1 pproached modern levels ( approximately
21%)
remains unresolved.
2 ections alone after a mean of 14.0 months,
8 remained unresolved through 72 months despite addition o
3 acy, many details of the mechanism of
action remain unresolved, despite the importance in translating
4 ails of its assembly and mechanism of
action remain unresolved.
5 cular drug for which the mechanism of
action remains unresolved.
6 vance of this to pharmacotherapeutic
actions remains unresolved.
7 these mutations confer constitutive
activity remain unresolved.
8 g, the mechanisms that control Hsf1
activity remain unresolved.
9 hanisms of this specific P stress
adaptation remain unresolved, we reveal a detailed phospholipid-rec
10 regulate FAK activity at the focal
adhesion remain unresolved.
11 specific local environment of the cognate
Ag remains unresolved.
12 ificant reductions in AI, but IDA and IDA+
AI remain unresolved.
13 anistic basis for GCK's homotropic
allostery remains unresolved.
14 gin flexibility on medusan swimming has
also remained unresolved.
15 ions, yet their role in atherosclerosis
also remains unresolved.
16 nsgene silencing and epigenetic
alternations remains unresolved for most transgenic plants.
17 low) or through environmental selection,
and remains unresolved due to lack of empirical data.
18 te interphase and Li trapping at the
anodes,
remains unresolved.
19 es triggered by different types of
antigens,
remains unresolved.
20 l question of when and how these cells
arise remains unresolved.
21 cardiac contractility and
arrhythmogenicity remain unresolved.
22 s of the B-chain of insulin in this
assembly remains unresolved.
23 uished in response to microtubule
attachment remains unresolved.
24 hwann cells that myelinate Ia-afferent
axons remains unresolved.
25 ity of Purkinje cells during motor
behaviour remains unresolved.
26 has been the subject of numerous studies
but remained unresolved due to difficulties in identifying d
27 50% of cases, the underlying molecular
cause remains unresolved.
28 Its
causes remain unresolved, with tectonic restrictions to the Atl
29 ating the nucleus in a migrating tissue
cell remain unresolved.
30 required to generate long-lived plasma
cells remain unresolved.
31 he mechanism of mtDNA movement between
cells remains unresolved.
32 ymphoblastic leukemia (ALL)-initiating
cells remains unresolved.
33 , the mechanism of granzyme entry into
cells remains unresolved.
34 serves a similar function in mammalian
cells remains unresolved.
35 hanism(s) driving this conformational
change remains unresolved and in most cases high-resolution str
36 s producing these behavioral
characteristics remain unresolved.
37 , many mechanistic aspects of this
chemistry remain unresolved including the full ligand set of the s
38 mber of families mapping to the X-
chromosome remained unresolved suggesting that more XLID genes or l
39 ogenicity, but the molecular basis of G-
CIMP remains unresolved.
40 omprising this putative hypnogenic
circuitry remains unresolved.
41 urons that lie at the core of these
circuits remain unresolved.
42 d the role of the medial and distal
clusters remain unresolved.
43 nderlying selective nerve pathology in
CMT2D remain unresolved, as does the cause of the mild-to-mode
44 between plant and soil microbial
communities remain unresolved.
45 ylase (HDAC) cooperate within NuRD
complexes remains unresolved.
46 rspective on why the utility of this
concept remains unresolved.
47 ternmost frontier of the European
continent,
remains unresolved.
48 ell responses but their in vivo
contribution remains unresolved.
49 ch vocalizations are produced and
controlled remain unresolved because of the extreme difficulty in o
50 y, and geographical footprint of YDS
cooling remain unresolved and pose a challenge to our understand
51 for decades, yet their behavioral
correlates remain unresolved.
52 l ratio of the CESA isoforms within the
CSCs remains unresolved.
53 ht trigger the polymerizing arm of the
cycle remains unresolved.
54 (100 m to tens of kilometers, hours to
days)
remain unresolved due to a lack of synoptic measurements
55 inhibition (HDACi) induces tumor cell
death remain unresolved.
56 changes, and long-term risk of sudden
death remain unresolved and need further research.
57 garding Golgi function, while hotly
debated,
remain unresolved.
