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1           Multi-label classification of data remains to be a challenging problem.
2 ficacy, best setting, and cost-effectiveness remain to be addressed in further studies.
3 ificant progress, many significant questions remain to be addressed to accelerate the development of
4                       However, major hurdles remain to be addressed to acquire an ultraclean, high-in
5 ections, from the fundamental questions that remain to be addressed to the design principles required
6                 However, several facts still remain to be addressed: What about PCI or CABG with a lo
7                                  However, it remains to be addressed if this approach can improve fle
8 ividual and population levels simultaneously remains to be an outstanding problem.
9 f allergic disease, many important questions remain to be answered regarding mechanisms disrupting no
10 arding the molecular mechanism of regulation remain to be answered.
11                                  However, it remains to be answered how these limiting factors are pr
12 ts, yet its impact on breast cancer behavior remains to be ascertained.
13 t its safety with regard to neurodevelopment remains to be assessed.
14 ponses in the FRT after systemic vaccination remain to be characterized.
15 ntrol mechanisms, but other modulators still remain to be characterized.
16         Due to this complexity, however, MHC remains to be characterized in many species including an
17 titutive cell cycle activity of these niches remains to be characterized in situ.
18 in of function of GmSHMT08 in SCN resistance remains to be characterized.
19  regulation of placental iron transfer still remains to be characterized.
20           The physical origins of the effect remain to be clarified but likely ensue from the transpo
21 ural mechanisms underlying this coordination remain to be clarified.
22 eta-cell death in T1D and their target genes remain to be clarified.
23  plants and their physiological significance remain to be clarified.
24 ic causes for approximately 20% of the cases remain to be clarified.
25 nderlying reduced insulin degradation in AAs remains to be clarified, as does the relative importance
26 eir secondary structure in mineral formation remains to be clarified.
27 p on ibrutinib, although the molecular basis remains to be clarified.
28 port across the additional plastid membranes remains to be clarified.
29 tion and possible function of these microbes remain to be confirmed and elucidated.
30 nitude of the resulting carbon cycle impacts remains to be confirmed, the radiocarbon data suggest an
31                                However, much remains to be considered before clinical applications, i
32 s that mediate FGF19-dependent tumorigenesis remain to be deciphered.
33 onal role of microbial metabolites in nature remains to be deciphered.
34 s for patients with young-onset colon cancer remain to be defined and their effects on prognosis are
35  or tumors with contiguous organ involvement remain to be defined.
36 pe of pathogenic T cells in peripheral blood remains to be defined, and how viruses promote MS is deb
37 se mechanism underlying autophagy initiation remains to be defined.
38 r, the structural basis for this interaction remains to be defined.
39 ble risk for female genital tract infections remains to be defined.
40              The feasibility of this therapy remains to be defined.
41 ributes to beta-1,4-linked galactose binding remains to be defined; however, binding may occur via ad
42 against each of the 4 dengue virus serotypes remains to be definitively determined.
43  tyrosine kinase, other mechanisms exist and remain to be delineated.
44 cteristics and regulatory mechanisms by HSCs remain to be determined, especially in livers from HBV-i
45 gnitive impairment and the target population remain to be determined, particularly in real-world sett
46 ut the underlying neurobiological substrates remain to be determined.
47 oavailability of other dietary (poly)phenols remain to be determined.
48 nking the reprogramming with radioresistance remain to be determined.
49 nd temporal consequences of this observation remain to be determined.
50 ctions of the greatest number of miRNA genes remain to be determined.
51 ysiological role and mechanism of engagement remain to be determined.
52 r this canonical case of virulence evolution remain to be determined.IMPORTANCE The species jump of m
53 tion in this process through mechanisms that remained to be determined.
54 he intraluminal migration of CX3CR1(+) cells remained to be determined.
55                                         Much remains to be determined about cannabis trends and the r
56  key regulator of brain and behavior, yet it remains to be determined if gut bacteria play a role in
57 serve as a therapeutic target in advanced SM remains to be determined in forthcoming studies.
58 eetles prepare the carcass for reproduction, remains to be determined in future work.
