ライフサイエンスコーパス: regulatory element

1 ated by the hepadnaviral posttranscriptional regulatory element.

2 tially dependent on the Sfpi1 14 kB upstream regulatory element.

3 abrogated critical functions of this T cell-regulatory element.

4 trolled via a conserved FOXG1/SOX2-bound cis-regulatory element.

5 ecific motor neuron subsets via discrete cis-regulatory elements.

6 ssion by regulating the accessibility of DNA regulatory elements.

7 s and preventing cross talk between distinct regulatory elements.

8 due to control of plasticity by short-range regulatory elements.

9 in such pairs revealed emerging asymmetry of regulatory elements.

10 served genomic regions displaying common cis-regulatory elements.

11 dependent feedback regulation through distal regulatory elements.

12 s of tissues or cells, e.g. lineage-specific regulatory elements.

13 which enabled the identification of putative regulatory elements.

14 esert that contains conserved putative PITX2 regulatory elements.

15 bserve an enrichment of reQTLs in distal cis-regulatory elements.

16 tors/co-factors and epigenetic states at cis-regulatory elements.

17 ise perturbation of the activity of specific regulatory elements.

18 gulation involves both positive and negative regulatory elements.

19 overlap with H4Acetylation, a mark of active regulatory elements.

20 d Nr4a1 protein directly bound to Mertk gene regulatory elements.

21 onarily conserved and are enriched in distal regulatory elements.

22 ential for endogenous functionality of these regulatory elements.

23 ignals in the same loci; and located in gene regulatory elements.

24 by PER, depending on the particular promoter regulatory elements.

25 oswitches and further suggest novel putative regulatory elements.

26 f cell and tissue types to identify putative regulatory elements.

27 , regulatory variants, haplotypes, and other regulatory elements.

28 ate genome-wide maps of interactions between regulatory elements.

29 ve disruptions of their binding sites at key regulatory elements.

30 mark that distinguishes cell types and marks regulatory elements.

31 on suggest the locus acts through changes to regulatory elements.

32 functions independently of the E1 and E2 cis-regulatory elements.

33 motifs for these TFs in alphaTC1/betaTC6 cis-regulatory elements.

34 I) in eukaryotes rely on the transcriptional regulatory elements.

35 embryonic stem cells, and identified 45 cis-regulatory elements.

36 xtensive binding of Smad2/3/4 to GC-rich cis-regulatory elements.

37 s in both protein-coding genes and noncoding regulatory elements.

38 fication of disease-causal mutations of gene regulatory elements.

39 nopus patterning, loss of the 11-bp negative regulatory elements (11-bp NREs) broadened dorsal expres

40 lso implement H3K4me3 at a subset of non-TSS regulatory elements, a subset of which shares epigenetic

41 ications in combination with CTCF binding at regulatory elements account for the transcriptional grad

42 e's transcriptome to predict its genome-wide regulatory element activities measured by DNase I hypers

43 a regulome database, predicting differential regulatory element activities, and facilitating regulome

44 e genome-engineering based evaluation of RNA regulatory element activity (GenERA), a clustered regula

45 S) for improved high-throughput screening of regulatory element activity in the native genomic contex

46 egulatory elements and/or cell type-specific regulatory elements an interactive and dynamic experienc

47 Regulatory element analysis of these deregulated snoRNA

48 erimental approaches) confirms that they are regulatory elements and affect the expression of cancer

49 ess affecting coding sequences and noncoding regulatory elements and contributing a continuum of driv

50 Collectively, these findings identify cis-regulatory elements and corresponding trans-acting facto

51 nce on contacts of DNA-binding proteins, cis-regulatory elements and DNA consensus motifs.

52 ts for copy number variation of the putative regulatory elements and found an overlapping deletion in

53 med a screen to identify H2-T6SS and H3-T6SS regulatory elements and found that the posttranscription

54 in B6 mice also altered the activity of gene regulatory elements and genome-wide occupancy of PPARgam

55 ith predicted changes in the activity of cis-regulatory elements and is associated with changes in ta

56 to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordere

57 riched in conserved regions, colocalize with regulatory elements and may modulate certain histone mod

58 tures that orient transcription at divergent regulatory elements and prime transcriptional responses

59 and the physical interactions between distal regulatory elements and promoters.

