ライフサイエンスコーパス: regulatory site

1 at vMIA contacts Bax at a previously unknown regulatory site.

2 a coli PabB, binds tryptophan in a vestigial regulatory site.

3 nding domain and the absence of metal in the regulatory site.

4 identify the basic patch on CP as a crucial regulatory site.

5 -Gly-NH2 at the dopamine receptor allosteric regulatory site.

6 ression was correlated with oxidation of the regulatory site.

7 ructure of *MtCM does not have an allosteric regulatory site.

8 , however, partially overlaps with the S100B-regulatory site.

9 states, it is unexpectedly different at the regulatory site.

10 bioactive lipids from a critical allosteric regulatory site.

11 ence of a previously unidentified allosteric regulatory site.

12 assign priority to a list of candidate MAPK regulatory sites.

13 that these sites were not the physiological regulatory sites.

14 opening at male-biased but not female-biased regulatory sites.

15 GTP/GDP and the absence of known allosteric regulatory sites.

16 ion of genes containing activation protein-1 regulatory sites.

17 ngs between transcriptional factors and gene regulatory sites.

18 e activities to ERG/FLI1 bound hematopoietic regulatory sites.

19 cription start site (TSS) regions and remote regulatory sites.

20 eved by at least two strategies for exposing regulatory sites.

21 that comprehensively mark cell-type-specific regulatory sites.

22 ic S129 site and the canonical S473 and T308 regulatory sites.

23 t mediates kinase dimerization, as potential regulatory sites.

24 ated intestine and its ability to bind these regulatory sites.

25 moters, regardless of the arrangement of cis-regulatory sites.

26 ly de rigeur for the identification of novel regulatory sites.

27 nd migration, regains phosphorylation at its regulatory sites.

28 ted to elongating RNA polymerase at specific regulatory sites.

29 h transcription factors (TFs) bind their DNA regulatory sites.

30 s human FOXO3 at six previously unidentified regulatory sites.

31 -conserved N-terminal domains proposed to be regulatory sites.

32 alpha subunit, Rnr1, contains catalytic and regulatory sites.

33 be extended to studying other classes of cis-regulatory sites.

34 ssion evidence, and the presence of upstream regulatory sites.

35 ment as well as at several distinct upstream regulatory sites.

36 chromatin remodeling at distal and proximal regulatory sites.

37 tionary losses/gains and massive rewiring of regulatory sites.

38 mapping robustly predicted functional miR-17 regulatory sites.

39 de repeat domain at a special class of Notch-regulatory sites.

40 (Mcidas, Rfx2, and Myb) with distinct Grhl2 regulatory sites.

41 ontrol of alternative splicing at cis-acting regulatory sites.

42 e previously identified dGTP-binding primary regulatory sites.

43 ) allows transcriptome-wide discovery of RNA regulatory sites.

44 d with inflammatory changes in thalamic pain regulatory sites.

45 evealed a previously unrecognized allosteric regulatory site 25 A from the active site.

46 th increased phosphorylation of the negative regulatory site 292 on Zap70 and a decrease in granzyme

47 (well below the concentration of TNC Ca(2+) regulatory sites, 67.6 mumol kg(-1)).

48 igenetic signature of thousands of potential regulatory sites across the genome.

49 tide polymorphism rs8050136 (located in this regulatory site) affects binding affinities of P200 and

50 Comparative analysis of candidate regulatory sites allowed us to characterize three differ

51 aptamer most likely binds to the receptor's regulatory site and inhibits it noncompetitively.

52 (3) Propionylphosphinate also binds at the regulatory site and its binding is reflected by catalyti

53 R interact with the clathrin light chain EED regulatory site and stimulate clathrin lattice assembly.

54 he predicted T4-like gene products and their regulatory sites and (e) content of open-reading frames

55 G4s play key roles as DNA regulatory sites and as kinetic traps that can inhibit b

56 and +6 mL/mol for the calcium binding to the regulatory sites and closed to open protein isomerizatio

57 olve fluctuations both in occupancies of DNA regulatory sites and copy numbers of protein products.

58 They are among the first factors to bind key regulatory sites and facilitate chromatin opening.

59 ramer contains four dGTP specific allosteric regulatory sites and four active sites.