59                                           It remains to be determined what the rates of implementatio
60                                           It remains to be determined whether all proteins are synthe
61                                  However, it remains to be determined whether p62 also plays a role i
62                                  However, it remains to be determined whether the microtubule-associa
63     Beyond its implications for contempt, it remains to be determined whether the sentiment concept m
64                                  However, it remains to be determined whether these alterations are s
65                                           It remains to be determined which of these abnormal neuroce
66 tations are drivers and which are passengers remains to be determined.
67 ontal lineI-Ph, or an Fe(V) horizontal lineO remains to be determined.
68 w cellular DNA gains access to the cytoplasm remains to be determined.
69        The purpose of this novel interaction remains to be determined.
70 ded microproteins in mammals, their function remains to be determined.
71 f MPA-mediated inhibition of HCV replication remains to be determined.
72 e, but a mechanism providing such protection remains to be determined.
73    How this may alter the outcome of disease remains to be determined.
74 e pathogenesis of H. pylori-induced diseases remains to be determined.
75 ansmission of regulators such as ROS or H(+) remains to be determined.
76  and a means of regulating ribosome function remains to be determined.
77 the clinical relevance of these associations remains to be determined.
78 ions in normal development and tumorigenesis remains to be determined.
79          The etiology of these abnormalities remains to be determined.
80 hibition in the context of allergic diseases remains to be determined.
81  its receptors in Mos/Mps in cardiac healing remains to be determined.
82 nificantly increased mutation rate in cancer remains to be determined.
83     However, the link between CB1R and GLUT2 remains to be determined.
84 lkalemia, but whether these truly cause harm remains to be determined.
85 ng for how this cellular process is mediated remains to be determined.
86 tion; however, their impact on FLCN function remains to be determined.
87 fection and particularly abortion in animals remains to be determined.
88 hrough computations whose neuronal substrate remains to be determined.
89 asts by vehiculing these mediators in asthma remains to be determined.
90 biological role of the encoded TRMT1 protein remains to be determined.
91 nd safe use of rituximab for this indication remains to be determined.
92 its role in the pathogenesis of osteoporosis remains to be determined.
93 ion of the interaction between cNCCs and SHF remains to be determined.
94 mpact of SZ-risk mutations on corticogenesis remains to be determined.
95 erpinning its effects on alcohol consumption remains to be determined.
96 tial cellular functions and yet most of them remain to be discovered and characterized.
97 insect species named, this suggests that 80% remain to be discovered and that a greater focus should
98 h the mechanistic details of such modulation remain to be discovered for many malignancies.
99 yclic biosynthetic enzymatic transformations remain to be discovered in naturally occurring enzyme 't
100 wer analyses indicate that more such regions remain to be discovered through deep sequencing of adequ
101                  It is likely that many more remain to be discovered, given the density of such seque
102 tly engaged in replication and transcription remain to be discovered.
103  known ligand, suggesting new ligand classes remain to be discovered.
104 consumption, suggesting that additional loci remain to be discovered.
105 ize ant larvae and suggests that many others remain to be discovered.
106                                However, much remains to be discovered regarding the molecular and cel
107 ence, the first X-bonded nucleic acid binder remains to be discovered.
108                           However, more work remains to be done to fully understand the antidiabetic
109 id electrolytes has increased; however, much remains to be done to increase the cathode capacity and
110 JC polyomavirus, what is suspected, and what remains to be done to understand the biology of how this
111 dition, many validated targets in this class remain to be drugged.
112 ling pathway, it is likely that interactions remain to be elucidated between miR-17-92 and as-of-yet
113 synthetic pathways of prenylated stilbenoids remain to be elucidated, and the genes encoding stilbeno
114  underlying the delayed electrosensitization remain to be elucidated.
115 ic cleft proteins participate in the process remain to be elucidated.
116 ural mechanisms of these inference processes remain to be elucidated.
117 ors responsible for attenuating this pathway remain to be elucidated.
118 n of SGs during late stages of MRV infection remain to be elucidated.
119 y, abundance, and fate in contaminated soils remain to be elucidated.
120 gative effect and the mechanisms responsible remain to be elucidated.
