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1 g religation after torsional stress has been relieved.
4 lectively, our results suggest a strategy to relieve a STAT1/3-dependent therapeutic barrier and enha
6 -mediated ubiquitination of RALY and hnRNP-C relieves a restriction on viral RNA processing and revea
7 K63-Ub3 in a 1:1 stoichiometric complex that relieves a UBA-regulated autoinhibitory state of TDP2.
9 signaling mechanism in which drought stress relieves ABI1 inhibition of BIN2, allowing BIN2 activati
10 (b) steric pressure/ring strain which can be relieved after protonation were identified as key tuning
11 NSGM that works in sync with the current CF-relieving agents, we developed a rigorous protocol based
12 olysis and fatty acid oxidation, and that PA relieves AHL4-mediated suppression and promotes TAG degr
13 ubunits, driving extensive rearrangements to relieve all inhibitory constraints on enzyme catalysis.
15 signaling, and, in SRC-2-CKO mice, partially relieved an NAD(+) deficiency and increased antioxidant
16 re consistent with phosphorylation of Ser-33 relieving an autoinhibitory intramolecular interaction w
17 ntions for patients with advanced disease to relieve and prevent depression, anxiety, and distress re
19 translational repression are implemented and relieved at different times during sporozoite maturation
20 all molecule FGIN-1-27 can be re-purposed to relieve autoimmunity by metabolic reprogramming of patho
21 f distal T8-CUB domains to the VWF D4 domain relieves autoinhibition and promotes cleavage of the nea
23 Current models propose Dsn1 phosphorylation relieves autoinhibition, allowing Mis12C binding to inne
26 nd to the purified kinase domain of aPKC and relieved autoinhibitory constraints, thereby activating
27 domain induces a conformational change that relieves autoinhibitory interactions with the ATPase mot
28 during infection antibacterial treatment may relieve bacterial imposed nutrient restriction resulting
30 peared when hTERT promoter repression became relieved because of the loss of distal regulatory elemen
31 liary SEMS system appears to be effective at relieving biliary obstruction and preventing re-interven
33 bic oxidation of tetrahydroisoquinolines, is relieved both by pai- and sigma-donating substituents.
36 due to unrelieved residual stress, or stress-relieved but recrystallizing into a polycrystalline micr
37 igraphy with (201)Tl/(123)I-BMIPP, which was relieved by 1-year treatment of glucocorticoid combined
38 subchondral bone thickening, which could be relieved by alleviating ER stress via PBA administration
40 on in a patient with continuous pain that is relieved by anti-inflammatory drugs may point to an oste
41 ADP inhibition of bacterial Hsp90 can be relieved by bacterial Hsp70 and an activating client pro
42 ymes exhibit an autoinhibitory state that is relieved by binding to nucleosomes, enabling dimethylati
43 logy (PH) domain and kinase domain, which is relieved by C-tail phosphorylation, but the precise mole
44 acking stress on the lipid bilayer, which is relieved by CL remodeling to form tightly packed lipid-p
47 participate in gene suppression that can be relieved by EGFR signal, but we found that cic also acti
50 dingly, repression in the absence of MLL2 is relieved by inhibition of PRC2 and DNA methyltransferase
51 ssed by the histone modifier HDAC2, which is relieved by pharmacological inhibition of histone deacet
53 eotide biosynthesis, and this inhibition was relieved by single amino acid replacements in IMP dehydr
58 cycle progression, we hypothesized that PIN1 relieves CDK2 inhibition by suppressing the CDK inhibito
59 ases enhance enzymatic biomass conversion by relieving cellobiose inhibition of endoglucanases and ce
60 T mitigates infarct risk in pediatric SCA by relieving cerebral metabolic stress at patient- and tiss
61 toward a paradigm of chemical synthesis that relieves chemists from routine tasks, combining artifici
62 liferator-activated receptor (PPAR) agonist, relieves cholestasis-associated itch by alleviating hepa
