ライフサイエンスコーパス: regulatory sequence

1 ct regions along approximately 600 bp of the regulatory sequence.

2 ression in mammalian organisms directly from regulatory sequence.

3 on by blocking access of other RBPs to a key regulatory sequence.

4 nding the mutation define an uncharacterized regulatory sequence.

5 of transcriptional regulation by a specified regulatory sequence.

6 gh a canonical DSX-binding site in the Fmo-2 regulatory sequence.

7 ations of single-nucleotide polymorphisms at regulatory sequences.

8 NAs with retrotransposons and pseudogenes as regulatory sequences.

9 fications, particularly methylation of their regulatory sequences.

10 A activity in vivo and also identifies novel regulatory sequences.

11 rexpress Dyrk1a under the control of its own regulatory sequences.

12 ion in other neurons is mediated by separate regulatory sequences.

13 te TFL1 mimic, even when expressed from TFL1 regulatory sequences.

14 ssion by direct and specific binding to gene regulatory sequences.

15 cilitates interactions between transcription regulatory sequences.

16 ence of polycomb at a subset of CG-dense cis-regulatory sequences.

17 nvolve protein-coding genes, as well as gene regulatory sequences.

18 oters, suggesting an overlap with endogenous regulatory sequences.

19 ing SOC1 heterodimers, are able to bind SOC1 regulatory sequences.

20 e H3K9acS10ph and H3K27acS28ph marks at both regulatory sequences.

21 o produce a map of nearly 300,000 murine cis-regulatory sequences.

22 equence conservation and genomic function of regulatory sequences.

23 ent epigenomic marks can be used to discover regulatory sequences.

24 f target human genome loci such as exons and regulatory sequences.

25 t with DNA have distinct preferences for cis regulatory sequences.

26 expression is controlled by endogenous zeta regulatory sequences.

27 lates independently of the nature of the cis-regulatory sequences.

28 tic MADS domain proteins appear to bind SOC1 regulatory sequences.

29 ly to be the outcome of neutral variation in regulatory sequences.

30 e-scale libraries of systematically designed regulatory sequences.

31 ere wired together by a vast spectrum of cis-regulatory sequences.

32 s technique as a nonbiased screen to isolate regulatory sequences.

33 ts ability to confer this property to linked regulatory sequences.

34 a DNA-BP, to identify putative FOXO1 genomic regulatory sequences.

35 n of the Prmt4 substrate, H3R17, at microRNA regulatory sequences.

36 rry out a genetic analysis of their upstream regulatory sequences.

37 ely in neurons expressing TH transcriptional regulatory sequences.

38 hed by transcription factor (TFs) binding to regulatory sequences.

39 ctions between Drosophila TFs and target cis-regulatory sequences.

40 actions and the specific genomic position of regulatory sequences.

41 the binding of transcription factors to gene regulatory sequences.

42 ing regions, splicing junctions and splicing regulatory sequences.

43 neocortex may involve the evolution of novel regulatory sequences.

44 utations in splice factors, splice sites, or regulatory sequences.

45 with beta-catenin displaced TCF4 from MMP13 regulatory sequences.

46 vertebrate genomes and the function of human regulatory sequences.

47 e binding and functionality of the predicted regulatory sequences.

48 the coordinates of core promoters and other regulatory sequences.

49 nteractions may serve as a marker for active regulatory sequences.

50 Two of them, named silencer regulatory sequence 1 (SRS1) and SRS2, are located on a

51 sed of Swi4 and Swi6) in the 700-bp upstream regulatory sequence 2 (URS2) promoter region.

52 (TEs) are uniquely equipped to deposit their regulatory sequences across a genome, which could also c

53 t manner and relies on gain/loss of splicing regulatory sequences across the exons.

54 ransposon transcripts, suggesting a class of regulatory sequences acting in trans.

55 asts within anterior fin rays, whereas hand2 regulatory sequences activated expression in these same

56 ease-associated SNPs, appears to behave as a regulatory sequence, affecting the expression of a neigh

57 sative polymorphisms occurring in coding and regulatory sequences alike.

