ライフサイエンスコーパス: reinitiation

1 ciated with high persistence after treatment reinitiation.

2 es (PICs), but permits few rounds of RNAP II reinitiation.

3 and duration of expression through frequent reinitiation.

4 by a mechanism involving delayed translation reinitiation.

5 t matter of upstream E6*I ORF by translation reinitiation.

6 formation of a pre-RC is not sufficient for reinitiation.

7 evels of active DnaA are reduced, preventing reinitiation.

8 bsequent activator-independent transcription reinitiation.

9 rty of the synthase is chain termination and reinitiation.

10 e Scaffold complex involved in transcription reinitiation.

11 verlapping mechanisms efficiently preventing reinitiation.

12 cation, oriC, from methylation and premature reinitiation.

13 TFIIF complex is competent for transcription reinitiation.

14 n complex activates replication and prevents reinitiation.

15 re of TBP interactions during initiation and reinitiation.

16 A and appeared to involve either shunting or reinitiation.

17 damage-induced activation through efficient reinitiation.

18 mulation of multiple cycles of transcription reinitiation.

19 mplex and leads to a defect in transcription reinitiation.

20 pendent loss of protein factors required for reinitiation.

21 initiation, without affecting transcription reinitiation.

22 ation for subsequent rounds of transcription reinitiation.

23 pressor specifically targets transcriptional reinitiation.

24 the occurrence of leaky scanning along with reinitiation.

25 ulate transcription preinitiation as well as reinitiation.

26 nthesis is resumed, resulting in cell growth reinitiation.

27 y of productive transcription initiation and reinitiation.

28 roughout the cell cycle but does not promote reinitiation.

29 nteracts directly with proteins required for reinitiation.

30 ing scanning ribosomes, and not by affecting reinitiation.

31 effect on the efficiency of termination and reinitiation.

32 n high rates of transcription initiation and reinitiation.

33 ome but not all nonviral sequences inhibited reinitiation.

34 intergenic region also influenced polymerase reinitiation.

35 considerably faster than product release or reinitiation.

36 regulate replication by preventing premature reinitiation.

37 ption elongation and maintains transcription reinitiation.

38 al functions in transcription initiation and reinitiation.

39 by promoting transcriptional initiation and reinitiation.

40 tron, a structure that facilitates ribosomal reinitiation.

41 ation complexes and the activity persists at reinitiation.

42 sid protein VP2 is expressed via termination/reinitiation.

43 contains three sequence motifs essential for reinitiation.

44 ith >/=1 day of statin supply 182 days after reinitiation.

45 otein, and resets the polymerase complex for reinitiation.

46 ncluding the facilitation of transcriptional reinitiation.

47 tion, which enhances the rate of translation reinitiation.

48 lease and thereby repressing transcriptional reinitiation.

49 n and also contributes to metastatic lesions reinitiation.

50 ntify miR-335 as a robust inhibitor of tumor reinitiation.

51 eEF3 action promotes ribosome recycling, not reinitiation.

52 ggesting CDK8 involvement in transcriptional reinitiation.

53 On reinitiation, 27.1% changed statin type, 6.9% up-titrate

54 In the 182 days after reinitiation, 45.8% had high persistence.

55 ion of eIF2 during stress delays translation reinitiation, allowing scanning ribosomes to bypass uORF

56 This delayed reinitiation allows for ribosomes to scan through the in

57 nuation, reinitiation, and persistence after reinitiation among Medicare beneficiaries after hospital

58 mechanisms for escaping the first-AUG rule--reinitiation and context-dependent leaky scanning--enabl

59 proteins not only by polyprotein processing, reinitiation and frameshifting but also by using multipl

60 persistently open state to facilitate rapid reinitiation and perhaps also to bypass TFIIH-dependent

61 ciated factors have been shown to facilitate reinitiation and regulate transcription in some species.

