ライフサイエンスコーパス: regulatory pathway

1 y co-option of the retinoblastoma cell cycle regulatory pathway.

2 C metastasis through the hTERT-miR-29a-ITGB1 regulatory pathway.

3 action of the C-repeat binding factor (CBF) regulatory pathway.

4 actors and is mediated by the Gac/Rsm global regulatory pathway.

5 for the activation of the central RpoN-RpoS regulatory pathway.

6 d identify downstream components of the ExoR regulatory pathway.

7 tyl) O-methyltransferase, suggesting a novel regulatory pathway.

8 lecular components of the NLRP3 inflammasome regulatory pathway.

9 unctions downstream of MED13 within a muscle-regulatory pathway.

10 identified as a new player in the T6P/SnRK1 regulatory pathway.

11 the carbohydrate metabolism and the ecdysone regulatory pathway.

12 iptional activation by the TGFbeta-SMAD gene regulatory pathway.

13 eric Kv7.4 channels were insensitive to this regulatory pathway.

14 the cell, including important signaling and regulatory pathways.

15 cal signaling molecule in diverse biological regulatory pathways.

16 e resource for analyzing plant metabolic and regulatory pathways.

17 94 were involved in three metabolic and four regulatory pathways.

18 Human islets shared many of these regulatory pathways.

19 f-renewing and pluripotent state by multiple regulatory pathways.

20 relocation of proteins forms the mainstay of regulatory pathways.

21 lung cancer through affecting all major cell regulatory pathways.

22 s implicated in an ever-increasing number of regulatory pathways.

23 important for uncovering their function and regulatory pathways.

24 d by altered metabolism of key molecules and regulatory pathways.

25 the melanocyte lineage by targeting diverse regulatory pathways.

26 vo, implicating another Ser5 kinase in these regulatory pathways.

27 pressing the expression of negative feedback regulatory pathways.

28 ology of muscular dystrophy through multiple regulatory pathways.

29 and methionine sulfoximine (Msx)-responsive) regulatory pathways.

30 field is the lipid-mediated inflammatory and regulatory pathways.

31 proteins in the regulation of diverse growth regulatory pathways.

32 t of PipX in at least three NtcA-independent regulatory pathways.

33 share immune-suppressing gene expression and regulatory pathways.

34 res that are orthogonal to the host's native regulatory pathways.

35 ifferentiation are influenced by a number of regulatory pathways.

36 utations affects several epigenetic and gene regulatory pathways.

37 e intriguing possibility of undiscovered NMD regulatory pathways.

38 Cancer is a disease of subverted regulatory pathways.

39 Gs/cAMP-dependent and Gs-independent/growth-regulatory pathways.

40 ffects on gene transcription and non-genomic regulatory pathways.

41 ne selection, and improving understanding of regulatory pathways.

42 known to play a substantial role in various regulatory pathways.

43 d sword" related to interference with immune-regulatory pathways.

44 inth infections can suppress allergy through regulatory pathways.

45 n disrupt cell-type-specific transcriptional regulatory pathways.

46 actors but do have a variety of adhesins and regulatory pathways.

47 e involved in a broad range of metabolic and regulatory pathways.

48 l roles in a host of different metabolic and regulatory pathways.

49 This novel regulatory pathway allows enhanced induction of regulato

50 This regulatory pathway allows the production of a neuron-spe

51 The findings represent a new mitochondrial regulatory pathway and a potentially powerful means to p

52 hich function sequentially in the neurogenic regulatory pathway and are also required for the differe

53 , by device type, and overall, stratified by regulatory pathway and modification type.