58 RSAT (Regulatory Sequence Analysis Tools) is a modular softwar

59 Although developed for regulatory sequence analysis, these methods can be appli

60 tory elements including a stem-cell specific regulatory sequence and an element that drives reporter

61 , the analysis of the role of a specific DNA regulatory sequence and the interacting proteins in the

62 comprehensive understanding of TF binding to regulatory sequences and allows the characterization of

63 Hypomethylation of ZNF423 regulatory sequences and BMP2 signaling result in transa

64 ining 30% of all genes that are enriched for regulatory sequences and depleted for genes involved in

65 se of epigenome maps to delineate human gene regulatory sequences and developmental programs.

66 Accurately predicting regulatory sequences and enhancers in entire genomes is

67 ually all known experimentally validated cis-regulatory sequences and expose a vast trove of novel el

68 ta identify thousands of prospective cardiac regulatory sequences and indicate that multiple TF co-oc

69 es that have been played by many plant-viral regulatory sequences and proteins in the creation of pla

70 harbors essential noncoding RNAs, promoters, regulatory sequences and replication origins.

71 We examine changes in constraints on known regulatory sequences and show that for the Rck1/Rck2, Fk

72 as well as the overlaps with exons, putative regulatory sequences and single-nucleotide polymorphisms

73 gene regulation that restrict access to both regulatory sequences and the underlying template.

74 re assumed to be determined primarily by DNA regulatory sequences and their associated activators, wh

75 ng of interactions between individual distal regulatory sequences and their target genes.

76 Transcription regulators bind to cis-regulatory sequences and thereby control the expression

77 ful platform to develop predictive tools for regulatory sequences and to study their sequence propert

78 Diversifying regulatory sequences and using native microalgal coding

79 The ProxTom transgene contained all Prox1 regulatory sequences and was faithfully expressed in LVs

80 rious [5% versus 0.4%] but not more often in regulatory sequences), and certain disease classes.

81 on requires direct binding of TTX-1 to ver-1 regulatory sequences, and is induced in dauers and at hi

82 by exploiting the cryptic activity of extant regulatory sequences, and this may reflect a general mec

83 smaller evolutionary distance) that its cis-regulatory sequence appears unrelated in different speci

84 n and out of regulons through changes in cis-regulatory sequences appears to be a general phenomenon.

85 types to identify which particular genes and regulatory sequences are causal.

86 ets and the binding motifs in associated cis-regulatory sequences are dispersed throughout the hierar

87 slational fusions and to ensure that all cis-regulatory sequences are included, we have used a bacter

88 all eukaryotic species, promoters and other regulatory sequences are more nucleosome-depleted, where

89 rlap is not coincidental; retrovirus-derived regulatory sequences are often used to control cellular

90 ment in which a library of partially mutated regulatory sequences are partitioned according to their

91 non-coding region, indicating that proximal regulatory sequences are sufficient for HPRT1 expression

92 provide evidence that rearrangements in the regulatory sequences around egr4 and mafb genes may acco

93 to UCUAUC in the context of unc-52 intronic regulatory sequences as well as to RNAs containing tande

94 ection correlate better with the presence of regulatory sequences, as predicted by the ENCODE Project

95 Our results demonstrate changes in a regulatory sequence associated with a major body plan tr

96 Regulatory sequences at DPP10 and additional loci carrie

97 ations located in cis-acting transcriptional regulatory sequences at the gene junctions of the genome

98 d, a flexible SVM workflow that predicts new regulatory sequences based on the annotation of known CR

99 , or 'unintelligibility', of orthologous cis-regulatory sequences between Molgula and Ciona.

100 mputational RNA-folding landscape as well as regulatory sequence binding data treated with the same f

101 tations identified create cryptic cis-acting regulatory sequence binding sites that drive aberrant OV

102 not alter MyoD binding at myogenic microRNA regulatory sequences but prevents the binding of both my

103 ion are associated with the evolution of cis-regulatory sequences, but it is not known how temporal r

104 sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular phenoty

105 We show that the regulatory sequences, but not other regions of genes exp

106 thought to be tightly coupled to changes in regulatory sequences, but specific molecular events asso

107 hundreds of thousands of tissue-specific cis-regulatory sequences, but the determinants critical to t

108 coupled with SpDamID reveals co-targeting of regulatory sequences by Notch and Runx1.

109 eering approaches to computationally predict regulatory sequences by using comparative genomics.

