ライフサイエンスコーパス: reinforcing effect

1 rs in the ventral tegmental area (VTA) has a reinforcing effect.

2 effects of methylphenidate in brain and its reinforcing effects.

3 rs where stimulation has both drive-like and reinforcing effects.

4 opamine in nucleus accumbens underlies their reinforcing effects.

5 e behavioral paradigms, we failed to observe reinforcing effects after stimulation of these fibers.

6 Importantly, TP003 had significant reinforcing effects, albeit at lower levels of self-admi

7 e 5-HT1B agonists do not produce significant reinforcing effects alone.

8 receptors play a role in modifying ethanol's reinforcing effects and voluntary intake, and that 5-HT1

9 n important site in the mediation of cocaine reinforcing effects, and MPFC self-stimulation (MPFCSS)

10 ed DA increases (as well as their subjective reinforcing effects) are markedly blunted compared with

11 Drugs of abuse exert their initial reinforcing effects by triggering supraphysiologic surge

12 hold for blood and brain levels required for reinforcing effects (drug liking) and for therapeutic ef

13 dala (CeA) nucleus has a complex role in the reinforcing effects effects of ethanol and the anxiogeni

14 s, whereas THC (0.01-10 mug/kg) did not have reinforcing effects in any subject.

15 R agonists (PRE-084, (+)-pentazocine) lacked reinforcing effects in drug-naive rats, over the course

16 shell--consistent with their lack of robust reinforcing effects in monkeys.

17 valuated intravenously administered 2-AG for reinforcing effects in nonhuman primates.

18 sts, and that the mechanism underlying these reinforcing effects is dopamine independent.

19 to inform us about mechanisms related to its reinforcing effects, less is known about clinically rele

20 cquisition and expression of the conditioned reinforcing effects maintained by drug-paired stimuli.

21 The reinforcing effects occur principally through GABA and d

22 Reinforcing effects occur when methylphenidate elicits l

23 rpeduncular (Hb-IPn) system can modulate the reinforcing effect of addictive drugs and the anxiolytic

24 The main reinforcing effect of cocaine happens by altering dopami

25 effect of cocaine while also modulating the reinforcing effect of cocaine in an operant-based self-a

26 addiction, mAb 15A10 blocked completely the reinforcing effect of cocaine in rats.

27 The main reinforcing effect of cocaine is alteration of dopaminer

28 o an increase in extracellular dopamine; the reinforcing effect of cocaine is associated with elevate

29 The reinforcing effect of cocaine is associated with increas

30 n as DAT has been implicated strongly in the reinforcing effect of cocaine.

31 We propose that this memory-reinforcing effect of novelty could be explained by mech

32 The reinforcing effect of picrotoxin was site-specific: Ante

33 ght envisions dopamine neurons conveying the reinforcing effect of the unconditioned stimulus during

34 release, which is critically involved in the reinforcing effect of tobacco smoking.

35 of cannabinoid self-administration, and the reinforcing effects of 2-AG were mediated by CB1 recepto

36 o assess involvement of CB1 receptors in the reinforcing effects of 2-AG, we pretreated monkeys with

37 e ventromedial striatum (VMS) mediates acute reinforcing effects of abused drugs, but with protracted

38 possibility that these receptors mediate the reinforcing effects of alcohol after consumption of one

39 delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye sacc

40 suppresses, rather than substitutes for, the reinforcing effects of alcohol.

41 ining GABAA receptors may have a role in the reinforcing effects of benzodiazepine-type compounds in

42 receptors may be important mediators of the reinforcing effects of benzodiazepine-type compounds in

43 anxiolytic, sedative, motor, subjective, and reinforcing effects of benzodiazepine-type drugs.

44 Finally, we show that the reinforcing effects of both anandamide and methanandamid

45 binol (THC) in adolescent rats might enhance reinforcing effects of cannabinoids in adulthood.