54 dentified a new regulator in the cytokinesis regulatory pathway and reiterated that a backup cytokine

55 press these responses by activating negative regulatory pathways and checkpoints such as PD-1/PD-L1 a

56 rmacological inhibitors targeting epigenetic regulatory pathways and discovered that NA activates bet

57 Cross-talk between sterol regulatory pathways and inflammatory pathways has been d

58 pathways) has elaborated different chromatin regulatory pathways and the involvement of noncoding RNA

59 nal regulation of almost every cellular gene-regulatory pathway, and it therefore is not surprising t

60 and glucose homeostasis through a PPARgamma regulatory pathway, and its inhibition could be clinical

61 l conidiation by controlling the conidiation regulatory pathway, and that all three pigmentation gene

62 the proper probiotic strain identification, regulatory pathways, and how healthcare providers can ch

63 urately delineate their identities, origins, regulatory pathways, and relevance to normal vascular st

64 rrelative link between central metabolic and regulatory pathways, and they suggest that the Gac syste

65 Many regulatory pathways are involved in liver regeneration a

66 Many regulatory pathways are involved in liver regeneration a

67 iple transcriptional and posttranscriptional regulatory pathways are triggered in response to cardiac

68 n, cytoskeleton organization, and cell-cycle regulatory pathways as major pathways controlled by PEAK

69 ether, these findings identify Trib3 and its regulatory pathways as potential targets to suppress the

70 several loci that may serve as hubs in gene regulatory pathways associated with GBM.

71 or the first time to our knowledge, a direct regulatory pathway between ERalpha and HIF-1alpha, which

72 ustrates the existence of potent competitive regulatory pathways between NK cells and CD8 T cells in

73 rget of rapamycin complex 1 as the major IEC regulatory pathway, but mechanistic target of rapamycin

74 This article focuses on the US federal regulatory pathway by which CancerLinQ will accept patie

75 actin oligomers and PMCA represents a novel regulatory pathway by which the cortical actin cytoskele

76 Collectively, our data reveal a regulatory pathway by which the negative regulator Foxo1

77 The regulatory pathways by which C. difficile initiates spor

78 onpolymorphic, the sulfatide-mediated immune-regulatory pathway can be targeted for development of no

79 Today, plant regulatory pathways can be reconstituted in heterologous

80 ring universally, but the upstream flowering regulatory pathways can differ markedly among plants.

81 tes an endogenous antitumor response, immune regulatory pathways can subvert the effector phase and e

82 n TAF6, which encodes a core transcriptional regulatory pathway component.

83 Identification of these regulatory pathway components will be critical for desig

84 PilB functions as an intermediary in the EPS regulatory pathway composed of the T4P upstream of the D

85 These findings establish a novel regulatory pathway connecting histone modification and h

86 This novel regulatory pathway connects an influx of energy as fat f

87 tively described as "immunometabolism." Core regulatory pathways conserved in all eukaryotic cells in

88 A conserved conidiation regulatory pathway containing Mr-BrlA, Mr-AbaA and Mr-We

89 al landscape to identify a context-dependent regulatory pathway controlling APA in the Caenorhabditis

90 of Rcy1 in chromosome regulation and another regulatory pathway controlling the Cse4 level and activi

91 This regulatory pathway controls the transcription of the fox

92 To meet this challenge, a complex set of regulatory pathways controls nearly every aspect of cell

93 matory COX2/PGE2 pathway and the YAP1 growth-regulatory pathway cooperate to recruit the stem cell fa

94 t Cbz-B3A reveals a previously unappreciated regulatory pathway coordinating cytosolic protein qualit

95 he differentiation of MDSC into TAM, and its regulatory pathway could be a potential target for thera

96 hich lack SKAP1, suggesting an ADAP integrin-regulatory pathway different from those in lymphocytes.

97 Drug Administration, and therefore stringent regulatory pathways do not exist to guide research and m

98 experiments support the existence of a novel regulatory pathway: ECs secrete factors that remodel RPE

99 CN) mouse, we examined whether an interorgan regulatory pathway exists, such that a loss of hepatic C

100 rameters to ideally be incorporated within a regulatory pathway for drug approval.

