1 Multi-label classification of data
remains to be a challenging problem.
2 ficacy, best setting, and cost-effectiveness
remain to be addressed in further studies.
3 ificant progress, many significant questions
remain to be addressed to accelerate the development of
4 However, major hurdles
remain to be addressed to acquire an ultraclean, high-in
5 ections, from the fundamental questions that
remain to be addressed to the design principles required
6 However, several facts still
remain to be addressed: What about PCI or CABG with a lo
7 However, it
remains to be addressed if this approach can improve fle
8 ividual and population levels simultaneously
remains to be an outstanding problem.
9 f allergic disease, many important questions
remain to be answered regarding mechanisms disrupting no
10 arding the molecular mechanism of regulation
remain to be answered.
11 However, it
remains to be answered how these limiting factors are pr
12 ts, yet its impact on breast cancer behavior
remains to be ascertained.
13 t its safety with regard to neurodevelopment
remains to be assessed.
14 ponses in the FRT after systemic vaccination
remain to be characterized.
15 ntrol mechanisms, but other modulators still
remain to be characterized.
16 Due to this complexity, however, MHC
remains to be characterized in many species including an
17 titutive cell cycle activity of these niches
remains to be characterized in situ.
18 in of function of GmSHMT08 in SCN resistance
remains to be characterized.
19 regulation of placental iron transfer still
remains to be characterized.
20 The physical origins of the effect
remain to be clarified but likely ensue from the transpo
21 ural mechanisms underlying this coordination
remain to be clarified.
22 eta-cell death in T1D and their target genes
remain to be clarified.
23 plants and their physiological significance
remain to be clarified.
24 ic causes for approximately 20% of the cases
remain to be clarified.
25 nderlying reduced insulin degradation in AAs
remains to be clarified, as does the relative importance
26 eir secondary structure in mineral formation
remains to be clarified.
27 p on ibrutinib, although the molecular basis
remains to be clarified.
28 port across the additional plastid membranes
remains to be clarified.
29 tion and possible function of these microbes
remain to be confirmed and elucidated.
30 nitude of the resulting carbon cycle impacts
remains to be confirmed, the radiocarbon data suggest an
31 However, much
remains to be considered before clinical applications, i
32 s that mediate FGF19-dependent tumorigenesis
remain to be deciphered.
33 onal role of microbial metabolites in nature
remains to be deciphered.
34 s for patients with young-onset colon cancer
remain to be defined and their effects on prognosis are
35 or tumors with contiguous organ involvement
remain to be defined.
36 pe of pathogenic T cells in peripheral blood
remains to be defined, and how viruses promote MS is deb
37 se mechanism underlying autophagy initiation
remains to be defined.
38 r, the structural basis for this interaction
remains to be defined.
39 ble risk for female genital tract infections
remains to be defined.
40 The feasibility of this therapy
remains to be defined.
41 ributes to beta-1,4-linked galactose binding
remains to be defined; however, binding may occur via ad
42 against each of the 4 dengue virus serotypes
remains to be definitively determined.
43 tyrosine kinase, other mechanisms exist and
remain to be delineated.
44 cteristics and regulatory mechanisms by HSCs
remain to be determined, especially in livers from HBV-i
45 gnitive impairment and the target population
remain to be determined, particularly in real-world sett
46 ut the underlying neurobiological substrates
remain to be determined.
47 oavailability of other dietary (poly)phenols
remain to be determined.
48 nking the reprogramming with radioresistance
remain to be determined.
49 nd temporal consequences of this observation
remain to be determined.
50 ctions of the greatest number of miRNA genes
remain to be determined.
51 ysiological role and mechanism of engagement
remain to be determined.
52 r this canonical case of virulence evolution
remain to be determined.IMPORTANCE The species jump of m
53 tion in this process through mechanisms that
remained to be determined.
54 he intraluminal migration of CX3CR1(+) cells
remained to be determined.
55 Much
remains to be determined about cannabis trends and the r
56 key regulator of brain and behavior, yet it
remains to be determined if gut bacteria play a role in
57 serve as a therapeutic target in advanced SM
remains to be determined in forthcoming studies.
58 eetles prepare the carcass for reproduction,
remains to be determined in future work.