58 ed subjects, the underlying molecular
defect remains unresolved.
59 The cause of these neurological
deficits remains unresolved.
60 but how it drives motor neuron
degeneration remains unresolved.
61 ogical role of OPTN in neuronal
degeneration remains unresolved, we created a yeast model to study it
62 tabolisms of bacterial hydrocarbon
degraders remain unresolved.
63 NisB uses glutamate to catalyse
dehydration remains unresolved.
64 cuprate superconductors at low hole
density remains unresolved.
65 usative agent, Pseudogymnoascus
destructans,
remains unresolved [2,4].
66 mortality among persons with type 2
diabetes remains unresolved, with some studies suggesting decreas
67 macrophage polarization and
differentiation remain unresolved.
68 es are dependent upon the development of
DIO remains unresolved.
69 hanistic basis of this chiral
discrimination remains unresolved.
70 istic basis of their contribution to
disease remains unresolved.
71 dual VSMCs, which underlie vascular
disease,
remain unresolved.
72 of water in hominin evolution and
dispersal remains unresolved.
73 However, the specific sources of glacier
DOC remain unresolved.
74 riptions of denatured state ensembles (
DSEs)
remain unresolved.
75 ecise mechanism of this immune
dysregulation remains unresolved.
76 for the overall performance of an
ecosystem remains unresolved.
77 echanism and significance behind this
effect remain unresolved.
78 al roles, and which serve as toxic
effectors remains unresolved.
79 al relationships and tissue-specific
effects remain unresolved.
80 ng, but the exact role of ligand
endocytosis remains unresolved.
81 mistry of Type III restriction
endonucleases remain unresolved despite being characterized by numerou
82 ormation and function of the native
envelope remain unresolved.
83 However, the sequence of
events remains unresolved.
84 wever, the role of coding sequence
evolution remains unresolved.
85 es muscle activity during movement
execution remains unresolved.
86 however, the origins of salmon
exploitation remain unresolved.
87 related to environmental asbestos
exposures remain unresolved.
88 semble and ultimately affect gene
expression remains unresolved.
89 er, the role of Lyn in mucin gene
expression remains unresolved.
90 or shared or nonshared environmental
factors remains unresolved.
91 ing or aerobic capacity, and its
feasibility remains unresolved in patients with heart failure.
92 than 150 years, yet many essential
features remain unresolved.
93 Important questions in this
field remain unresolved, including whether HIV-1 itself encode
94 f research, the causes of these
fluctuations remain unresolved and heavily debated, with significant
95 e strength of bottom-up and top-down
forcing remain unresolved.
96 rsors of colorectal cancer (CRC),
frequently remains unresolved in patients with adenomatous polyposi
97 r components in mediating titin N2B
function remained unresolved.
98 ar sensory elements control channel
function remains unresolved.
99 Their
functions remain unresolved.
100 ges thus groomed for innate immune
functions remains unresolved.
101 4,5)P2 act together to induce channel
gating remains unresolved.
102 viruses replicated and populated the
genome remains unresolved.
103 The reasons for this complex
geometry remain unresolved.
104 SIF tracks spatiotemporal variations in
GPP remains unresolved.
105 ystematics and divergence times of the
group remain unresolved.
106 a stable classification scheme for the
group remains unresolved.
107 xt of genome-wide association studies (
GWAS)
remains unresolved.
108 V-associated neurocognitive disorders (
HAND)
remains unresolved.
109 the mechanism underlying the antagonism
has remained unresolved.
110 ood, but the function of ATP/ADP binding
has remained unresolved.
111 itability, epilepsy, and premature death
has remained unresolved.
112 sist on nutritionally insufficient diets
has remained unresolved.
113 ent to induce testicular differentiation
has remained unresolved.
114 The function of these enzymes
has remained unresolved until now.
115 nd evolutionary importance of this group
has remained unresolved, largely because of their poorly con
116 nctional consequence of this interaction
has remained unresolved.
117 However, it
has remained unresolved from where APCs in the CNS acquire m
118 ificance of the LSC microenvironment, it
has remained unresolved whether LSCs preferentially situate
119 In this work we propose that LPB
has remained unresolved because previous research has neglec
120 nescence (PL), the brightening mechanism
has remained unresolved.