60 The regulatory elements and the environmental signals contro

61 development will require determining how cis-regulatory elements and their cognate transcription fact

62 Recent studies suggest that gene regulatory elements and their target genes generally occ

63 However, RNA cis-regulatory elements and trans-acting factors contributin

64 Integration of these data revealed regulatory elements and transcription factors that under

65 ns between heterogeneously methylated distal regulatory elements and transcription of key pluripotenc

66 , while CHD2 coassociated with NKX2-1 at cis-regulatory elements and was required for their transacti

67 ed assessment of the genome using predefined regulatory elements and within the first intron of all g

68 that they choose, making detection of common regulatory elements and/or cell type-specific regulatory

69 ing variants enriched at enhancers and other regulatory elements, and 52 were linked to genome-wide a

70 e polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data t

71 of gene regulation imposed by each class of regulatory elements, and found the strongest elements we

72 l arrangement of the genes, and their distal regulatory elements, and it provides an update on the me

73 Downstream regulatory element antagonist modulator (DREAM), a trans

74 erization of the genomic features underlying regulatory elements, applicable to the design of synthet

75 nucleus involving gene promoters and distal regulatory elements are currently considered major force

76 ains even when all these major categories of regulatory elements are excluded, and this constraint is

77 However, active gene regulatory elements are generally hypomethylated relativ

78 results have broad implications for how cis-regulatory elements are identified, prioritized and func

79 eus and the interactions of genes with their regulatory elements are key features of transcriptional

80 anscription initiation start (TIS) where two regulatory elements are located.

81 YY1-mediated interactions between NPC regulatory elements are often nested within constitutive

82 Millions of cis-regulatory elements are predicted to be present in the h

83 on and our results suggest that a set of cis-regulatory elements are primed in early postnatal life w

84 hways are intimately linked and that certain regulatory elements are shared between them.

85 Thus, three hijackings of regulatory elements are sufficient to explain all aspect

86 leiotropic risk loci are enriched for B-cell regulatory elements, as well as an over-representation o

87 eage-specific enhancer repertoire, including regulatory elements associated with the Notch1, Rag1, an

88 e authors show that a non-coding polymorphic regulatory element at 7p14.3 may predispose to SPOP muta

89 iptomes to identify a non-coding polymorphic regulatory element at 7p14.3 that associates with DNA re

90 from direct binding of EBNA3A and EBNA3C to regulatory elements at these loci, producing stable repr

91 ding its 5' and 3' UTR) under the control of regulatory elements (Atoh1 3' enhancer/beta-globin basal

92 Sterol regulatory element binding protein (SREBP) is a major tr

93 been shown to be an inhibitor of the sterol regulatory element binding protein (SREBP), a key regula

94 id regulator the transcription factor sterol regulatory element binding protein 1 (SREBP-1) and its t

95 licated CpGs, cg11024682 (intronic to sterol regulatory element binding transcription factor 1 [SREBF

96 lines by inhibiting the activation of sterol regulatory-element binding protein 2 and downregulating

97 nse element consensus sequence in the sterol regulatory-element binding protein-1c (Srebp-1c) promote

98 Suppression of PIM3 involves the sterol regulatory element-binding (SREBP) transcription factors

99 godendrocyte-specific inactivation of sterol regulatory element-binding protein (SREBP) cleavage-acti

100 n a manner analogous to the mammalian sterol regulatory element-binding protein (SREBP)-1 and SREBP-2

101 within intron 16 of the gene encoding sterol regulatory element-binding protein 1 (Srebp1), an activa

102 K), which in turn directly suppresses sterol regulatory element-binding protein 1 (SREBP1)-directed t

103 proliferator-activated receptor gamma/sterol regulatory element-binding protein 1/CD36 in hepatocytes

104 Sterol regulatory element-binding protein 1c (SREBP-1c) is a ce

105 antly increased in WT mice, including sterol regulatory element-binding protein 1c target gene fatty-

106 olesterol synthesis by a reduction in sterol regulatory element-binding protein 2 (SREBP2)-regulated

