ライフサイエンスコーパス: relapsing fever

1 , another spirochete pathogen and a cause of relapsing fever.

2 ered species is a causal agent of tick-borne relapsing fever.

3 sis, and B. hermsii, the agent of tick-borne relapsing fever.

4 rrelia recurrentis, the agent of louse-borne relapsing fever.

5 of several spirochete species that can cause relapsing fever.

6 s of pathogenesis and immunity of tick-borne relapsing fever.

7 rsistence of Lyme borreliosis and tick-borne relapsing fever.

8 mission and pathogenesis of Lyme disease and relapsing fever.

9 of mammalian hosts, causing Lyme disease and relapsing fever.

10 oles in the pathogenesis of Lyme disease and relapsing fever.

11 lia species associated with Lyme disease and relapsing fever.

12 Unlike Borrelia burgdorferi, the relapsing fever agent Borrelia hermsii and the related B

13 The antigenic variation of the relapsing fever agent Borrelia hermsii is associated wit

14 The relapsing fever agent Borrelia hermsii undergoes multiph

15 proteins: VspB of B. turicatae, Vsp26 of the relapsing fever agent Borrelia hermsii, and OspC of the

16 deficiency (scid mice) and infected with the relapsing fever agent Borrelia turicatae develop manifes

17 The relapsing fever agent Borrelia turicatae has two antigen

18 ntly infected with isogenic serotypes of the relapsing fever agent Borrelia turicatae.

19 enic variation is similar to that of another relapsing fever agent, B. hermsii.

20 ent mice infected with Borrelia turicatae, a relapsing fever agent, have a disorder that resembles di

21 e vector-borne bacterium Borrelia hermsii, a relapsing fever agent, switches gene expression of a sur

22 smids 180 and 170 kb in size, present in the relapsing fever agents B. hermsii and B. turicatae but n

23 llow serological confirmation of louse-borne relapsing fever and determination of disease prevalence.

24 anism previously isolated from patients with relapsing fever and from ticks in Spain that is designat

25 The spirochaetes that cause tick-borne relapsing fever and Lyme disease are closely related hum

26 ochetes and help clarify the distribution of relapsing fever and Lyme disease in situations in which

27 n products serve functions essential to both relapsing fever and Lyme disease spirochetes.

28 ologic disease manifestations develop during relapsing fever and that T cells play a critical role in

29 persistent infections, such as anaplasmosis, relapsing fever, and sleeping sickness, remains untested

30 r human diseases, including epidemic typhus, relapsing fever, and trench fever.

31 Between 1996 and 1998, 12 cases of relapsing fever associated with two exposure sites in no

32 IL-10-deficient mice infected with the relapsing fever bacterium Borrelia turicatae rapidly suc

33 Analysis of another relapsing fever bacterium, B. parkeri, indicated that it

34 ividual episodes of bacteremia caused by the relapsing fever bacterium, Borrelia hermsii.

35 ch pathogens, we studied Borrelia hermsii, a relapsing fever bacterium.

36 e that some Borrelia species associated with relapsing fever bind fH, but not those associated with a

37 burgdorferi, the agent of Lyme disease, and relapsing fever Borrelia in the absence of complement.

38 udies have shown that antigenic variation in relapsing fever Borrelia not only permits the evasion of

39 stigated during the course of infection of a relapsing fever Borrelia species in plasminogen-deficien

40 l Spanish isolates of SRF Borrelia and other relapsing fever Borrelia species.

41 estations in humans depends on the infecting relapsing fever Borrelia species.

42 ular and linear plasmids of Lyme disease and relapsing fever Borrelia spirochetes carry genes for mem

43 Relapsing fever Borrelia spp. undergo antigenic variatio

44 e for the PAS in heart and brain invasion by relapsing fever Borrelia, resulting in organ injury.

45 endent bactericidal monoclonal IgM against a relapsing fever Borrelia, was constructed to investigate

46 served in the plasma of mice infected with a relapsing fever borrelia.