59 It
remains to be determined what the rates of implementatio
60 It
remains to be determined whether all proteins are synthe
61 However, it
remains to be determined whether p62 also plays a role i
62 However, it
remains to be determined whether the microtubule-associa
63 Beyond its implications for contempt, it
remains to be determined whether the sentiment concept m
64 However, it
remains to be determined whether these alterations are s
65 It
remains to be determined which of these abnormal neuroce
66 tations are drivers and which are passengers
remains to be determined.
67 ontal lineI-Ph, or an Fe(V) horizontal lineO
remains to be determined.
68 w cellular DNA gains access to the cytoplasm
remains to be determined.
69 The purpose of this novel interaction
remains to be determined.
70 ded microproteins in mammals, their function
remains to be determined.
71 f MPA-mediated inhibition of HCV replication
remains to be determined.
72 e, but a mechanism providing such protection
remains to be determined.
73 How this may alter the outcome of disease
remains to be determined.
74 e pathogenesis of H. pylori-induced diseases
remains to be determined.
75 ansmission of regulators such as ROS or H(+)
remains to be determined.
76 and a means of regulating ribosome function
remains to be determined.
77 the clinical relevance of these associations
remains to be determined.
78 ions in normal development and tumorigenesis
remains to be determined.
79 The etiology of these abnormalities
remains to be determined.
80 hibition in the context of allergic diseases
remains to be determined.
81 its receptors in Mos/Mps in cardiac healing
remains to be determined.
82 nificantly increased mutation rate in cancer
remains to be determined.
83 However, the link between CB1R and GLUT2
remains to be determined.
84 lkalemia, but whether these truly cause harm
remains to be determined.
85 ng for how this cellular process is mediated
remains to be determined.
86 tion; however, their impact on FLCN function
remains to be determined.
87 fection and particularly abortion in animals
remains to be determined.
88 hrough computations whose neuronal substrate
remains to be determined.
89 asts by vehiculing these mediators in asthma
remains to be determined.
90 biological role of the encoded TRMT1 protein
remains to be determined.
91 nd safe use of rituximab for this indication
remains to be determined.
92 its role in the pathogenesis of osteoporosis
remains to be determined.
93 ion of the interaction between cNCCs and SHF
remains to be determined.
94 mpact of SZ-risk mutations on corticogenesis
remains to be determined.
95 erpinning its effects on alcohol consumption
remains to be determined.
96 tial cellular functions and yet most of them
remain to be discovered and characterized.
97 insect species named, this suggests that 80%
remain to be discovered and that a greater focus should
98 h the mechanistic details of such modulation
remain to be discovered for many malignancies.
99 yclic biosynthetic enzymatic transformations
remain to be discovered in naturally occurring enzyme 't
100 wer analyses indicate that more such regions
remain to be discovered through deep sequencing of adequ
101 It is likely that many more
remain to be discovered, given the density of such seque
102 tly engaged in replication and transcription
remain to be discovered.
103 known ligand, suggesting new ligand classes
remain to be discovered.
104 consumption, suggesting that additional loci
remain to be discovered.
105 ize ant larvae and suggests that many others
remain to be discovered.
106 However, much
remains to be discovered regarding the molecular and cel
107 ence, the first X-bonded nucleic acid binder
remains to be discovered.
108 However, more work
remains to be done to fully understand the antidiabetic
109 id electrolytes has increased; however, much
remains to be done to increase the cathode capacity and
110 JC polyomavirus, what is suspected, and what
remains to be done to understand the biology of how this
111 dition, many validated targets in this class
remain to be drugged.
112 ling pathway, it is likely that interactions
remain to be elucidated between miR-17-92 and as-of-yet
113 synthetic pathways of prenylated stilbenoids
remain to be elucidated, and the genes encoding stilbeno
114 underlying the delayed electrosensitization
remain to be elucidated.
115 ic cleft proteins participate in the process
remain to be elucidated.
116 ural mechanisms of these inference processes
remain to be elucidated.
117 ors responsible for attenuating this pathway
remain to be elucidated.
118 n of SGs during late stages of MRV infection
remain to be elucidated.
119 y, abundance, and fate in contaminated soils
remain to be elucidated.
120 gative effect and the mechanisms responsible
remain to be elucidated.