110 prinkled throughout the genome are a million regulatory sequences called transcriptional enhancers th

111 nstrate that even a severely constrained cis-regulatory sequence can be significantly rewired over a

112 ructs can increase the efficiency with which regulatory sequences can be assayed, restricting analysi

113 Our data indicates that ancient conserved regulatory sequences can be tested effectively in transg

114 sly thought and that seemingly unrelated cis-regulatory sequences can nonetheless be homologous.

115 Specific DNA demethylation of regulatory sequences can result in upregulation of genes

116 in the methods for discovery of putative cis-regulatory sequences, characterisation of their spatio-t

117 od and combines these with allele frequency, regulatory sequences, chromosomal topological domains, a

118 sed approach to identify frequently used cis-regulatory sequence combinations in the promoter sequenc

119 In addition, with known cis-regulatory sequence combinations, gene function annotati

120 and selection have shaped variation in a cis-regulatory sequence controlling gene expression by empir

121 these two species, little is known about the regulatory sequences controlling hand2 expression in zeb

122 Together, our results identify new regulatory sequences controlling IE1 and IE2 expression

123 The majority of known TE-derived regulatory sequences correspond to relatively ancient in

124 TCP20 targets, and binding of TCP20 to their regulatory sequences could be confirmed by chromatin imm

125 rthermore, several uncharacterized genes and regulatory sequences demonstrated convergence and thus c

126 HSV-1 contains no such regulatory sequences, demonstrating different mechanisms

127 ion alteration in cancer cells of the distal regulatory sequences described as super-enhancers.

128 let us use comparative genomics to identify regulatory sequences directing expression in the DVA int

129 e1, H3K27ac, H3K4me3 and H3K9ac), active cis-regulatory sequences (DNA hypersensitivity sites (DHS)),

130 We further demonstrate that adt-2 regulatory sequences drive expression in glial-like and

131 nope regulatory sequences drive reporter gene expression in g

132 In BAC transgenic zebrafish, cav1 regulatory sequences drove strong expression in ostensib

133 tion at this site is inhibited by a negative regulatory sequence element, and potentially by the H-NS

134 controlled by proteins that bind directly to regulatory sequence elements and either activate or repr

135 h the transcription factors binding to these regulatory sequence elements and their ability to recrui

136 e caused by mutations in splicing signals or regulatory sequence elements, recent studies have noted

137 which have identical open reading frames and regulatory sequences-encode functional toxin-antitoxin s

138 s in gene expression due to mutations in cis-regulatory sequences (enhancers).

139 protein (GFP)-KOR1 expressed from its native regulatory sequences established that all eight N-glycos

140 ata to computationally identify relevant cis regulatory sequences flanking syn-expressed genes in the

141 distantly related ERVs have been exapted as regulatory sequences for many host genes in a wide range

142 We propose a model in which the regulatory sequences form a hydrophobic core that recipr

143 Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate

144 We further demonstrate how different regulatory sequences give rise to nucleosome-mediated TF

145 duced (Scr) is directed by an unusually long regulatory sequence harboring diverse cis elements and a

146 regions of noncoding DNA for functional cis-regulatory sequences harboring variation implicated in c

147 novel transgenic rodent model in which Zeb2 regulatory sequence has been disrupted, resulting in a p

148 Removing nucleosomes from regulatory sequences has been proposed to play a signifi

149 A large number of cis-regulatory sequences have been annotated in the human ge

150 Two cis-regulatory sequences have been identified upstream of th

151 Millions of regulatory sequences have been predicted in the human ge

152 A cis-regulatory sequence here corresponds to a DNA motif boun

153 ty arises from the coordinated action of two regulatory sequences: (i) a WASP homology 2 (WH2) domain

154 Moreover, the wealth of new regulatory sequences identified here provides an invalua

155 therefore identified GARRPR as a novel BF-3 regulatory sequence important for fine-tuning the activi

156 Purified Bil1 bound to the regulatory sequence in Bud6 and triggered NPF effects on

157 t rs2237895 influenced methylation levels of regulatory sequence in fetal pancreas but without demons

158 nd characterize natural variation in the cis-regulatory sequence in the transcription factor CONSTANS

159 immunoprecipitation, STAT1 bound a putative regulatory sequence in the ULK1 5'-flanking region, the

160 oximately 6.9 kb MIR137/MIR2682 and upstream regulatory sequences in 2,610 SZ cases and 2,611 control

161 chloroplast genomes, the number of known DNA regulatory sequences in chloroplast genomes are limited.