60 tor specificity, improving identification of regulatory sites and reconstructing regulatory interacti

61 Here, we review the importance of these regulatory sites and what role they may play in the disr

62 is controlled by the presence of iron in the regulatory site, and iron-catalyzed oxidation of PerR by

63 e importance of its effects on gluconeogenic regulatory sites, and 3) to correlate those changes with

64 oxide could specifically oxidize APSK at its regulatory site, APSK was irradiated in the presence of

65 ipate in each other's regulation and distant regulatory sites are in communication with each other.

66 termine the organization of chromatin around regulatory sites are not fully known.

67 ve to Ca(2+) regulation, suggesting that the regulatory sites are not intrinsic to the channel protei

68 e genome background, amino acid and putative regulatory sites are not significantly enriched in allel

69 The identified regulatory sites are present in mammalian Musashi protei

70 DNaseI-seq identified putative regulatory sites around genes enriched in Sertoli and pr

71 Our results suggest the creation of miRNA regulatory sites as a novel function for ADAR activity.

72 rinsic to the mobilized vesicles and a novel regulatory site at the fusion pore itself.

73 tus in normal cells points to locally active regulatory sites at super-enhancers, which are targeted

74 h which nucleosomes form in regions flanking regulatory sites before induction, and the extent of the

75 ng the presence of a novel AE2a pH-sensitive regulatory site between amino acids 99 and 198.

76 Pausing at these regulatory sites blocks the formation of alternate struc

77 Super-enhancers are clusters of gene-regulatory sites bound by multiple transcription factors

78 MS2 coat protein is recruited to a splicing regulatory site by binding to an artificially inserted M

79 ting autophosphorylation of the tyrosine-831 regulatory site by site-directed mutagenesis enhances sh

80 alities in variant burden on tissue-specific regulatory sites by calculating the enrichment of allerg

81 To test this, we determined the number of regulatory sites by measuring the concentration of tropo

82 Regulatory site Ca(2+) binding altered dynamic propertie

83 To investigate this process, regulatory site Ca(2+) binding in the NH(2)-lobe of subu

84 ings demonstrate highly selective effects of regulatory site Ca(2+), including opposite changes in pr

85 e in response to 1,25D revealed a cluster of regulatory sites (cis-regulatory module; CRM) at -28 kb

86 motrypsins and elastases are inactive on the regulatory sites cleaved by CTRC, suggesting that CTRC r

87 How these regulatory sites communicate with catalytic residues is

88 This regulation occurs via a single AATAAATA regulatory site (conserved in the mouse) within the FTO

89 strongest transcriptional effects are on cis-regulatory sites containing the RORalpha binding motif.

90 Notably, some regulatory sites control the kinetic rather than the ove

91 Unexpectedly, rearranging sparkling's regulatory sites converts it into a robust photoreceptor

92 Using BBLS, we predict 1.5 million regulatory sites, corresponding to 380 known regulatory

93 While substitutions at the different Ca(2+)-regulatory sites could either slightly enhance or marked

94 The 'Regulatory sites' dataset includes curated information a

95 The environment at the regulatory site dictates the charge and the structural c

96 inding to a previously unidentified specific regulatory site distal to the Ifnb1 promoter.

97 These dynamic changes in functional regulatory sites, distal to the imatinib binding pocket,

98 To identify regulatory sites during sex determination, we subjected

99 Because binding to regulatory sites enables activators to stimulate transcr

100 d NF-kappaB and binds to proximal and distal regulatory sites enriched for genes involved in apoptosi

101 ; abdominal fat emerged as an important gene-regulatory site for blood lipids, such as for the low-de

102 e implicating the ER-to-Golgi transport as a regulatory site for control of cardiomyocyte growth.

103 that f-loop residues 562-679 may contain the regulatory site for endogenous XIP, but this site is dis

104 ancies, indicating this site as an important regulatory site for hematopoiesis.

105 The presence of a regulatory site for monovalent cations that affects the

106 ays, and also reveals a potential functional regulatory site for RPTPgamma.

107 membrane conductance regulator as a critical regulatory site for S1P signaling; its tumor necrosis fa

108 ively, our results identify Y1494 as a major regulatory site for signaling from the alpha6beta4 integ

109 onserved steroid binding site could reveal a regulatory site for steroids or structurally related mol

110 activation of caspases and suggest a common regulatory site for the allosteric control of inflammati

111 he medial preoptic area (MPOA) is a critical regulatory site for the control of male sexual behavior.

