ライフサイエンスコーパス: relevance to

1 creasing number of studies demonstrating its relevance to a broad variety of disease states, the bioe

2 at insights derived from this work will have relevance to a broader field of clinical medicine.

3 We investigated the relevance to AD of coat protein complex I (COPI)-depende

4 human AD patients, indicating its potential relevance to AD.

5 ned with receptor-binding assays might be of relevance to aid in the diagnosis of total or partial ED

6 Of relevance to Alzheimer's disease, beta-secretase (BACE1)

7 CLINICAL RELEVANCE: To analyze vitreoretinal procedural trends, w

8 ies of nanocrystals but also determine their relevance to, and performance in, various applications.

9 ve lymphatic vessel paradigm and discuss its relevance to antitumor immunity.

10 of great fundamental interest and of direct relevance to areas that include the de novo design of gr

11 al mechanisms, advantages and limitations in relevance to arsenic biosensors developed so far are int

12 a function of dopaminergic tone and may have relevance to aspects of therapeutic responses.

13 of genomics tools to conservation and their relevance to assessing the wide-ranging impact of fisher

14 Ten loci selected based on the relevance to asthma, magnitude of methylation change, an

15 ined whether these in vitro findings were of relevance to atherosclerotic lesion development in vivo.

16 luminate novel pharmacological pathways with relevance to autism.

17 The relevance to autoimmunity and unregulated inflammation o

18 This characteristic is of great relevance to be able of apply the method in the field of

19 ck was poorly understood and thought to lack relevance to bedside nursing practice.

20 signal transmission at this synapse and its relevance to behavior remain poorly understood.

21 l oscillations and more importantly in their relevance to behaviour (initiate versus reset conditione

22 n in myocardial contraction, with particular relevance to beta-adrenergic signaling, heart failure, a

23 Our unprecedented new mechanism may have relevance to biological and biomimetic chemistry process

24 ion is a rapidly developing study field with relevance to biological, physical and material sciences.

25 include water, alcohols, and solutions with relevance to biology and energy technology.

26 ubstrates and inhibitors, which are of great relevance to biology, medicine and biotechnology.

27 stable phase calcite--which is of tremendous relevance to biomineralization, carbon sequestration, pa

28 in biological reactions and has considerable relevance to biosynthetic reactions in organic chemistry

29 es for plant lignocellulose degradation with relevance to biotechnological applications as biofuel pr

30 ndow into microvascular structure, of likely relevance to both the cerebrovasculature and broader car

31 OA and BMD, highlight genes with biological relevance to both traits, and establish a robust new OA

32 hich GPCRs transduce these signals and their relevance to brain disorders are not well understood.

33 velopmental trajectories, underscoring their relevance to brain organization and function.

34 research has provided information of direct relevance to bTB management, and a better appreciation o

35 tissue, new regulatory schemes interpreting relevance to BW regulation are proposed for three GWAS g

36 migration remains an important problem, with relevance to cancer invasion and metastasis.

37 e protein-protein interactions (PPIs) are of relevance to cancer.

38 led several functionally-related clusters of relevance to cancer.

39 t dictate competition between them and their relevance to cancers that display complex genomic rearra

40 a fundamental cell-biological question with relevance to cancers, which often exhibit enlarged nucle

41 en based on strength of association with and relevance to cardiogenic shock.

42 little evidence of their long-term clinical relevance to cardiovascular health.

43 lency with the ligand, a feature of possible relevance to catalyst design in synthetic and natural sy

44 benzylic borylation reactions, which are of relevance to catalytic methylarene (di)borylation, are r

45 an experimentally advantageous tool of broad relevance to cell biology researchers within both discov

46 structure of pluripotent stem cells and its relevance to cell fate.

47 Despite their relevance to cell function and pathogenesis, structural

48 but how this interaction is mediated and its relevance to cerebral vasculature are unknown.

49 ently in response to replication stress with relevance to chemotherapeutic regimes.

