ライフサイエンスコーパス: releasable

1 e to extracellular protease and is detergent releasable.

2 ent led to AbetaO binding that was no longer releasable.

3 re docked at the plasma membrane and readily releasable.

4 th low probability despite being immediately releasable.

5 hasic release of insulin from both a readily releasable and a storage pool of beta-granules.

6 ted terminals relies on well-defined readily releasable and cytoplasmic vesicle pools.

7 lay a kinetic defect in refilling of readily releasable and immediately releasable vesicle pools (RRP

8 educed or undetectable, suggesting that both releasable and membrane-bound alpha-granule constituents

9 ially targets the transporter to the readily releasable and recycling pool of vesicles.

10 y area and number of vesicles in the readily releasable and recycling pools, all correlated with incr

11 tion, a Ca(2)(+) sensitive K(+) current, and releasable and reserve pools of vesicles.

12 ptic vesicle recycling, and enlarged readily-releasable and reserved vesicle pools.

13 A model that accounts for the releasable and unreleasable components of MWNTs was used

14 e demonstrate the generation of systemically releasable anti-cancer drugs from multilayer nanofilms.

15 enabled the identification of seven thrombin-releasable antimicrobial peptides from human platelets:

16 We show that sphingosine, a releasable backbone of sphingolipids, activates synaptob

17 e aging (AR) and analyzed for free and Brine Releasable (BR) VSCs and redox potential.

18 Brine-releasable (BR-) and free fractions of Volatile Sulfur C

19 response to strong stimulation and were also releasable by hypertonic sucrose.

20 terminal by providing both a local source of releasable Ca and by effects on luminal Ca-dependent RyR

21 The sarcoplasmic reticulum (SR) had more releasable Ca(2+) and contributed more to the response t

22 Moreover, the releasable Ca(2+) content of the stores did not change b

23 reticulum (SR) Ca(2+) release and maximal SR-releasable Ca(2+) contributes to decreased specific forc

24 BI-1 overexpression also reduces releasable Ca(2+) from the ER.

25 d junctional SR, and 2), the availability of releasable Ca(2+) in the junctional SR.

26 Quantification of caffeine-releasable Ca(2+) pools consistently showed larger centr

27 ochondria that reduces the available pool of releasable Ca(2+) within the ER, thereby inhibiting calc

28 -contraction coupling, but not in maximal SR-releasable Ca(2+), account for the age-dependent decline

29 hat regulates PDG luminal pH and the pool of releasable Ca(2+).

30 lished the effect of thapsigargin on the IP3-releasable Ca2+ pool.

31 The difference suggests that 75% of the releasable calcium is normally bound to calsequestrin.

32 een wild-type and Cmpt fibers, the amount of releasable calcium was significantly reduced in the latt

33 In course of time, the amount of releasable compounds decreased, pointing to altering pro

34 (w,0)) in the pore water and the accessible (releasable) concentration in the sediment (C(as,0)) are

35 The releasable conjugate regenerated Luminespib activity and

36 d toward overcoming such limitations through releasable conjugates in which the drug is covalently li

37 the production of an NMDA receptor-dependent releasable copper pool within hippocampal neurons, a fin

38 lls were grown on arrays of microfabricated, releasable elements composed of SU-8 polymer termed "cel

39 prior methods for creating cell arrays with releasable elements, no chemical modification of the sub

40 icated that Mn reduced the available pool of releasable ER Ca(2+) at concentrations as low as 1 muM.

41 The releasable factor adenosine blocks the formation of long

42 n=12) annuloplasty rings were implanted in a releasable fashion.

43 n=12) annuloplasty rings were implanted in a releasable fashion.

