ライフサイエンスコーパス: remethylation

1 ong global demethylation and drastic focused remethylation.

2 romotes transposon silencing via de novo DNA remethylation.

3 oplasm, a required cofactor for homocysteine remethylation.

4 ylate biosynthesis and impaired homocysteine remethylation.

5 uration and transmethylation or homocysteine remethylation.

6 is pathway and folate-dependent homocysteine remethylation.

7 ie, as p53 expression continues unchecked by remethylation.

8 f the 5' region for over 40 days, preventing remethylation.

9 ed by waves of genome-wide demethylation and remethylation.

10 methionine were labeled through homocysteine remethylation.

11 ined by differences in rates of homocysteine remethylation.

12 for methyl group production and homocysteine remethylation.

13 n through CpG islands does not inhibit their remethylation.

14 plasma homocysteine levels by impairing its remethylation.

15 th inhibition of CD8 gene expression through remethylation and concludes with up-regulation of surfac

16 tures inhibits folate-dependent homocysteine remethylation and enhances thymidylate biosynthesis.

17 but its overall contribution to homocysteine remethylation and sulfur amino acid homeostasis is not k

18 B-6 restriction on the rates of homocysteine remethylation and synthesis in healthy humans.

19 of origins that are methylated, the rate of remethylation and the effect of hypomethylation were det

20 nine coordinately regulates the flux through remethylation and transsulfuration, and glycine N-methyl

21 Remethylation at ori-beta did not begin until approximat

22 ed IFN-gamma/IL-4 and IL-10/IL-4 ratios, DNA remethylation at the IL-4 promoter and demethylation at

23 ssues and evidence for impaired homocysteine remethylation but surprisingly exhibited depressed level

24 te deficiency at the expense of homocysteine remethylation, but the mechanisms are unknown.

25 their cognate sequences and thereby prevent remethylation by DNA methyltransferase.

26 ration of high levels of expression requires remethylation by DNMT3B.

27 cob(I)alamin to the folate (Fol) domain for remethylation by methyltetrahydrofolate (CH(3)-H(4)folat

28 ings demonstrate that defective homocysteine remethylation caused by deficiency of either MS or folat

29 o and that serine synthesis and homocysteine remethylation compete for one-carbon units in the cytopl

30 DH impairs the folate-dependent homocysteine remethylation cycle.

31 s, cancer-testis gene promoters also undergo remethylation during CTCF/BORIS switching in germ cells.

32 biosynthesis at the expense of homocysteine remethylation during folate deficiency.

33 ivity of the folate-independent homocysteine remethylation enzyme betaine-homocysteine S-methyltransf

34 Both remethylation events are attributable to CheR using S-ad

35 tween thymidylate synthesis and homocysteine remethylation for THF cofactors.

36 Here, we analysed global remethylation from the mouse preimplantation embryo into

37 Although the homocysteine remethylation gene MTHFR has emerged as a risk factor in

38 eductase, an enzyme involved in homocysteine remethylation, has been reported to render the enzyme th

39 n and its transsulfuration, and homocysteine remethylation in children with SCU.

40 onstrated that both global demethylation and remethylation in early development correlate with chroma

41 ine-derived one-carbon units in homocysteine remethylation in hepatic and whole-body metabolism.

42 coincides with genome-wide demethylation and remethylation in mice which most imprinted genes resist.

43 hese regions also exhibited higher levels of remethylation in single-cell clones and subclones derive

44 negative in vivo and because zygotic genome remethylation is a key biological event during cleavage,

45 This lack of DNA remethylation leaves the Pdcd1 locus poised for rapid ex

46 0 microg/d) of vitamin B12, the cofactor for remethylation; low intake (<2.1 mg/d) of vitamin B6, the

47 riants of two genes involved in homocysteine remethylation/methionine biosynthesis--methionine syntha

48 ents in the absence of cell division, yet no remethylation occurred at CpG islands under these condit

49 On DAC withdrawal, gradual resilencing and remethylation occurred in both GFP-positive and GFP-nega

50 Remethylation occurred most rapidly in the p16, PAX-6, a

51 occurs in the nucleus, whereas homocysteine remethylation occurs in the cytosol.

52 urthermore, AID or Mbd4 knockdown caused the remethylation of a set of common genes.