121           However, the underlying mechanisms remain to be elucidated.
122 ks control host immunity and viral infection remain to be elucidated.
123 ing altered NMDAR signalling in hypertension remain to be elucidated.
124  the precise location of affinity maturation remain to be elucidated.
125 ut the upstream initiator(s) of this process remain to be elucidated.
126 derlying these negative effects on cognition remain to be elucidated.
127 redicted chloroplast lipid-degrading enzymes remain to be elucidated.
128 nisms that are associated with these effects remain to be elucidated.
129 ical information to influence cell behaviors remain to be elucidated.
130 ble and the drug resistance mechanisms still remain to be elucidated.
131 ate/modulator binding and catalytic activity remain to be elucidated.
132 e p53 field, with several aspects that still remain to be elucidated.
133 r antitumor immune responses in this setting remain to be elucidated.
134                                         What remains to be elucidated to inform functional hypotheses
135 hanges in epidermal innervation, although it remains to be elucidated to what extent such changes can
136 al significance of the vast majority of them remains to be elucidated.
137 t the nature of many polyploidization events remains to be elucidated.
138       However, the complete set of allergens remains to be elucidated.
139 ific role for the C-terminal set of five ZFs remains to be elucidated.
140 initiation and/or progression of the disease remains to be elucidated.
141  minimal frustration in protein folding thus remains to be elucidated.
142 role of interneurons in the theta generation remains to be elucidated.
143 nd the interaction of CLCuD with G. arboreum remains to be elucidated.
144 ata1 gene in early hematopoietic progenitors remains to be elucidated.
145 tanding osteocyte biology and function, much remains to be elucidated.
146 Ms) and HIF1alpha-induced tumor angiogenesis remains to be elucidated.
147 e sequence determinants of this modification remains to be elucidated.
148 to the common house dust mite (HDM) allergen remains to be elucidated.
149 of seven nonstructural viral proteins, which remains to be elucidated.
150 re of their role in these cellular processes remains to be elucidated.
151          However, its physiological function remains to be elucidated.
152 r, their relationship to bladder cancer risk remains to be elucidated.
153 equisite pyridine/dehydropiperidine synthase remains to be elucidated.
154 ion of TF binding to cis-regulatory elements remains to be elucidated.
155  The origin of this astounding heterogeneity remains to be elucidated.
156 ated complications in the transplant setting remain to be established.
157       The mechanisms behind this association remain to be established.
158 n effectors responsible for nsPEF bioeffects remain to be established.
159 lar behaviours to generate such deformations remain to be established.
160 urodegenerative diseases, but the mechanisms remain to be established.
161  within the context of metabolic dysfunction remain to be established.
162 spatiotemporal resolution for the estimation remain to be established.
163 al growth, however the underlying mechanisms remain to be established.
164 ubunit of the viral polymerase, but it still remains to be established how these mutations enable hos
165 past 40 years; the role of anti-VEGF therapy remains to be established in current treatment strategie
166                                           It remains to be established whether PML pathogenesis is dr
167  mortality from prostate cancer; however, it remains to be established whether this association is ca
168 mission from Ca(2+) to ABD2 through EF-hands remains to be established.
169 he specific role of NOTCH1 in leukemogenesis remains to be established.
170 otics, trial designs, and medical conditions remains to be established.
171 thromboprophylaxis for the prevention of CRT remains to be established.
172 ty, cathepsin B and proteasome subunit PBA1, remains to be established.
173       However, their causal role in learning remains to be established.
174 s between BR signalling and drought response remains to be established.
175 t of chemotherapy in grade II and III glioma remains to be established.
176  adipose tissue inflammation and metabolism, remains to be established.
177 confers differences in fertility among males remains to be established.
178 the generation of Pm during cardiac fibrosis remains to be established.
179 uch as sex-differences, on light sensitivity remains to be established.
180  structural coupling between these functions remains to be established.
181 he pathological role of this receptor in GBM remains to be established.
182     How these stimuli act in diurnal species remains to be established.
183  health benefits of tyrosol-containing foods remain to be evaluated in light of CYP pharmacogenetics.