107 yeast by controlling activity of the sterol regulatory element-binding protein transcription factor

108 rated that ER stress can activate the sterol regulatory element-binding protein-2 (SREBP2), an ER-loc

109 OPC/OLs show a strong increase in the sterol-regulatory element-binding protein-2 yet are unable to m

110 ed Scap, we have learned how it binds sterol regulatory element-binding proteins (SREBPs) and transpo

111 Sterol regulatory element-binding proteins (SREBPs) in the fiss

112 mTORC1 is known to activate sterol regulatory element-binding proteins (SREBPs) including S

113 GK5 formed a complex with the sterol regulatory element-binding proteins (SREBPs) through the

114 iculum (ER) membranes that transports sterol regulatory element-binding proteins to the Golgi complex

115 alterations of chromatin organization at cis-regulatory elements, but the molecular basis, extent, an

116 Therefore, the target genes of these regulatory elements can be considered candidate genes.

117 be a CRISPR affinity purification in situ of regulatory elements (CAPTURE) approach to unbiasedly ide

118 entifying chromatin features associated with regulatory elements (ChIP-seq, Bis-Seq, ChiA-PET).

119 cts the sign of epistasis in a canonical cis-regulatory element consisting of overlapping RNA polymer

120 tering burst fraction or burst size, but how regulatory elements control bursting parameters remains

121 ow plant transcription factors (TFs) and cis-regulatory elements control spatially specific stress re

122 accompanied the evolution of an antagonistic regulatory element controlling root hair development.

123 hIP-seq (H3K27ac and H3K4me1) to profile cis-regulatory elements (CREs) and using RNA-seq to characte

124 Cis-regulatory elements (CREs) are commonly recognized by co

125 widely used to identify the location of cis regulatory elements (CREs) including promoters and enhan

126 their influence through rearrangement of cis-regulatory elements (CREs) remains unclear.

127 transcription factors and the gene's own cis-regulatory elements (CREs), which remain unknown for mos

128 Cis-regulatory elements (CREs, e.g., promoters and enhancers

129 We identified a cis-regulatory element demarcated by a long non-coding RNA (

130 rge DNA loops that encompass genes and their regulatory elements depend on CTCF-CTCF interactions, bu

131 ng the functions of the millions of putative regulatory elements discovered in these studies remains

132 ncoded by a complex locus with candidate cis-regulatory elements distributed over a 329 kbp wide geno

133 In this study, we hypothesized that distal regulatory elements (DREs) are involved in optimal expre

134 uated the effect of genetic variation on DNA regulatory elements (DREs).

135 r genomics efforts have identified genes and regulatory elements driving cancer development and neopl

136 he promoter connectivity and activity of cis-regulatory elements during lineage commitment is crucial

137 simultaneous evolution of both the viral cis regulatory element (e.g., the DNA-binding site) and the

138 dies of the human genome have indicated that regulatory elements (e.g. promoters and enhancers) at di

139 Here, we identify two cis-regulatory elements (E1 and E2) functioning as shadow en

140 Thus, CATAC represents a novel cis-regulatory element encoding clock-controlled regulation.

141 ethods and ENCODE data, we have identified a regulatory element encompassing the ARHGAP42 SNP rs60472

142 It is unclear how many cis-regulatory elements exist, where these elements lie rela

143 mic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of b

144 as) using formaldehyde-assisted isolation of regulatory element (FAIRE)-sequencing.

145 The 300 bp Fms intronic regulatory element (FIRE), within the second intron of C

146 ntified, revealing details of this important regulatory element for allosteric regulation.

147 itating differential utilization of the same regulatory element for disparate functions.

148 a previously unrecognized type of downstream regulatory element for genes transcribed by RNA polymera

149 We sequenced coding and regulatory elements for 608 genes potentially involved i

150 indicate that ATAC-seq detects cell-specific regulatory elements for cell types comprising >/= 20% of

151 uctures that facilitate interactions between regulatory elements for gene expression.

152 eposition of newly synthesized H3.3 to these regulatory elements for gene regulation.

