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of 48 it 54 unclear 131 understood 83 however 219
the 37 has 44 poorly 95 be 37 unclear 139
and 37 the 34 a 72 unknown 29 mechanisms 114
this 28 and 17 unknown 69 in 23 unknown 102
in 27 have 16 elusive 69 and 20 poorly 100
cell 18 mechanisms 15 largely 56 to 17 understood 90
these 18 that 14 to 38 whether 16 although 88
however 17 cells 13 challenging 24 of 14 cell 82
to 10 mechanism 12 the 20 defined 14 role 81
underlying 8 function 10 an 19 how 14 cells 80
molecular 8 but 9 obscure 15 major 13 molecular 79
but 7 still 8 controversial 15 challenge 11 elusive 75
although 7 data 7 in 14 the 11 mechanism 74
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gene 7 processes 7 unexplored 10 because 7 largely 62
specific 7 questions 7 limited 10 for 7 underlying 52
many 6 to 7 one 9 at 7 disease 50
it 6 involved 5 incompletely 9 characterized 6 yet 49
mechanisms 6 which 5 uncertain 9 unexplored 6 function 47
their 6 process 5 intact 7 but 6 many 40
cancer 5 individuals 5 important 7 unclear 6 specific 40
nuclear 5 vivo 5 undefined 7 elusive 5 development 39
for 5 however 5 unchanged 6 significant 5 challenge 37
such 4 responses 5 mysterious 6 mystery 5 protein 37
rna 4 development 5 high 6 important 5 cancer 37
signaling 4 properties 5 incomplete 5 by 5 during 37
action 4 differentiation 5 on 5 most 5 high 36
functional 4 action 5 highly 5 or 5 human 34
virus 4 structure 4 constant 5 despite 5 expression 33
its 4 activity 4 regarding 4 when 4 s 33
disease 4 cancer 4 difficult 3 open 4 signaling 32
species 4 can 4 stable 3 about 4 gene 32
pathogenic 4 expression 4 low 3 key 4 proteins 31
that 4 much 4 of 3 which 4 treatment 30
tissue 3 infection 4 about 3 due 4 understanding 29
membrane 3 activation 4 ill 3 as 3 into 29
within 3 molecules 3 unaffected 3 especially 3 studies 28
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tumor 3 interactions 3 unanswered 3 leading 3 challenging 28
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genomic 3 phenomena 3 at 3 one 3 major 27
vascular 3 homeostasis 3 relatively 3 mainstay 3 other 27
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factor 3 there 3 underexplored 2 studied 2 two 26
chromatin 3 genes 3 effective 2 challenging 2 processes 25
regulation 3 significance 3 debated 2 priority 2 control 25
target 3 specificity 3 untested 2 difficult 2 genetic 25
metabolic 3 inflammation 3 unsettled 2 is 2 infection 25
therapy 3 species 3 unsolved 2 undefined 2 complex 24
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particular 2 level 3 contentious 2 subject 2 interactions 22
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