ライフサイエンスコーパス: regulatory signal

1 ces in order to identify transcriptional DNA regulatory 'signals'.

2 ronmental control and molecular and physical regulatory signals).

3 d driving force or whether it functions as a regulatory signal.

4 o channels as an important posttranslational regulatory signal.

5 highly conserved N terminus of PilA was the regulatory signal.

6 eam element, polyadenylation signal and DICE regulatory signal.

7 sion and that limiting glucose in urine is a regulatory signal.

8 motif of RAG1 functions as a self-initiated regulatory signal.

9 emaker anterior burster cell for producing a regulatory signal.

10 ome and the DNA conformation can provide key regulatory signals.

11 tinguish primary from secondary responses to regulatory signals.

12 sensitivity of the enzyme to other negative regulatory signals.

13 in response to metabolic stress and to other regulatory signals.

14 ing to tryptophan and uncharged tRNA(Trp) as regulatory signals.

15 g for the possibility of a rapid response to regulatory signals.

16 but only CXCR1 mediates cytotoxic and cross-regulatory signals.

17 f complex networked systems driven by hidden regulatory signals.

18 hts are not recognized by the cytochromes as regulatory signals.

19 l regulators important in transducing growth-regulatory signals.

20 rinsically tied to inflammatory and hormonal regulatory signals.

21 l circadian E-Boxes in response to competing regulatory signals.

22 ions, which are thought to typically contain regulatory signals.

23 ology with important applications in finding regulatory signals.

24 function to transmit calcium-dependent cell regulatory signals.

25 subject to regulation by both cis- and trans-regulatory signals.

26 various diversification mechanisms and some regulatory signals.

27 lity of RNA polymerase to respond to various regulatory signals.

28 s tumor development by integrating different regulatory signals.

29 tes in response to a diverse range of growth-regulatory signals.

30 otential for responsiveness to physiological regulatory signals.

31 bcellular location and distinct responses to regulatory signals.

32 in the absence of additional cis-acting RNA regulatory signals.

33 , and also serve to integrate diverse growth-regulatory signals.

34 lcrum for transmitting mechanical forces and regulatory signals.

35 step in a putative cascade of developmental regulatory signals.

36 nt pathway is a source of specialized growth regulatory signals.

37 transcription in response to two cell cycle regulatory signals.

38 both tissue-specific and mitogen-responsive regulatory signals.

39 apacity of the complex to integrate multiple regulatory signals.

40 often change their operation in response to regulatory signals.

41 thesis of several phytohormones and proposed regulatory signals.

42 new antiviral drugs targeting cis-acting RNA regulatory signals.

43 odes, indicating the existence of additional regulatory signals.

44 areful balance of both positive and negative regulatory signals.

45 systems have required proteins to propagate regulatory signals.

46 ntly regulate multiple targets and integrate regulatory signals.

47 (BRC1) has been proposed to integrate these regulatory signals.

48 Ag-specific T cell responses is governed by regulatory signals.

49 o developmental, mechanical, and homeostatic regulatory signals.

50 sufficient time for complete degeneration of regulatory signals.

51 o reduced, suggesting abrogation of negative regulatory signaling.

52 in dynamic state are believed to facilitate regulatory signaling.

53 he data indicate that inhibition of negative regulatory signaling accounts for the amplification of c

54 eans to disseminate captured transcriptional regulatory signals across the genome.

55 ain that is indispensable for LMP-1's growth-regulatory signaling activities.

56 or initiating and temporally maintaining the regulatory signaling activity of a phosphatase.

57 linked chains, which act as a nonproteolytic regulatory signal, adopt an extended conformation that l

58 sented coincidence of this posttranslational regulatory signal and local conformational bias within u

59 developing an elevated set-point of myeloid regulatory signalling and sugar-lipid metabolism with co

60 rative genomic approaches: identification of regulatory signals and analysis of the genomic positions

61 parts that serve as the ultimate acceptor of regulatory signals and as the target of inhibitory drugs

62 mmatory stimuli can bypass CD154-CD40 immune regulatory signals and cause activation of autoreactive

63 e complex RNA structural elements to monitor regulatory signals and control expression of downstream

64 transduction pathways involving NO-mediated regulatory signals and NOSIII activity in human endothel

65 nce they contain a statistical enrichment of regulatory signals and pairs of signals that enable the

66 nts can be configured in tandem to integrate regulatory signals and perform genetic logic.