121 However, the underlying mechanisms
remain to be elucidated.
122 ks control host immunity and viral infection
remain to be elucidated.
123 ing altered NMDAR signalling in hypertension
remain to be elucidated.
124 the precise location of affinity maturation
remain to be elucidated.
125 ut the upstream initiator(s) of this process
remain to be elucidated.
126 derlying these negative effects on cognition
remain to be elucidated.
127 redicted chloroplast lipid-degrading enzymes
remain to be elucidated.
128 nisms that are associated with these effects
remain to be elucidated.
129 ical information to influence cell behaviors
remain to be elucidated.
130 ble and the drug resistance mechanisms still
remain to be elucidated.
131 ate/modulator binding and catalytic activity
remain to be elucidated.
132 e p53 field, with several aspects that still
remain to be elucidated.
133 r antitumor immune responses in this setting
remain to be elucidated.
134 What
remains to be elucidated to inform functional hypotheses
135 hanges in epidermal innervation, although it
remains to be elucidated to what extent such changes can
136 al significance of the vast majority of them
remains to be elucidated.
137 t the nature of many polyploidization events
remains to be elucidated.
138 However, the complete set of allergens
remains to be elucidated.
139 ific role for the C-terminal set of five ZFs
remains to be elucidated.
140 initiation and/or progression of the disease
remains to be elucidated.
141 minimal frustration in protein folding thus
remains to be elucidated.
142 role of interneurons in the theta generation
remains to be elucidated.
143 nd the interaction of CLCuD with G. arboreum
remains to be elucidated.
144 ata1 gene in early hematopoietic progenitors
remains to be elucidated.
145 tanding osteocyte biology and function, much
remains to be elucidated.
146 Ms) and HIF1alpha-induced tumor angiogenesis
remains to be elucidated.
147 e sequence determinants of this modification
remains to be elucidated.
148 to the common house dust mite (HDM) allergen
remains to be elucidated.
149 of seven nonstructural viral proteins, which
remains to be elucidated.
150 re of their role in these cellular processes
remains to be elucidated.
151 However, its physiological function
remains to be elucidated.
152 r, their relationship to bladder cancer risk
remains to be elucidated.
153 equisite pyridine/dehydropiperidine synthase
remains to be elucidated.
154 ion of TF binding to cis-regulatory elements
remains to be elucidated.
155 The origin of this astounding heterogeneity
remains to be elucidated.
156 ated complications in the transplant setting
remain to be established.
157 The mechanisms behind this association
remain to be established.
158 n effectors responsible for nsPEF bioeffects
remain to be established.
159 lar behaviours to generate such deformations
remain to be established.
160 urodegenerative diseases, but the mechanisms
remain to be established.
161 within the context of metabolic dysfunction
remain to be established.
162 spatiotemporal resolution for the estimation
remain to be established.
163 al growth, however the underlying mechanisms
remain to be established.
164 ubunit of the viral polymerase, but it still
remains to be established how these mutations enable hos
165 past 40 years; the role of anti-VEGF therapy
remains to be established in current treatment strategie
166 It
remains to be established whether PML pathogenesis is dr
167 mortality from prostate cancer; however, it
remains to be established whether this association is ca
168 mission from Ca(2+) to ABD2 through EF-hands
remains to be established.
169 he specific role of NOTCH1 in leukemogenesis
remains to be established.
170 otics, trial designs, and medical conditions
remains to be established.
171 thromboprophylaxis for the prevention of CRT
remains to be established.
172 ty, cathepsin B and proteasome subunit PBA1,
remains to be established.
173 However, their causal role in learning
remains to be established.
174 s between BR signalling and drought response
remains to be established.
175 t of chemotherapy in grade II and III glioma
remains to be established.
176 adipose tissue inflammation and metabolism,
remains to be established.
177 confers differences in fertility among males
remains to be established.
178 the generation of Pm during cardiac fibrosis
remains to be established.
179 uch as sex-differences, on light sensitivity
remains to be established.
180 structural coupling between these functions
remains to be established.
181 he pathological role of this receptor in GBM
remains to be established.
182 How these stimuli act in diurnal species
remains to be established.
183 health benefits of tyrosol-containing foods
remain to be evaluated in light of CYP pharmacogenetics.
