation of Vav3 in Vav1/

26 Down-regulation of expression and activity of erbB2, a member

27 We investigated the regulation of expression and activity of the MC1R in pri

28 nic changes in sodium intake caused parallel regulation of expression and amount of receptor protein

29 However, few demonstrate the exquisite regulation of expression and breadth of functional impor

30 y have dramatically different mechanisms for regulation of expression and enzymatic activation.

31 is a secreted, pentameric glycoprotein whose regulation of expression and function are not well under

32 lectively, the present results shed light on regulation of expression and function of ICAM-1 on neutr

33 ere, we investigated the role of MTA1 in the regulation of expression and function of MyD88, a proxim

34 asiveness of tumor cells may also involve up-regulation of expression and function of the autocrine m

35 expression of NeuroD1 subsequently leads to regulation of expression and function of the nicotinic a

36 that Nrf2 regulates Cul3-Rbx1 by controlling regulation of expression and induction of Cul3-Rbx1.

37 These results implicated Nrf2 in the regulation of expression and induction of INrf2.

38 n human and mouse kidney was studied and the regulation of expression and localization of this subuni

39 cells, inhibition of PI3K was followed by up-regulation of expression and phosphorylation of multiple

40 Taken together, these data indicate that the regulation of expression and processing of LAT RNA withi

41 homeotic gene as a result of changes in both regulation of expression and specific alterations in the

42 Relatively little is known about the regulation of expression and stability of BubR1 (or othe

43 present study is the first demonstration of regulation of expression and transactivation ability of

44 rates of murein hydrolases as well as in the regulation of expression and/or activity of some murein

45 Our results implicate ct in the regulation of expression and/or function of two homeotic

46 s within TR genes may be relevant to complex regulation of expression and/or organelle- and cell type

47 ncomitant loss of function in Chk2 (via down-regulation of expression) and p53 (via mutation) occurs

48 , genomic organization, molecular structure, regulation of expression, and function.

49 er analysis of the transcriptional function, regulation of expression, and phenotypic effects will he

50 o explore the cells of origin, localization, regulation of expression, and putative functions of IHH

51 to examine CCRL2 expression in RA, cytokine regulation of expression, and the source of a putative l

52 These data indicate that there is a mutual regulation of expression between p53 and AR.

53 ding was the dramatic change observed in the regulation of expression between proteases and their cog

54 e fragmentation pattern of the mRNA, and the regulation of expression by a repression mechanism descr

55 ressed from a foreign promoter to circumvent regulation of expression by FlgM, which is itself a fila

56 r the control of class II expression and the regulation of expression by interferon-gamma.

57 course of regeneration, direct and indirect regulation of expression by p53 is mediated in a gene-sp

58 sential vitamins, with an overall twofold up-regulation of expression compared with free-living cells

59 Because glycolytic enzyme up-regulation of expression contributes to glycolytic flux,

60 n mouse and man and striking spatio-temporal regulation of expression during embryogenesis, suggest t

61 n, we characterized its tissue distribution, regulation of expression during hematopoietic differenti

62 R shortening in S. pombe coordinates with up-regulation of expression for genes involved in translati

63 ession quantitative trait and determined cis regulation of expression for nine of the miRNAs and of t

64 cific ribosomal proteins to allow autogenous regulation of expression from large multi-gene operons,

65 The regulation of expression from the URE2 internal ribosome

66 The regulation of expression from this promoter may involve

67 Aspergillus fumigatus induced differential regulation of expression in 1,827 genes (P < 0.05).

68 e cDNAs, their genomic arrangement and their regulation of expression in different fly tissues and sp

69 For the otpb enhancer, regulation of expression in dopamine neurons requires mu

70 edium (4710 +/- 2643), and verified the down-regulation of expression in medium that contained only g

71 ple of the utilization of different modes of regulation of expression in T and B cells.

72 Efficient regulation of expression in these systems makes use of s

73 While numerous studies have investigated regulation of expression level, little is known about ge

74 1) direct interaction between receptors, 2) regulation of expression levels and localization, and 3)

75 cations appear to confer risk of T2D via the regulation of expression levels for a large number (266)

76 ose of wild-type mice indicating possible co-regulation of expression levels.

77 inding in tick-transmitted bacteria, and the regulation of expression may be broadly applicable to un

78 ly regulated Ras isoform with significant up-regulation of expression observed pre-term in stomach, i

79 associated with metformin IC50 through trans-regulation of expression of 11 or 26 genes with P-value

80 Marked up-regulation of expression of 24p3/lcn2 was seen throughou

81 been shown to play an important role in the regulation of expression of a subclass of adipocyte gene

82 hain reaction (Q-RT-PCR) was used to confirm regulation of expression of a subset of 6 genes with imp

83 a role for the daf-7 TGF-beta pathway in the regulation of expression of a subset of chemoreceptor ge

84 ed from a past insertion participates in the regulation of expression of a useful gene.