63 aims to develop engineered systems that can relieve clinical conditions by stimulating the periphera
64 then suppressed endogenous LPAT activity to relieve competition and knocked out phosphatidylcholine:
65 deling by reducing preload on the heart, and relieves congestion by clearing interstitial fluid witho
66 decreases its affinity for beta subunits and relieves constitutive inhibition of Ca(V)1.2, observed a
67 its, while NTW avoids thermal limits and may relieve constraints of cooler night-time temperatures; a
68 a custom-designed microfluidic device, which relieves contraction of the model membrane surface area
69 plants, the chilling-sensitive phenotype was relieved, demonstrating that TGS1 is required for chilli
70 from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial (n = 4039) were used t
71 tonergic psychedelics such as psilocybin may relieve depression, and could possibly do so by promotin
72 ent evidence suggests that NMDAR antagonists relieve depressive symptoms by forming new synapses resu
73 entional antidepressant drugs, could help to relieve depressive symptoms in patients with metabolic c
75 rate that Cugamycin broadly and specifically relieves DM1-associated defects in vivo without detectab
77 idal photodynamic priming (PDP) strategy can relieve drug delivery barriers in the tumor microenviron
79 l treatment of ob/ob mice with the ER stress-relieving drug tauroursodeoxycholic acid (TUDCA) causes
82 and the protracted phase of the syndrome to relieve early immunopathology and late immunosuppression
83 te cortex, in the mouse, has a profound pain relieving effect against nerve injury-induced neuropathi
84 e CAI-CORM hybrid (5b) induced a higher pain-relieving effect compared to the one exerted by the sing
86 erties were evaluated, along with their pain-relieving effect, in a model of rheumatoid arthritis.
87 of STN local cells in mediating the symptom-relieving effects of STN DBS using cell type-specific op
88 ponse (UPR) is a cytoprotective pathway that relieves endoplasmic reticulum (ER) stress by promoting
91 ing pharmaceutical interventions designed to relieve ER stress or modulate the UPR during enamel deve
96 necessary for the action of DOR agonists in relieving headache-related symptoms and suggest that for
98 actice changing as it safely and effectively relieves hot flush symptoms without the need for oestrog
99 overexpression of M-channels' subunit KCNQ3, relieved hyperalgesia and decreased relapse-like alcohol
102 demonstrate for the first time that CDDO-Me relieves immunosuppression in the breast TME and unleash
103 Some gene expression changes were partially relieved in Ki-67-depleted hTERT-RPE1 cells by codepleti
107 he hairpin, these structural constraints are relieved in the absence of RNA secondary structure.
108 tinct, mechanisms by which autoinhibition is relieved in the course of canonical CARD9 or CARD11 acti
109 nal analysis reveals how this frustration is relieved in the tricyclic peroxide products, where stron
112 for postengulfment FS gene expression, which relieves inhibition of SpoIVFB, an intramembrane proteas
115 the cytosolic localization of HDAC4, thereby relieving inhibition of Mef2-dependent transcription of
116 entricular drain (EVD) is used clinically to relieve intracranial pressure and occasionally to delive
117 e spectrin repeats of Trio, allowing them to relieve intramolecular repression of Trio GEF activity b
121 ng to the inhibitory subunit p85alpha, which relieves its catalytic inhibition, and increased p110alp
122 and Akt/S6K1 dissociates it from 5'UTRs and relieves its inhibitory activity on RP mRNA translation.
127 with the aim of improving hepatic function, relieving jaundice, and reducing adverse effects of obst
129 nal for stochasticity when drought stress is relieved, likely due to renewed selection by the host.
131 c administration of the mGluR4 PAM VU0155041 relieves long-term deleterious consequences of morphine
132 rther confirmed by our in vitro studies, may relieve lysosomal stress due to accumulated substrates.