162 s proven to be a powerful method for mapping regulatory sequences in cultured cells, chromatin states

163 However, the cis-acting regulatory sequences in DE and L genes that mediate thei

164 gration, LedPred excels at the prediction of regulatory sequences in Drosophila and mouse datasets co

165 methods to systematically study putative DNA regulatory sequences in intergenic regions near chloropl

166 d comprehensive identification of functional regulatory sequences in mammalian genomes remains a majo

167 equencing, we would like to quickly annotate regulatory sequences in newly-sequenced genomes.

168 use genome have yet to be found, and the cis-regulatory sequences in particular are still poorly anno

169 d describe how core protein circuits and cis-regulatory sequences in promoters integrate with chromat

170 program, as evidenced by induction of gata4 regulatory sequences in regenerating cardiomyocytes.

171 opposes Gli1 activity by binding cis-acting regulatory sequences in the 5' flanking regions of Snai1

172 id not change the DNA-methylation pattern of regulatory sequences in the caspase-8 gene.

173 on factors are adaptor molecules that detect regulatory sequences in the DNA and target the assembly

174 IKE1 (PHL1) were identified to bind to P5CS1 regulatory sequences in the first intron, which carries

175 d discovery and functional assessment of cis-regulatory sequences in the genome.

176 rial ribosomal protein S12 (MRPS12), contain regulatory sequences in their 3'-untranslated region (UT

177 ential of MYC stems from its ability to bind regulatory sequences in thousands of target genes, which

178 ive/repressive function of SMARCA4 at distal regulatory sequences in vivo and support its role in tis

179 show that Hnf1b occupies novel Ngn3 putative regulatory sequences in vivo.

180 , the BAG-1-p50 complex was detected at gene regulatory sequences including the epidermal growth fact

181 , revealed MEF2C motif enrichment within cis-regulatory sequences, including neuron-specific promoter

182 e widespread loss of cytosine methylation at regulatory sequences, including promoter regions of prot

183 ion and contains at least three required cis-regulatory sequences, including the 10-bp motif (5'-GAAA

184 ge part, on the activation and repression of regulatory sequences, including transcriptional enhancer

185 ne the positions from which certain intronic regulatory sequences increase mRNA accumulation, the eff

186 nhibited ERalpha, but not PR binding to both regulatory sequences, indicating that an interaction bet

187 Understanding how regulatory sequences interact in the context of chromoso

188 ons, and the other subset subdivides the Scr regulatory sequences into independent enhancer access do

189 n FGF19 (ortholog to mouse Fgf15), including regulatory sequences, into the FRGN mice to create FRGN1

190 both biased codon usage and conservation of regulatory sequences involved in mRNA processing, althou

191 ng-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and

192 fic single CpG dinucleotide in the ZAP-70 5' regulatory sequence is a highly predictive and reproduci

193 Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control of

194 Elucidating the function of highly conserved regulatory sequences is a significant challenge in genom

195 Activation of gata4 regulatory sequences is also prevented by NF-kappaB sign

196 Prediction of gene expression levels from regulatory sequences is one of the major challenges of g

197 ediction of gene expression levels driven by regulatory sequences is pivotal in genomic biology.

198 antitatively predict TF binding to different regulatory sequences is still limited.

199 Although these regulatory sequences likely arose in ancient viruses, th

200 H20 or SLC28A3, suggesting that variation in regulatory sequences may affect expression.

201 Characterization of these five PPARgamma regulatory sequences may enable isolation of the transcr

202 A conserved regulatory sequence module attached to the AAA+ helicase

203 The identification of regulatory sequence motifs and the characterization of s

204 gly appreciated that coding sequences harbor regulatory sequence motifs in addition to encoding for p

205 that distinct epigenetic signatures and cis-regulatory sequence motifs predicted to bind putative co

206 ions and 96% of these regions contained NRF2-regulatory sequence motifs.

207 ke; NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes.