112 ated in the VRN1 promoter is the most likely regulatory site for the interaction with this second rep

113 ot used as a substrate, Na(+)-NQR contains a regulatory site for this ion, which acts as a nonessenti

114 enetic data implicating this domain as a key regulatory site for tuning stimulus sensitivity.

115 However, critical regulatory sites for Afp activation, overlapping Foxa1/p

116 The gene contains putative cis-regulatory sites for E2F, Caudal (Cdx) and Dearolf (Dfd)

117 ve not been considered because no allosteric regulatory sites for PINK1 are known.

118 gly phases flanking nucleosomes and presents regulatory sites for ready access.

119 located in intergenic regions that comprise regulatory sites for TFs or miRNA.

120 ch intriguingly also accommodate binding and regulatory sites for the key complement activation-speci

121 re mRNA allelic imbalances associated with a regulatory site found in mRNA transcribed from one allel

122 re, variants that affect chromatin at distal regulatory sites frequently also direct changes in chrom

123 Nonetheless, distinguishing regulatory sites from among the thousands identified by

124 structural transitions and could distinguish regulatory sites from nonfunctional conserved residues.

125 Phosphor mutants of CAP1 at the S307/S309 regulatory site had compromised rescue effects for both

126 ruitment in mammals remain unclear since few regulatory sites have been identified.

127 quent to removal of the calcium ion from the regulatory sites I and II.

128 ilitating genome-wide chromatin dynamics and regulatory site identification in C. elegans.

129 stimulate eNOS phosphorylation at a critical regulatory site, (ii) increase eNOS activity, and (iii)

130 urrence of surface pockets at the active and regulatory sites; ii) a simulated ensemble of unliganded

131 actors (TFs) assemble at tissue-specific cis-regulatory sites, implying that different TF combination

132 ong the first detailed analyses of a complex regulatory site in a GPCR, and provides insight into GPC

133 lates VDAC and that VDAC may be an important regulatory site in ischemia/reperfusion injury.

134 horylation at serine residue 536, a critical regulatory site in its transactivating domain.

135 ts 5-coordinate NO-binding capability to the regulatory site in soluble guanylate cyclase.

136 P response element (CRE) is a major positive regulatory site in the bcl-2 promoter.

137 the C terminus, but also at a more proximal regulatory site in the cytoplasmic C terminus (Ser-300);

138 tation (ChIP) confirmed binding of ATF4 to a regulatory site in the VEGF gene.

139 and p53 bind simultaneously to their shared regulatory site in wild type liver.

140 t-transcriptionally repress mRNA through cis-regulatory sites in 3' UTRs.

141 simultaneous interaction with both basal and regulatory sites in a given promoter.

142 eferentially targets female-biased genes and regulatory sites in a sex-independent chromatin state.

143 en receptor alpha binding to transcriptional regulatory sites in breast cancer cells.

144 ovides insight into mechanisms that maintain regulatory sites in chromatin and into functional compen

145 to form part of NF-kappaB bound to specific regulatory sites in chromatin.

146 operate differently through the same 3' cis-regulatory sites in distinct populations of retinal prog

147 iments identified Ser-413 and Ser-424 as key regulatory sites in IRF6.

148 encing to produce condition-specific maps of regulatory sites in male and female mouse livers and in

149 ed by FOXO3 when phosphorylated at these six regulatory sites in mammalian cells.

150 ily be applied to mapping condition-specific regulatory sites in mammalian tissues under a wide varie

151 FII-I is capable of acting at both basal and regulatory sites in one promoter and that the human VEGF

152 source has allowed the identification of cis-regulatory sites in previously unexplored regions of the

153 ls access to ribosome binding sites or other regulatory sites in RNA.

154 ) transport through the channel, feeding the regulatory sites in the cytoplasmic domain.

155 m Tcf3 without inhibiting its binding to cis-regulatory sites in the DNA.

156 Little is known about the nature of AR cis-regulatory sites in the human genome.

157 etics to study an entire layer of short, cis-regulatory sites in the human genome.