46 Parkinsonian rodent models show enhanced reinforcing effects of chronic dopaminergic medication,

47 and that the D1 receptor is critical for the reinforcing effects of cocaine and other dopamine agonis

48 In monkeys, social status influences the reinforcing effects of cocaine and the effects of some d

49 determined by in vivo microdialysis, on the reinforcing effects of cocaine and the opioid agonist, r

50 the role of the dopamine transporter in the reinforcing effects of cocaine and the ultimate identifi

51 We tested the hypothesis that the reinforcing effects of cocaine are decreased in M5 recep

52 current data suggest that the satiating and reinforcing effects of cocaine are mediated by different

53 Although the reinforcing effects of cocaine are mediated primarily by

54 The reinforcing effects of cocaine have been related to incr

55 te that buspirone selectively attenuates the reinforcing effects of cocaine in a nonhuman primate mod

56 on of galanin could affect the locomotor and reinforcing effects of cocaine in mice.

57 suggests a critical role for dopamine in the reinforcing effects of cocaine in rats and primates.

58 -01] produced surmountable antagonism of the reinforcing effects of cocaine in the commonly used stra

59 For subordinate monkeys, sensitivity to the reinforcing effects of cocaine increased while sensitivi

60 ditioned reinstatement extend to the primary reinforcing effects of cocaine or SCM.

61 nsporter (DAT) plays a prominent role in the reinforcing effects of cocaine that can lead to addictio

62 consistent with a partial attenuation of the reinforcing effects of cocaine under a fixed-ratio sched

63 e the effects of social confrontation on the reinforcing effects of cocaine using a food-drug choice

64 ibutions of D2-like receptor subtypes in the reinforcing effects of cocaine using new genetic and pha

65 Dopamine is an important mediator of the reinforcing effects of cocaine, and alterations in dopam

66 ndings suggest that Kal7 participates in the reinforcing effects of cocaine, and that Kal7 and cocain

67 ave been shown to regulate the rewarding and reinforcing effects of cocaine, but the underlying mecha

68 the dopamine system is known to mediate the reinforcing effects of cocaine, the dopaminergic variati

69 concentrations of dopamine mediate the acute reinforcing effects of cocaine.

70 ter is thought to be the primary mediator of reinforcing effects of cocaine.

71 receptor subtype plays a pivotal role in the reinforcing effects of cocaine.

72 ive ratio schedule, consistent with enhanced reinforcing effects of cocaine.

73 t not the SERT, is critical in mediating the reinforcing effects of cocaine.

74 r both (DAT(-/-)SERT(-/-)) exhibit decreased reinforcing effects of cocaine.

75 in mice has not been reported to reduce the reinforcing effects of cocaine.

76 cc may play a role in mediating the behavior reinforcing effects of cocaine.

77 PP-32 play important roles in modulating the reinforcing effects of cocaine.

78 Reinforcing effects of Delta(9)-tetrahydrocannabinol (TH

79 ocal anesthetic properties may influence the reinforcing effects of dopamine uptake inhibitors, we in

80 but not the acquisition, of the conditioned reinforcing effects of drug-paired stimuli.

81 racterizing orderly interactions between the reinforcing effects of drugs and environmental context t

82 dum (VP) is a well-established locus for the reinforcing effects of drugs of abuse and reinstatement

83 The reinforcing effects of drugs of abuse result from the co

84 nown for its prominent role in mediating the reinforcing effects of drugs of abuse such as cocaine, a

85 eA) is an important integrative site for the reinforcing effects of drugs of abuse, such as ethanol.

86 pamine is widely implicated in mediating the reinforcing effects of drugs of abuse.

87 A) are well known for mediating the positive reinforcing effects of drugs of abuse.

88 for investigating mechanisms involved in the reinforcing effects of endocannabinoids.

89 ying the neural areas underlying the primary reinforcing effects of ethanol, few studies have examine

90 the VTA, have been implicated in the primary reinforcing effects of ethanol, the roles these areas pl

91 action in CeA plays an important role in the reinforcing effects of ethanol.

92 brain region thought to be critical for the reinforcing effects of ethanol.

93 mPOA in the neural circuitry underlying the reinforcing effects of female sexual behavior and raise

94 ism may specifically suppress the hedonic or reinforcing effects of food, thus blocking its capacity

95 ine (DA) D2-like receptor involvement in the reinforcing effects of food.