101 , we have identified a SUMOylation-dependent regulatory pathway for GlyR endocytosis, which may have

102 This study describes a regulatory pathway for IL-27 expression and cytotoxic T

103 tein kinase (PKA) signaling is a fundamental regulatory pathway for mediating cellular responses to h

104 with previous findings implicate a dual PIP2 regulatory pathway for NBCe1 involving both PIP2 itself

105 The regulatory pathway for this new group A meningococcal co

106 Here, we report the definition of a novel regulatory pathway for translational initiation with pos

107 In summary, we describe here a novel regulatory pathway for vitamin B3 that could provide a n

108 on from multiple systems to identify a novel regulatory pathway for Wnt signaling and potential thera

109 results highlight the importance of multiple regulatory pathways for interactions of plasticity mecha

110 l gammadelta T cells, we reveal two separate regulatory pathways for Ly49E expression, as follows: a

111 Although recent studies have identified regulatory pathways for the control of growth during veg

112 indicate the presence of previously unknown regulatory pathways for the production of toxoflavin tha

113 p computational tools to efficiently extract regulatory pathways from the resultant experimental shap

114 The extent to which this branch of m(6)A RNA-regulatory pathway functions in vivo and contributes to

115 This study identifies an innate immune regulatory pathway governing goblet cell mucus secretion

116 Reestablishment of competent regulatory pathways has emerged as a strategy to reduce

117 The identification of aging-regulatory pathways has enabled scrutiny of this hypothe

118 Several international regulatory pathways have been developed to expedite entr

119 A variety of feedback regulatory pathways have evolved to prevent an inappropr

120 Multiple regulatory pathways impact RB function, including the ub

121 factor (IGF) system is a well-studied growth regulatory pathway implicated in breast cancer biology.

122 Despite this, the regulatory pathways implicated in the HSC DNA damage res

123 a physical link at the crossroads of various regulatory pathways important for the growth and virulen

124 haracterize molecular responses and identify regulatory pathways important to cardiovascular health.

125 ding protein 2 (SREBP-2) cholesterol genetic regulatory pathway in a hepatocyte.

126 current study, we identify the role of a key regulatory pathway in alcohol-induced persistent molecul

127 study demonstrates a previously unidentified regulatory pathway in fibrogenesis in which a macrophage

128 onstrate the requirement of the GATA3/CTLA-4 regulatory pathway in fresh neoplastic CD4+ T cells.

129 Our findings reveal a novel regulatory pathway in ILC2-mediated pulmonary inflammati

130 al role for neurotrophins and identify a new regulatory pathway in insulin secretion that can be targ

131 Our results define a novel regulatory pathway in KRAS-driven cancers, which offers

132 Autophagy is a regulatory pathway in liver fibrosis.

133 al and distal components of this unique ENaC regulatory pathway in lung fluid balance.

134 Our findings reveal a novel regulatory pathway in myeloma cells through which JNK2 s

135 to provide insight into an epigenetic-miRNA regulatory pathway in pressure overload-induced cardiac

136 he present study, we characterized the FOSL1 regulatory pathway in rat trophoblast cells.

137 e existence of a novel B7-H1-mediated immune-regulatory pathway in T cells, which selectively limits

138 ew study by Murakami et al. uncovers a novel regulatory pathway in which an N-terminal di-proline mot

139 In this work, we describe a novel regulatory pathway in which reduced translational fideli

140 We propose a regulatory pathway in which spermatogenic leucine zipper

141 Collectively, our findings reveal a novel regulatory pathway in which the REGgamma-proteasome cont

142 infection stimulates unique transcriptional regulatory pathways in A. fumigatus.

143 Our results revealed multiple inter-regulatory pathways in Arg-auxotrophic response, consist

144 aceae-specific FIS-PRC2 complex modified the regulatory pathways in female gametophyte and seed devel

145 in levels, and functional assays for calcium regulatory pathways in human HCM surgical samples with (

146 and murine ILC2s confirms the activation of regulatory pathways in ILC2s by IFN-alpha.

147 The present data suggest that cytokine regulatory pathways in macrophages predominate over othe

148 ronal cells indicate that actin cytoskeletal regulatory pathways in nuclei have a direct role in the

149 c proteolytic complex involved in nearly all regulatory pathways in plant cells.

150 Blocking epigenetic regulatory pathways in specific regions of the spinal co

151 Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance antitumor immu

152 to therapeutic agents designed to block the regulatory pathways in T cells, such as programmed death

153 Recent discoveries of new ion transport and regulatory pathways in the distal nephron and collecting

154 NA decay (NMD), an RNA surveillance and gene-regulatory pathway, in noncycling cells.

155 Negative regulatory pathways include extrinsic suppression mechan

156 s host cell proteins to dysregulate multiple regulatory pathways, including apoptosis and senescence.