85 thelial cells is associated with up-and-down regulation of expression of a variety of genes including

86 of the organism at acidic pH also results in regulation of expression of a variety of genes, such as

87 reorganization of the actin cytoskeleton to regulation of expression of a wide range of genes, inclu

88 ymphoid tissue organization, we analyzed the regulation of expression of adhesion molecules and chemo

89 on of DC function was associated with the up-regulation of expression of Ag-processing machinery comp

90 Down-regulation of expression of AKT kinase by RNA interferen

91 The independent regulation of expression of all of these genes, implied

92 ulatory system is an important mechanism for regulation of expression of aminoacyl-tRNA synthetase, a

93 ene expression and the first report of viral regulation of expression of an RNA processing factor.

94 eptide Y and agouti-related protein and down-regulation of expression of anorexigenic neuropeptides p

95 d the transcription of PSA not only via down-regulation of expression of AR, but also by a direct inh

96 y plasmalemma Ca2+ channels, and (b) cold up-regulation of expression of at least a subset of the TCH

97 d in activation of lymph node T cells and up-regulation of expression of B220, CD11a, and CD44 and ca

98 Regulation of expression of both human GCS subunit genes

99 a correlation with the complex developmental regulation of expression of btk.

100 To understand the regulation of expression of cagA, picB, associated with

101 ulation of exit from the cell cycle; and (d) regulation of expression of carbonic anhydrases 9 and 12

102 Regulation of expression of CARD15/NOD2 by cytokines was

103 This enhancement was associated with the up-regulation of expression of CCR5, a primary coreceptor f

104 rapid induction of expression of CD80 and up-regulation of expression of CD86, incubation with killed

105 Down-regulation of expression of Cep55 was accompanied by rep

106 However, little is known about the regulation of expression of chemokine receptors in the b

107 The regulation of expression of components and substrates of

108 This study tests the hypothesis that the regulation of expression of connexin 43, a gap junction

109 However, the molecular regulation of expression of Cosmc, which is encoded by a

110 s, because these cells showed significant up-regulation of expression of costimulatory molecules B7.1

111 owever, molecular mechanisms involved in the regulation of expression of COX-2 are not well understoo

112 Currently, knowledge of the regulation of expression of COX-2 by endogenous cell-sur

113 se loops can be generated by auto- and cross-regulation of expression of CREB proteins, via CRE eleme

114 However, the mechanisms responsible for the regulation of expression of cutaneous adhesion molecules

115 ment of Drosophila is at least partly due to regulation of expression of cuticle patterning genes by

116 fungal cell, and report the transcriptional regulation of expression of CWDE genes in both saprophyt

117 important factors in the differentiation and regulation of expression of dendritic cell-associated ma

118 We conclude that through regulation of expression of DNA damage response genes, C

119 factor HNF-3beta has been implicated in the regulation of expression of each of these MODY genes, su

120 ion, consistent with their role in circadian regulation of expression of eas(ccg-2).

121 ific transcription factor likely involved in regulation of expression of endogenous genes.

122 rogenesis at least in part through molecular regulation of expression of endothelial adhesion molecul

123 scussed, addressing the associated roles and regulation of expression of endothelial cell luminal and

124 enomic sequences that may be involved in the regulation of expression of exons 1b and 1c of the RFC1

125 We demonstrate that regulation of expression of extracellular matrix compone

126 knowledge, this is the first example for the regulation of expression of flagella by hydrogen in any

127 NA immediately flanking fruA, to explore the regulation of expression of fruA by the carbohydrate sou

128 A better understanding of the regulation of expression of FUS may give insight into ho

129 a broad range of biological roles, including regulation of expression of genes and chromosomes.