53 brogated the protective effect of AC whereas remethylation of AC DNA reversed the effects of activati

54 Furthermore, we show that the remethylation of asparagine-bound McpB requires the resp

55 The rates of remethylation of both CpG islands were associated with t

56 e also examined the relationship between the remethylation of coding sequence CpG islands and gene tr

57 Genome-wide demethylation and remethylation of DNA during early embryogenesis is essen

58 Counter-regulation included remethylation of Hcy to methionine concurrent with decre

59 bon metabolism, during which it promotes the remethylation of homocysteine -- a cytotoxic sulfur-cont

60 xes of total homocysteine remethylation, the remethylation of homocysteine from serine, and rates of

61 tilized for de novo purine synthesis and the remethylation of homocysteine in liver.

62 Remethylation of homocysteine is dependent on the produc

63 Folate B12-dependent remethylation of homocysteine is important, but less is

64 antifolate drug, aminopterin (which prevents remethylation of homocysteine to methionine by methionin

65 In the cytosol, vitamin B12 functions in the remethylation of homocysteine to methionine, which regen

66 This enzyme catalyzes the remethylation of homocysteine to methionine, with betain

67 hesis of dTMP and purine nucleotides and for remethylation of homocysteine to methionine.

68 f folate, which serves as a methyl donor for remethylation of homocysteine to methionine.

69 ltetrahydrofolate, the major carbon donor in remethylation of homocysteine to methionine.

70 hesis of three of the four DNA bases and the remethylation of homocysteine to methionine.

71 nthesis of purines, thymidylate, and for the remethylation of homocysteine to methionine.

72 synthase (MS) catalyzes the folate-dependent remethylation of homocysteine to methionine.

73 hesis of purines and thymidylate and for the remethylation of homocysteine to methionine.

74 rahydrofolate is a major methyl donor in the remethylation of homocysteine to methionine.

75 s in humans, betaine, a methyl donor for the remethylation of homocysteine, may be a therapeutic agen

76 ction of N(5)-methyltetrahydrofolate and the remethylation of l-homocysteine to form l-methionine sho

77 utilizes an unusual mechanism for control of remethylation of newly replicated DNA.

78 Remethylation of tHcy may be more dependent on the betai

79 This pattern is transient as remethylation of the ALF promoter in haploid germ cell D

80 Demethylation and remethylation of the CpG island within the LIFR promoter

81 on from myeloma to plasma cell leukemia with remethylation of the genome, particularly of genes invol

82 cytidine followed by zebularine hindered the remethylation of the p16 5' region and gene resilencing,

83 but not with the rate of cell division, and remethylation of the p16 exon 2 CpG island occurred at a

84 The kinetics of remethylation of the p16 exon 2, PAX-6 exon 5, c-ABL exo

85 and then compared the timing and kinetics of remethylation of the p16 gene locus under conditions of

86 netics of mRNA induction, demethylation, and remethylation of the p16 promoter and second-exon CpG is

87 Furthermore, we provide evidence that the remethylation of the p16 promoter CpG island in T24 cell

88 is is susceptible to TDCPP-induced delays in remethylation of the zygotic genome, a mechanism that ma

89 Remethylation of these sequences was also compromised in

90 e no significant differences in homocysteine remethylation or methionine transsulfuration and transme

91 ignificantly alter the rates of homocysteine remethylation or synthesis in healthy young adults in th

92 did not affect in vivo rates of homocysteine remethylation or the appearance of homocysteine and cyst

93 t the thymidylate synthesis and homocysteine remethylation pathways compete for a limiting pool of me

94 ated disturbances in the transsulfuration or remethylation pathways for homocysteine metabolism.

95 ate between the thymidylate and homocysteine remethylation pathways.

96 functional memory cells coincided with Pdcd1 remethylation, providing an adapted program for regulati

97 Whereas adjustment of remethylation rates for fat-free mass tended to attenuat

98 However, women had significantly higher remethylation rates than did men (P < 0.005) and a tende

99 Remethylation studies after drug-induced hypomethylation

100 In vivo fluxes of total homocysteine remethylation, the remethylation of homocysteine from se

101 used as a source of methyl for homocysteine remethylation to methionine, but choline synthesis requi

102 stands at the intersection of two pathways: remethylation to methionine, which requires folate and v

103 yltetrahydrofolate, utilized in homocysteine remethylation to methionine.

104 ine; the rates of homocysteine synthesis and remethylation (total and vitamin B-6-dependent); and the

105 ulates the early embryonic demethylation and remethylation waves.

106 Variable levels of remethylation were detected in CpG poor regions of DNA,

107 e propose that [(2)H(2)]methionine occurs by remethylation with [(2)H(2)]methyl groups (as 5-methylte