157 Interrogation of three RNA regulatory pathways indicated that the expanded CGG repe

158 "Orbital-deconvolution" elucidated upstream, regulatory pathways interconnecting human susceptibility

159 ort, we have identified a Pitx2:beta-catenin regulatory pathway involved in epithelial cell different

160 to microenvironmental stimuli; however, the regulatory pathways involved in epigenetic dysfunction a

161 However, the regulatory pathways involved in goblet cell-induced mucu

162 y Fur in NTHi and likely identify additional regulatory pathways involved in iron utilization.

163 or GWAS hits and important insights into the regulatory pathways involved in many diseases.

164 The proteins and regulatory pathways involved in Plasmodium sexual develo

165 esponses to pathogens and the maintenance of regulatory pathways involved in the maintenance of toler

166 esponses to pathogens and the utilization of regulatory pathways involved in the sustained tolerance

167 Our study uncovers a new regulatory pathway involving miR-19a that is critical to

168 Our data highlight a novel immune-regulatory pathway involving NKT subset interactions lea

169 enal glucose transporter, uncovering a novel regulatory pathway involving Olfr1393 and Sglt1.

170 uence on the reprogramming process through a regulatory pathway involving prodifferentiation factors,

171 proteomic datasets identified potential ECM regulatory pathways involving inhibition of matrix metal

172 Here, we summarize elaborate regulatory pathways involving this transcription factor

173 sume glucose before galactose, the galactose regulatory pathway is activated in a fraction of the cel

174 The mechanism of this regulatory pathway is proposed to entail a displacement

175 Because the relevance of this regulatory pathway is unknown in human sepsis, this pilo

176 t mutation or aberrations in one of its many regulatory pathways, is a hallmark of virtually every tu

177 rride other low-density lipoprotein receptor regulatory pathways leading to cardiovascular disease.

178 levels, which may play central roles in the regulatory pathways leading to the different chlorophyll

179 o make explicit predictions for the types of regulatory pathways likely to underlie each type of exag

180 i identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood p

181 ibrillary degeneration and suggest that this regulatory pathway may be useful for developing therapeu

182 Potential manipulation of this regulatory pathway may have significant clinical potenti

183 strate that manipulating posttranscriptional regulatory pathways may be a potential strategy to rever

184 Targeted modulation of microenvironmental regulatory pathways may be essential to control myeloma

185 esmoglein tail and suggests that these novel regulatory pathways may possibly be exploited in treatin

186 lpha/pRb and Smad2/3 signaling are important regulatory pathways mediating defective muscle growth in

187 s of cardiac mesoderm that is central to the regulatory pathways mediating second heart field (SHF) d

188 Bacterial Nod factors (NFs) and plant regulatory pathways modulating NF signalling control rhi

189 Here we show that the regulatory pathways modulating seed oil content, which i

190 le suggests that extensive crosstalk between regulatory pathways must exist.

191 volved in a previously undescribed virulence regulatory pathway of an important human pathogen and su

192 effects of celR and other components of the regulatory pathway of cellulose production were explored

193 t recruited human monocyte subsets trigger a regulatory pathway of cytokine-mediated signaling at the

194 ar rats, we unmask a previously unrecognized regulatory pathway of erythropoiesis involving suppresso

195 ptional elongation, thus deciphering a novel regulatory pathway of gene expression.

196 Thus, our findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and sugge

197 s, caused mitochondrial dysfunction, altered regulatory pathways of cell differentiation and survival

198 ed epigenetic mechanisms presents additional regulatory pathways of genes involved in maintaining chr

199 the context of atherosclerosis and possible regulatory pathways of MC1-R beyond anti-inflammation.

200 sting that CLEC16A may be involved in immune regulatory pathways of relevance to CVID.

201 of BCR signaling and links actin to negative regulatory pathways of the BCR.

202 Helminths exploit intrinsic regulatory pathways of the mammalian immune system to da

203 Helminths evoke immune regulatory pathways often involving dendritic cells, reg

204 tem cells (ESCs) are established by multiple regulatory pathways operating at several levels.