50 ime to examine published studies with direct relevance to clinical care and, more broadly, to examine

51 , we defined AML genomic subgroups and their relevance to clinical outcomes.

52 RELEVANCE TO CLINICAL PRACTICE: This paper highlights th

53 immune microenvironment that may be of great relevance to clinical trials.

54 Thus, biochemical composition had little relevance to coal accumulation.

55 t that cerebral WM damage may have a greater relevance to cognitive dysfunction than physical disabil

56 tion within hippocampal neuronal circuits of relevance to cognitive processing in male mice at 6, 24,

57 ork organization of the human brain, yet its relevance to cognitive task activations has been unclear

58 Due to their relevance to coherent spiking, synfire chains are one of

59 current attractor networks, and its possible relevance to conscious perception has been suggested by

60 ude current or former prisoners but may have relevance to criminal justice health was not included.

61 sms that regulate AID expression are of much relevance to CSR and genomic integrity; however, effecto

62 The study has particular relevance to cultural heritage, where heterogeneous laye

63 be involved in immune regulatory pathways of relevance to CVID.

64 The upregulated genes are of functional relevance to cytoskeleton-related processes, whereas the

65 agnets-including collective spin-vortices of relevance to data storage applications-are realized in t

66 Conclusions and Relevance: To date, this study is the first systematic r

67 with age, it is of fundamental and clinical relevance to decipher new determinants that control TEC

68 directly on the podocyte, with translational relevance to designing new selective synthetic Gc molecu

69 an autoimmune response in breast cancer has relevance to detection and treatment strategies.

70 Our findings might also be of the utmost relevance to development of therapeutic interventions in

71 GPT2 enzyme in mitochondrial metabolism with relevance to developmental as well as potentially to neu

72 study we specifically analyzed the potential relevance to diabetes of human CB1 receptor isoforms in

73 ese findings clarify the role of coffee with relevance to dietary guidelines and suggest intervention

74 omosomal topological domains, and phenotypic relevance to discover variants associated to specific Me

75 ere, we discuss the molecular mechanisms and relevance to disease of necroptosis.

76 ated as biomarkers of disease, with no clear relevance to disease pathogenesis.

77 however they have limited functionality and relevance to disease processes.

78 ges and neural correlates may have potential relevance to disease progression and prognosis.

79 n, their contribution to behavior, and their relevance to disease.

80 etion, suggesting that this pathway may have relevance to disease.

81 elucidating their physiological function and relevance to disease.

82 ent, and individuals with AD to assess their relevance to disease.

83 l methods developed here may have particular relevance to disorders of attention, such as unilateral

84 This topic is of practical relevance to diverse fields, ranging from neuroscience t

85 the agonists used, which should be of broad relevance to drug discovery and disease treatment.

86 eactions enable rapid access to molecules of relevance to drug discovery, agrochemistry, material sci

87 ning persistent anxiety and to clarify their relevance to early-life phenotypic risk.

88 teria and biomarker, which would be of great relevance to either outcome evaluation or study design.

89 he mammalian developing brain with potential relevance to EMARDD patients and other CNS disorders.

90 This material system has relevance to emerging classes of biologically and enviro

91 ), and citizen science, and to explore TEK's relevance to environmental health research.

92 he oxidation of proteins by haem proteins of relevance to food oxidation and should be applicable to

93 e and 50 degrees C was studied in situ, with relevance to geological carbon sequestration.

94 ions for understanding reactive transport in relevance to groundwater remediation, CO2 sequestration,

95 bolism in the digestive system with clinical relevance to gut homeostasis and diseases.

96 n intestinal barrier integrity/function with relevance to gut permeability and the development of dis

97 ect on many areas of US society are of great relevance to health care, public health, mental health,

98 These findings have direct relevance to HSC transplantation and the increasing clin

99 context-specific animal models with greater relevance to human AKI is urgently needed.

100 action in health and in a disease state with relevance to human asthma.