44 These results demonstrate that releasable FIX can be expressed and stored in platelet a

45 cytoplasmically sequestered 5-HT is readily releasable from both COS-7 cells and the guinea pig ileu

46 eal and bacterial lipids relative to what is releasable from their respective high-pressure catalytic

47 ranule exocytosis, facilitating refilling of releasable granule pools while also limiting the rate of

48 wn that approximately 90-95 % of the heparin-releasable (HR) LPL activity normally present in rat mus

49 ells reduced the Ca(2+) content of ionomycin-releasable intracellular stores and decreased endoplasmi

50 re we describe the synthesis of a chemically releasable, irreversible K(+) channel inhibitor and its

51 te peptide and TAT were conjugated through a releasable linker, either a disulfide or photolabile bon

52 The releasable linkers provide additional benefits that incl

53 Myocardial heparin-releasable lipoprotein lipase (LPL) activity was moderat

54 the plasma membrane and associates in an ATP-releasable manner to the actin-containing insoluble pell

55 thioglycollate, greater pools of epinephrine-releasable marginated neutrophils, greater sensitivity t

56 e that the RH5Nt-P113 interaction provides a releasable mechanism for anchoring RH5 to the merozoite

57 Arrays of transparent, releasable micrometer-scale structures termed "microcups

58 ibed is the construction of a large array of releasable microstructures (micropallets) along with scr

59 mor cells from whole blood using an array of releasable microstructures termed micropallets.

60 viding an array of approximately 1.3 million releasable microstructures.

61 For comparable cytoplasmic Ca(2+) loads, the releasable mitochondrial Ca(2+) in SNL L5 neurons was le

62 ased and the release rate coefficient of the releasable MWNTs also increased.

63 ancer cell lines, can be incorporated into a releasable octaarginine conjugate that is effective agai

64 od was stored in platelets, most of which is releasable on activation of platelets.

65 e variety of cargo attachment strategies for releasable or nonreleasable transporter applications.

66 hanges in either the size or mobilization of releasable or reserve pools, and (3) a decrease in rabph

67 vidence of these intracellular DPPs cleaving releasable peptides, such as NPY, in live cells.

68 ch epidermis, using microneedles coated with releasable polyelectrolyte multilayers.

69 This immediately releasable pool (IRP) of granules, identified both struc

70 endence of the effective size of the readily releasable pool (RRP) also contributes to the calcium de

71 nge applies to the release of both a readily releasable pool (RRP) and a slower secondary pool of ves

72 cal and functional properties of the readily releasable pool (RRP) and the reserve pool of synaptic v

73 e pool awaiting recruitment into the readily releasable pool (RRP) for exocytosis.

74 docked synaptic vesicles within the readily releasable pool (RRP) from synaptic vesicle clusters in

75 in release probability (Pr ) and/or readily-releasable pool (RRP) in many synapses, but the role of

76 in release probability (Pr ) and/or readily-releasable pool (RRP) in many synapses, but the role of

77 ted in a significant increase in the readily releasable pool (RRP) of secretory granules, and decreas

78 tion of the rate of refilling of the readily releasable pool (RRP) of secretory granules.

79 ed to a reduction in the size of the readily releasable pool (RRP) of SVs.

80 in release probability (Pr ) and/or readily-releasable pool (RRP) of synaptic vesicles (SVs), but th

81 flux, and diminishes the size of the readily-releasable pool (RRP) of synaptic vesicles, consistent w

82 eed the rate of replenishment of the readily releasable pool (RRP) of synaptic vesicles, depression o

83 lutions that measure the size of the readily releasable pool (RRP) of synaptic vesicles.

84 letion of synaptic vesicles from the readily releasable pool (RRP) of transmitter.

85 ggested that complexin maintains the readily releasable pool (RRP) of vesicles and clamps spontaneous

86 but does not change the size of the readily-releasable pool (RRP) of vesicles as measured by stimula

87 The readily releasable pool (RRP) of vesicles is a core concept in s

88 The size of the readily releasable pool (RRP) of vesicles is critically importan

89 uIPSCs in granule cells to evaluate readily releasable pool (RRP) size and resupply rate of recyclin

90 ow that another presynaptic feature, readily releasable pool (RRP) size, is tonotopically distributed

91 l fate of vesicles endocytosed after readily releasable pool (RRP) stimulation in rat hippocampal syn

92 cytosis recycles vesicles within the readily releasable pool (RRP) via a kiss-and-run mechanism that

93 ascent synapses without a functional readily releasable pool (RRP) was unresponsive to PMA applicatio

94 acilitates release efficacy from the Readily Releasable Pool (RRP), and regulates SV distribution to

95 comitant increase in the size of the readily releasable pool (RRP).

96 pses by a high-calcium stimulus, the readily releasable pool (RRP).