121 in the nucleus, its role in mitochondria
has remained unresolved.
122 ions independently of Hrd1 stabilization
has remained unresolved.
123 lastocysts, but their X chromosome state
has remained unresolved.
124 etween structure and enzymatic activity
have remained unresolved.
125 s within Hemichordata and Echinodermata
have remained unresolved, compromising our ability to extrapo
126 , whose composition and chemical nature
have remained unresolved until recently.
127 the mechanisms triggering disease onset
have remained unresolved.
128 ronts; however, details of this process
have remained unresolved.
129 ific significance of GDF9:BMP15
heterodimers remained unresolved.
130 igin of the bandgap in such
heterostructures remain unresolved.
131 hondrial Ca2+ plays a mechanistic role in
HF remains unresolved.
132 hanisms generating context effects,
however,
remain unresolved.
133 on to reprogram gene transcription,
however,
remains unresolved.
134 l changes and the global expansion of
humans remain unresolved.
135 selection of most TSSs by RNA polymerase
II remain unresolved.
136 lung epithelium versus dysregulated
immunity remain unresolved.
137 function, their precise roles and
importance remain unresolved.
138 tive way, particularly in high-risk
infants,
remains unresolved.
139 and establishment of primary HIV-1
infection remain unresolved.
140 g Mycobacterium tuberculosis (Mtb)
infection remains unresolved.
141 underlying mechanism that sustains
infection remains unresolved.
142 l communities, but their combined
influences remain unresolved.
143 t serine and/or cysteine protease
inhibition remains unresolved.
144 lization of lasing with electrical
injection-
remains unresolved, largely due to fast nonradiative Aug
145 hanisms of renal ischemia-reperfusion
injury remain unresolved, and effective therapies are lacking.
146 m channel function to arrhythmic
instability remain unresolved.
147 erstanding of this lipid-protein
interaction remains unresolved.
148 ) cause many infections, some
investigations remain unresolved.
149 lemic conditions and the mechanisms
involved remain unresolved.
150 c mechanisms and the glial subtypes
involved remain unresolved, infection of NG2 glia was recently ob
151 Ischemia/reperfusion injury (
IRI)
remains unresolved problem in clinical organ transplanta
152 y CAZ proteins and their respective
isoforms remains unresolved.
153 gh charge carrier mobility, important
issues remain unresolved that prevent its widespread use in tec
154 dical relevance, basic SULT mechanism
issues remain unresolved.
155 Despite such enthusiasm, a number of
issues remain unresolved regarding the nature of MMN impairment
156 acterized clinically, many pathogenic
issues remain unresolved, among them a basic understanding of t
157 sease (AD), but the mechanisms leading to
it remain unresolved.
158 It remains unresolved how the amount of rotation occurring
159 attachments to the underlying bacterium,
it remains unresolved whether different bacterial subcapsul
160 ecause of contradictory results, however,
it remains unresolved as to whether CD28 costimulation is n
161 However,
it remains unresolved how acute and chronic changes in ener
162 However,
it remains unresolved how commissural neurons specifically
163 However,
it remains unresolved how multiple BMPs would cooperate to
164 However,
it remains unresolved what mediates these spectral shifts a
165 However,
it remains unresolved whether changes in one's own pain sen
166 However,
it remains unresolved whether feeding leads to endogenous o
167 However,
it remains unresolved whether schizophrenia-associated cort
168 importance to diverse human populations,
it remains unresolved how the bottle gourd came to be so wi
169 Despite extensive studies,
it remains unresolved how cis-elements just downstream of t
170 l telencephalon (pallium) of vertebrates,
it remains unresolved which ancestral neurogenesis mode pre
171 oute for the expansion out of Africa ~60
kya remains unresolved.
172 in speech encoding at the subcortical
level remains unresolved.
173 ic positions of Halteriida and
Linconophoria remain unresolved and are thus regarded as incertae sedi
174 genetic relationships of many major
lineages remain unresolved.
175 e, relationships among major spider
lineages remain unresolved or poorly supported.
176 tributions of variants residing in risk
loci remain unresolved.
177 ntibodies neutralize toxins in the gut
lumen remains unresolved, although it has been suggested that
178 e most fundamental aspects of
macroautophagy remain unresolved.
