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of 46 it 53 unclear 128 understood 74 however 223
the 41 has 39 poorly 84 be 43 unclear 133
and 34 the 38 unknown 77 unknown 34 mechanisms 116
this 30 have 20 elusive 65 in 25 unknown 115
in 28 and 18 a 56 and 21 although 99
these 22 that 16 largely 56 the 20 poorly 89
however 18 mechanisms 15 to 46 to 18 understood 81
cell 15 still 12 challenging 22 how 16 cell 79
it 13 cells 11 controversial 18 defined 14 cells 73
but 12 but 11 an 18 major 14 role 72
underlying 10 disease 10 in 16 whether 13 elusive 71
to 9 mechanism 8 the 16 of 10 largely 63
human 7 process 8 stable 13 at 9 despite 61
gene 6 questions 7 uncertain 13 a 9 mechanism 57
their 6 individuals 6 incompletely 11 because 9 underlying 56
its 6 infection 6 unresolved 10 for 8 molecular 56
mechanisms 5 which 6 at 9 unexplored 8 during 45
yet 5 function 6 undefined 9 challenge 7 yet 43
clinical 5 patients 5 limited 8 with 7 disease 43
many 5 system 5 obscure 8 important 6 human 42
molecular 5 effects 5 high 8 despite 6 protein 38
tissue 4 to 5 intact 8 characterized 6 specific 37
cancer 4 processes 5 unexplored 7 as 5 function 36
although 4 factors 5 unchanged 7 when 5 challenge 36
complex 4 differentiation 5 highly 7 but 5 many 36
such 4 however 5 one 6 after 5 gene 36
is 4 states 5 constant 6 risk 4 high 35
functional 4 systems 5 and 5 over 4 development 34
metabolic 4 responses 5 unanswered 4 elusive 4 cancer 33
disease 4 activation 4 unsolved 4 or 4 complex 31
or 3 level 4 enigmatic 4 is 4 into 31
cells 3 of 4 about 4 during 4 factors 31
processes 3 variation 4 on 4 however 4 associated 31
species 3 there 4 incomplete 4 controversial 4 challenging 30
infection 3 outcomes 4 regarding 4 formidable 3 treatment 30
treatment 3 memory 4 under 4 unclear 3 important 29
physiological 3 challenges 4 important 3 key 3 infection 29
control 3 activity 4 less 3 due 3 patients 28
for 3 vivo 4 mostly 3 open 3 genome 27
major 3 functions 4 difficult 3 most 3 major 27
genome 3 data 4 unexplained 3 leading 3 one 25
external 3 tumorigenesis 3 however 3 that 3 proteins 25
transcription 3 cancer 3 significant 3 only 3 expression 25
are 3 viruses 3 low 3 by 3 hiv 24
mediated 3 phenotypes 3 unaffected 2 although 3 controversial 24
infected 2 structures 3 completely 2 central 2 response 24
receptor 2 interaction 3 mysterious 2 into 2 genetic 24
synthetic 2 genome 3 ill 2 are 2 functions 24
level 2 action 3 unsatisfactory 2 largely 2 known 23
neuronal 2 virus 3 bound 2 clear 2 understanding 23
vascular 2 largely 3 approximately 2 free 2 two 23
fundamental 2 this 3 uncharacterized 2 subject 2 cellular 23
histone 2 role 3 confined 2 limited 2 studies 23
causes 2 should 3 associated 2 if 2 dna 23
causal 2 assembly 3 open 2 about 2 because 22
protein 2 properties 3 such 2 isolated 2 process 22
beta 2 expression 3 conductive 2 mainstay 2 regulation 22
viral 2 also 3 poor 2 matter 2 time 22
rna 2 while 3 problematic 2 challenging 2 stable 22
eukaryotic 2 humans 3 valid 2 even 2 defined 22
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a 2 lineages 3 before 2 what 2 neurons 21
therapeutic 2 association 3 somewhat 2 unchanged 2 type 21
liver 2 significance 3 elevated 2 their 2 transcription 21
lineage 2 formation 3 susceptible 2 active 2 years 21
within 2 involved 3 two 2 approaches 2 identified 21
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challenges 2 ibd 2 fixed 1 bound 1 activity 20
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biological 2 genes 2 tightly 1 goal 1 data 19
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