97 tivated for transmitter release, the readily releasable pool (RRP).

98 ependent increase in the size of the readily releasable pool (RRP).

99 st and slow releasing SVs within the readily releasable pool (RRP).

100 r component) after exocytosis of the readily releasable pool (RRP).

101 ainly control the fast fusion of the readily releasable pool (RRP); that is, they encode the phasic e

102 , and redirecting them to refill the readily releasable pool after relaxation of the calcium signal.

103 tic vesicles were detected: a small, rapidly releasable pool and a larger and more slowly releasable

104 in Rett syndrome (RTT), but the state of its releasable pool and downstream signaling in mice lacking

105 n (GSIS) resulting from reduction in readily releasable pool and granule pool refilling.

106 aptic vesicle pools, including the immediate releasable pool and the ready releasable pool-key elemen

107 ltaneously released vesicles) in the readily releasable pool and their replenishment time constant ca

108 s associated with a reduction in the readily releasable pool and vesicle recycling which impaired the

109 of vesicle membrane retrieval for the entire releasable pool appears to be sufficiently fast to compe

110 at Epac2 is required to maintain the readily releasable pool at MF synapses in the hippocampus.

111 n of docked synaptic vesicles into a readily releasable pool by activating SNAREs for efficient membr

112 in this system replenishment of the readily releasable pool by the reserve vesicles was strictly GTP

113 In Ringer solution, the Ca2+ in the light-releasable pool can be discharged merely by the decrease

114 tosis of synaptic vesicles after the readily releasable pool has either been physiologically exhauste

115 e plasma membrane (complete discharge of the releasable pool in approximately 200 msec).

116 e size and replenishment rate of the readily releasable pool in autaptic neurons.

117 First, the spatial distribution of the releasable pool is altered; peptide release from untreat

118 f release, and the number of vesicles in the releasable pool is comparable to the number of vesicles

119 e absence of UNC-18, the size of the readily releasable pool is severely reduced.

120 Recruitment of SVs to the releasable pool is thought to be an important component

121 ikely at the level of replenishing the ready releasable pool of beta-granules.

122 om the storage pool to replenish the readily releasable pool of beta-granules.

123 availability of an NMDA receptor-dependent, releasable pool of copper in hippocampal neurons and dem

124 ethyl-p-tyrosine, which depletes the readily releasable pool of dopamine, cocaine was still capable o

125 brane-attached vesicles comprise the readily releasable pool of fusion-competent vesicles and that sy

126 ression to endothelial cells may establish a releasable pool of FVIII and normalize plasma FVIII leve

127 esicles but regulate the size of the readily releasable pool of GABAergic vesicles.

128 ned to test whether there are changes in the releasable pool of GnRH in the hypothalamus in response

129 KO mice due to impaired replenishment of the releasable pool of granules and that the Ide gene is hap

130 sing from an increase in size of the readily releasable pool of insulin SGs and enhanced SG pool refi

131 exo-endocytosis, they populate a reluctantly releasable pool of limited size.

132 ted that estradiol increases the potentially releasable pool of NPY in inhibitory presynaptic boutons

133 l GTPase in reducing the size of the readily releasable pool of SVs and in channeling retrieved SVs t

134 esicle dispersion did not affect the readily releasable pool of SVs, whereas the total number of SVs

135 The segregation of the readily releasable pool of synaptic vesicles (RRP) in sub-pools

136 Ca(2+) channels and the size of the readily releasable pool of synaptic vesicles at active zones.

137 s release and limits the size of the readily-releasable pool of synaptic vesicles at the active zone

138 d docking and their loss reduces the readily releasable pool of synaptic vesicles by up to 75%.

139 ng the homeostatic modulation of the readily releasable pool of synaptic vesicles following inhibitio

140 revealed that pregabalin reduces the readily releasable pool of synaptic vesicles in an N-methyl-d-as

141 and acceptor vesicles, mimicking the readily releasable pool of synaptic vesicles prior to an action

142 al extent of evoked release, size of readily releasable pool of synaptic vesicles, and release probab

143 forms, SV2A and SV2B, have a reduced readily releasable pool of synaptic vesicles, indicating that SV

144 nt of synaptotagmin 1 suppressed the readily releasable pool of synaptic vesicles, whereas wild-type

145 ngth, by stabilizing the size of the readily releasable pool of synaptic vesicles.