130 ithelial cell growth is mediated by androgen regulation of expression of genes controlling cell cycle

131 produced at 37 degrees C and are involved in regulation of expression of genes encoding stress respon

132 Marked up regulation of expression of genes involved in interferon

133 of intracellular redox state by Nrf2-related regulation of expression of genes involved in intracellu

134 re accepted effects of this pathway, but the regulation of expression of genes involved in mesoderm s

135 ated the cis-acting elements involved in the regulation of expression of germ-line transcripts by pre

136 he hexosamine biosynthesis pathway (HBP) via regulation of expression of glutamine:fructose-6-phospha

137 Up-regulation of expression of group I and II mGluRs is cor

138 It is concluded that although a degree of regulation of expression of GSTs occurs in human pancrea

139 We conducted experiments to study the regulation of expression of heat shock proteins (HSPs) i

140 activation of interleukin-6-STAT3 signaling, regulation of expression of hepatic C/ebpalpha, C/ebpbet

141 We have examined the regulation of expression of human colonic MCT1 by butyra

142 due to inhibition of the fasting-induced up-regulation of expression of hypothalamic orexigenic neur

143 lls and differentiated T cells results in up-regulation of expression of I.1 isoform of HIF-1 alpha m

144 hanism of action, and the molecular basis of regulation of expression of IL-21 and its receptor.

145 ions demonstrating both S. aureus-induced up-regulation of expression of IL-6 and IL-12p40 mRNA and s

146 nscription activation, which is important in regulation of expression of immediate-early response gen

147 The fast initial down-regulation of expression of inflammatory mediators coinc

148 Regulation of expression of inflammatory mediators was e

149 Temporal and spatial regulation of expression of introduced genes, or of RNAi

150 equences of depletion of isoprenoid pools on regulation of expression of isoprenylated proteins have

151 Mechanisms governing the regulation of expression of its subunit genes remain lar

152 nfiltration was followed by the transient up-regulation of expression of LIFR, IL-6, and IL-6R in ens

153 Hence, discordant regulation of expression of major histocompatibility com

154 tion factors also play critical roles in the regulation of expression of many functional genes in the

155 f the POU domain factors, is involved in the regulation of expression of many tissue-specific and hou

156 e results indicate a key role for Ids in the regulation of expression of Math1 and hair cell differen

157 dy, we investigated the role of SphK1 in the regulation of expression of matrix metalloproteinase 1 (

158 esults suggest that TIMP3 is involved in the regulation of expression of matrix metalloproteinases in

159 ed immunosorbent assays were used to examine regulation of expression of metalloproteinases and chemo

160 reduction in iron cofactor availability, and regulation of expression of methyl-modifying enzymes.

161 gulation might play an important role in the regulation of expression of miRNAs in acute leukemias.

162 Recent studies implicated E2F in regulation of expression of mitochondria-associated gene

163 MKK4 signaling cascade showed a loss or down-regulation of expression of MKK4 or c-Jun, a downstream

164 RK-MAPK and PKC pathways are involved in the regulation of expression of MMP-2 and TIMP-1 and -2.

165 on antitumor agents results in p53 dependent regulation of expression of most TLR genes in human prim

166 Analyses of hormone regulation of expression of mRNA for the aleurone RNase

167 developed slowly, and was associated with up-regulation of expression of mRNA for the MAC inhibitor C

168 ping study and functional analyses implicate regulation of expression of MSMB as a plausible mechanis

169 ons, CD63, MMP-3 and Cdc42, and that PYY/NPY regulation of expression of mucosal proteins such as vil

170 n promoter that may contribute to coordinate regulation of expression of multiple cell-type specific

171 vo results suggest a carbon source-dependent regulation of expression of Mxr1-activated genes by 14-3

172 Here, pre-let-7a transfections led to down-regulation of expression of MYC and its target genes and

173 This includes up-regulation of expression of N-cadherin and c-MYC and dow

174 d with an increased proliferation and a down-regulation of expression of negative regulators of the J

175 asmic-interacting protein, BOD1, leads to up-regulation of expression of numerous genes modulating fa

176 Noncoding RNAs have been implicated in the regulation of expression of numerous genes; however, the

177 ate an important role for these genes in the regulation of expression of other CoA biosynthesis genes

178 pecies-specific and conserved mechanisms for regulation of expression of P-selectin, we cloned the 5'

179 ingly, one cell line exhibited complete down-regulation of expression of p14(ARF), with only slight d

180 xpression of p14(ARF), with only slight down-regulation of expression of p16(INK4a).

181 expression of N-cadherin and c-MYC and down-regulation of expression of p53 and E-cadherin.

182 ort that DNA methylation plays a role in the regulation of expression of pathogenically relevant gene

183 ons indicate that CsrABb plays a role in the regulation of expression of pathophysiological determina

184 pilB, a transcription factor involved in the regulation of expression of pili, from Neisseria gonorrh

185 of PLD (hPLD1-K898R or mPLD2-K758R) or down-regulation of expression of PLD with PLD1 or PLD2 siRNA

186 and NF-kappaB signaling, as well as the down-regulation of expression of prosurvival genes.