184 e pharmacodynamic characteristics of CPP-115 remain to be evaluated.
185     The biological defects underpinning this remain to be explained.
186 nterspecific variation in migratory response remains to be explained.
187 ontrol for tailoring hierarchical structures remains to be exploited, especially in the creation of n
188 r the origins and functions of many lincRNAs remain to be explored.
189 and treatment, there are several areas of NM remaining to be explored.
190 logy in schistosomiasis; however, validation remains to be explored in further work.
191                                           It remains to be explored whether and how memory reactivati
192                                           It remains to be explored whether and how selective memory
193 n to sepsis-associated inflammatory response remains to be explored.
194 c influence of a specific ERalpha-AF1 action remains to be explored.
195 l functions, is involved in symptoms of TMDs remains to be explored.
196 al for pulmonary arterial hypertension (PAH) remains to be explored.
197  play a critical role in virus infection but remain to be fully characterized.
198 ology, the factors critical for this process remain to be fully defined, which has severely limited o
199 ical settings, but the mechanisms driving it remain to be fully determined.
200 anisms of inflammation-associated hemostasis remain to be fully elucidated, they can differ notably f
201 -mediated intracellular Ca(2+) release in AD remain to be fully elucidated.
202 zation, stability, and long-term maintenance remain to be fully elucidated.
203 mentalized space, but the precise mechanisms remain to be fully elucidated.
204 ibution to metabolic inflammation in obesity remain to be fully elucidated.
205 ms underlying the covalent attachment of FAD remain to be fully elucidated.
206 olic diseases, yet the underlying mechanisms remain to be fully elucidated.
207  BMAA toxicity to neurodegenerative diseases remain to be fully resolved.
208 en these proteins during assembly and egress remain to be fully understood.
209 ow virus-host interactions impact pathology, remain to be fully understood.
210 e metabolism, while the underlying mechanism remains to be fully clarified.
211 ification both in bacteria and in eukaryotes remains to be fully determined.
212                                  However, it remains to be fully elucidated how progression of second
213 of the BBB during viral infection of the CNS remains to be fully elucidated.
214 es have a phenotypic impact on other cancers remains to be fully elucidated.
215 cle formation, the mechanism of this process remains to be fully elucidated.
216 ypes of cancer, but the underlying mechanism remains to be fully established.
217 oclonal antibodies on lipoprotein metabolism remains to be fully evaluated.
218 whose contribution to disease susceptibility remains to be fully understood.
219 combinations of sugars in the glycan on ADCC remains to be further addressed, however.
220  RelA/p65 is regulated under EGFR activation remains to be further clarified.
221 ough the mechanisms leading to these changes remain to be identified, the transgenic plants presented
222 uscle physiological causes for the condition remain to be identified.
223 mately 40% of HCM patients, the causal genes remain to be identified.
224 cture abnormalities in treated HIV infection remain to be identified.
225 roup belongingness and altruistic motivation remain to be identified.
226  for most segment-committed progenitor cells remain to be identified.
227 yme; however, the specific pathways involved remain to be identified.
228 A repair have been reported, many regulators remain to be identified.
229 ncing strategies suggests that further genes remain to be identified.
230 c ion channels essential to these activities remain to be identified.
231 and mortality, but the underlying mechanisms remain to be identified.
232 basis for development of full-blown leukemia remains to be identified, but the appearance of leukemia
233 potential role for galanin as neuromodulator remains to be identified.SIGNIFICANCE STATEMENT The late
234  oral microbiome and their impact on disease remain to be investigated.
235 al effects in the healthy large-bowel mucosa remain to be investigated.
236 s of CD40L deficiency on macrophage function remain to be investigated.
237 s been well studied for some allergens, this remains to be investigated for animal patients, where ow
238                                           It remains to be investigated to what extent the observed e
239                                Although much remains to be investigated, these new discoveries have c
240  in hematopoiesis and myeloid transformation remains to be investigated.
241 e or whether they are genetically determined remains to be investigated.
242 they interact and influence its pathogenesis remains to be investigated.
243 ands in patients with four-gland hyperplasia remains to be investigated.