47 th during the cell cycle is also observed in relapsing fever Borrelia.

48 role for MyD88 signaling in host defense to relapsing fever Borrelia.

49 fect of nonantibody, innate host defenses to relapsing fever Borrelia.

50 e B. burgdorferi sensu lato isolates and the relapsing-fever Borrelia species.

51 The Lyme disease (Borrelia burgdorferi) and relapsing-fever (Borrelia hispanica) agents have distinc

52 Relapsing fever borreliae replicate to high levels in th

53 cytopenia is common in persons infected with relapsing fever Borreliae.

54 tem that closely resembles the VMP system of relapsing fever borreliae.

55 We conclude that persistent infection with relapsing fever borrelias causes significant loss of car

56 Relapsing fever borreliosis is a multisystemic infection

57 nificant injury during experimental Lyme and relapsing fever borreliosis when the immune response is

58 During relapsing fever borreliosis, a high pathogen load in the

59 pathogen load, as during peak bacteremia in relapsing fever borreliosis, IL-10 protects innate immun

60 M required for the control and resolution of relapsing fever borreliosis.

61 (JHR) observed after antibiotic treatment of relapsing fever caused by Borrelia recurrentis is associ

62 Tick-borne relapsing fever caused by the spirochaete Borrelia dutto

63 Tick-borne relapsing fever, caused by pathogenic Borrelia such as B

64 Relapsing fever, caused by the spirochete Borrelia herms

65 on, whereas the role of adaptive immunity to relapsing fever-causing spirochetes is well documented,

66 k of disease caused by tick- and louse-borne relapsing fever due to Borrelia infection is cyclic febr

67 continuous monitoring in an animal model of relapsing fever due to Borrelia infection.

68 To evaluate the pathogenesis of relapsing fever due to spirochetes in an animal model cl

69 s, pentoxifylline treatment of patients with relapsing fever fails to prevent or diminish JHR or the

70 l test antigen for discriminating tick-borne relapsing fever from Lyme disease.

71 confirmed the presence of these genes in the relapsing fever group of spirochetes but not in B. burgd

72 B. lonestari is more closely related to the relapsing fever group spirochetes than to borreliae that

73 , a spirochete that is classified within the relapsing-fever group of spirochetes.

74 the Western Front reported on a soldier with relapsing fever, headache, dizziness, lumbago, and shin

75 as a human pathogen causing hard tick-borne relapsing fever (HTBRF) across the Northern Hemisphere.

76 Abs are protective against Lyme disease and relapsing fever, illnesses caused by Borrelia spirochete

77 Therefore, the potential for tick-borne relapsing fever in humans and other animals exists in Fl

78 relia hermsii, a spirochaete responsible for relapsing fever in humans, grows to high density in the

79 The spirochetemia of relapsing fever in mice is cleared by a complement-indep

80 ations for understanding the epidemiology of relapsing fever in North America and can be applied to t

81 The primary causative agent of tick-borne relapsing fever in North America is Borrelia hermsii.

82 hermsii, an etiological agent of tick-borne relapsing fever in North America, binds host-derived ser

83 the primary etiological agent of tick-borne relapsing fever in North America, binds the complement r

84 a hermsii is the primary cause of tick-borne relapsing fever in North America.

85 Relapsing fever is also associated with the infection of

86 Relapsing fever is an infection characterized by peaks o

87 Relapsing fever is associated with high-level bacteremia

88 Tick-borne relapsing fever is caused by numerous Borrelia species m

89 se findings suggest that thrombocytopenia of relapsing fever is the result of platelet clearance afte

90 Agents that cause Lyme disease, relapsing fever, leptospirosis, and syphilis belong to t

91 era from individuals with syphilis (n = 43), relapsing fever (n = 8), Lyme disease (n = 8), and lepto

92 Human louse-borne relapsing fever occurs in sporadic outbreaks in central

93 ng sera of patients suspected to have either relapsing fever or Lyme disease.