96 clear, although self-selection and mutually reinforcing effects of HIV treatment and prevention mess

97 apse rates among alcoholics by modifying the reinforcing effects of initial alcohol consumption and a

98 recent levels of activity, results from the reinforcing effects of La-Nina-like climate conditions a

99 ate that M5 receptor deletion diminished the reinforcing effects of low doses of cocaine and identifi

100 mulus-reward learning and are induced by the reinforcing effects of many drugs of abuse, including al

101 The addictive and reinforcing effects of many drugs of abuse, such as coca

102 bic dopaminergic system is implicated in the reinforcing effects of many drugs, including nicotine, t

103 activation of the pelvic nerve mediates the reinforcing effects of mating for female rats.

104 results show that the pathway conveying the reinforcing effects of mating stimulation does not depen

105 2) Pharmacokinetics--the reinforcing effects of methylphenidate are associated wi

106 esponses, may mediate the enhancement of the reinforcing effects of methylphenidate by expectation an

107 The reinforcing effects of nicotine administration into the

108 de that buspirone selectively attenuates the reinforcing effects of nicotine alone and nicotine+cocai

109 that varenicline selectively attenuates the reinforcing effects of nicotine alone but not cocaine al

110 choline receptors (nAChRs) are linked to the reinforcing effects of nicotine and maintaining smoking

111 mediate the development of tolerance to the reinforcing effects of nicotine and the manifestation of

112 The reinforcing effects of nicotine are mediated by brain re

113 We first investigated the reinforcing effects of nicotine in drug-naive alpha5(-/-

114 The reinforcing effects of nicotine into the posterior VTA o

115 The reinforcing effects of nicotine into the three brain reg

116 ibitor, increases sensitivity to the primary reinforcing effects of nicotine, shifting the dose-respo

117 Sex differences exist in the reinforcing effects of nicotine, smoking cessation rates

118 al tegmental area (VTA) mediate the positive reinforcing effects of nicotine.

119 e examined whether these regions mediate the reinforcing effects of nicotine.

120 forcement, and whether dependence alters the reinforcing effects of opiates by examining the effect o

121 extended amygdala may be responsible for the reinforcing effects of opiates in dependent animals and

122 evious studies revealed that blockade of the reinforcing effects of opiates with systemic administrat

123 and has been implicated in the analgesic and reinforcing effects of opiates.

124 medial shell of the NAc are critical for the reinforcing effects of oral ethanol.

125 tio choice procedure was used to measure the reinforcing effects of oxycodone.

126 lts indicate that cocaine experience induces reinforcing effects of previously inactive sigma(1)R ago

127 er and Lewis rats may differ in the initial, reinforcing effects of psychoactive drugs, but not in re

128 are capable of increasing the rewarding and reinforcing effects of select psychostimulant drugs, and

129 Here, we examine the reinforcing effects of several compounds that vary with

130 content of cigarettes decreased the relative reinforcing effects of smoking in all 3 populations.

131 om those that are critical for conveying the reinforcing effects of sugar.

132 eptor [6] specifically convey the short-term reinforcing effects of sweet taste [4].

133 Many of the reinforcing effects of THC are mediated by the dopamine

134 Reinforcing effects of THC have been demonstrated in exp

135 he left, consistent with potentiation of the reinforcing effects of THC.

136 se curves, consistent with antagonism of the reinforcing effects of THC.

137 The reinforcing effects of the alpha1-sparing compounds were

138 nnel blockers can prevent the behavioral and reinforcing effects of the drug and also cocaine-induced

139 es may further predispose an organism to the reinforcing effects of the drug or enhance the susceptib

140 nd the capacity of these titers to block the reinforcing effects of the drug, rats were tested at var

141 s in the amygdala that regulate the positive reinforcing effects of the drug.

142 attributable in part to a diminution of the reinforcing effects of vaginocervical stimulation.

143 Cocaine produces its reinforcing effects primarily by inhibiting the dopamine

144 ose-positron emission tomography) and on its reinforcing effects (self-reports of drug effects) were

145 Opioid action was thought to exert reinforcing effects solely via the initial agonism of op

146 netics, which results in fewer addictive and reinforcing effects than cocaine; the effects of the dru

147 -dependent individuals by reducing alcohol's reinforcing effects through facilitation of gamma-aminob

148 e anthropogenic environmental stressors with reinforcing effects to the deterioration of ecosystem st

149 Sugar exerts its potent reinforcing effects via both gustatory and post-ingestiv

150 The induced reinforcing effects were long lasting; a response for wh

151 In contrast to those mice, cocaine's reinforcing effects were not diminished in SERT(-/-) mic