205 al alleles that specifically abrogate either regulatory pathway or both, we demonstrate that tight co

206 The interplay between inflammatory and regulatory pathways orchestrates an effective immune res

207 ses leading to irregular gene expression and regulatory pathway perturbations, in the cells, resultin

208 he CF lung and that changes in iron and heme regulatory pathways play a crucial role in adaptation of

209 tion, we integrated GFR-associated loci with regulatory pathways, producing a molecular map of CKD.

210 Here, we report that the miR156/SPL2 regulatory pathway regulates pollen production, fertilit

211 and as endpoints for clinical trials, clear regulatory pathways, reliability and reproducibility of

212 The key steps in cellular signaling and regulatory pathways rely on reversible noncovalent prote

213 lammatory responses; however, the underlying regulatory pathways remain ill defined.

214 bal chromatin remodeling, yet the underlying regulatory pathways remain incompletely understood.

215 ailed molecular mechanisms coordinating such regulatory pathways remain poorly understood.

216 Genetic manipulation of mitochondrial regulatory pathways represents a potential therapeutic a

217 The regulatory pathways required to maintain eukaryotic lipi

218 This regulatory pathway resembles the p53-dependent nucleolar

219 hese findings point toward a distinct immune regulatory pathway responsible for the development of FV

220 The regulatory pathway(s) that links oxygen limitation to in

221 e/protease signaling protein SltB comprise a regulatory pathway specific to filamentous fungi.

222 lled through key microenvironmental cues and regulatory pathways, such as Wnt signaling.

223 ncovered a novel RXR-dependent innate immune regulatory pathway, suggesting that the downregulation o

224 L-23 and AAR pathways and identifies a novel regulatory pathway targeting Stat3 that may underlie sel

225 , our data define a distinct GR-induced gene regulatory pathway that contributes to therapeutic effec

226 es incidence and led to the development of a regulatory pathway that controlled autoimmune progressio

227 Here, we report a miRNA-based autocrine regulatory pathway that controls differentiation of prea

228 also provide evidence of a newly identified regulatory pathway that could promote angiogenesis.

229 These findings highlight a novel regulatory pathway that creates a critical period in bra

230 identify PI(3,5)P2-dependent signaling as a regulatory pathway that is critical for activity-depende

231 Overall, these results demonstrate a novel regulatory pathway that links CaN, RCAN1, and Kv3.4 in D

232 common BRAF(V600E)-directed transcriptional regulatory pathway that mediates epigenetic silencing in

233 ssential role for HMMR in the PLK1-dependent regulatory pathway that orients progenitor cell division

234 Here, we identify a regulatory pathway that promotes stalled forks recovery

235 In this study, we uncovered an immune-regulatory pathway that tempers the intensity of the hos

236 medical devices, enter the market through a regulatory pathway that was not designed to assure safet

237 rom the canonical cell cycle, endocycles use regulatory pathways that also function in diploid cells,

238 Rather than reinforcing or replacing regulatory pathways that are conserved between organisms

239 yses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in re

240 Thus, elucidating the full complement of regulatory pathways that control BACE1 expression is key

241 review recent progress in understanding the regulatory pathways that control biofilm formation and h

242 Malfunctions in regulatory pathways that control cell size are prominent

243 ration of external and internal signals into regulatory pathways that control cellular responses to c

244 the T6SS as well as the diverse signals and regulatory pathways that control its activation in V. ch

245 Regulatory pathways that control responses to changes in

246 n is essential for disease transmission, the regulatory pathways that control this developmental proc

247 groups were discussed in the context of the regulatory pathways that could accelerate the translatio

248 To further our knowledge of novel regulatory pathways that could contribute to gliomagenes

249 ut unlike animals, little is known about the regulatory pathways that determine the sex of plants.