62 Then, we observed the reinitiation and reorientation of protein synthesis, acc

63 role for ABCE1 in translation recycling and reinitiation and revisits the interpretation of Simonett

64 uch as scanning, start codon recognition, or reinitiation and suggest that poor translation initiatio

65 ning the patterns of statin discontinuation, reinitiation, and persistence after reinitiation among M

66 chanisms - context-dependent leaky scanning, reinitiation, and possibly direct internal initiation -

67 in AAV DNA replication: terminal resolution, reinitiation, and strand displacement.

68 combination of leaky ribosomal scanning and reinitiation, and that the sequences surrounding the PB1

69 yploid macronucleus, mechanisms that prevent reinitiation appear intact.

70 events that could be important for efficient reinitiation are also described.

71 hat properties of uORFs that permit ribosome reinitiation are critical for directing gene-specific tr

72 Signals for termination-reinitiation are found within a 32-nucleotide stretch of

73 The consequences of reinitiation are unknown.

74 The gradual decrease in reinitiation as an upORF is lengthened, confirmed here u

75 ve initiation, and promoter clearance and/or reinitiation, as measured by multiple rounds of transcri

76 G codon, suggesting downstream translational reinitiation at a putative TTG start.

77 ontaining scaffold facilitates transcription reinitiation at active promoters.

78 ll cycle reassembly of the pre-RC, and hence reinitiation at an origin, is directly inhibited by S an

79 tion delays ribosome capacitation and favors reinitiation at ATF4 over the inhibitory uORF2.

80 affect translation initiation or by ribosome reinitiation at downstream AUG codons, which would incre

81 ement that facilitates ribosome scanning and reinitiation at downstream coding regions in the ATF4 mR

82 sed reinitiation at uORFs 3 or 4 and reduced reinitiation at Gcn4p.

83 en implicated in the prevention of premature reinitiation at newly replicated chromosomal origins in

84 on control switch that specifically prevents reinitiation at replicated origins.

85 etween R-loops and Sgs1-mediated replication reinitiation at stalled forks and identifies R-loops uni

86 ha-P via an uORF that allows for translation reinitiation at the CReP coding region independent of st

87 ll elongating ribosomes and prevent ribosome reinitiation at the downstream CHOP coding sequence.

88 RF in GADD34 acts as a barrier that prevents reinitiation at the GADD34 coding region.

89 of F protein by interfering with termination/reinitiation at the M-F gene junction, thus promoting th

90 Although reinitiation at the original start site is independent o

91 nd removed from the nascent plus-strand DNA, reinitiation at the resulting plus-strand primer terminu

92 Adding purified eIF2 increased reinitiation at uORFs 3 or 4 and reduced reinitiation at

93 Target of rapamycin (TOR) promotes reinitiation at upstream ORFs (uORFs) in genes that play

94 ased replication blockage and thus increased reinitiation away from oriC, also exacerbates DnaB-induc

95 he initiation of DNA replication and prevent reinitiation before mitosis, presumably through phosphor

96 resulted in longer wait times for treatment reinitiation, but no adverse visual outcomes were identi

97 ion abolishes ROP2 regulation of translation reinitiation, but not its effects on cytoskeleton or int

98 e promoting cyclin-dependent kinases prevent reinitiation by blocking the repetition of an early step

99 of isomerization, promoter clearance, and/or reinitiation by phosphorylated KID to enhance target gen

100 d transcription termination, and La-mediated reinitiation by pol III.

101 ribosomal tethering of mRNA by TURBS allows reinitiation by post-termination 80S ribosomes and dimin

102 on eukaryotic initiation factor 3 (eIF3) of reinitiation by recycled 40S subunits, which can be medi

103 itro, a subset of Pol II factors facilitates reinitiation by remaining very stably bound to the promo

104 scription is achieved through many rounds of reinitiation by RNA polymerase (pol) III on stable DNA-b

105 facilitates transcriptional termination and reinitiation by RNA polymerase III.