153 e sites throughout the genome, especially in regulatory elements for genes involved in T lymphopoiesi

154 ss- and gain-of-function screens to identify regulatory elements for the beta-globin and HER2 loci in

155 d that the psoriasis signals are enriched in regulatory elements from different T cells (CD8(+) T-cel

156 tively in cis to protect linked heterologous regulatory elements from methylation, thereby conferring

157 bility, transcription factor co-binding, and regulatory element function in mouse embryonic stem cell

158 which contains three overlapping cis-acting regulatory elements (GCN4, Skn1 and the RY-element) know

159 richment filters in order to identify distal regulatory elements harboring putative driver mutations

160 However, identifying functional gene regulatory elements has been challenging in the context

161 Relatedly, the vast majority of candidate regulatory elements have yet to be functionally validate

162 elements have undergone exaptation into gene regulatory elements, how transcribed SINE RNA impacts tr

163 ctivation, revealing environmentally-induced regulatory elements implicated in lung carcinogenesis.

164 r and highlight the lasso extension as a key regulatory element in ADP's ability to override ATP inhi

165 ion is regulated by a cell type-specific cis-regulatory element in group 1 ILCs that is demarcated by

166 illed by direct binding to a RY (CATGCA) cis-regulatory element in the GmWRI1a promoter, which was ab

167 r direct functional interrogation of RNA cis-regulatory elements in a native cellular environment.

168 for identifying candidate layer-specific cis-regulatory elements in adult mouse cortex.

169 opment and DNA methylation of imprinted gene regulatory elements in adulthood.

170 roaches to identify putative transcriptional regulatory elements in Atgl and then tested the effect o

171 matin sequencing was employed to map the cis-regulatory elements in CD8 T cells responding to acute a

172 nerate chromatin-state maps and identify cis-regulatory elements in clinical samples from various tum

173 nergized to underscore the importance of cis-regulatory elements in development as well produce count

174 investigations: e.g. discovery of structured regulatory elements in differential gene expression data

175 Epigenetic and genetic cis-regulatory elements in diploid organisms may cause allel

176 erved stronger cross-species conservation of regulatory elements in inhibitory neurons than in excita

177 order of events animating TF assembly at cis-regulatory elements in living cells and the long-range m

178 point to a possible role for H3K4me1 on cis-regulatory elements in specific settings to fine-tune tr

179 ic annotation can highlight potential causal regulatory elements in T2D-relevant tissues.

180 A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs.

181 on factors (TFs) that recognize specific cis-regulatory elements in the genes that they control.

182 ched DNA sequence motifs that may act as cis-regulatory elements in the promoters of LEC1 target gene

183 binding protein beta (C/EBPbeta) to discrete regulatory elements in the Wt1 locus.

184 pathogenic viruses had modifications in the regulatory elements in their long terminal repeats and d

185 throughput functional annotation of putative regulatory elements in their native chromosomal context.

186 Our study suggests that mutations of regulatory elements in tumors likely play an important r

187 hus, our comprehensive, unbiased analysis of regulatory elements in vivo reveals critical mechanisms

188 asymmetrically-modified nucleosomes occur at regulatory elements in vivo.

189 Further analysis identified other Cdx2 regulatory elements including a stem-cell specific regul

190 view of our regulatory genome, e.g. defining regulatory elements including all promoters and enhancer

191 ons affect both protein-coding genes and cis-regulatory elements, including a noncoding intronic tele

192 in-looping interactions between multiple cis-regulatory elements, including the TMEM106B promoter.

193 oducing a short 3'-UTR isoform that excludes regulatory elements, including the TTP- and miRNA-223-bi

194 -affinity binding sites within Teff cell cis-regulatory elements, including those of Prdm1.

195 ROD1 contains several short conserved cis-regulatory elements, including three copies of the motif

196 Second, we associated enriched regulatory elements inside differentially expressed mRNA

197 from the anterior side, bringing distant cis-regulatory elements into contact with Hox genes.

198 Our results suggest that no singular distal regulatory element is required for HPRT1 expression and

199 of single nucleotide polymorphisms (SNPs) in regulatory elements is an important goal.