134 ation sites previously reported to induce or relieve mania symptoms.RESULTSLesion locations associate
135 of strain, dislocations alone can no longer relieve mechanical loads; instead, another mechanism, kn
138 be facilitated by the Mediator, then acts to relieve Mediator-induced repression to generate an activ
141 ated by two complementary mechanisms: (i) by relieving membrane tension, possibly by TANGO1-mediated
142 lantarum and Savinase in alkaline conditions relieves metabolic alterations and oxidative stress in Z
144 factor ZEB1 stimulated Golgi compaction and relieved microRNA-mediated repression of the Golgi scaff
146 diate-scale pCO2 change and, if high pCO2 is relieved mid-succession, whether past acidification effe
147 of the miR-134 binding site in Sabin-1 IRES relieved miR-134-mediated repression indicating that the
149 date, the prosthesis was highly effective in relieving MR and improving symptoms, with an acceptable
152 higher repetitive firing rates, possibly by relieving Na(+) channel inactivation, and thus contribut
153 sically interact in vitro, that this complex relieves NadE(Gln) negative feedback inhibition by NAD(+
154 nals are synaptically transmitted to acutely relieve nCa(V) inactivation, enabling mechanosensitive-t
156 n of EAAT2 represents a valuable strategy to relieve neuropathic pain, we synthesized novel activator
157 ) and for its anxiolytic-like and ability to relieve neuropathic painful conditions evaluated in CCI
159 re, clinical efficacy of nicotinic agents in relieving neuropathic pain best correlated with their ac
161 ells and blocked gabapentin preference (i.e. relieved ongoing pain) in a conditioned place preference
162 he mitochondrial uncoupling protein 2 (UCP2) relieves oxidative and neuronal damage in a variety of n
164 l' cannabis or cannabinoid-based medications relieve pain in human diseases such as cancer, multiple
165 oups, steroids application could effectively relieve pain on postoperative day (POD)1; decrease C-Rea
166 d with radiotherapy to maintain mobility and relieve pain, although there is no standard radiotherapy
167 hemia, the goals of revascularization are to relieve pain, help wound healing, and prevent limb loss.
171 e short-term and long-term effectiveness for relieving pain and improving physical function differ be
175 e session of intervention NIBS significantly relieved PLP, with effects lasting at least 1 week.
176 SL4), X-ray irradiation has the potential to relieve pressures on conventional diagnostic bottlenecks
180 Therefore, deuterosomes may have evolved to relieve, rather than supplement, the centriolar pathway
182 Sp1-binding site within the +38/+187 region relieved repressed luciferase activity of this region by
183 he IRE1-XBP1 pathway early post infection to relieve repression by XBP1u, the product of the unsplice
184 r prospero homeobox protein 1 (PROX1), which relieved repression of the matrix metalloproteinase MMP1
186 f JASMONATE ZIM-DOMAIN (JAZ) proteins, which relieves repression on MYC transcription factors that ex
187 in which the light-induced degradation of D1 relieves repressive interactions between D1 and translat
196 atic nerve block as an alternative method to relieve severe rest pain during endovascular treatment o
198 ruit SKIP to the lysosomal membrane but also relieves SKIP autoinhibition, promoting kinesin-1-driven
199 uture therapies that clear HIV infection may relieve society of the affliction of the HIV pandemic.
200 temic circulation is a potential strategy to relieve solid tumor hypoxia in order to increase the eff
201 in the N-terminal conformation of Kv1.5 that relieves Src-mediated tonic channel inhibition and resul
204 osslinking directly increases its ability to relieve stress under the constant strain imposed by soli
205 o this Coble creep mechanism can effectively relieve stress, maintain electronic and ionic contacts,
206 rystalline plasticity of quartz and feldspar relieves stress by aseismic creep and earthquakes are in
207 ncer, palliative care should be available to relieve suffering in patients with advanced disease and
211 t strategies include the use of diuretics to relieve symptoms and application of an expanding armamen
213 obstruction, improve exercise capacity, and relieve symptoms of oHCM in the PIONEER-HCM phase 2 stud
214 letal injuries with oral NSAIDs to reduce or relieve symptoms, including pain, and to improve physica
215 nthol gel as first-line therapy to reduce or relieve symptoms, including pain; improve physical funct
216 tment for atopic rhinitis is aimed mostly to relieve symptoms, only allergen-specific immunotherapy (
219 efractory IBS with predominant bloating, FMT relieved symptoms compared with placebo (autologous tran
220 primary ciliary dyskinesia; therapies aim at relieving symptoms and reducing the effects of reduced c
222 her clarify the involvement of omalizumab in relieving symptoms associated with the complex, multifac
224 not vice versa; and why (iii) mutations that relieve the autoinhibition are likely to be drivers-even
225 et it; (ii) inhibitors can straightforwardly relieve the autoinhibition but not vice versa; and why (
227 on, improving patients' quality of life, and relieve the economic and societal burden due to variable
228 ExsD in ExsA binding explains how ExsC might relieve the ExsD-mediated inhibition of T3SS gene expres
229 away the ROS from tumour microenvironment to relieve the immunosuppressive ICD elicited by specific c
230 cesses, while the void space can effectively relieve the overall volume change, and the plastic carbo
231 side would effectively serve as a switch to relieve the repression of early transcription found in l
233 uit NCOR1DeltaID to form a repressor complex relieved the deleterious actions of TRalpha1 mutants in
234 ance to both inorganic As(V) and As(III) and relieved the oxidative stress undergone by cells exposed
235 type wherein reduced local abundance of 2-AG relieves the CB2-mediated steady-state resistive tuning
238 ition of histone acetyltransferases CBP/p300 relieves the HMGN1-associated differentiation block.