94 tein (vmp) system for antigenic variation of relapsing fever organisms.

95 e propose to use strain SP1, isolated from a relapsing fever patient in 1994 in southern Spain, as th

96 Immunoblot analyses demonstrated that relapsing fever patients produced antibodies to Mlp prot

97 Serum samples from relapsing fever patients reacted with recombinant PBH-51

98 ic cross-reactivity (98% if the samples from relapsing fever patients were excluded).

99 that Borrelia hermsii, a causative agent of relapsing fever, produces a factor H (FH) and FH-like pr

100 nship with borreliae causing Lyme disease or relapsing fever remains undescribed.

101 aracterize surface proteins expressed by the relapsing fever (RF) agent Borrelia hermsii in the blood

102 orthologous thymidylate synthase gene in the relapsing fever (RF) agent Borrelia hermsii, located it

103 Surface-exposed lipoproteins of relapsing fever (RF) and Lyme borreliosis Borrelia spiro

104 Borrelia species of relapsing fever (RF) and Lyme disease (LD) lineages have

105 Tick-borne relapsing fever (RF) borreliosis is a neglected disease

106 ement is common in the spirochetal infection relapsing fever (RF) in both humans and experimental ani

107 a variety of species of Borrelia that cause relapsing fever (RF) in humans.

108 Relapsing fever (RF) is a multisystemic spirochetal infe

109 Relapsing fever (RF) is a spirochetal infection characte

110 Relapsing fever (RF) is a spirochetal infection characte

111 Relapsing fever (RF) is caused by tick- and louse-borne

112 Borrelia hermsii and other relapsing fever (RF) species are noted for their highly

113 orreliosis (LB) group Borrelia species and 7 Relapsing-fever (RF) group Borrelia species.

114 previously described BBK32-like proteins in relapsing fever species, indicates that BHA007 is a memb

115 arly after infection, Borrelia crocidurae, a relapsing fever species, induced a striking loss of marg

116 he vlp/vsp antigenic variation system of the relapsing fever spirochaete, Borrelia hermsii.

117 icatae directly promoted GAG binding by this relapsing fever spirochaete.

118 Thus, relapsing fever spirochaetes have the potential to expre

119 esponse and contribute to the ability of the relapsing fever spirochaetes to achieve high cell densit

120 minoglycans (GAGs) mediate the attachment of relapsing fever spirochaetes to mammalian cells.

121 GAGs mediated the attachment of relapsing fever spirochaetes to potentially relevant tar

122 Genome sequencing of two species of relapsing fever spirochaetes, Borrelia hermsii and Borre

123 ein and enzymatic activity were found in all relapsing fever spirochaetes, but not in Lyme disease or

124 s a unique and functional serine protease in relapsing fever spirochaetes.

125 rtant contributor to the pathogenesis of the relapsing fever spirochete B. hermsii.

126 cA of B. burgdorferi, as well as RecA of the relapsing fever spirochete Borrelia hermsii and the free

127 We previously showed that the relapsing fever spirochete Borrelia hermsii binds to and

128 The tick-borne relapsing fever spirochete Borrelia hermsii evades the m

129 Serotypes A and B of the relapsing fever spirochete Borrelia turicatae produce di

130 ed with serotype A but not serotype B of the relapsing fever spirochete Borrelia turicatae, early inv

131 the Borrelia parkeri-B. turicatae tick-borne relapsing fever spirochete group with a late-term aborti

132 Borrelia miyamotoi is a relapsing fever spirochete in Ixodes ticks that has been

133 Some Lyme disease and relapsing fever spirochete species bind factor H to thei

134 ted the polyclonal IgM Ab response against a relapsing fever spirochete to determine the specificity

135 Lyme disease spirochete) and B. turicatae (a relapsing fever spirochete).

136 The relapsing fever spirochete, Borrelia hermsii, alternates

137 The relapsing fever spirochete, Borrelia hermsii, escapes im

138 B. turicatae, confirming this bacterium as a relapsing fever spirochete.

139 urgdorferi sensu stricto strain CA4, and the relapsing-fever spirochete B. parkeri (undesignated).