200 at erosion of X. laevis genes and functional regulatory elements is associated with repeats and non-a

201 lencing, combined with the use of repetitive regulatory elements, led to aggressive transposon-like s

202 Counter-regulatory elements maintain dynamic equilibrium ubiquit

203 10,504 differentially methylated regions in regulatory elements marked by H3K27ac in MCL primary cas

204 Identification of HVR3 as a transcriptional regulatory element may contribute to between-individual

205 We identify proximal and distal regulatory elements necessary for expression of four emb

206 accumulating bicarbonate and CO2, but other regulatory elements of carbon concentration mechanisms i

207 at transcription factor LHX2 binds to distal regulatory elements of Fezf2 and Sox11, critical determi

208 We have discovered that specific promoter regulatory elements of glutamic acid decarboxylase isofo

209 estingly, we found CDX2 binding sites within regulatory elements of key pluripotent genes such as Pou

210 ncer and experimentally demonstrate they are regulatory elements of known cancer genes.

211 ous DNA modification frequently found within regulatory elements of mammalian genes.

212 llular stress pathways by binding to genomic regulatory elements of target genes and recruiting coreg

213 embly of the MyoD-Baf60c-Brg1 complex on the regulatory elements of target genes.

214 q and found that unlike the naive cells, the regulatory elements of the cytokine genes in the memory

215 e diminished the abundance of H3K4me1 at the regulatory elements of the gene encoding the transcripti

216 me differentially methylated in AML occur in regulatory elements of the human genome.

217 mains in several HECT family members are key regulatory elements of their catalytic activities.

218 hibiting the recruitment of PPARgamma to the regulatory elements of thermogenic genes.

219 at recruitment of KLF4 to the methylated cis-regulatory elements of these genes result in chromatin r

220 Changes in the cis-regulatory elements of these regulators are thought to c

221 sites (DHSs) enables the detection of active regulatory elements of transcription, including promoter

222 says revealed that C/EBPepsilon binds to the regulatory elements of Trem1 and regulates its expressio

223 ments, applicable to the design of synthetic regulatory elements or the interpretation of human genet

224 = 4.28) and breast-specific 'super-enhancer' regulatory elements (OR = 3.54).

225 We identified alphaTC1/betaTC6 cis-regulatory elements orthologous to those containing type

226 The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelia

227 l, we identified a set of 1,894 putative cis-regulatory elements (pCREs) that are associated with hig

228 n transcriptional promoters and their distal regulatory elements play an important role in transcript

229 Here, we present an algorithm, regulatory element prediction based on tissue-specific l

230 agents that counter the function of negative regulatory elements present in the 5' UTRs of some mRNAs

231 we systematically review and integrate those regulatory elements previously described in the literatu

232 association peaks overlapped with different regulatory elements related to cell types and tissues in

233 analysis showed the presence of several cis-regulatory elements related to stress and hormone respon

234 ures and the regulation of TF binding to cis-regulatory elements remains to be elucidated.

235 Transcriptional gene silencing of this regulatory element repressed TERT expression in an allel

236 BETi treatment, BETs are evicted from these regulatory elements, resulting in AMIGO2 silencing and c

237 sequences and the discovery of two root hair regulatory elements (RHE1 and RHE2) consistently and spe

238 RNA regulatory elements (RREs) are an important yet relative

239 whole transcriptome rather than limited to a regulatory element's neighboring genes.

240 Here we report a high-throughput method, cis-regulatory element scan by tiling-deletion and sequencin

241 ere we describe CRISPR-Cas9-based epigenomic regulatory element screening (CERES) for improved high-t

242 elerated regions (HARs), a subset of genomic regulatory elements showing accelerated evolution betwee

243 Large regulatory elements, so-called super-enhancers (SEs), ar

244 identified known and previously unidentified regulatory elements, some of which were dependent on cel

245 -genome scan of genetic variants in splicing regulatory elements (SREs) and evaluated the extent to w

246 Long-range cis-regulatory elements such as enhancers coordinate cell-sp

247 d on the effects of genomic variation at cis-regulatory elements such as promoters and enhancers that

248 Cis-regulatory elements such as transcription factor (TF) bi

249 Open chromatin regions allow regulatory elements such as transcription factors and po

250 between these RNA-binding proteins and other regulatory elements, such as miRNAs and long noncoding R

251 Here we present 'survey of regulatory elements' (SuRE), a method that assays more t

252 and long-distance cooperativity between gene-regulatory elements target a single chromosome for regul

253 ons between constituent transcription factor regulatory elements (TFREs).