179 response to the development of
malignancies remains unresolved.
180 ociated with major depressive disorder (
MDD)
remains unresolved.
181 DA5 is activated through a similar
mechanism remain unresolved.
182 The causal gene and underlying
mechanism remain unresolved.
183 to their offspring, but the exact
mechanism remains unresolved.
184 ivation has been observed, but the
mechanism remains unresolved because they lack a canonical voltage
185 rtical synapses, but the cellular
mechanisms remain unresolved.
186 ne, but the underlying regulatory
mechanisms remain unresolved.
187 rent neurologic diseases, but the
mechanisms remain unresolved.
188 Cdk inhibitor (CKI), although the
mechanisms remain unresolved.
189 of plasticity, but the underlying
mechanisms remain unresolved.
190 disease (FAD), but the underlying
mechanisms remain unresolved.
191 of plasticity, but the underlying
mechanisms remain unresolved.
192 tical neurons, but the underlying
mechanisms remained unresolved.
193 ric communication among these
mechanoenzymes remain unresolved.
194 ported role on glucose and energy
metabolism remains unresolved.
195 trate of plant and animal
methyltransferases remains unresolved.
196 nformational entropy in the continuum
models remains unresolved.
197 physical mechanisms of most such
modulations remain unresolved.
198 d why species exhibit conserved
morphologies remains unresolved.
199 ogenetic position as suggested by
morphology remains unresolved.
200 fluences the risk of postoperative
mortality remains unresolved.
201 illin-resistant Staphylococcus aureus (
MRSA)
remains unresolved.
202 a cognitive ability essential to
musicality,
remains unresolved [1-5].
203 istent neuronal encoding within this
network remain unresolved.
204 rain barrier (BBB) and induce
neuropathology remain unresolved.
205 ect deficient central 5-HT
neurotransmission remains unresolved.
206 It
nevertheless remains unresolved to what extent variable ocean heat is
207 Cs project to each of the various AOS
nuclei remain unresolved.
208 ryonic origin of trunk denticle
odontoblasts remains unresolved.
209 he evolutionary history of such mixed
origin remains unresolved, and contradictory reports on the pre
210 nchronous climate oscillations, whose
origin remains unresolved.
211 ncer-relevant pathways within these
outcomes remains unresolved.
212 bances such as land clearing and
overfishing remains unresolved.
213 e preparation method and extent of
oxidation remain unresolved for catalytic applications.
214 I spectrin functions to neuronal
pathologies remain unresolved.
215 ortant control points between these
pathways remain unresolved.
216 erable mortality rate for young HCM
patients remains unresolved.
217 diet in large-scale diversification
patterns remains unresolved.
218 d that about one-third of the detected
peaks remained unresolved by MALDI-TOF, which led to a 3-5 tim
219 especially among those of the
Pentapetalae,
remain unresolved.
220 ction and response affects plant
performance remains unresolved.
221 y, particularly the role of
phosphorylation,
remain unresolved.
222 Yet, its internal
phylogeny remains unresolved owing to limited sampling.
223 hanisms that drive it in natural
populations remain unresolved.
224 can impact the formation of Trm
populations remains unresolved.
225 are causally related to symptom
presentation remains unresolved.
226 eural circuit mechanisms for these
processes remain unresolved.
227 ersies such as use of antibiotic
prophylaxis remain unresolved.
228 f thrust augmentation by flexible
propulsors remained unresolved, so the impact of bell margin flexib
229 ple tyrosine residues in a substrate
protein remain unresolved.
230 of acetylation across the parasite
proteome remains unresolved.
231 nopathogenic mechanisms leading to
psoriasis remain unresolved.
232 developing nervous system, a role for
PTCH2 remains unresolved.
233 ickens were first used for economic
purposes remains unresolved.
234 Yet not only does this
question remain unresolved, it has largely fallen into disregard.
235 After a decade of controversy, the
question remains unresolved-how do vortex flows interact with dif
236 guistic research; however, central
questions remain unresolved.