146 BK channels, and an increase in the readily releasable pool of synaptic vesicles.

147 leased synchronously with the normal readily releasable pool of synaptic vesicles.

148 nce between the reserve pool and the readily releasable pool of synaptic vesicles.

149 release probability and size of the readily releasable pool of the synapse.

150 ynaptic currents and the size of the readily releasable pool of transmitter.

151 hapsigargin or cyclopiazonic acid primes the releasable pool of vasopressin in the dendrites, so that

152 lease-ready vesicles from an unusually large releasable pool of vesicles (approximately 300 per site)

153 e hearing onset, and by an increased readily releasable pool of vesicles (RRP) thereafter.

154 believed to mobilize sequentially a readily releasable pool of vesicles (RRP) underneath the synapti

155 The readily releasable pool of vesicles (RRP) varies in size during

156 EPSCs and decreased the size of the readily releasable pool of vesicles (RRP).

157 underneath the synaptic ribbons and a slowly releasable pool of vesicles (SRP) at farther distance fr

158 balance persists for turnover of the entire releasable pool of vesicles and allows for efficient esc

159 evented decreases in the size of the readily releasable pool of vesicles and in the percentage of act

160 1 which results in a decrease in the readily releasable pool of vesicles at a synapse, suggesting tha

161 size, but not the properties, of the readily-releasable pool of vesicles at inhibitory synapses.

162 r, with adaptation, depletion of the readily releasable pool of vesicles diminishes quantal content a

163 ritical for the proper maturation of readily releasable pool of vesicles during early development but

164 onous release completely empties the readily releasable pool of vesicles during sustained elevations

165 ce PTP by increasing the size of the readily releasable pool of vesicles evoked by high-frequency sti

166 rains of activity suggested that the readily releasable pool of vesicles is reduced in Epac2(-/-) mic

167 After neurotransmission, the readily releasable pool of vesicles must be refilled in less tha

168 lpha causes a large reduction in the readily releasable pool of vesicles, alters short-term plasticit

169 to an alteration of the size of the readily releasable pool of vesicles, but are attributable to red

170 anced synaptic depression, a smaller readily releasable pool of vesicles, delayed endocytosis and slo

171 mini frequency, mini amplitude, the readily releasable pool of vesicles, or the apparent Ca(2+) sens

172 I mutations reduced the size of the readily releasable pool of vesicles, whereas the region II mutat

173 nts in motor neurons and an enlarged readily releasable pool of vesicles.

174 ed vesicles did not preferentially enter the releasable pool of vesicles.

175 up to 2-fold, with no effect on the readily releasable pool of vesicles.

176 dogs pretreated with rhIL-11 retain a DDAVP-releasable pool of VWF and FVIII, suggesting that rhIL-1

177 erve pool first and subsequently the readily releasable pool over a period of several minutes.

178 voked-release amplitudes (indicating readily-releasable pool refilling) occurred within approximately

179 obilization and replenishment of the readily releasable pool require GTP and Ca2+ but do not necessit

180 ion revealed that as P declines, the readily releasable pool size (N) increases so that the net EPSC

181 Consistently, the readily releasable pool size and formation of SNARE complexes ar

182 near active zones (AZs) predict the measured releasable pool size and replenishment rate from the res

183 ponse fitting of Stx1 levels against readily releasable pool size and vesicular release probability s

184 ther recent evidence links alteration of the releasable pool size with changes in p(r), our results s

185 paired, as demonstrated by a smaller readily releasable pool size, slower refilling rate of primed ve

186 tic calcium channel localization and readily releasable pool size.

187 eplenishment mechanisms but also by altering releasable pool size.

188 evoked release with no change in the readily releasable pool size.

189 synaptic ribbons participate in the readily releasable pool that is tapped rapidly during depolariza

190 d Tomo1 actions to extend beyond the Readily Releasable Pool to mediate the Total Recycling Pool and

191 Doc2b, release was shifted from the readily releasable pool to the subsequent sustained component.

192 ion of the number of vesicles in the readily releasable pool using phorbol ester treatment suggested

193 nt was largely inhibited whereas the readily releasable pool was augmented.