254 ved region C (CR-C), a promoter proximal cis-regulatory element that is critical to PD-1 expression i

255 ing to a consensus forkhead site in this cis-regulatory element that we show is crucial for Rag expre

256 Divergence between interacting regulatory elements that affect gene expression (i.e., r

257 Enhancers are modular regulatory elements that are central to the spatial and

258 ins NA and HA also function as translational regulatory elements that are controlled by the viral RNA

259 mans, may be explained by FEZF2-mediated cis-regulatory elements that are found only in higher primat

260 ge to position the TAL1/LMO2/LDB1 complex to regulatory elements that are important for the establish

261 connectivity patterns associated with these regulatory elements that are robust across cell types an

262 n of genes requires communication with their regulatory elements that can be located elsewhere along

263 atin interaction data sets for 37 active DNA regulatory elements that colocalize with known susceptib

264 tures to the binding and activity of genomic regulatory elements that contain motifs for PPARgamma, a

265 Riboswitches are regulatory elements that control gene expression by alte

266 ve enabled the genome-wide identification of regulatory elements that control limb development, yield

267 tion factors interact to select and activate regulatory elements that control microglia development a

268 This approach identified putative regulatory elements that control MYB expression.

269 ose binding is a signature of enhancers, cis-regulatory elements that control patterns of gene expres

270 This suggests the presence of additional regulatory elements that determine the time and order of

271 The cis-acting regulatory elements that direct expression in the anteri

272 Riboswitches are structural genetic regulatory elements that directly couple the sensing of

273 d the atlas of brain cell types and identify regulatory elements that drive conserved brain cell dive

274 eosinophils and enzymatic lipid oxidation as regulatory elements that facilitate both hemostasis and

275 oad domain promoters and super enhancers are regulatory elements that govern cell-specific functions

276 rt 3'-untranslated region (UTR) form lacking regulatory elements that guide local translation.

277 he predictive design of post-transcriptional regulatory elements that regulate translation rate.

278 in modifications, we identify putative novel regulatory elements that repress gene expression in a li

279 ision points in the lineage tree, identified regulatory elements that were enriched in cell-type-spec

280 icking required either of two cis-acting RNA regulatory elements: the 5' packaging signal (Psi) bound

281 ility is a feature of cell-type-specific cis-regulatory elements; therefore, mapping of DNase I hyper

282 activates MYC via binding to B-cell-specific regulatory elements, thus implicating this oncogene in C

283 with human genetic disorders can affect cis-regulatory elements to alter RNA editing.

284 uncovered that MYF5 and MYOD bind common DNA regulatory elements to alter transcription of genes that

285 filing integrates information across diverse regulatory elements to reveal the transcriptionally acti

286 4C-Seq assays showed that several distal cis-regulatory elements upstream of the disrupted ZPBP2 CTCF

287 xpression by modulating activities of distal regulatory elements, we adapt the self-transcribing acti

288 ncover specific sequence requirements within regulatory elements, we developed a bisulfite-mediated n

289 essibility and binding of Helios at PD-1 cis-regulatory elements were increased, resulting in enhance

290 o be repaired and expressed under its native regulatory elements, which are essential for genes invol

291 on factor (TF) footprints embedded in active regulatory elements, which are highly enriched for islet

292 genes, housekeeping genes, and constitutive regulatory elements, which are known to show increased e

293 tic modifications and CTCF binding at select regulatory elements, which corresponded to the alteratio

294 ease susceptibility loci colocalize with DNA regulatory elements, which influence gene expression thr

295 pe-specific distributions, and we identified regulatory elements with differential methylation across

296 0-15% of bacterial genomes, and contain many regulatory elements with key functions.

297 identified a significant number of putative regulatory elements with signals for both P53 and cMYC.

298 h MTP-C translation is strongly inhibited by regulatory elements within its 5'-UTR.

299 Cis-regulatory elements within the respective promoter seque

300 is achieved through the interactions of the regulatory elements within them or if these interactions