184 e pharmacodynamic characteristics of CPP-115
remain to be evaluated.
185 The biological defects underpinning this
remain to be explained.
186 nterspecific variation in migratory response
remains to be explained.
187 ontrol for tailoring hierarchical structures
remains to be exploited, especially in the creation of n
188 r the origins and functions of many lincRNAs
remain to be explored.
189 and treatment, there are several areas of NM
remaining to be explored.
190 logy in schistosomiasis; however, validation
remains to be explored in further work.
191 It
remains to be explored whether and how memory reactivati
192 It
remains to be explored whether and how selective memory
193 n to sepsis-associated inflammatory response
remains to be explored.
194 c influence of a specific ERalpha-AF1 action
remains to be explored.
195 l functions, is involved in symptoms of TMDs
remains to be explored.
196 al for pulmonary arterial hypertension (PAH)
remains to be explored.
197 play a critical role in virus infection but
remain to be fully characterized.
198 ology, the factors critical for this process
remain to be fully defined, which has severely limited o
199 ical settings, but the mechanisms driving it
remain to be fully determined.
200 anisms of inflammation-associated hemostasis
remain to be fully elucidated, they can differ notably f
201 -mediated intracellular Ca(2+) release in AD
remain to be fully elucidated.
202 zation, stability, and long-term maintenance
remain to be fully elucidated.
203 mentalized space, but the precise mechanisms
remain to be fully elucidated.
204 ibution to metabolic inflammation in obesity
remain to be fully elucidated.
205 ms underlying the covalent attachment of FAD
remain to be fully elucidated.
206 olic diseases, yet the underlying mechanisms
remain to be fully elucidated.
207 BMAA toxicity to neurodegenerative diseases
remain to be fully resolved.
208 en these proteins during assembly and egress
remain to be fully understood.
209 ow virus-host interactions impact pathology,
remain to be fully understood.
210 e metabolism, while the underlying mechanism
remains to be fully clarified.
211 ification both in bacteria and in eukaryotes
remains to be fully determined.
212 However, it
remains to be fully elucidated how progression of second
213 of the BBB during viral infection of the CNS
remains to be fully elucidated.
214 es have a phenotypic impact on other cancers
remains to be fully elucidated.
215 cle formation, the mechanism of this process
remains to be fully elucidated.
216 ypes of cancer, but the underlying mechanism
remains to be fully established.
217 oclonal antibodies on lipoprotein metabolism
remains to be fully evaluated.
218 whose contribution to disease susceptibility
remains to be fully understood.
219 combinations of sugars in the glycan on ADCC
remains to be further addressed, however.
220 RelA/p65 is regulated under EGFR activation
remains to be further clarified.
221 ough the mechanisms leading to these changes
remain to be identified, the transgenic plants presented
222 uscle physiological causes for the condition
remain to be identified.
223 mately 40% of HCM patients, the causal genes
remain to be identified.
224 cture abnormalities in treated HIV infection
remain to be identified.
225 roup belongingness and altruistic motivation
remain to be identified.
226 for most segment-committed progenitor cells
remain to be identified.
227 yme; however, the specific pathways involved
remain to be identified.
228 A repair have been reported, many regulators
remain to be identified.
229 ncing strategies suggests that further genes
remain to be identified.
230 c ion channels essential to these activities
remain to be identified.
231 and mortality, but the underlying mechanisms
remain to be identified.
232 basis for development of full-blown leukemia
remains to be identified, but the appearance of leukemia
233 potential role for galanin as neuromodulator
remains to be identified.SIGNIFICANCE STATEMENT The late
234 oral microbiome and their impact on disease
remain to be investigated.
235 al effects in the healthy large-bowel mucosa
remain to be investigated.
236 s of CD40L deficiency on macrophage function
remain to be investigated.
237 s been well studied for some allergens, this
remains to be investigated for animal patients, where ow
238 It
remains to be investigated to what extent the observed e
239 Although much
remains to be investigated, these new discoveries have c
240 in hematopoiesis and myeloid transformation
remains to be investigated.
241 e or whether they are genetically determined
remains to be investigated.
242 they interact and influence its pathogenesis
remains to be investigated.
243 ands in patients with four-gland hyperplasia
remains to be investigated.