208 represses excitatory cell fate by binding to regulatory sequences near the Tlx1 and Tlx3 genes to sil

209 Finally, we observe that regulatory sequences occur at genomic locations correspo

210 nstructed pVASpf containing pf linked to the regulatory sequence of medaka germ gene vasa and generat

211 translocate into adjacent cells, bind to the regulatory sequence of Nkx3.1 target genes and impact th

212 rent DNA methylation patterns within the cis-regulatory sequence of the agn43 gene turn on or off a f

213 ator-1, and RNA polymerase II binding at the regulatory sequence of the SCNN1A gene and also remarkab

214 atures are likely a result of changes at the regulatory sequence of the target genes.

215 tire coding region and flanking intronic and regulatory sequences of 88 genes and 40 microRNAs associ

216 e researcher does not have to guess what the regulatory sequences of a gene are, as tens of thousands

217 sed genes are preferentially found in the 5' regulatory sequences of cis-NAT-encoding genes.

218 clude that FCGR3B deletion juxtaposes the 5'-regulatory sequences of FCGR2C with the coding sequence

219 Under these conditions, the regulatory sequences of late gene loci were not in close

220 chii, due in part to multiple changes in cis-regulatory sequences of mFAS.

221 ally expressed EGFP under the control of the regulatory sequences of the bHLH transcription factor ge

222 line, where eGFP expression is driven by the regulatory sequences of the embryonic betaH1 hemoglobin

223 through hypermethylation of CpG sites in the regulatory sequences of the gene.

224 cate a dynamic association of Prmt5 with the regulatory sequences of the PPARgamma2 gene that facilit

225 BACH2 peaks overlap with BCL6, including cis-regulatory sequences of the PRDM1 gene.

226 Transgenic reporter strains revealed that regulatory sequences of the transcription factor gene al

227 nd that natural variation in both coding and regulatory sequences of these paralogs responded to a co

228 Here, we find that regulatory sequences of tph1b, which encodes an enzyme t

229 Furthermore, by altering the gene regulatory sequences on the Rubisco transgenes, cyanobac

230 wo genes in a DGP potentially share the same regulatory sequence, one might expect that they should b

231 s - for example, through the modification of regulatory sequences or chromatin architecture - can lea

232 010 and C. elegans that are likely to encode regulatory sequences or previously unknown ncRNAs.

233 ntisense vivo-morpholinos (vMOs) to mask cis-regulatory sequences or to disrupt splicing factor expre

234 ent have been identified, the distant-acting regulatory sequences orchestrating their in vivo express

235 Monoallelic expression not due to cis-regulatory sequence polymorphism poses an intriguing pro

236 pendent cluster, and more notably, important regulatory sequences present in Borna disease virus but

237 on does not involve the IDRS (iron-dependent regulatory sequence) present in the AtFer1 promoter and

238 ed matching of methylation status of the key regulatory sequences (promoters and CpG islands) to expr

239 that amino acid region 1000-1008 of fV is a regulatory sequence protecting the organisms from sponta

240 Genetic lineage tracing systems based on Wt1 regulatory sequences provided evidence that epicardium-d

241 's expression pattern through changes at its regulatory sequence, rather than changes at the coding s

242 varphiC31 att site positioned adjacent to a regulatory sequence recognized by Tn3 resolvase.

243 cific manner, and we identify the set of cis-regulatory sequences recognized by Wor3.

244 in (FNIII)-like domains, along with a unique regulatory sequence referred to as the M-domain, whose s

245 III (FNIII)-like domains along with a unique regulatory sequence referred to as the MyBP-C motif or M

246 th of genomic data, functional annotation of regulatory sequences remains difficult.

247 minants of differences in cis-regulation for regulatory sequences residing in episomes versus chromos

248 The genetic alteration in this critical regulatory sequence resulted in reduced reporter gene ac

249 Analysis of Id3 regulatory sequences revealed a novel enhancer, located

250 tion by examining the evolution of important regulatory sequences (short linear motifs) in retained d

251 pregnancy; this might be due to variation in regulatory sequences-some of which are progesterone and

252 -NTR tadpoles the myelin basic protein (MBP) regulatory sequences, specific to mature oligodendrocyte

253 CPEB is a translational regulatory sequence-specific RNA-binding protein that co

254 p53 is a master regulatory, sequence-specific transcription factor that

255 is a chromatin feature enriched at gene cis-regulatory sequences such as promoters and enhancers.