158 To identify regulatory sites in the murine c-myb upstream region, we

159 s, we show that Nek2 phosphorylates the same regulatory sites in the N-terminus of beta-catenin as gl

160 Evi1 binds with C/EBPbeta to regulatory sites in the Ppargamma locus at early stages

161 Variants at regulatory sites in the promoter and intronic regions le

162 The finding of multiple regulatory sites in the promoters supplements the bioche

163 while cellulases are controlled by different regulatory sites in three organisms.

164 identify condition-specific transcriptional regulatory sites in vivo to help elucidate the molecular

165 transcription factors to promoters and other regulatory sites in vivo.

166 high affinity site in two conserved Sostdc1 regulatory sites in vivo.

167 CLAM recovered a large number of novel RNA regulatory sites inaccessible by uniquely mapped reads.

168 Mutated regulatory sites include known sites in the TERT promote

169 As TFII-I is known to act at regulatory sites including E boxes as well as at the bas

170 s GC-rich, and harbored several putative cis-regulatory sites including KLFs, AP-2, EGRF and Sp-1.

171 The accessible regions contain functional regulatory sites, including promoters, insulators and en

172 -1903 of IP3R1) that is adjacent to numerous regulatory sites, including sites for proteolysis.

173 imately 100-bp region is densely packed with regulatory sites, including two promoters and three repr

174 Furthermore, EBF1 binding to Gata3 regulatory sites induced repressive histone modification

175 development of specific substrate active- or regulatory-site inhibitors with therapeutic potential.

176 determine whether the 3614-3643 region is a regulatory site/interaction domain within RyR in muscle

177 quilibrium dissociation constant of a single regulatory site is 8 mM for K(+).

178 ability of miR-155 to interact with the cis-regulatory site is decreased.

179 The novel upstream regulatory site is important for the maturation of sever

180 c factor Srf (serum response factor) to Egr1 regulatory sites is dependent on Bptf function.

181 e information encoded by combinations of cis-regulatory sites is interpreted primarily through simple

182 Metal binding to regulatory sites is through a reversible metal exchange

183 t subsequently binds to UAS2 (a critical cis-regulatory site located approximately 600 base pairs dow

184 transcriptional activators, which work from regulatory sites located between the divergently transcr

185 tream of the TSS, as well as at a cluster of regulatory sites located even further upstream between -

186 orylated H1 histone reacting with these same regulatory sites may decrease transcription frequency.

187 pamine-stimulated phosphorylation of Cx36 at regulatory sites, mediated by protein kinase A.

188 and nuclear factor kappaB (NFkappaB) as key regulatory sites mediating the induction of sPLA(2).

189 tion by binding to partial complementary cis-regulatory sites (miRNA binding sites) in their target m

190 BF-3 is a previously unrecognized allosteric regulatory site needed for AR activity in vivo and a pos

191 ranscriptional level but neither the AP1/Ets regulatory sites nor the redox sensitive (-1607/2G) site

192 et genes in both species, occurred at distal regulatory sites not promoters, and were strongly enrich

193 stimate that a typical gene harbors 7-15 cis-regulatory sites (nucleotides) at which a selectively ne

194 al lambdoid bacteriophages contain the three regulatory sites O(R)1, O(R)2 and O(R)3, to which the Cr

195 Mutations in the upstream regulatory site of ADAM17, ADAM10, and ADAM9 do not prev

196 roid pregnenolone sulfate, or the allosteric regulatory site of benzodiazepines/beta-carbolines.

197 free Cu ion and the BCB may serve as a main regulatory site of Cu in the CSF.

198 tagenesis showed that serine 1935 is a major regulatory site of NMII-B function.

199 gree, by dephosphorylation of Tyr(P)(346), a regulatory site of Syk, which becomes phosphorylated soo

200 ate requires the binding of a coagonist to a regulatory site of the receptor.

201 Pathogen-mediated selection often targeted regulatory sites of genes belonging to the same biologic

202 We found FXR to bind to regulatory sites of genes encoding these proteins in con

203 Whereas PTF1-L bound regulatory sites of genes in normal adult pancreatic cel

204 pecific expression, and to identify putative regulatory sites of membrane transport proteins.

205 To identify the regulatory sites of phosphorylation under physiologicall

206 lower change requires Ca(2+) binding to both regulatory sites of sTnC.