101 To assess relevance to human beings, T4SS function and cagY recomb

102 research because of its stereotyped anatomy, relevance to human biology, and capacity for genetic man

103 To demonstrate relevance to human cancer, we performed a modified gene

104 blic datasets suggest that our data may have relevance to human cancers.

105 an NKR-P1A:LLT1 system and may have a direct relevance to human CMV infection.

106 One model of persistence that has relevance to human disease involves tryptophan limitatio

107 riguing aggregation properties and their own relevance to human disease.

108 Relevance to human DN is also demonstrated.

109 iation mapping, with attention to phenotypic relevance to human exposures.

110 d embryonic survival, with important broader relevance to human female infertility and mitochondrial

111 ne model of hepatocarcinogenesis with direct relevance to human HCC.

112 For example, of particular relevance to human health is the lateral transfer of ant

113 Despite the relevance to human health, little is known about the mos

114 levels of several POP congeners of potential relevance to human health.

115 To increase relevance to human infection, studies of inflammasome-de

116 the current models in order to enhance their relevance to human infection.

117 ns for disease dynamics and control, but its relevance to human influenza virus is still unclear.

118 intestinal tract and GALT, and discuss their relevance to human intestinal homeostasis and inflammati

119 imize the potential for future translational relevance to human neuropsychiatric disease.

120 glucose metabolism and lipid oxidation, with relevance to human physiology and type 2 diabetes.

121 NA damage and premature SMC senescence, with relevance to human thoracic aortopathy.

122 ion in the taiep rat model and determine its relevance to human white matter disease.

123 xacerbated atherosclerosis and discusses the relevance to humans and areas in which more research is

124 lating cardiomodulatory factors of potential relevance to humans using the Drosophila nephrocyte-card

125 lable in simple model organisms with limited relevance to humans.

126 eresis cycles in magnetic nanoparticles with relevance to hyperthermia applications in biomedicine.

127 ion highlighted 20 proteins of possibly high relevance to IgAN and/or kidney disease.

128 2 kinases has not been examined despite its relevance to immune-based therapies.

129 ose-response relationship may exist, but its relevance to improving progression-free survival is unce

130 dy this parasite and that have physiological relevance to in vivo infection remain suboptimal.

131 Relevance to in vivo Treg biology was established by int

132 acrophage immune responses and discuss their relevance to inflammation-related diseases.

133 les inform evolutionary forecasting and have relevance to interpreting the diverse array of mutations

134 erentiated cultures to show their functional relevance to ion transport physiology and pathophysiolog

135 nd its downstream consequences, of potential relevance to its signature disorders such as migraine.

136 id ammonia are discussed, as is the possible relevance to life forms in liquid ammonia.

137 ing capacity for surveillance of diseases of relevance to local populations can provide a mechanism f

138 ns during formulation evaluation to those of relevance to lung deposition.

139 Due to its relevance to many aspects of human health, the ability t

140 ficial receptors is important because of its relevance to many biological and environmental applicati

141 ons containing nanometer-sized powders is of relevance to many branches of industry.

142 r nanoparticle suspensions and are of direct relevance to many industrial sectors including materials

143 has been a longstanding issue because of its relevance to many systems and to the design of nanoscale

144 ng features into inert materials is of great relevance to material scientists, since it is expected t

145 we identified key differences with potential relevance to mechanisms, biomarkers and outcomes.

146 e the bulk of methane oxidation, with global relevance to methane emission in the ocean.

147 (CFG) approach to prioritize these genes for relevance to mood disorders and stress.

148 However, their relevance to multi-ethnic populations from Southeast Asi

149 periods of epileptiform activity, which has relevance to multiple processes including neurometabolic

150 ptor on T cells, and highlight the potential relevance to mycobacterial recognition.