240 GFR4 to recruit and phosphorylate NF2, which relieves the inhibitory effect of Raf on the Hippo kinas
241 fertilization, directly interacts with, and relieves the inhibitory function of eukaryotic initiatio
242 he malaria vector, Anopheles stephensi, that relieves the load in females caused by integration of th
246 of the C-terminal extension is critical for relieving the auto-inhibition of full-length Drs2p, wher
248 ent therapeutics typically involve partially relieving the heart's workload after the onset of heart
249 xendin-4 reversed the lysosomal dysfunction, relieving the impairment in autophagic flux and further
250 ic acid, decreases alpha-synuclein levels by relieving the inhibition exerted on alpha-synuclein prot
251 sphorylation stimulates DNA end resection by relieving the negative effect that Rad9 exerts over the
252 ylation of the docking protein Gab2, thereby relieving the negative inhibition on AKT and promoting t
254 range of diseases at point-of-care, thereby relieving the pressure on overstretched healthcare servi
255 though antipsychotic drugs are effective for relieving the psychotic symptoms of first-episode psycho
256 p2.7 to downregulate its expression, thereby relieving the repression of the florigen gene ZCN8 and c
257 , as early as after 2 weeks of treatment, in relieving the signs of DED, as measured by corneal and c
258 phosphorylates and inhibits HNF1alpha, thus relieving the suppression of hepatic PPARgamma expressio
262 l advances provide us potential solutions to relieve this bottleneck and to explore advanced methods
263 he histone variant H2A.Z serves to partially relieve this confinement, inducing a different type of n
265 hibitors that stabilize an open conformation relieve this interference and reduce the formation of LR
268 jugate vaccines (TCVs) in these settings may relieve this selective pressure, thereby reducing resist
270 njury-induced hypersensitivity and partially relieved this hypersensitivity after it was established.
272 t to generate the heterotrimeric FLA8/10/KAP relieved this inhibition, thus providing a mechanistic r
274 rther experiments showed that RNA polymerase relieves this autoinhibition by interacting with the C-t
276 lyzed activation of the G protein transducin relieves this inhibition and enhances PDE6 catalysis.
277 romising experimental technique to probe how relieving this barrier on the helicase can allow for inc
278 eates a barrier to transcription that can be relieved through ATP-dependent chromatin remodeling via
286 ion on organoarsenicals, ArsH contributes to relieve toxicity of As species by mediating reduction of
287 oxia-inducing factor, (4) nanoparticles that relieve tumor hypoxia for enhancement of chemotherapy, p
290 oportion of the population reporting NSSH to relieve unpleasant feelings of anger, tension, anxiety,
293 lciparum translation enhancing factor (PTEF) relieves upstream open reading frame repression and ther
296 ave significant anti-inflammatory effects to relieve various forms of pain and possibly treat various
297 prohibitive for lower concentrations and is relieved via twist and bend deformations in this unique
299 ring elongation and that this suppression is relieved when CMGs converge, leading to CMG unloading.
300 ion by Delta in the follicle cells, which is relieved when the miRNA pathway represses Delta expressi