140 ed characterization of the Bdr proteins in a relapsing-fever spirochete species, enhancing our unders

141 Borrelia hermsii, a tick-borne relapsing-fever spirochete, contains orthologs to glpQ a

142 the bdr gene family of Borrelia turicatae, a relapsing-fever spirochete.

143 n will identify people exposed previously to relapsing fever spirochetes and help clarify the distrib

144 standing of the pathogenic mechanisms of the relapsing fever spirochetes and of the molecular nature

145 ay be involved in the pathogenicity of these relapsing fever spirochetes and provide a mechanism for

146 , and Borrelia afzelii strains as well as in relapsing fever spirochetes Borrelia hermsii and Borreli

147 Genome sequencing of the relapsing fever spirochetes Borrelia hermsii and Borreli

148 infected with B. hermsii or other species of relapsing fever spirochetes contained antibodies recogni

149 The relapsing fever spirochetes contained six open reading f

150 s complete pathway for purine salvage in the relapsing fever spirochetes may contribute, in part, to

151 poproteins are serotype-defining antigens of relapsing fever spirochetes that undergo multiphasic ant

152 poproteins are serotype-defining antigens of relapsing fever spirochetes that undergo multiphasic ant

153 Genome sequencing projects on two relapsing fever spirochetes, Borrelia hermsii and Borrel

154 from but most closely related to that of the relapsing fever spirochetes.

155 icipate in long-lasting immunity to Lyme and relapsing fever spirochetes.

156 discernible ortholog to the hpt gene in the relapsing fever spirochetes.

157 tion and pathogen load during infection with relapsing fever spirochetes.

158 systems for the genetic manipulation of the relapsing fever spirochetes.

159 molecular mechanisms of pathogenesis of the relapsing fever spirochetes.

160 Relapsing-fever spirochetes achieve high cell densities

161 losely related sequence) is multicopy in the relapsing-fever spirochetes and is carried on variably s

162 s of borreliae demonstrated GlpQ activity in relapsing-fever spirochetes but not in Lyme disease spir

163 hern blots demonstrated glpQ and glpT in all relapsing-fever spirochetes but not in the Lyme disease

164 zation of a gene from B. turicatae and other relapsing-fever spirochetes that exhibits homology with

165 The unique ability of relapsing-fever spirochetes to hydrolyze phospholipids m

166 The complexity of disease caused by relapsing-fever spirochetes was demonstrated in the nonh

167 ssible importance in the pathogenesis of the relapsing-fever spirochetes.

168 with the glpQ sequences obtained from other relapsing-fever spirochetes.

169 icks in Spain that is designated the Spanish relapsing fever (SRF) Borrelia.

170 Tick-borne relapsing fever (TBRF) is a spirochetal disease caused b

171 In North America, tick-borne relapsing fever (TBRF) is caused by the spirochete speci

172 a relapse followed febrile illness caused by relapsing fever, trench fever, epidemic typhus, and Malt

173 Borrelia hermsii, an agent of relapsing fever, undergoes antigenic variation of seroty

174 chaetes, although similar in sequence to the relapsing fever vlp genes, has evolved a completely diff

175 The structures confirm that relapsing fever Vsp proteins share a common helical fold

176 Borrelia hermsii, an agent of tick-borne relapsing fever, was found to contain multiple circular

177 To develop a specific serological test for relapsing fever, we created a genomic DNA library of B.

178 Fifteen patients with confirmed relapsing fever were infused intravenously with pentoxif

179 s obtained from 42 patients with louse-borne relapsing fever were tested with an indirect immunofluor

180 Borrelia hermsii, agents of Lyme disease and relapsing fever, were examined by epifluorescence micros

181 ination of spirochetemia in murine models of relapsing fever, without the assistance of complement.