106 e for chain extension of the zwitterions and reinitiation by the N-heterocyclic carbenes liberated up

107 esulting gene loops facilitate transcription reinitiation by the same molecule of RNAP II in a manner

108 To determine the advantages conferred on reinitiation by TURBS, we reconstituted this process in

109 Interestingly, we were able to show that reinitiation can occur at AUG codons downstream of the c

110 hat the uORF length-dependence of changes in reinitiation competence is affected by peptide elongatio

111 ore linked to the kinetics of acquisition of reinitiation-competence by post-termination ribosomes in

112 as a scaffold for formation of a functional reinitiation complex.

113 The inhibition of F gene reinitiation correlated with foreign sequences having a

114 Reinitiation, defined by a statin fill, was identified i

115 ed mRNAs are sorted and processed for either reinitiation, degradation, or packaging into stable nonp

116 tion-initiation, elongation, and termination/reinitiation-determine protein synthesis rates even at l

117 to be translated is progressively truncated, reinitiation downstream of an uORF of 105nt is found to

118 int signaling and triggering DNA replication reinitiation during the S-phase checkpoint recovery.

119 a result of a novel translation termination/reinitiation event between the nonstructural-protein and

120 To shed light on polymerase termination and reinitiation events at the crucial leader-N gene junctio

121 2 undergoes multiple consecutive replication reinitiation events at the genomic termini.

122 posttermination ribosomes suggests that some reinitiation events could involve 80S ribosomes rather t

123 placement replication strategy, the multiple reinitiation events from one parental template yield hig

124 , the CDK8 submodule strongly represses even reinitiation events, suggesting a means to fine tune tra

125 o help regulate transcription initiation and reinitiation events.

126 igins, some of which are capable of multiple reinitiation events.

127 ropose a new model in which TAFs function as reinitiation factors, accounting for the differential re

128 p), has been proposed to depend on ribosomal reinitiation following termination of the upstream ORF,

129 ucose sensitivity is a function of ribosomal reinitiation following translation of an upstream open r

130 This indicates that eIF2 affects the site of reinitiation following translation of GCN4 uORF1 in vitr

131 The probability of wean from PN without reinitiation for at least 1 year, as determined by logis

132 lude leaky scanning, shows barely detectable reinitiation from an AUG codon positioned 4 nt upstream

133 from the terminator codon and no detectable reinitiation from an AUG codon positioned farther upstre

134 mark of activated transcription is efficient reinitiation from promoter-bound scaffold complexes that

135 ot essential for but regulates transcription reinitiation in a length-dependent but sequence-independ

136 ly need eIF4G and eIF4A: There was efficient reinitiation in a standard reticulocyte lysate, when ini

137 ion would be largely driven by eIF4F, but no reinitiation in an eIF4G-depleted lysate.

138 This genome-wide analysis suggests that reinitiation in G2/M phase primarily occurs at a subset

139 The efficiency of reinitiation in mammalian translation systems depends in

140 ERK was not sufficient to promote cell cycle reinitiation in MMC-treated KSR1(-/-) cells.

141 ed visualization of packaging initiation and reinitiation in real time and quantification of motor as

142 ignificant effect on the number of rounds of reinitiation in the S100 extract.

143 xamine the underlying mechanism, we examined reinitiation in vitro using a series of mRNAs that diffe

144 TERMINI repeat unit enables the quantitative reinitiation, in the presence or absence of a catalyst,

145 Features required for this reinitiation include an upstream translation start and a

146 d elongation assays using heparin to prevent reinitiation indicated that LEF-5 was active only in the

147 d not influence M gene termination or F gene reinitiation, indicating that M-F intergenic length per

148 Here we describe the isolation of a reinitiation intermediate that includes transcription fa

149 al mechanisms involving either translational reinitiation, internal ribosomal entry, or leaky ribosom

150 to be in the range of 60 to 75 nt/s, with a reinitiation interval of approximately 1.2 s.