207 t, blocking catalysis without disrupting the regulatory sites of the enzyme does not affect filament

208 is less efficient in dephosphorylating other regulatory sites of this kinase.

209 However, occupancy of the transcriptional regulatory site on DNA by BirA is exquisitely tuned by t

210 ructure-based validation of a new allosteric regulatory site on Ras that is targetable in a mutant-sp

211 efects despite phosphorylation of a negative regulatory site on SLP-76 by HPK1, a function that is lo

212 ting phosphorylation at the primary positive regulatory site on the enzyme and hampering mechanisms o

213 escaped attention, including a potential new regulatory site on the opposite face to that involved in

214 tyrosine kinase whose target is the Src-SH2 regulatory site on the phospholipase C [PLC] complex.

215 PDGFA, by inhibiting its occupancy at a key regulatory site on the proximal PDGFA promoter.

216 phosphorylate the essential activation loop regulatory site on these kinases.

217 ivity, which prevents the phosphorylation of regulatory sites on C/EBPbeta.

218 Mechanistically, Evx1as RNA binds to regulatory sites on chromatin, promotes an active chroma

219 es histone H4 acetylation levels at specific regulatory sites on HOXB4, a transcription factor gene w

220 ase-III, we identified three putative Ca(2+)-regulatory sites on TGase-II.

221 modes, suggesting the presence of allosteric regulatory sites on the enzyme.

222 Sleep deprivation affects phosphorylation of regulatory sites on the kinase, suggesting a role for SI

223 with our goals being to identify the Ca(2+)-regulatory sites on the protein and determine whether th

224 ed to target a nitro group to redox-mediated regulatory sites on the receptor.

225 tants of the reaction between Ca(2+) and the regulatory sites on troponin; values of 0.4 x 10(8) m(-1

226 e allows users to search the database with a regulatory site or matrix to identify the TFs most likel

227 th residue 159 contributing to an anesthetic regulatory site or sites, and they suggest that volatile

228 Knowledge of regulatory sites outside the active and effector sites a

229 ng among the three sites, and (3) complement regulatory sites overlap with each of the three heparin

230 hyperphosphorylation of S6K1 at a subset of regulatory sites, particularly those of two essential re

231 ich binds with negative cooperativity to two regulatory sites per dimer to form, sequentially, Zur2:Z

232 the structural transitions occurring at this regulatory site, potentially altering transcription fact

233 r signaling pathway, possesses an allosteric regulatory site previously validated both in vitro and i

234 DNA-binding transcription factor and its cis-regulatory site, reminiscent of the coevolution of prote

235 ontains mitogen-activated kinase (MAPK)-like regulatory sites, responsible for MAPK inhibitor-sensiti

236 by phosphorylation and that mutations in key regulatory sites resulted in dominant negative alleles.

237 The interaction between calcium and the regulatory site(s) of striated muscle regulatory protein

238 stimulation also provoked phosphorylation of regulatory site Ser(916) on PKD.

239 e JNK can phosphorylate IRS1 on the negative regulatory site Ser-307.

240 ntially regulated Akt phosphorylation of the regulatory sites Ser-473 and Thr-450 and the catalytic T

241 This study reports how phosphorylation of a regulatory site (Ser-500) integrates with Ca(2+) and CaM

242 with phosphorylation at its transcriptional regulatory site, Ser133.

243 quires the phosphorylation of p53 at the key regulatory site, Ser15.

244 nteraction of NsrR with an A+T-rich class II regulatory site showed relaxed sequence specificity.

245 Mutational analysis of the regulatory site showed that the PerR metal ligands are i

246 Here we report identification of an Na(+) regulatory site, similar to an Na(+) coordination motif

247 nded by overlaps between the labels; e.g. if regulatory sites specific to a given cell type are also

248 these parental features and the depletion of regulatory sites such as post-translational modification

249 Putative intergenic regulatory sites, such as the conserved combox sequence

250 e at an artificial, multi-copy array of gene regulatory sites, supporting the use of multi-copy array

251 g) B cells enhanced c-Myc phosphorylation at regulatory sites, sustained higher c-Myc protein levels,

252 mplexes, we have solved the structure of the regulatory site synapse in the Sin resolvase system.