151 Thus, cortical superficial siderosis is of relevance to neurologists working in neurovascular, memo

152 new threat to global health, with particular relevance to neuroscientists, due to associated newborn

153 dentities, origins, regulatory pathways, and relevance to normal vascular structure and function, as

154 nflammation affects DA neurotransmission and relevance to novel therapeutic strategies to treat reduc

155 Our findings have primary relevance to obese individuals who are at an increased r

156 and thermogenic properties with therapeutic relevance to obesity and diabetes.

157 atal output abnormalities and behaviors with relevance to OCD and show the tractability of acute mGlu

158 of this class of peptides and discusses the relevance to organismal metabolism.

159 roliferation of CMs in ischemia and may have relevance to other diseases, including cancer.

160 he effect of E3 ligase binding affinity with relevance to other drug discovery efforts in targeted pr

161 ogen precursor prethrombin-2 and have direct relevance to other members of the trypsin fold.

162 of neuronal lysosomes that may have broader relevance to other neurodegenerative diseases with a lys

163 uantity of biomarkers, or different ones, of relevance to other specific diseases.

164 infection, but the underlying mechanism and relevance to other viruses or in vivo infections remaine

165 d neural development and function, and their relevance to our understanding of neurodegenerative dise

166 Conclusions and Relevance: To our knowledge, the current study illustrat

167 Conclusions and Relevance: To our knowledge, this investigation is the f

168 Conclusions and Relevance: To our knowledge, this is the largest study t

169 The findings have relevance to overcoming infertility and other trisomic p

170 uced greater changes in gene expression with relevance to oxidative stress, apoptosis, and ion transp

171 c stresses in the host environment and their relevance to pathogenesis, with a particular focus on th

172 d Ca(2+) signals in cardiomyocytes and their relevance to pathological cardiac remodeling.

173 logical fuel management during exercise, and relevance to pathophysiological conditions (e.g. fatty a

174 measure of treatment benefit that has direct relevance to patients and health care professionals.

175 sociated with improved function and clinical relevance to patients, to arrive at recommendations.

176 culated with R. leguminosarum has particular relevance to PGPB enhanced phytoremediation of soils con

177 molecular crystals has grown thanks to their relevance to pharmaceuticals, organic semiconductor mate

178 With its particular relevance to pharmacogenetic GWAS, SurvivalGWAS_SV will

179 m for regulating vasculogenesis, with direct relevance to physiological and pathological angiogenesis

180 eview, we discuss these mechanisms and their relevance to physiology and disease, and propose a model

181 c transition in the dense liquid, due to its relevance to planetary science.

182 Recovery time is of direct relevance to policies governing management practices (i.

183 rker-based approach that provides biological relevance to positive genotoxicity assay data, particula

184 ial activity for bacterial species of direct relevance to postoperative infection and bacteremia.

185 nd tumor-promoting functions, as well as the relevance to potential new therapies in HCC.

186 es of solution samples with yet to be proven relevance to practical devices.

187 ith a focus on their biological and clinical relevance to progression of active disease.

188 using pathway activation signatures of known relevance to prostate cancer, developed a novel classifi

189 evelopment is partly driven by its potential relevance to prostate cancer, in particular the apparent

190 n-protein interaction inhibitors that are of relevance to proteasome assembly, no synthetic work has

191 great biological interest due to its direct relevance to protein function and disease pathogenesis.

192 echanism for homeostatic threat detection of relevance to psychiatric conditions such as panic disord

193 for NRG2 in the modulation of behaviors with relevance to psychiatric disorders.

194 t genotype-phenotype relationships that have relevance to psychiatric practice.

195 mine signaling and impact adult behaviors of relevance to psychiatry.

196 Of relevance to PTSD, elevation of prefrontal NPY attributa

197 ghlight cell-specific gene associations with relevance to RA pathogenesis including the identificatio

198 of MAIT cells, which can be of translational relevance to rapidly orchestrate adaptive immunity throu

199 ecies coordinated to a metal ion of possible relevance to reductive elimination/oxidation addition re

200 pathway) medium spiny neurons (MSNs) and its relevance to repetitive grooming behavior in Shank3B mut

201 fers new and substantial evidence that is of relevance to researchers, physicians and therapists, and

202 rnative to surgery for tumor treatment, with relevance to resource-limited settings.