151 Another aspect of reinitiation investigated here is whether post-terminati

152 ts suggest that the mechanism of translation reinitiation involving uORFs is conserved from yeast to

153 Transcriptional reinitiation is a distinct phase of the RNA polymerase I

154 Reinitiation is a strategy used by viruses to express se

155 Once an origin has initiated, reinitiation is blocked until the completion of mitosis,

156 Prior work has shown that reinitiation is deficient in nuclear extracts from Chine

157 Studies in yeast have shown that the rate of reinitiation is increased by facilitated recycling, a pr

158 stress suggest that modulating recycling and reinitiation is involved in responding to environmental

159 These data indicate that cell cycle reinitiation is not actively signaled in the absence of

160 detailed analyses revealed that the site of reinitiation is not fixed to a single codon and does not

161 show that pulsatile mRNA production, through reinitiation, is crucial for the dependence of noise on

162 in how ribosomes bypass the uORFs, including reinitiation, leaky scanning, and internal initiation of

163 help to define the circumstances under which reinitiation may be expected to occur in the growing num

164 uORFs facilitates ORF35 expression, while a reinitiation mechanism after translation of the uORFs en

165 s of the process, disrupts the gene-specific reinitiation mechanism for translation of GCN4 mRNA and

166 gulates PB1-N40 expression, most likely by a reinitiation mechanism that permits skipping of AUG4.

167 A coupled termination-reinitiation mechanism that requires host or eukaryotic

168 translated by an unconventional termination/reinitiation mechanism.

169 ) expression is regulated by a translational reinitiation mechanism.

170 fect of slowing elongation is limited to the reinitiation mode.

171 iate structure, initiation, termination, and reinitiation must be accurate and efficient.

172 Our data show that recycling and reinitiation must be distinct processes in Saccharomyces

173 pen reading frames (ORFs) on cellular mRNAs, reinitiation occurs efficiently on subgenomic bicistroni

174 Reinitiation occurs in either of two reading frames in t

175 rnation) states with additional recovery for reinitiation of a new active state by observing the meta

176 Reinitiation of active therapy led to viral decay and re

177 9.3%) patients maintained sinus rhythm after reinitiation of antiarrhythmic drugs, and an additional

178 patients who had a relapse had a response to reinitiation of antibiotic therapy.

179 ent developed new efavirenz resistance after reinitiation of antiretroviral therapy.

180 sponded to discontinuation of tacrolimus and reinitiation of antiviral therapy.

181 ,640 HIV-1 copies/ml 5 days later, prompting reinitiation of ART.

182 spiked but rapidly returned to baseline with reinitiation of ART.

183 Recurrent ONJ followed reinitiation of bisphosphonates in six of 12 patients.

184 delayed maturation of palisade, and ectopic reinitiation of blade primordia along the midrib.

185 In addition, our findings suggest that reinitiation of cambial activity and transdifferentiatio

186 ion of protein synthesis, accompanied by the reinitiation of cell division and de novo cell wall synt

187 and polarized mammary acini initially led to reinitiation of cell proliferation, increased survival o

188 r 402 phosphorylation also ensures efficient reinitiation of cell tip growth and cell division during

189 discontinuation of zafirlukast treatment and reinitiation of corticosteroid treatment or addition of

190 cle replication products, thereby permitting reinitiation of DNA chain elongation following spontaneo

191 ring each cell cycle in these cells to allow reinitiation of DNA replication in the next cell cycle.

192 in A-Cdk2-dependent process, suggesting that reinitiation of DNA replication is prevented by removal

193 pression of Cdc18 causes a mitotic delay and reinitiation of DNA replication, suggesting that the ina

194 l, an early event in recombination-dependent reinitiation of DNA replication.

195 8 and Cdt1, contributes to the prevention of reinitiation of DNA replication.

196 Cdc2 kinase activity is required to prevent reinitiation of DNA replication.

197 microM, a range similar to that reported for reinitiation of DNA synthesis and activation of the seru

198 et-derived growth factor (PDGF), promote the reinitiation of DNA synthesis and cell growth through mu

199 e promotion of translesion synthesis and the reinitiation of DNA synthesis by homologous recombinatio

200 phase and failure of cytokinesis; subsequent reinitiation of DNA synthesis results in polyploidy.