250 Triggers and regulatory pathways that effectively link human cytomega

251 The differentiation state and regulatory pathways that enable continuous natural antib

252 xic, underscoring the critical importance of regulatory pathways that ensure proper expression of his

253 ged as key components of the transcriptional regulatory pathways that govern cardiac development as w

254 In this review, we discuss the key regulatory pathways that govern translational control in

255 nd up-regulation of genes involved in cancer regulatory pathways that include apoptosis (p53, Fas, an

256 verting control over and dominating cellular regulatory pathways that influence translation initiatio

257 ing are orchestrated by a complex network of regulatory pathways that involve both the innate and ada

258 mechanism bridging the antioxidant and iron-regulatory pathways that is intimately linked to pH home

259 r studies are needed to elucidate the common regulatory pathways that may lead to MR irrespective of

260 Mammary epithelial cells engage regulatory pathways that permit dynamic responses to mec

261 The cell cycle-regulatory pathways that produce specific temporal TE pa

262 nscripts, but facilitates the remodelling of regulatory pathways that restore the transcription of ke

263 To further elucidate regulatory pathways that safeguard the somatic state, we

264 with a platform to interrogate the molecular regulatory pathways that shape APA profiles in different

265 During RNA interference and related gene regulatory pathways, the endonuclease Dicer cleaves prec

266 A down-regulatory pathway through which encephalitogenic CD4Th1

267 chanistic link between Zbtb7b and the lncRNA regulatory pathway through which Zbtb7b recruits the bro

268 ose, play important roles in many of the RNA regulatory pathways through multiple mechanisms.

269 in the CF lung affects iron acquisition and regulatory pathways through the use of longitudinal CF i

270 nal framework for delineating B. burgdorferi regulatory pathways throughout the enzootic cycle as wel

271 inges on hepatic BA production among several regulatory pathways to control BA homeostasis.

272 responses, NCR peptides target intracellular regulatory pathways to drive S. meliloti endoreduplicati

273 use of monoclonal antibodies to block immune regulatory pathways to enhance tumor-specific immune res

274 es to demonstrate vaccine effectiveness, and regulatory pathways to licensure.

275 Glioblastomas co-opt stem cell regulatory pathways to maintain brain tumor-initiating c

276 GF1 activates 2 ISC populations via distinct regulatory pathways to promote growth of normal intestin

277 F1c integrates inputs from several flowering-regulatory pathways to synchronize flowering time to env

278 The circadian clock interacts with other regulatory pathways to tune physiology to predictable da

279 Several regulatory pathways, typically involved in immune cell h

280 Here, we characterize the regulatory pathway underlying nucellus and endosperm tis

281 will lead to new insights into the genes and regulatory pathways underlying disease phenotypes.

282 Altogether, our results reveal a novel regulatory pathway, underscoring a previously unknown an

283 ts on motility are indirect, perhaps through regulatory pathways upstream of the motors, such as the

284 data uncover a novel Bcl11a/Sema3c-dependent regulatory pathway used by migrating cortical neurons.

285 al tissues, where local synthesis influences regulatory pathways via paracrine and autocrine mechanis

286 This regulatory pathway was also functional in primary hippoc

287 Expression of PLN, phospho-PLN, and its regulatory pathway was analyzed in the ESM of biopsy spe

288 For a global view of IFN signatures and regulatory pathways, we performed gene expression and ch

289 However, we also uncover a regulatory pathway whereby suppression of p53 Ser(15) ph

290 ls a GATA3/miR-125a-5p/IL-6R and STAT3/FOXP3 regulatory pathway, which determines how Treg cells resp

291 For supplements approved via the 180-day regulatory pathway, which often involve significant desi

292 erstanding microRNA-mediated transcriptional-regulatory pathways will result in development of noninv

293 Our data delineate a post-transcriptional regulatory pathway with a conserved role in regenerative

294 confer partial resistance to PCSK9 and IDOL regulatory pathways with improved reduction in cholester

295 We reasoned that we could uncover regulatory pathways with new roles in hepatocyte differe

296 , LY75) blood cell traits, suggesting common regulatory pathways with shared genetic architecture amo

297 tion of the complement system and respective regulatory pathways, with concordant findings at the pro

298 fe can affect the development of body weight regulatory pathways, with permanent consequences for ris

299 rpha exhibits low genetic redundancy in most regulatory pathways, with this portion of its genome res

300 the Hippo signaling pathway, a major growth regulatory pathway within metazoa [4], but at least in s