194 -induced increase in the size of the readily releasable pool was blocked by alphaBgTx and by the calm

195 ration train, which interrogates the readily releasable pool, but depleted release elicited by a long

196 ith low release probability, a large readily releasable pool, fast presynaptic calcium clearance and

197 l close to the calcium channels (immediately releasable pool, IRP).

198 Once Ca2+ has been discharged from the releasable pool, it is restored following dim illuminati

199 ilitated vesicle mobilization to the readily releasable pool, probably by clearing fused vesicle memb

200 the immediate releasable pool and the ready releasable pool-key elements of short-term plasticity th

201 g the reserve pool and enhancing the readily releasable pool.

202 is required for the full size of the readily releasable pool.

203 oot pool approximately 1.8 times the readily releasable pool.

204 release preferentially involves the readily releasable pool.

205 terminals, reducing release from the readily releasable pool.

206 l-known exponential refilling of the readily releasable pool.

207 les, presumably corresponding to the readily releasable pool.

208 ich reenter the reserve pool and finally the releasable pool.

209 ycling vesicles partitioned into the readily releasable pool.

210 utative regulator of the presynaptic Readily Releasable Pool.

211 hibited vesicle replenishment to the readily releasable pool.

212 hibited vesicle replenishment to the readily releasable pool.

213 inhibits vesicle mobilization to the readily releasable pool.

214 releasable pool and a larger and more slowly releasable pool.

215 vert docked synaptic vesicles into a readily releasable pool.

216 ility of release and the size of the readily releasable pool.

217 ed this by selectively labeling the "readily releasable" pool, those vesicles released first during p

218 ficient mutants-restores the size of the the releasable pools in knockout cells, and in WT cells it m

219 ue to a reduction of cytoplasmic and readily releasable pools of vesicles.

220 atter indicating defects in replenishment of releasable pools required to sustain second-phase GSIS.

221 cle pools (comprising the readily and slowly releasable pools), while showing no change in the kineti

222 lting from a decreased number of vesicles in releasable pools.

223 ntact with platelets but is mediated through releasable products, namely IL-1beta.

224 alpha-granules constitute the major rapidly releasable reservoir of thrombospondin-1 in higher anima

225 re dominant function in the replenishment of releasable SG pools in human beta-cells than its previou

226 tent with the hypothesis that the content of releasable small molecules in secretory vesicles is incr

227 idative stress, which, in turn, increase the releasable soluble pool of cytochrome c within the mitoc

228 ol priming of synaptic vesicles to a readily releasable state, and interact with each other via their

229 potential waveforms, Ca(2+) influx, readily releasable SV pool size, and quantal size were unaltered

230 ed, leading to a progressive loss of readily releasable SVs and abnormal neurotransmission.

231 ic release of neurotransmitters from readily releasable synaptic vesicles (SVs) at the active zone.

232 on of intracellular Ca(2+) and diminution of releasable synaptic vesicles.

233 as only encountered for hydrogels containing releasable, target-specific siRNAs, accompanied by minim

234 Using releasable tethered Clr4 reveals that an active process

235 ycling, which constitutes the main source of releasable transmitter at glycinergic synapses.

236 tic biodegradable materials: charge-altering releasable transporters (CARTs) for mRNA delivery into c

237 decreased probability of releasing a readily releasable vesicle during an action potential.

238 largely attributed to depletion of a readily releasable vesicle pool (RRP) and a decreased probabilit

239 Light-evoked depletion of the readily releasable vesicle pool (RRP) at rod bipolar cell ribbon

240 loading, by hypertonic shock, of the readily releasable vesicle pool (RRP) showed that LTD of release

241 s) and did not alter the size of the readily releasable vesicle pool (RRP), the kinetics of RRP deple

242 nflux, and (3) limited access to the readily releasable vesicle pool (RRP).

243 Surprisingly, despite a smaller readily releasable vesicle pool and fewer docked vesicles, a str

244 UMOylatable mutant decreases the size of the releasable vesicle pool and impairs stimulated SV exocyt

245 his enzyme caused a reduction of the readily releasable vesicle pool and its refilling rate, with a s

246 ing upregulates replenishment of the readily releasable vesicle pool during high-frequency firing.