201 , as indicated by derepression of cyclin D1, reinitiation of DNA synthesis, and acquisition of basal

202 f EGFR tyrosine kinase activity, blocked the reinitiation of DNA synthesis, demonstrating that growth

203 utrient replenishment and growth factors for reinitiation of DNA synthesis, whereas HCT116 cells requ

204 posure to proximal tubular cells resulted in reinitiation of DNA synthesis, whereas no such effect wa

205 dant with regulation of Cdc18 for preventing reinitiation of DNA synthesis.

206 oid, presumably as a result of inappropriate reinitiation of DNA synthesis.

207 whereas lymphocyte turnover decreased after reinitiation of drug treatment.

208 ppeared at points of cell contact during the reinitiation of epithelial continuity.

209 Reinitiation of epoetin therapy among individuals could

210 To maintain genomic stability, reinitiation of eukaryotic DNA replication within a sing

211 a mechanism for loss of tissue polarity and reinitiation of growth associated with MMP9 activity.

212 ormalization of RA levels is associated with reinitiation of hf development.

213 e showed that these motifs are essential for reinitiation of huNV VP2 translation.

214 even patients were treated with increased or reinitiation of immunosuppression therapy; all returned

215 This GTP hydrolysis was required for reinitiation of import of a nuclear localization sequenc

216 terioration in glycemic control, followed by reinitiation of insulin therapy.

217 In conclusion, these results suggest that reinitiation of kidney development from a population of

218 ng-term respiratory outcomes associated with reinitiation of mechanical ventilation prevents assessme

219 hronic respiratory morbidity associated with reinitiation of mechanical ventilation.

220 ication was sufficient and necessary for the reinitiation of meiosis.

221 During chemically induced reinitiation of MEL cell terminal differentiation, expre

222 th interphase chromosomes is involved in the reinitiation of mitotic chromosome condensation in conju

223 ing acute phase, systolic BP at 4 hours, and reinitiation of OAC for long-term treatment.

224 to PhaC was approximately 60, which required reinitiation of polymer formation on PhaC.

225 Moreover, temporal control over reinitiation of polymer growth was achieved during on/of

226 ferentiation but did inhibit Ca(2+)-mediated reinitiation of proliferation and reversion in different

227 When the shock strength was low, immediate reinitiation of reentry and ventricular fibrillation mig

228 ression of RNF4, AURKA, or PLK1 returned the reinitiation of replication in Atr-deleted cells to near

229 CtrA approximately P then blocks the reinitiation of replication while regulating the transcr

230 e expression of the nuclear isoform requires reinitiation of ribosomes at the M27 AUG after terminati

231 es downstream translation due to inefficient reinitiation of ribosomes that translate uORF, the hairp

232 We conclude that CDK inhibits reinitiation of S phase during G(2), and if G(2)/M CDK i

233 ation of the genome once in each cell cycle, reinitiation of S phase is prevented in G(2) and origins

234 The reinitiation of smallpox vaccination has renewed interes

235 ror agent has heightened the interest in the reinitiation of smallpox vaccination.

236 cision repair, homologous recombination, and reinitiation of stalled replication forks [3, 4].

237 s role in lagging-strand DNA replication and reinitiation of stalled replication forks, we propose th

238 e further demonstrate a role for KSR1 in the reinitiation of the cell cycle and proliferation followi

239 does not influence the site of transcription reinitiation of the downstream gene.

240 their degradation may be necessary to allow reinitiation of the endocycle.

241 The altered morphology is not a result of reinitiation of the myonuclei cell cycle nor is it due t

242 p dual-deallylation reaction thus allows the reinitiation of the polymerase reaction and increases th

243 Reinitiation of therapy at the prior effective dose led

244 these populations again contracted following reinitiation of therapy.

245 o pre-HAART-termination levels 8 weeks after reinitiation of therapy.

246 To obtain insights into the mechanism of reinitiation of this proliferative response in different

247 Reinitiation of tocilizumab therapy led to good uveitis

248 ns to affect both termination and initiation/reinitiation of transcription by human RNA polymerase II

249 ermination of upstream transcript as well as reinitiation of transcription of downstream transcript.

250 tively affects multiple-round transcription (reinitiation of transcription) and termination.

