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of 41 the 50 unclear 141 understood 61 however 233
this 39 it 47 unknown 71 unknown 40 unclear 144
and 31 has 33 poorly 69 be 35 unknown 115
the 28 and 20 largely 64 in 27 mechanisms 103
however 26 mechanisms 16 a 53 the 27 cells 81
these 25 have 14 elusive 44 whether 20 although 80
in 23 cells 12 to 35 to 19 poorly 72
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but 10 questions 10 the 19 and 16 understood 68
molecular 10 but 10 challenging 17 defined 13 largely 66
for 9 still 9 incompletely 17 challenge 12 patients 62
underlying 9 that 9 in 16 for 12 associated 52
it 8 process 8 obscure 14 unexplored 10 cell 51
cancer 8 mechanism 7 significant 14 with 9 underlying 51
to 8 function 7 stable 13 after 9 yet 50
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with 6 however 7 unchanged 10 significant 8 elusive 48
disease 5 to 7 an 9 patients 8 molecular 48
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tumor 4 also 6 at 7 major 8 during 43
membrane 4 mortality 6 unresolved 6 as 7 disease 41
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that 4 disease 5 constant 5 however 5 treatment 40
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gene 4 activity 5 one 5 because 5 specific 37
or 3 interactions 5 on 5 during 5 many 36
treatment 3 this 4 unexplored 4 by 5 high 34
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brain 3 expression 4 high 4 than 4 function 34
protective 3 formation 4 difficult 4 under 4 cancer 33
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many 3 interaction 4 undefined 3 even 3 development 31
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