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and 41 it 48 unclear 128 understood 73 however 236
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these 24 the 25 poorly 75 in 29 unknown 109
the 22 have 20 a 70 to 26 mechanisms 94
however 20 and 17 elusive 64 and 24 understood 82
this 19 mechanisms 14 largely 38 for 16 poorly 81
in 18 that 10 to 32 whether 15 elusive 66
molecular 10 function 9 the 18 unknown 15 cell 64
cell 10 however 8 challenging 17 the 14 although 59
underlying 9 but 8 limited 16 unexplored 14 patients 58
its 7 to 7 incompletely 16 how 14 despite 58
to 7 cells 7 stable 16 challenge 13 molecular 56
disease 6 disease 7 uncertain 15 major 11 disease 51
cancer 6 infection 7 in 14 significant 11 underlying 49
but 6 who 6 an 13 characterized 8 during 46
s 5 there 6 obscure 10 due 8 p 45
on 5 cancer 6 on 10 but 8 role 44
such 5 this 6 significant 8 of 8 cells 44
for 5 patients 6 high 8 which 7 largely 43
therapeutic 4 mechanism 6 unchanged 8 because 7 associated 41
patient 4 population 5 relatively 8 with 7 yet 41
a 4 which 5 unexplored 7 defined 7 function 40
cellular 4 properties 5 enigmatic 6 as 6 significant 38
that 4 questions 5 difficult 6 challenging 6 mechanism 37
with 4 still 4 undefined 6 at 5 challenge 36
heart 4 association 4 intact 6 after 5 cancer 36
clinical 4 response 4 constant 5 even 4 risk 35
cells 3 effects 3 debated 5 critical 4 development 35
species 3 therapy 3 significantly 5 despite 4 high 34
significant 3 tissues 3 controversial 5 were 4 treatment 34
by 3 rates 3 associated 5 most 4 many 33
human 3 structures 3 low 5 on 4 specific 31
pathways 3 stroke 3 poor 4 during 4 protein 30
within 3 activation 3 unresolved 4 key 4 clinical 28
their 3 risk 3 active 4 unclear 3 effects 27
t 3 pathway 3 one 4 although 3 low 26
brain 3 therefore 3 open 4 untested 3 brain 25
two 3 sources 3 elevated 4 when 3 one 25
after 3 formation 3 more 4 by 3 challenging 25
covid 3 phenotype 3 underexplored 3 or 3 s 24
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rna 2 proteins 3 ambiguous 3 elucidated 2 due 24
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female 2 control 3 similar 3 improved 2 processes 23
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