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1                                     As lipid identification remains a bottleneck of modern untargeted lipidomics, we deve
2 ial relationship of individual proteins in dense assemblies remains a challenge for superresolution nanoscopy.
3       Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-oc
4 ion of high-performance, small-footprint, on-chip inductors remains a challenge in radio-frequency and power microelectro
5                     Understanding and treating this disease remains a challenge, as seizures manifest through mechanisms
6 st and direct method for the in situ detection of H. pylori remains a challenge, mainly due to the strong acidic/enzymati
7 orientation.Mapping the sequence specificity of DNA ligands remains a challenge, particularly for small drugs.
8 hell nanoparticle geometry, and controlling its properties, remains a challenge.
9 tem cells in vitro, but generating a human ovarian follicle remains a challenge.
10 n 95% in many centres but improvement of long-term function remains a challenge.
11 nd volatilities in different phases at atmospheric pressure remains a challenge.
12                                                     Suicide remains a clear, present and increasing public health problem
13 molecules (e.g., proteins, nucleic acids) into cell cytosol remains a critical challenge for the development of macromole
14 anding the factors that promote or prevent HIV transmission remains a critical component of the global battle against HIV
15                            Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide.
16                        Scaling up of interventions for PWID remains a crucial priority for halting the HIV and HCV epidem
17                                                Pancreatitis remains a diagnostic challenge in patients with mild to moder
18 despite the exploration of innovative molecular designs, it remains a formidable scientific challenge to access Earth-abu
19 ylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge because of the absen
20 The interaction between biofilm structure and hydrodynamics remains a fundamental question concerning biofilm dynamics.
21                                                Tuberculosis remains a global health problem with an enormous burden of di
22 d functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modeling,
23 ing of human neuron specification and functional maturation remains a key challenge that hampers the routine application
24  poor prognosis and high relapse after treatment, but there remains a lack of biomarkers and effective targeted therapies
25                                              However, there remains a lack of statistically sound frameworks to model the
26                                                       There remains a large discrepancy between the known genetic contrib
27                                Despite mass vaccination, it remains a leading cause of death in children in developing re
28  advances in antimicrobial therapy, pneumococcal meningitis remains a life-threatening disease.
29 articles, spatial control of nanoparticle surface chemistry remains a major challenge.
30                           Respiratory syncytial virus (RSV) remains a major human pathogen, infecting the majority of inf
31 cs of protein networks, but chromatographic time scheduling remains a major limitation for dissemination and implementati
32 ) mediated by ATP-binding cassette (ABC) transport proteins remains a major problem in the chemotherapeutic treatment of
33                                    Schistosomiasis japonica remains a major public health and socioeconomic concern in So
34 rosy, the leading infectious cause of disability worldwide, remains a major public health challenge in the most severely
35 , the role of PET during treatment (iPET) in daily practice remains a matter of significant debate.
36         When and how this initiator substrate hairpin forms remains a mystery.
37                 How BTX autoresistance arises in such frogs remains a mystery.
38  all matter in the universe yet its microscopic composition remains a mystery.
39                                              However, there remains a need to anticipate supply given the rapid growth of
40         Despite progress, early childhood development (ECD) remains a neglected issue, particularly in resource-poor coun
41                                           Fortunately, this remains a rare condition.
42 mune-mediated control of clade B HIV-1 infection, yet there remains a relative paucity of data regarding the role of HIV-
43 i-67 expression varies due to cell-cycle regulation, but it remains a reliable readout for effects of CDK4/CDK6 inhibitor
44 vel phenomena to drive such movements in artificial systems remains a scientific challenge.
45 While the utility of NFL declines in advanced glaucoma, GCC remains a sensitive progression detector from early to advanc
46 ntial, structural characterization of these glycan epitopes remains a significant challenge in mAb preclinical developmen
47 e door to a wide range of biomedical applications, yet this remains a significant challenge.
48 s have yet to be made because measuring amorphous structure remains a significant challenge.
49 nsport of hydraulic fracturing fluid compounds and mixtures remains a significant data gap.
50  perceptual organization of ALT and SYNC sequences and thus remains a viable model of auditory stream segregation.SIGNIFI

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