247 h the rapidly releasing vesicle pool and the releasable vesicle pool of the retinal bipolar cell are

248 ld, without altering the presynaptic readily-releasable vesicle pool or postsynaptic neurotransmitter

249 e probability per vesicle and larger readily releasable vesicle pool size at synapses onto interneuro

250 orms of short-term plasticity of the readily releasable vesicle pool size, release probability per ve

251 aptic transmission by increasing the readily releasable vesicle pool size; these mutants also increas

252 (Open) synapses, and the size of the readily releasable vesicle pool was decreased; however, the rate

253 lso facilitates replenishment of the readily releasable vesicle pool, likely via endocytic clearance

254 te without affecting the size of the readily releasable vesicle pool, linking C1 domain activation to

255 P-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate o

256 cytosis, but not for the size of the readily releasable vesicle pool.

257 so underlie the developmental control of the releasable vesicle pool.

258 with the comparable reduction of the readily releasable vesicle pool.

259 is accompanied by a partial recovery of the releasable vesicle pool.

260 ase without changing the size of the readily-releasable vesicle pool.

261 ld synapse decreased the size of the readily releasable vesicle pool.

262 is process lead to abnormal depletion of the releasable vesicle pool.

263 ore Munc18-1 after stimulation have a larger releasable vesicle pool.

264 al content but reduces the size of the ready-releasable vesicle pool.

265 of Munc13-3 nor replenishment of the readily releasable vesicle pool.

266 II knockout mice exhibit markedly diminished releasable vesicle pools (comprising the readily and slo

267 illing of readily releasable and immediately releasable vesicle pools (RRP and IRP, respectively) in

268 sence of Doc2b, the refilling of the readily releasable vesicle pools is faster, but incomplete.

269 trength is determined by the pool of readily releasable vesicles (RRP) and the probability of release

270 calcium channels and 1-10 (mean, 5) readily releasable vesicles (RRVs) and released 0-5 vesicles dur

271 In contrast, the readily releasable vesicles after depletion recover normally in

272 These satellite boutons contain releasable vesicles and normal complements of synaptic p

273 itter release is determined by the number of releasable vesicles and their probability of release.

274 The data suggest that readily releasable vesicles are retrieved as noncoated vesicles

275 atory synaptic drive, their pools of readily releasable vesicles are smaller, and transmission failur

276 urons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7

277 king and to enhance release probability, but releasable vesicles can be localized distant from the pr

278 sensory neurons must provide a large pool of releasable vesicles for sustained release, while minimiz

279 obilization of a small population of readily releasable vesicles is a Munc13-4-dependent but Rab27a-i

280 that synaptotagmin 2 helps to align readily releasable vesicles near calcium channels at nerve termi

281 Positioning releasable vesicles near voltage-gated calcium channels

282 Exocytosis of readily releasable vesicles remained unchanged, in accordance wi

283 13 and RIM and of docked vesicles, a pool of releasable vesicles remained.

284 in receptor (SNARE)-driven fusion of readily releasable vesicles that are docked and primed at the pr

285 ransient insures the availability of readily releasable vesicles to support a second, sustained compo

286 The readily releasable vesicles were not clustered close to the pres

287 identified a highly Ca(2+)-sensitive pool of releasable vesicles with a relatively shallow relationsh

288 elease probability and the number of readily releasable vesicles with no effects on the rate of recov

289 s with few docked vesicles, a larger pool of releasable vesicles, and a higher efficiency of release

290 e developed a method to assess the number of releasable vesicles, rate constants for vesicle priming,

291 ered the rapid fusion of a subset of readily-releasable vesicles, revealing a rapid role of PI(4,5)P2

292 ng the effective size of the pool of readily releasable vesicles.

293 sistent with a smaller population of readily releasable vesicles.

294 inst preferential local reuse of the readily releasable vesicles.

295 d by 50-70%, demonstrating a loss of readily releasable vesicles.

296 volved a decrease in the size of the pool of releasable vesicles.

297 asic release by reducing the availability of releasable vesicles.

298 of active zones and the continuous supply of releasable vesicles.

299 lse facilitation and the size of the readily releasable vesicular pool are not dependent on synapse l

300 The functional role of releasable Zn2+ in the central nervous system remains un