244 behavioral impairments have been established remains to be investigated.
245 ntributes to the pathogenesis of the disease remains to be investigated.
246 r GABA contributes to a specific CG function remains to be investigated.
247 he existence of APJ homodimers and oligomers remains to be investigated.
248 nted by other classes of inhibitory neurons, remains to be investigated.SIGNIFICANCE STATEMENT Cortic
249                                However, much remains to be learned about how B1 and VRKs overlap func
250          Despite major recent advances, much remains to be learned about iron physiology and pathophy
251     Here, we focus on what is known and what remains to be learned about the accessory proteins that
252                                         Much remains to be learnt about how bone turnover markers can
253 tilis and T. brucei, ms2ct6A disappeared and remained to be ms2t6A and ct6A by depletion of tcdA and
254 tential parameter for tolerance development, remain to be optimized.
255 mes continue to grow, but several challenges remain to be overcome before LVADs will be considered as
256 going challenges in experimental design that remain to be overcome in order to advance the field.
257 asia, although suggested by several studies, remains to be precisely evaluated, particularly in a lon
258 ng target for treatment of disease, but this remains to be realized due to rapid proteolysis of apeli
259 f established polyploids that have been, and remain to be, recognized.
260 val are apparent within each subgroup, which remain to be resolved.
261 e directionality of feedbacks in this system remain to be resolved.
262  or predict patients' responses to treatment remains to be resolved.
263 ical significance in multicellular organisms remains to be resolved.
264 ment for a TRPV4-AQP4 macromolecular complex remains to be resolved.
265                                           It remains to be seen to what extent these inter-ST differe
266  genetic relationship of these two hosts, it remains to be seen whether or not this conservation of s
267 th in patients receiving long-term treatment remains to be seen.
268        Whether these associations are causal remains to be seen.
269 uced the quantity of host cell proteins that remained to be separated from the two vaccine candidates
270                                           It remains to be shown whether this strategy is effective i
271 nd their removal are significant issues that remain to be solved.
272 ts prognostic value in PTC-related mortality remains to be specifically established.
273 diotherapy and concomitant chemoradiotherapy remains to be specifically tested.
274 ces sudden and unexpected infant death rates remains to be studied.
275 e CRISPR-Cas9 technology, several challenges remain to be tackled before its successful applications
276 ade in the recent years, some key challenges remain to be tackled.
277 GFR, using readily available variables; this remains to be tested and incorporated in prognostic scor
278 herapies targeting the pulmonary circulation remains to be tested by properly designed randomized con
279 count solely for predialysis BP measurements remains to be tested in a clinical trial.
280                  Their validity as standards remains to be tested in future studies.
281 pecies, generality of mechanistic inferences remains to be tested in tissue culture systems.
282 ne on dopamine levels ex vivo, although this remains to be tested in vivo.
283 sic mechanisms that control CST regrowth, it remains to be tested whether such methods can promote fu
284                                  However, it remains to be tested whether the evolutionary modificati
285 on evolutionary and environmental mechanisms remains to be tested.
286 r, its role in allergen-induced inflammation remains to be tested.
287 ine Bacteria restructures their biogeography remains to be tested.
288 ucleotide polymorphisms, we identified these remains to be those of Kent by comparing his genetic dat
289         This analysis predicts new functions remain to be uncovered within the superfamily.
290 nderlying mechanisms of radiochemoresistance remain to be uncovered.
291 specific molecular mechanism for PIP2 action remains to be uncovered, data support a hypothesis for P
292 bit coupling, but details of the interaction remain to be understood and the role of proximity induce
293 tes; yet, the mechanisms behind such effects remain to be understood in detail.
294  these specialized neuron types are acquired remain to be understood.
295 rkable physical and chemical phenomena, much remains to be understood to engineer devices.
296 r interactions, but the underlying mechanism remains to be understood.
297 on uses to confer and fine-tune the activity remains to be understood.
298          How these responses are prioritized remains to be understood.
299               These cross-sectional findings remain to be validated prospectively.
300 ent, yet the underlying mechanism of miR-152 remains to be well elucidated.

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