187 Its primary function is the regulation of expression of pyrimidine biosynthetic (pyr

188 t cause cell cycle arrest but did cause down-regulation of expression of RB, p107, p130, and other pr

189 The deduced structure and the regulation of expression of rDEP-1 suggest that it may p

190 ic acid biosynthesis in murine liver through regulation of expression of regucalcin or senescence mar

191 the first evidence that this is mediated by regulation of expression of replication-dependent core h

192 utant cspE was functional with respect to up-regulation of expression of rpoS, but, unlike the wild-t

193 3)-dependent 32Dcl3 did not result in the up-regulation of expression of secondary granule genes comp

194 ting possibility that fungi use differential regulation of expression of secondary metabolite gene cl

195 of tooth morphogenesis through antagonistic regulation of expression of secreted Wnt antagonists, in

196 umber of genes was performed and a strong up-regulation of expression of secretory phospholipase A(2)

197 ia nitrite reductase NirS contributes to the regulation of expression of selected virulence factors i

198 ersus P-selectin represents a novel level of regulation of expression of selectin ligands and lymphoc

199 morphogenesis by pathways other than through regulation of expression of semaphorin and ephrin.

200 first of which we are aware, to demonstrate regulation of expression of SERCA2a, a critical determin

201 our results show that there is differential regulation of expression of several genes in the mannose

202 protein responsible for post-transcriptional regulation of expression of several iron metabolism prot

203 s may be patterned during development by the regulation of expression of single genes.

204 mal phenotype is accompanied by gradual down-regulation of expression of Smad3.

205 Such ribosome stalling is used for regulation of expression of some bacterial and eukaryoti

206 for cell proliferation in contrast with the regulation of expression of specific genes.

207 osphorylation targets that might explain Stk regulation of expression of specific operons and the pos

208 can respond to fetal demand signals through regulation of expression of specific placental transport

209 the Type I IFN receptor (IFNR), there is up-regulation of expression of Sprouty (Spry) proteins 1, 2

210 results provide insight into KstR2-mediated regulation of expression of steroid catabolic genes and

211 role played by host-pathogen interactions in regulation of expression of streptococcal virulence fact

212 s in muscle fibers that may experience local regulation of expression of structural proteins that are

213 ion of spontaneous cytotoxicity based on the regulation of expression of surface molecules involved i

214 We found that K-201 significantly reduced up-regulation of expression of terminal differentiation mar

215 In the current study, we investigated the regulation of expression of the A3 AR gene, focusing on

216 revious results, a model is proposed for the regulation of expression of the alpha IIb gene.

217 hese studies establish a role for Sp1 in the regulation of expression of the angiogenic factor TP in

218 of Src or Stat3 is also accompanied by down-regulation of expression of the anti-apoptotic genes, Bc

219 nes affect production of antibiotics through regulation of expression of the antibiotic-specific regu

220 RE activation by a mechanism other than down-regulation of expression of the AR.

221 Regulation of expression of the Arabidopsis COB gene fam

222 The up-regulation of expression of the B7 family of molecules h

223 stand this regulatory system, studies of the regulation of expression of the beta-glycosidase gene (l

224 Regulation of expression of the catalytic subunit, human

225 of TCR signaling in lineage commitment, the regulation of expression of the CD4 and CD8 genes, and t

226 here that the GC reaction required biphasic regulation of expression of the cell-cycle regulator c-M

227 These data support a model of regulation of expression of the CFTR gene in which multi

228 Regulation of expression of the CFTR gene is poorly unde

229 ze of Dunaliella salina, we investigated the regulation of expression of the Chl a oxygenase (CAO) an

230 FOXO1 in these cells is also involved in regulation of expression of the critical master regulato

231 ast formation, and suggest that differential regulation of expression of the CSF-1 isoforms may influ

232 s indispensable for the post-transcriptional regulation of expression of the cyclins.

233 show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pi

234 f poly(ADP-ribose) polymerase (PARP), and up-regulation of expression of the Fas ligand.

235 Regulation of expression of the fatty acid desaturase Ol

236 Regulation of expression of the gene encoding interleuki

237 ter effect was found to be accompanied by up-regulation of expression of the gene for the F-box prote

238 We have investigated the regulation of expression of the genes encoding CS1 pili

239 The regulation of expression of the genes encoding the cellu

240 We propose that loss of up-regulation of expression of the genes for glucose transp

241 Transcriptional regulation of expression of the human mitochondrial thia

242 ral nervous system often show a transient up-regulation of expression of the immediate early gene c-f

243 such as nitroxyl and peroxynitrite, after up-regulation of expression of the inducible nitric oxide s

244 indings that expand our understanding of the regulation of expression of the iscRSUA genes in Salmone

245 vity may provide a basis for the coordinated regulation of expression of the Klf4 gene in the intesti

246 that has been proposed to be involved in the regulation of expression of the LEE1 operon.