251 e case for Set2 in yeast, MET-1 prevents the reinitiation of transcription.

252 high levels by promoting multiple rounds of reinitiation of transcription.

253 Curiously, the N184X mutation triggers the reinitiation of translation at a third start codon in SP

254 sharply under osmotic stress, the subsequent reinitiation of translation is retarded, and "processing

255 ent during interruption of therapy and after reinitiation of treatment.

256 duplex DNA followed by rapid reannealing and reinitiation of unwinding in several successions.

257 otes activation of TOR, and thus translation reinitiation of uORF-containing mRNAs.

258 formation, thereby preventing the post-shock reinitiation of ventricular fibrillation.

259 of actin) was used as an intervention after reinitiation of vesicular transport.

260 NA replication, thereby preventing premature reinitiations of chromosome replication.

261 r complexes greatly facilitate transcription reinitiation on chromatin in vitro, and act at a limitin

262 initiator moieties are deactivated to avoid reinitiation on existing brushes.

263 nit joining to influence AUG recognition and reinitiation on GCN4 mRNA.

264 ype BLM and hRPA was necessary for unwinding reinitiation on hRPA-coated DNA.

265 Here we model the effect of ribosome reinitiation on translation and show that, at high level

266 ypes of polymerase at either the initiation, reinitiation or both stages of the transcription cycle.

267 ROP2 coordinates TOR function in translation reinitiation pathways in response to auxin.

268 covalently cross-linked templates yielded a reinitiation pattern with a wider spacing than in more p

269 Reinitiation probably occurs through a different pathway

270 The multiple reinitiation process ensures rapid copying of the parent

271 (negative RNA2) hampers the reattachment and reinitiation processes.

272 to form a complex with PriA, the primosomal reinitiation protein.

273 translation and show that, at high levels of reinitiation, protein synthesis rates are dominated by t

274 ately 60 nucleotides/s for yeast Pol I and a reinitiation rate of less than 1 s on the most heavily t

275 polymerase could be a primary determinant of reinitiation rate, allowing diversity in promoter streng

276 d by the same TATA box mutation that reduced reinitiation rate.

277 ying this reduction by lowering the apparent reinitiation rate.

278 no direct correlation between IR length and reinitiation rates but demonstrated that specific IR len

279 lear extract system was established in which reinitiation rates were observed to be kinetically facil

280 With resolution of stress, translation reinitiation reverses this process and SGs disassemble.

281 respond to an authentic VSV termination and reinitiation signal present at each gene junction, we re

282 dividual DI-RNAs, identified breakpoints and reinitiation sites, and predicted their structural featu

283 with an unintended translational termination-reinitiation (split) near the finger tip, dramatically i

284 and demonstrated that a coupled termination-reinitiation (stop-restart) strategy is indeed used.

285 les (SGs), wherein mRNAs undergo sorting for reinitiation, storage, or decay.

286 ity of a soluble factor that is limiting for reinitiation, that the factor increases the number of el

287 llowed by global impairment of transcription reinitiation through MTI.

288 We recapitulated reinitiation using a reconstituted mammalian translation

289 On the other hand, when transcription reinitiation was allowed to occur, ER, but not p300, was

290 Efficient reinitiation was found to occur only if the eIF4F comple

291 II complexes in transcription initiation and reinitiation was investigated by supplementing extracts

292 initiate treatment, statin persistence after reinitiation was low.

293 the duration of elongation is what matters, reinitiation was nearly abolished when a pseudoknot that

294 ntrast to transcription of G-free cassettes, reinitiation was unaffected by the transcription factor

295 g a purified system to examine transcription reinitiation, we found that Pol II-TFIIF was active in p

296 nt for observed rapid rates of transcription reinitiation were explored.

297 c region had a differential effect on F gene reinitiation, where some but not all nonviral sequences

298 the specific chemical probe does not affect reinitiation, which requires the re-entry of Pol II, thu

299 us detection of both specific initiation and reinitiation with any combination of promoter and transc

300 why nuclear permeabilization is required for reinitiation within one cell cycle.