256 tionally related genes via binding to shared regulatory sequences, such as the adenylate-uridylate-ri

257 , but its NPF effects were masked by a short regulatory sequence, suggesting that additional factors

258 nt retroviral insertions were used to co-opt regulatory sequences targeted by KDM1A for epigenetic si

259 hosphoserines in an intrinsically disordered regulatory sequence that integrates cellular signaling a

260 nd the alternatively spliced exon 11 contain regulatory sequences that affect insulin receptor splici

261 CTCF-binding locations represent regulatory sequences that are highly constrained over th

262 abidopsis and Brassica to identify conserved regulatory sequences that are responsible for specific e

263 ,638 combinations composed of two to six cis-regulatory sequences that are shared by the two plant sp

264 a powerful approach to the investigation of regulatory sequences that can be applied to other cell t

265 omoter was studied in detail to identify cis regulatory sequences that confer tapetal specific expres

266 few and there are no reports on specific cis regulatory sequences that control tapetal gene expressio

267 The regulatory sequences that control the expression of such

268 Enhancer elements are genomic regulatory sequences that direct the selective expressio

269 Enhancers are genomic cis-regulatory sequences that integrate spatiotemporal signa

270 zation elements identified several candidate regulatory sequences that may be responsible for PB-ER t

271 cartilage development, SoxE, gained new cis-regulatory sequences that subsequently directed its nove

272 ry protein modularity, conversion of one cis-regulatory sequence to another, distribution of binding

273 ast, modular cloning and accommodate diverse regulatory sequences to drive reagent expression.

274 ly interacts with a distinct site in its cis-regulatory sequences to maintain its own expression, and

275 control of the glycine transporter 2 (GLYT2) regulatory sequences to study for the first time the gly

276 rus (MHV), the NTD binds the transcriptional regulatory sequence (TRS) RNA, a conserved hexanucleotid

277 f these ORFs, a single genomic transcription regulatory sequence (TRS) was identified.

278 at orients SL1, SL2, and the transcriptional regulatory sequence (TRS), and this spacer function may

279 inuous transcription involving transcription regulatory sequences (TRSs) located in the 5' leader seq

280 raction of T187 with the 11mer GRE consensus regulatory sequence UGUUUGUUUGU and has significant cons

281 hanism, and maps of hap-ASM and mQTLs reveal regulatory sequences underlying supra- and sub-threshold

282 or exon(s) only, or ultraconserved potential regulatory sequences upstream of PMP22, further supporti

283 the detection of functional conservation of regulatory sequences using predicted occupancy levels of

284 Such maps can nominate regulatory sequence variants that underlie GWAS signals

285 er (gkm-SVM) that encodes cell type-specific regulatory sequence vocabularies.

286 he search of somatosensory specific genes or regulatory sequences, we mapped the H-2Z1 transgene inse

287 s densely populated with previously unmapped regulatory sequences, which interact in complex ways to

288 ey murine leukemia virus contains inhibitory/regulatory sequences, which prevent export and mediate n

289 by Polycomb-group response elements (PREs), regulatory sequences whose activity depends on the bindi

290 ut the selection of modified transcriptional regulatory sequences with passage facilitated the restor

291 lowing us to identify thousands of genes and regulatory sequences with signatures of adaptive evoluti

292 seudoknots that integrate ligand-binding and regulatory sequences within a single folded domain, the

293 nsight into the complexity of Drosophila cis-regulatory sequences within exon-poor regions, we have u

294 raction between RNA-binding proteins and cis-regulatory sequences within miRNA precursor loops.

295 Identification of regulatory sequences within non-coding regions of DNA is

296 egy and used it to interrogate 174 candidate regulatory sequences within the 1-Mbp POU5F1 locus in hu

297 iated from the TAD(cPcdh) fringes toward cis-regulatory sequences within the cPcdh locus, counterbala

298 further demonstrated to bind directly to cis-regulatory sequences within the first intron of CSE to a

299 Regulatory sequences within the gene, which are subject

300 tion, suggesting the existence of additional regulatory sequences within the locus.