203 ch, especially relating to studies of direct relevance to routine clinical care, is needed.

204 This is of special relevance to safeguard human health considering Palythoa

205 These recordings are of relevance to safety of human habitation and resettlement

206 ets demonstrated UClncR's accuracy and their relevance to sample clinical phenotypes.

207 ry object features, a cognitive process with relevance to schizophrenia.

208 nge of behavioral changes with translational relevance to schizophrenia.

209 omplex process of microglia activation, with relevance to several neurologic and psychiatric disorder

210 evaluated for underlying pathophysiology and relevance to sex-specific prevention strategies.

211 ts this energy wasting reaction is of direct relevance to solar energy conversion.

212 rious and confusing results that bear little relevance to solving the problem of cyanobacteria blooms

213 ent on odor context with particularly strong relevance to stress-related disorders such as PTSD, whic

214 l pathway could have important translational relevance to stroke patients.

215 independence of magnetic fields, and a close relevance to structural disorder.

216 COS have equal relevance to studies conducted in these areas, and, subs

217 embling key aspects of ALS, highlighting its relevance to study disease pathogenesis.

218 biomarkers from the prioritization step for relevance to suicidal behavior, in a demographically mat

219 Despite more than 40 years of research and relevance to symbiont-induced speciation, as well as con

220 ntify the patterns of SERT pathology and the relevance to symptoms.

221 alance is controlled in neurons and may bear relevance to synaptic dysfunction in autism.

222 in the glymphatic system and it has obvious relevance to TBI.

223 scientific approaches used in 1976 and their relevance to the 3-country (Guinea, Sierra Leone, and Li

224 to highlight biological processes of likely relevance to the aetiology of ADHD.

225 formed if the environment is of motivational relevance to the animal.

226 Because of its relevance to the ASCO membership, ASCO reviewed the guid

227 ive and abstract decision signals and are of relevance to the assumptions founding functional neuroim

228 These interrelationships may have relevance to the biological actions of retinol, includin

229 overly simplified model compounds often lack relevance to the chemistry of lignin, the direct use of

230 indings provide key clinical and preclinical relevance to the conformational immunoassay, and provide

231 Its relevance to the control of fungal germination was also

232 y deleterious genetic variations in genes of relevance to the cornification process.

233 This study aimed to identify mechanisms of relevance to the cross talk between human neutrophils an

234 This study establishes a clinical relevance to the DDR induced SAC in oocytes.

235 tures is currently of great interest due its relevance to the design of novel mechanical metamaterial

236 EMB and thus the incidence of pAMR2 and its relevance to the diagnosis of clinical AMR.

237 s between cases and controls show functional relevance to the diseases.

238 overy that permeate all ecosystems, and with relevance to the evolving Society of Critical Care Medic

239 he underlying molecular mechanisms and their relevance to the functions of intact B cells have thus f

240 The results have direct relevance to the fundamental understanding of ferrihydri

241 We describe those cases and discuss their relevance to the global HIV epidemic.

242 or in breast cancer; however, its functional relevance to the hormonal regulation of breast cancer re

243 Options to study these functions with direct relevance to the human condition remain severely limited

244 detect key muoniated intermediates of direct relevance to the hydride chemistry of these systems.

245 critical review were selected based on their relevance to the incidence of HIE, pathophysiology, neur

246 critical review were selected based on their relevance to the incidence, pathophysiology, laboratory

247 These observations are of likely relevance to the influence of ketamine upon mood and its

248 r and involved in lipid homeostasis, but its relevance to the long-term risk of developing metabolic

249 hormone, sclerostin, or vitamin D and their relevance to the management of different pathologies in

250 CHD patients, suggesting that they may have relevance to the more complex genetics of CHD overall.

251 n of the cell wall assembly may have general relevance to the morphogenesis of walled cells.