67 ular function will require interactions with regulatory signals and substrate availability, which bea

68 The transcriptional regulatory signals and the genes that orchestrate this s

69 ent component analysis (ICA), to first infer regulatory signals and then identify biologically releva

70 The goal is to infer knowledge-relevant regulatory signals and then identify corresponding bioma

71 i) the phase II response integrates multiple regulatory signals, and (iii), by inhibiting this respon

72 The control of nodes in gene regulatory, signaling, and metabolic networks is governe

73 However, many of the actual regulatory signals are composite patterns that are group

74 Determining how transcriptional regulatory signals are encoded in vertebrate genomes is

75 nges can affect how specific combinations of regulatory signals are mapped to particular gene express

76 The two regulatory signals are nonredundant: changes in iNTP con

77 During cytokinesis, regulatory signals are presumed to emanate from the mito

78 ement, highlighting checkpoints across which regulatory signals are rewired paralleling changes in ce

79 orms with varying boundaries and alternative regulatory signals are transcribed from the genome, even

80 d in our understanding of how these positive regulatory signals are transmitted to the kinase domain.

81 n by batimastat (BB94) showed that different regulatory signals are used by different stimuli and EGF

82 ative ptsP operon, including transcriptional regulatory signals, are characterized.

83 AS proteins might mediate situation-specific regulatory signaling at the TBP interface and that previ

84 nd cerebellum suggest the presence of unique regulatory signals at these locations that may reflect c

85 We show that activation of the vascular regulatory signalling axis mediated by Norrin (an atypic

86 onal development of bone cells requires that regulatory signals be temporally and spatially ordered.

87 ns, is apparently defective in responding to regulatory signals, because it induces hyperactive initi

88 -functional DNA, while maintaining essential regulatory signals, because of which the content of non-

89 es that emerging research shows can transmit regulatory signals between cells in health and disease.

90 results reinforce the idea that mediation of regulatory signals between cytoplasmic- and membrane-int

91 -activated signaling endosomes that transmit regulatory signals between soma and growth cones.

92 e CaM- and spoke-associated complex mediates regulatory signals between the radial spokes and dynein

93 provided evidence that this complex mediates regulatory signals between the radial spokes and dynein

94 n may be due to the direct transmission of a regulatory "signal" between the regulatory site and the

95 induced in this model by B7-driven negative regulatory signaling, but tolerance is maintained by a l

96 reases receptor-induced exocytosis and cross-regulatory signals, but not phosphoinositide hydrolysis

97 positively charged methyl-lysine or create a regulatory signal by allowing or inhibiting binding of o

98 mologs of the SNF1 kinase complex respond to regulatory signals by analogous mechanisms.

99 can be configured to directly propagate RNA regulatory signals by constructing an RNA-meditated tran

100 IPH2101 prevents negative regulatory signals by inhibitory KIR, whereas lenalidomi

101 romoter platform upon which complex upstream regulatory signals can be integrated, targeting multiple

102 lt of specific protein mutations or aberrant regulatory signals, can be both a cause and an effect of

103 this study, we examined aspects of the Igf1r regulatory signaling cascade in beta cells.

104 Our data define a complex regulatory signaling cascade initiated by LPP and sugges

105 is- and trans-acting elements comprising the regulatory signalling cascade that governs the photobiol

106 HDACs and DUSP5 as integral components of a regulatory signaling circuit that controls cardiac hyper

107 Our results define a regulatory signaling circuit within the innate immune sy

108 aced under the control of the S. mutans spaP regulatory signals, complemented LDH deficiency.

109 Thus, O-GlcNAc is a novel regulatory signaling component of excitatory synapses, w

110 patterns, they often fail to find composite regulatory signals consisting of weak monad parts.

111 imately involved in the transmission of cell regulatory signals controlling proliferation and differe

112 d may offer a means by which general nuclear regulatory signals could be transmitted to Pol I.

113 Eukaryotic transcriptional regulatory signals, defined as core and activator promot

114 The results of these studies suggest that regulatory signals delivered by the 4-1BB receptor play

115 n exerting both positive and negative growth-regulatory signals, depending on the timing, pathway, or

116 found in 3'-untranslated regions (UTRs) are regulatory signals determining mRNA stability and transl

117 n kinases C (PKC) and may thereby serve as a regulatory signal during cell stimulation.