253 rotein interactions of splicing factors with regulatory sites termed silencers or enhancers, RNA-RNA

254 . melanogaster and D. simulans is greater at regulatory sites than expected from levels of intraspeci

255 e show that this cytosolic loop is part of a regulatory site that also includes residues in the G-loo

256 In summary, we have identified a new regulatory site that controls Bax's subcellular distribu

257 pose that Ser(87) of Bim(EL) is an important regulatory site that is targeted by Akt to attenuate the

258 ence of FKBP12, and identify a potential new regulatory site that may be exploited in the design of n

259 on Thr-686, a highly conserved intracellular regulatory site that was required for the PKA-mediated s

260 or, Ndt80, or for a new sporulation-specific regulatory site that we identified and several neutral s

261 domain, and the gamma subunits containing 2 regulatory sites that bind the activating and inhibitory

262 Together our results argue that the regulatory sites that control CTP synthase function, but

263 This locus contains multiple regulatory sites that could potentially affect expressio

264 ARVA highlights several novel highly mutated regulatory sites that could potentially be noncoding dri

265 lly dephosphorylating these kinases at a key regulatory site, the hydrophobic motif (Ser-473 in Akt1)

266 strates and products and the proteolytic and regulatory sites; the locations of these sites and the i

267 se risk-susceptibility regions encompass cis-regulatory sites, their transcriptional potential has ne

268 At some regulatory sites, this specificity confers distinct sile

269 for the first time information flux between regulatory sites through a conserved kinase infrastructu

270 s of the cyclin A2 promoter mapped the c-Jun regulatory site to an ATF site at position -80.

271 pled amino acids in Src kinase that connects regulatory sites to the ATP- and substrate-binding sites

272 We propose that distinct regulatory sites uniquely characteristic of individual A

273 eposits histone H2A.Z at promoters and other regulatory sites via an ATP-driven histone exchange reac

274 Although NsrR binding to the class II regulatory sites was NO insensitive in vitro, transcript

275 omoters regardless of the arrangement of cis-regulatory sites we studied.

276 t CaV1.2 channels harboring mutations at key regulatory sites, we show that adrenergic regulation of

277 al recruitment of NF-kappaB to specific gene regulatory sites, we used NF-kappaB p65 in a tandem affi

278 Potential miR-200 (b and c) and miR-217 regulatory sites were identified in mortalin mRNA.

279 analysis implied a second upstream positive regulatory site, which corresponded to a site of weak co

280 the +1166 A/C polymorphism occurred in a cis-regulatory site, which is recognized by a specific micro

281 BAFF-R-expressing cells suggested potential regulatory sites, which allowed the generation of EMSA p

282 In cleaving these regulatory sites, which are characterized by multiple fl

283 ance acetylated residues are proximal to the regulatory sites while the lower abundance phosphorylati

284 sm predicts that compounds that bind to this regulatory site with equal or higher affinity for the op

285 regulation, substitutions of individual Chk1 regulatory sites with alanine (A) residues have differen

286 data to optimize thresholds for identifying regulatory sites with each matrix.

287 tion and desaturation of the troponin Ca(2+) regulatory sites with each twitch during calling.

288 We develop a procedure for identifying regulatory sites, with high levels of conservation acros

289 y revealed is the existence of an additional regulatory site within GPSM3 directed toward monomeric G

290 at SATB proteins physically associate with a regulatory site within the Eomes promoter.

291 in-capping site, there appears to be another regulatory site within the tropomodulin C-terminal domai

292 teraction of the vitamin D receptor (VDR) at regulatory sites within both the Cyp24a1 and the Trpv6 g

293 Ikaros directly associates with regulatory sites within Cebpa and Hes1 and regulates the

294 ent, the PtREV gene contains three potential regulatory sites within noncoding regions at the gene's

295 asis of allosteric coupling between two Ca2+ regulatory sites within the domain.

296 port that Egr-1 binds and activates multiple regulatory sites within the pdx-1 promoter.

297 he Il4, Il5, and Il13 genes as well as other regulatory sites within the Th2 locus.

298 to form nucleosomes--such that, for example, regulatory sites would be 'nucleosome-free'.

299 P-1 dephosphorylates TonEBP/OREBP at a known regulatory site, Y143, both in vivo and in vitro.

300 eruginosa study these were designated as the regulatory site (Zn1) and structural site (Zn2).