252 ns to separations technologies and for their relevance to the origins of biological homochirality.

253 gnitive and motor functions, and support its relevance to the pathophysiology and treatment of SZ and

254 ansmission in the striatum, supporting their relevance to the pathophysiology and, potentially, manag

255 m of altered connectivity that has potential relevance to the pathophysiology of macrocephaly/autism

256 ugs for stabilizing the MT lattice and is of relevance to the possible use of combinations of MSAs to

257 a-hemoglobin gene (HBB), which also has high relevance to the potential application of gene editing a

258 es was assembled based on novelty and direct relevance to the primary focus of this review.

259 stem and platelet adhesive function that has relevance to the primary haemostatic and prothrombotic f

260 umerical content of the dataset to determine relevance to the query entity.

261 ence, and scores the remainder on biological relevance to the query phenotype.We take advantage of se

262 tural changes and highlight their particular relevance to the regulation of the alignment of ECM in t

263 of the Hg-C bond, an observation that is of relevance to the report that selenoneine demethylates Cy

264 , and applying eligibility criteria based on relevance to the research question, studies were subject

265 lant-associated bacteria and discusses their relevance to the rhizosphere lifestyle.

266 ent of chronic hyperarousal, giving clinical relevance to the role of REM sleep in emotion regulation

267 pective for the rare cheetah, with potential relevance to the species' natural history, physiological

268 frontal cortex, results with strong clinical relevance to the study of cognitive impairment and treat

269 model of the cell surface, and indicate its relevance to the study of membrane organization.

270 s target protein in live cells is of pivotal relevance to the successful outcome of the drug discover

271 atherosclerosis pathogenesis, of particular relevance to the use of BAFF-targeted therapies in syste

272 ual display of locations that are of special relevance to their research domain.

273 Providing clinical relevance to these findings, by real-time PCR analysis,

274 gues of Fe-(NxHy) intermediates of potential relevance to these processes.

275 for inclusion in this article based on their relevance to these topics.

276 Of relevance to this aim, preclinical models of threat memo

277 patients, summarize previous publications of relevance to this field, and discuss future directions.

278 ating that the model developed is of generic relevance to this important microbial community.

279 e/substrate relationship provides functional relevance to this interaction.

280 PubMed queries were reviewed for articles of relevance to this review.

281 Of particular relevance to this study, is the antibiotic abuse in pig

282 may uncover pathophysiological mechanisms of relevance to those with the disorder more widely.

283 This feature has relevance to tissue preparation, handling, and unscrolli

284 with strong spin-orbit coupling have direct relevance to topological quantum materials and potential

285 y large-effect regulatory variants and their relevance to traits.

286 or nociceptive processing in SSDHN with high relevance to transcriptional changes and the development

287 report, using in vitro and in vivo models of relevance to traumatic spinal cord injury (SCI), new dat

288 radigm for identifying genes or processes of relevance to type 2 diabetes mellitus (T2D).

289 al neurotransmitter system and circuitry, of relevance to understanding interindividual variations in

290 mplex structures of the GR is of fundamental relevance to understanding its interactions and function

291 ith strong in-plane anisotropy, and may have relevance to understanding of vibrational properties in

292 not recent threat memories and have clinical relevance to understanding overgeneralization characteri

293 rmation, influx and efflux transporters with relevance to understanding peripheral nerve homeostasis

294 the genetics of neurocognitive function with relevance to understanding the pathophysiology of neurop

295 f reduction assays, of increasing biological relevance, to validate the bioreductive prodrug.

296 y represent a novel homeostatic mechanism of relevance to vascular health and disease.

297 t for cardiomyocyte cell cycle reentry, with relevance to ventricular noncompaction cardiomyopathy an

298 r varying the set point, and demonstrate its relevance to vessel remodeling in vivo.

299 Of particular relevance to viral infections are those pattern recognit

300 under-resourced healthcare settings and has relevance to wider global health.