118 that L-arginine availability functions as a regulatory signal during Legionella intracellular growth

119 a indicate that Cek-8 expression responds to regulatory signals during limb patterning and suggest th

120 Our data suggest that BAFF may be providing regulatory signals during specific T cell-independent ev

121 usly known as the ultimate recipients of cdk regulatory signals, E2F4/5 and p107 act here as transduc

122 Regulatory signals feed into the system through post-tra

123 Here, we identify the target and the regulatory signal for a c-di-GMP-responsive Escherichia

124 lasma membrane or serves as an intracellular regulatory signal for differentiation of immature hair c

125 ycle of Cool-1 at Tyr-442 can serve as a key regulatory signal for focal complex assembly-disassembly

126 e that ligation of CD137 receptor delivers a regulatory signal for T-cell anergy and implicate manipu

127 ement for almost every organism, serves as a regulatory signal for the expression of virulence determ

128 der of neurocan may function as a cis-acting regulatory signal for the modulation of neurocan express

129 interaction with self-antigen and resultant regulatory signaling for its maintenance.

130 This environment provides key regulatory signals for and tightly controls cardinal fea

131 Hematopoietic stem cells receive the regulatory signals for cell production in adult mammals

132 nning tyrosine kinase receptors that mediate regulatory signals for cell proliferation and differenti

133 essenger, cAMP, is one of the most important regulatory signals for control of steroidogenesis.

134 hese sequences that may serve as controls or regulatory signals for gene expression.

135 CXCR1-, CCR5-, and DeltaCXCR2-mediated cross-regulatory signals for GTPase activity, Ca(2+) mobilizat

136 ole of SepJ in the intercellular transfer of regulatory signals for heterocyst differentiation.

137 evolved to integrate several protein kinase regulatory signals for progression through S phase.

138 with B7 expressed by APCs generates critical regulatory signals for T cell activation.

139 NA levels requires the continued presence of regulatory signals from both pre- and postganglionic tis

140 rate of CoA biosynthesis to be controlled by regulatory signals from CoA thioesters involved in diffe

141 to deduce bipartite network connectivity and regulatory signals from data without any need for prior

142 rk component analysis, for uncovering hidden regulatory signals from outputs of networked systems, wh

143 proteins in the nodes, and receives negative regulatory signals from Pom1.

144 AGI-1 may participate in the transmission of regulatory signals from the cell surface to the nucleus.

145 imeric G protein of S. cerevisiae has a self-regulatory signaling function.

146 The regulatory signals generated at enhancer elements are co

147 Intestinal immune regulatory signals govern gut homeostasis.

148 odel of neural development, in which several regulatory signals have been identified.

149 d G1/S/G2/M phases and respond adaptively to regulatory signals; however the nature of the robustness

150 Monoubiquitination serves as a regulatory signal in a variety of cellular processes.

151 e results suggest that Notch1 provides a key regulatory signal in determining T lymphoid versus B lym

152 odification of histones has emerged as a key regulatory signal in eukaryotic gene expression.

153 downstream coding sequence in response to a regulatory signal in the absence of a trans-acting prote

154 Moreover, data suggest NO pathway as a key regulatory signaling in AMPA-induced Src activation in n

155 onfiguration with altered NF-kappaB and TATA regulatory signals in contradistinction with HIV-1B.

156 nd/or the presence of mechanisms to separate regulatory signals in different tissues.

157 cturally altered DNA elements might serve as regulatory signals in gene expression or in telomere dyn

158 actor binding sites (TFBSs) encoding complex regulatory signals in metazoan genomes remains a challen

159 method will be useful for the extraction of regulatory signals in multiple genomes.

160 o define, at the molecular level, the growth-regulatory signals in neoplastic cells that are associat

161 isoprenyl phosphates (PIPPs) as natural down-regulatory signals in neutrophils.

162 apoptosis might result from aberrant growth regulatory signals in non-aggregated, cycling cells.

163 diverse array of conformations to respond to regulatory signals in signaling pathways.

164 ine-threonine kinases that mediate important regulatory signals in the cell.

165 tion with DNA, VP16 is able to interpret cis-regulatory signals in the DNA to direct the assembly of

166 y comes under the influence of extracellular regulatory signals in the form of hematopoietic cytokine

167 0 by CKII and PKC are determined by distinct regulatory signals in vivo.

168 Disorders that disturb ubiquitin regulatory signaling include at least two subtypes of Fa

169 s and aligned them with developmentally cued regulatory signaling including IL-7/STAT5 and cellular e

170 GATA FACTOR1 is controlled by several growth regulatory signals including light and the phytohormones

171 to the abrogation of various negative growth regulatory signals, including a p53-mediated G1 growth a

172 that can involve multiple mechanisms and cis-regulatory signals, including a role for RNA splice site

173 (NG2 cells) are exposed to various extrinsic regulatory signals, including the neurotransmitter GABA.