247 he specification of serotonergic neurons via regulation of expression of the Lmx1b transcription fact

248 Inhibition of RNA editing by down-regulation of expression of the mitochondrial RNA editin

249 rmation is currently available regarding the regulation of expression of the multiple protease genes.

250 one abscisic acid (ABA), are involved in the regulation of expression of the NPR1 gene of Lemna gibba

251 In parallel, we examined the regulation of expression of the PAF acetylhydrolase gene

252 port here that parS also participates in the regulation of expression of the par genes.

253 for transcriptional and posttranscriptional regulation of expression of the pIgR.

254 Both RpoN and PilR are involved in regulation of expression of the pilA gene, whose product

255 S) to experimental animals results in the up-regulation of expression of the plasma form of platelet-

256 The cell type specificity of the regulation of expression of the potent growth inhibitory

257 from our murine models revealed DMA-mediated regulation of expression of the proinflammatory cytokine

258 port that Rbm15 may function in part through regulation of expression of the proto-oncogene c-Myc.

259 at this H1b protein plays a specific role in regulation of expression of the replication-dependent hi

260 , these results revealed a difference in the regulation of expression of the TCR/CD3 complex on CD4+

261 Down-regulation of expression of the transporters for CMP-sia

262 The distinct patterns of regulation of expression of the two isoforms suggest dis

263 However, a link between regulation of expression of the two transporters in resp

264 domain of the type III receptor resulting in regulation of expression of the type III receptor at the

265 The up-regulation of expression of these genes during forelimb

266 This process leads to regulation of expression of these genes.

267 However, the regulation of expression of these HAS isoforms at transc

268 transcripts, suggesting posttranscriptional regulation of expression of these latter genes.

269 The regulation of expression of these receptors occurs at th

270 ty complex class II, suggesting a coordinate regulation of expression of these various B-cell-specifi

271 Differential regulation of expression of this complex gene family sug

272 anism of action of these two hormones in the regulation of expression of this gene, we cloned the 127

273 translational fusion construct to study the regulation of expression of this gene.

274 ating liver, indicating post-transcriptional regulation of expression of this gene.

275 To increase our understanding of the regulation of expression of this imprinted gene, we have

276 Our data further suggest a dynamic regulation of expression of this pathway in the gastroin

277 Down-regulation of expression of trmD, encoding the enzyme tR

278 the present study, we have investigated the regulation of expression of two key heparan sulfate chai

279 ve PI 3-kinase controls cell motility by the regulation of expression of uPA through the activation o

280 ands in attenuation of new vessel growth via regulation of expression of VEGF or soluble fms-like tyr

281 rt of transcription are not required for the regulation of expression of vrg6.

282 rly, there is no information on the hormonal regulation of expression of WNK kinases.

283 for therapeutic targeting of RGS proteins by regulation of expression or allosteric modulation to per

284 ntal settings, but little is known about the regulation of expression or function of neutrophil ICAM-

285 n in the DRG may be due to glucose-driven up-regulation of expression or the result of impaired axona

286 colonic expression of meprin alpha, although regulation of expression, particularly under inflammator

287 Regulation of expression studies showed that the malE ge

288 n chemical, functional, pharmacological, and regulation of expression studies, human alpha4 and beta2

289 nfectious cycle of B. burgdorferi, the tight regulation of expression suggests a beneficial contribut

290 e endogenous ligase by RNA interference down-regulation of expression, the added proteins were integr

291 thrombospondin 2 gene (THBS2) important for regulation of expression, the sequences of 5 kb of the p

292 extent by nucleosome prepositioning but that regulation of expression through these sites is dictated

293 is more similar in primary sequence and the regulation of expression to levansucrases of gram-negati

294 Studying the genetic regulation of expression variation is a key method to di

295 d in a series of pathways such as epigenetic regulation of expression (via TLE1 and HTATIP), biosynth

296 For the majority of the miRNAs, genetic regulation of expression was independent of the expressi

297 vated AKT resulted in rapamycin-induced down-regulation of expression, whereas low levels resulted in

298 CFTR shows tight tissue-specific regulation of expression, which is largely determined by

299 1R activity in vitro with NVP-AEW541 or down-regulation of expression with siIGF1R led to cytotoxicit

300 esence of specific mRNAs, but do not address regulation of expression within a single cell at a singl