244 behavioral impairments have been established
remains to be investigated.
245 ntributes to the pathogenesis of the disease
remains to be investigated.
246 r GABA contributes to a specific CG function
remains to be investigated.
247 he existence of APJ homodimers and oligomers
remains to be investigated.
248 nted by other classes of inhibitory neurons,
remains to be investigated.SIGNIFICANCE STATEMENT Cortic
249 However, much
remains to be learned about how B1 and VRKs overlap func
250 Despite major recent advances, much
remains to be learned about iron physiology and pathophy
251 Here, we focus on what is known and what
remains to be learned about the accessory proteins that
252 Much
remains to be learnt about how bone turnover markers can
253 tilis and T. brucei, ms2ct6A disappeared and
remained to be ms2t6A and ct6A by depletion of tcdA and
254 tential parameter for tolerance development,
remain to be optimized.
255 mes continue to grow, but several challenges
remain to be overcome before LVADs will be considered as
256 going challenges in experimental design that
remain to be overcome in order to advance the field.
257 asia, although suggested by several studies,
remains to be precisely evaluated, particularly in a lon
258 ng target for treatment of disease, but this
remains to be realized due to rapid proteolysis of apeli
259 f established polyploids that have been, and
remain to be,
recognized.
260 val are apparent within each subgroup, which
remain to be resolved.
261 e directionality of feedbacks in this system
remain to be resolved.
262 or predict patients' responses to treatment
remains to be resolved.
263 ical significance in multicellular organisms
remains to be resolved.
264 ment for a TRPV4-AQP4 macromolecular complex
remains to be resolved.
265 It
remains to be seen to what extent these inter-ST differe
266 genetic relationship of these two hosts, it
remains to be seen whether or not this conservation of s
267 th in patients receiving long-term treatment
remains to be seen.
268 Whether these associations are causal
remains to be seen.
269 uced the quantity of host cell proteins that
remained to be separated from the two vaccine candidates
270 It
remains to be shown whether this strategy is effective i
271 nd their removal are significant issues that
remain to be solved.
272 ts prognostic value in PTC-related mortality
remains to be specifically established.
273 diotherapy and concomitant chemoradiotherapy
remains to be specifically tested.
274 ces sudden and unexpected infant death rates
remains to be studied.
275 e CRISPR-Cas9 technology, several challenges
remain to be tackled before its successful applications
276 ade in the recent years, some key challenges
remain to be tackled.
277 GFR, using readily available variables; this
remains to be tested and incorporated in prognostic scor
278 herapies targeting the pulmonary circulation
remains to be tested by properly designed randomized con
279 count solely for predialysis BP measurements
remains to be tested in a clinical trial.
280 Their validity as standards
remains to be tested in future studies.
281 pecies, generality of mechanistic inferences
remains to be tested in tissue culture systems.
282 ne on dopamine levels ex vivo, although this
remains to be tested in vivo.
283 sic mechanisms that control CST regrowth, it
remains to be tested whether such methods can promote fu
284 However, it
remains to be tested whether the evolutionary modificati
285 on evolutionary and environmental mechanisms
remains to be tested.
286 r, its role in allergen-induced inflammation
remains to be tested.
287 ine Bacteria restructures their biogeography
remains to be tested.
288 ucleotide polymorphisms, we identified these
remains to be those of Kent by comparing his genetic dat
289 This analysis predicts new functions
remain to be uncovered within the superfamily.
290 nderlying mechanisms of radiochemoresistance
remain to be uncovered.
291 specific molecular mechanism for PIP2 action
remains to be uncovered, data support a hypothesis for P
292 bit coupling, but details of the interaction
remain to be understood and the role of proximity induce
293 tes; yet, the mechanisms behind such effects
remain to be understood in detail.
294 these specialized neuron types are acquired
remain to be understood.
295 rkable physical and chemical phenomena, much
remains to be understood to engineer devices.
296 r interactions, but the underlying mechanism
remains to be understood.
297 on uses to confer and fine-tune the activity
remains to be understood.
298 How these responses are prioritized
remains to be understood.
299 These cross-sectional findings
remain to be validated prospectively.
300 ent, yet the underlying mechanism of miR-152
remains to be well elucidated.