174 al transcription machinery can also generate regulatory signals independent of enhancer-generated int

175 hese results suggest that distinct extrinsic regulatory signals influence the expression of synapse-r

176 evidence that endogenous RA acts as a major regulatory signal integrating Wnt and Tgfbeta pathways i

177 translates both maternal and early embryonic regulatory signals into spatial distribution of transcri

178 mechanism whereby plants incorporate diverse regulatory signals into the developmental programme of L

179 Little is known about the regulatory signals involved in tendon and ligament forma

180 tg1p.Rtg3p complex, yet the precise upstream regulatory signals involved remain unclear.

181 This indicates that evolution of cis-regulatory signals is a major contributor to the emergen

182 Monoubiquitylation is a regulatory signal, like phosphorylation, that can alter

183 Though it is a target for multiple regulatory signals, little is known about the dynamics/t

184 rovide mechanistic insight into an autocrine regulatory signaling loop that regulates beige adipocyte

185 Thus, transcription regulatory signals may serve as "punctuation marks" for

186 Furthermore, our study identifies a self-regulatory signaling mechanism from CARM1's catalytic do

187 gnaling as a novel thin filament contractile regulatory signaling mechanism.

188 nation of cis- and transacting secretory and regulatory signals, micromolar secretion levels of the a

189 ation in the expression and translocation of regulatory signaling molecules in membrane domains of B

190 le checkpoint, the production of conflicting regulatory signaling molecules induces apoptosis in canc

191 nchoring protein, suggesting that additional regulatory signals must be required to release active en

192 r receptors (TNFRs) and their ligands form a regulatory signaling network that controls immune respon

193 tween genes within this signature revealed a regulatory signalling network consistent with a model of

194 Further integration of multiple regulatory signaling networks, involving regulators such

195 Mucosal immunity depends on regulatory signals; nutritional elements, including fats

196 For differentially regulated DGPs, the regulatory signal of one gene can stochastically 'leak'

197 rboxylate fuel, and that cellular sources of regulatory signaling of lactate utilization exist within

198 glucose substrate imbalance are initiated by regulatory signals of periventricular origin.

199 ) exclusively mediates chemotactic and cross-regulatory signals of the PAFR, but both G(i) and G(q) a

200 e a foundation for investigating the role of regulatory signals on the stability of this interface.

201 ar checkpoint for DNA loading in response to regulatory signals or antibiotics.

202 ons that encode protein interaction domains, regulatory signals, or translation initiation or termina

203 ma cells remain sensitive to negative growth regulatory signals originating from fibrillar collagen,

204 interacts with RTA at the protein abundance regulatory signal (PARS) motifs, and the association pre

205 econd regulatory region, a protein abundance regulatory signal (PARS), consists of two components.

206 uliar structural features and uncovers a new regulatory signaling path distinct from the MAPK signali

207 Therefore, we define a regulatory signaling pathway mediated by Barkor that pos

208 r coordinating protein synthesis and diverse regulatory signal pathways.

209 nt Cl(-) secretion through multiple negative regulatory signaling pathways and inhibition of specific

210 However, little is known about the regulatory signaling pathways in brain pericytes.

211 p7a1 proximal promoter and the expression of regulatory signaling pathways in postpartum rats at day

212 Additionally, the activation of counter-regulatory signaling pathways leads to chronic metabolic

213 ial raft redistribution and whether negative regulatory signaling pathways target this phase of cellu

214 As two major regulatory signaling pathways that regulate epidermal ho

215 Mutants fail to activate two important regulatory signaling pathways, mediated by phosphatidyli

216 rmal growth factor receptor and other growth regulatory signaling pathways.

217 Here we show that the pocket integrates two regulatory signals, phosphorylation and ligand binding,

218 We identify two cell cycle regulatory signals, ppGpp and polyphosphate (polyP), tha

219 f these genes increases our understanding of regulatory signals present in human urine, blood, and as

220 nd is dynamic enough to serve as a nitrative regulatory signaling process that likely affects cellula

221 We propose that miR-9 links regulatory signaling processes with dynamic translation

222 Regulatory signals provide negative input to immunologic

223 ns and leukotrienes, are balanced by counter-regulatory signals provided by a class of molecules call

224 ly determined by intrinsic properties and by regulatory signals provided by the microenvironment.

225 regulated by inherent programs and extrinsic regulatory signals received from their microenvironmenta

226 troyed by the ablation and that unidentified regulatory signals released in response to localized dam

227 nse has been largely attributed to providing regulatory signals required for the priming of major his

228 ereby cellular loading could activate growth regulatory signals responsible for cardiac hypertrophy.