237 nconventional lymphocytes, but key
questions remain unresolved in the field, including why these cell
238 Many
questions remain unresolved about the cellular regulation of telom
239 However, many
questions remain unresolved in the transport of lipid components t
240 mental questions central to their
reactivity remain unresolved.
241 esterase substrate specificity was
realized remained unresolved, however.
242 , and evolutionary dynamics of the SR
region remains unresolved.
243 affiliative, and kinship-based
relationships remains unresolved.
244 GF axis, its impact on the IGF-IR
repertoire remains unresolved.
245 which significant questions in CO2
research remain unresolved: (1) mechanisms of CO2 effects on plan
246 the mechanism(s) underpinning this
response remain unresolved.
247 circuits interact to sculpt diverse
rhythms remains unresolved.
248 the mechanism of membrane remodeling by
Sar1 remain unresolved.
249 ystem multifunctionality at landscape
scales remains unresolved.
250 ell type responsible for MAIT cell
selection remains unresolved.
251 evance for chronic pulmonary oxygen
sensing,
remain unresolved.
252 rs to known cell types and their
sensitivity remains unresolved.
253 eterminants within the RyR1 protein
sequence remain unresolved.
254 ains the magnitude of this ecosystem
service remains unresolved.
255 ecretase cleaves Notch to initiate
signaling remains unresolved.
256 membrane for conversion to chemical
signals remains unresolved.
257 his activity and its functional
significance remain unresolved.
258 minant mechanism of O2 transport into
silage remains unresolved.
259 In humans, the
situation remains unresolved, in particular with advanced age.
260 eyond a +2 oxidation state in a stable
solid remains unresolved.
261 f sexual selection as a driver of
speciation remains unresolved, not least because we lack a clear em
262 functional implications of their
specificity remain unresolved.
263 ween TEX86 and sea surface temperature (
SST)
remains unresolved: How does TEX86 predict surface tempe
264 rs influencing reorganization patterns
still remains unresolved.
265 their relevance to the electronic
structure remains unresolved.
266 ons in living tissue, the protein
structures remain unresolved.
267 ils of their diets and community
structuring remain unresolved.
268 nels, a founding member of this
superfamily,
remains unresolved.
269 rsive behavioral states via the LC-NE
system remain unresolved.
270 The origins of neural
systems remain unresolved.
271 her results while also examining issues
that remain unresolved and future directions that seem promis
272 quantum or classical origins are issues
that remain unresolved.
273 ed, and emphasizes the essential issues
that remain unresolved.
274 ew highlights recent advances, problems
that remain unresolved, and avenues for future exploration.
275 Among those
that remain unresolved are the existence of an inactivated in
276 from vesicles by a retention mechanism
that remains unresolved.
277 ents are known, the relationships among
them remain unresolved.
278 the utility of surgery and radiation
therapy remains unresolved.
279 The mechanisms governing
this remain unresolved.
280 ormation above this characteristic
threshold remains unresolved.
281 r, the specific function of its cognate
ToxS remains unresolved.
282 olecular mechanisms of these
transformations remain unresolved, largely owing to the fact that key re
283 diversity of MTOR-regulated mRNA
translation remains unresolved.
284 prioritized to address cholera
transmission remains unresolved.
285 onal role of LETM1-mediated Ca(2+)
transport remains unresolved.
286 tperform supertrees as individual gene
trees remain unresolved and additional sequences contribute to
287 ion channel and how it is regulated by
TrkA remain unresolved.
288 regarding the dynamics of quantum
tunnelling remain unresolved.
289 gy with roots, shoots, or neither of the
two remains unresolved.
290 le of each of the various stromal cell
types remains unresolved.
291 o UTI and its role in protection against
UTI remain unresolved.
292 basis of others, such as xylose
utilization,
remains unresolved.
293 ive breeding relates to ecological
variation remains unresolved.
294 their electrophysiological behaviour in
vivo remain unresolved.
295 hapes granule cell sensory responses in
vivo remains unresolved.
296 ificance of increased pHi for cancer in
vivo remains unresolved.
297 y and sensory information processing in
vivo remains unresolved.
298 , yet whether they learn their
vocalizations remains unresolved.
299 espiration responses to soil moisture,
which remain unresolved in ecosystem models.
300 ediately after birth, the mechanism of
which remains unresolved.