229 s may be controlled at some level by similar regulatory signal(s).

230 ion of the LCV and the identification of the regulatory signals sensed during intracellular replicati

231 ly affects synonymous sites, suggesting that regulatory signals significantly constrain synonymous su

232 which viral inhibition is activated by viral regulatory signals such as defective-interfering particl

233 dent sites are not predicted by pre-existing regulatory signals, suggesting that Cdx2 can bind to a s

234 We have used these mutants to determine the regulatory signal that allows ATP to bind to the forward

235 pha-chain signal peptide contains a negative regulatory signal that prevents expression of an immunor

236 hways are not responsible for generating the regulatory signal that results in repression of INO1 and

237 nely tuned by multiple positive and negative regulatory signals that appropriately scale the magnitud

238 mRNA 3'-UTRs, are potent posttranscriptional regulatory signals that can rapidly effect changes in mR

239 a platform for multiple DNA damage-dependent regulatory signals that control DNA replication.

240 amic structures that are apparent targets of regulatory signals that control the function of focal ad

241 unctional actin cytoskeleton and transducing regulatory signals that control the paracellular barrier

242 on as a sensor, integrator, and processor of regulatory signals that converge on protein-coding gene

243 The models account for known regulatory signals that exert control over the pathway.

244 y heterogeneous and provide multiple complex regulatory signals that have the potential to enhance or

245 pacity of hematopoietic stroma to respond to regulatory signals that normally augment blood cell prod

246 , perhaps through the endocytosis of unknown regulatory signals that organize morphogenesis at synapt

247 3-kinase (PI3K)-Akt pathway transmits growth-regulatory signals that play a central role in promoting

248 interaction between extrinsic and intrinsic regulatory signals that regulate the myogenic process.

249 Here, we have dissected the regulatory signals that repress the expression of the st

250 t melanoma cells remain responsive to growth regulatory signals that result from contact with type I

251 pA bind to the C-type lectin SIGNR3 to exert regulatory signals that result in mitigation of colitis,

252 ring transposons to carry reporter genes and regulatory signals, the expression of target genes can b

253 in a genome in which they are surrounded by regulatory signals they must ignore.

254 ed inhibitory motifs that transduce negative regulatory signals through the cell membrane are found i

255 example, the interferon receptors transduce regulatory signals through the JAK/STAT pathway, resulti

256 Glutamine synthetase transmits the nitrogen regulatory signal to GlnR.

257 gh avidity and appears to deliver a negative regulatory signal to the T cell.

258 ass of regulators, a protein that transduces regulatory signals to a separable core motor machinery.

259 APCs provide costimulatory and down-regulatory signals to Ag-activated T cells through inter

260 l conditions and allow DNA sequence-mediated regulatory signals to be communicated to the active site

261 mmune cells to bacterial components provides regulatory signals to cognate immune cells.

262 uginosa, the GacS/GacA system transduces the regulatory signals to downstream genes exclusively by di

263 l protein kinase C isoforms (aPKCs) transmit regulatory signals to effector proteins located in the c

264 rces of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virul

265 re than simple tethering devices and mediate regulatory signals to the host protein.

266 ns related to the origin and transmission of regulatory signals to the myofiber.

267 Thus, SE could potentially deliver regulatory signals to the recipient mucosa via transfer

268 al role of the Mediator complex in conveying regulatory signals to the transcriptional apparatus.

269 the intracellular domain, including the key regulatory signal transduction elements and all of the c

270 suggested that they may be activating growth-regulatory signal transduction pathways.

271 ty of PPs is epigenetic modulation of growth-regulatory signal transduction pathways.

272 However, the regulatory signal transduction processes that control sC

273 le for activation of the MtrAB two-component regulatory signal transduction system, which includes se

274 is and Escherichia coli respond to identical regulatory signals, tryptophan and uncharged tRNA(Trp),

275 different cellular events, but that distinct regulatory signals ultimately control when and where unl

276 ytes by providing both positive and negative regulatory signals via multiple signaling pathways invol

277 e circumstances might be to provide negative regulatory signals via the CD28 homologue CTLA-4.

278 sponse of ectomesenchyme cells to epithelial regulatory signals was found to be different in the mand

279 e first exon of BTK contains transcriptional regulatory signals, we tested various portions of the se

280 icipate in previously unanticipated roles as regulatory signals with hormone-like functions.

281 atory RNA elements to specifically sense the regulatory signal, without accessory components, and con