ライフサイエンスコーパス: remodel

1 n suggests a new role of SPARC during tissue remodeling.

2 tion to new conditions by delaying chromatin remodeling.

3 inflammation, proliferation, and resolution/remodeling.

4 nases that participate in actin cytoskeleton remodeling.

5 r respiratory tract infection-induced airway remodeling.

6 f function of these mutants in promoting NMJ remodeling.

7 anges in cardiac metabolism cause myocardial remodeling.

8 el function for drug-induced neuroepigenetic remodeling.

9 key mechanism in synapse and neural circuit remodeling.

10 nd its predictive value for left ventricular remodeling.

11 actic protein 1 (MCP1)-induced vascular wall remodeling.

12 tors involved in specific aspects of cardiac remodeling.

13 on is indicated to avoid adverse ventricular remodeling.

14 d IGC did not change such adverse epigenetic remodeling.

15 ely investigate normal and impaired cervical remodeling.

16 through increased inflammation and vascular remodeling.

17 E2 synthesis has been associated with airway remodeling.

18 erapeutic target for airway inflammation and remodeling.

19 ment and a paradigm for tissue formation and remodeling.

20 rks to prevent left ventricular (LV) adverse remodeling.

21 s involved in axon guidance and cytoskeletal remodeling.

22 m response that leads to deleterious cardiac remodeling.

23 vasoconstriction and subsequent blood vessel remodeling.

24 secondary to cardiomyocyte loss and cardiac remodeling.

25 ex differences in aortic valve fibrocalcific remodeling.

26 r and function and to slow this pathological remodeling.

27 B and greatly enhance CSB-mediated chromatin remodeling.

28 neovascularization, and promoting myocardial remodeling.

29 I progression, concomitant with phospholipid remodeling.

30 alcium kinetics studies, and markers of bone remodeling.

31 n of PtdIns(4,5)P2 microdomains and membrane remodeling.

32 only for long bone growth, but also for bone remodeling.

33 d fatty acids, which is indicative of active remodeling.

34 atch may be generally required for chromatin remodelling.

35 idases, which plays an important role in ECM remodelling.

36 iation, nascent transcription, and chromatin remodelling.

37 imicrobial peptides to facilitate microbiota remodelling.

38 ng Se transference during metamorphic tissue remodelling.

39 ; P=0.009), and lower incidence of eccentric remodeling (12% versus 48%; P=0.03).

40 nd electron microscopy to elucidate how EGCG remodels Abeta oligomers.

41 we studied CSB's DNA-binding and nucleosome-remodeling activities at the single molecule level in re

42 st-microbes interplay potentially determines remodeling activities in the transplanted lung, highligh

43 fferentially modified nucleosomes, directing remodelling activity towards specific nucleosome substra

44 ing PW1(+) and their involvement in fibrotic remodeling after MI.

45 -specific Smad3 loss had accentuated adverse remodeling after reperfused infarction and exhibited an

46 ated with significant atrial and ventricular remodeling, along with systolic dysfunction and comparab

47 rogram for fibrosis and extracellular matrix remodeling, although deletion of Tgfbr1/2 uniquely alter

48 sociated with airway tissue inflammation and remodeling, although persistent airflow obstruction in t

49 F or death risk and in the degree of reverse remodeling among comorbidity groups.

50 We propose, therefore, that eosinophils remodel and migrate on periostin-rich extracellular matr

51 h the TCA cycle are essential for epigenetic remodeling and are transiently and partially localized t

52 endocytosis pathways and supports organelle remodeling and biogenesis.

53 of mucus is an important component of airway remodeling and contributes to the mucus plugs and airflo

54 DNA and recruiting the associated nucleosome remodeling and deacetylase (NuRD) complex.

55 o dCas9 to recruit the endogenous nucleosome remodeling and deacetylase complex, were both successful

56 Here we show that the Mbd3/nucleosome remodeling and deacetylation (NuRD) chromatin remodeling

57 insult caused cofilin activation and F-actin remodeling and decreased microtubule dynamics in the AIS

58 e used to assess microglia-mediated neuronal remodeling and dendritic spine density in the medial PFC

59 The histological analysis showed that remodeling and destruction of the bronchiolar and alveol

60 Adverse LV remodeling and deteriorating LV ejection fraction occurr

61 erable syndrome to one that leads to chronic remodeling and dilated cardiomyopathy.

62 ws the role of the ECM in cardiac repair and remodeling and discusses matrix-based therapies that may

63 Z-ring, which coordinates peptidoglycan (PG) remodeling and envelope constriction.

64 aled an upregulation of extracellular matrix remodeling and focal adhesion processes in tumors with h

65 nisms underlying lymphatic vessel formation, remodeling and function in a human cell context.

66 from LVD and sham hearts did not improve LV remodeling and function, cardiac MSCs from LVD exacerbat

67 ction was associated with alterations in HDL remodeling and functionality.

68 /Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling and global methylation patterns that may allo

69 r recruitment to SpAs in the early stages of remodeling and has identified potential key candidate fa

70 may shed light onto obesity-related cardiac remodeling and heart failure.

71 as a new therapeutic target for pathological remodeling and heart failure.

72 Nuclear localization and nucleosome remodeling and histone deacetylase (NuRD) complex bindin

73 's osteoimmunomodulatory effects on skeletal remodeling and homeostasis are unclear in the healthy ad

74 zed by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR).

75 thological cardiac structural and functional remodeling and improves left ventricular functional rese

76 a multifunctional IDP involved in chromatin remodeling and in the development and progression of pan

77 vated GDF-15 correlates with lack of reverse remodeling and increased mortality after TAVR and improv

78 Parameters of ventricular remodeling and modulation of cardio-renal sympathetic ax

79 ll as regulation of the growth, cytoskeleton remodeling and motility, invasion of PDAC cells-all coll

80 o ubiquitous proteins implicated in membrane remodeling and mutated in centronuclear myopathies (CNMs

81 y and mortality and different patterns of LV remodeling and recovery of LV function when compared wit

82 lammation that may eventually lead to tissue remodeling and respiratory disease.Cystic fibrosis is ca

83 recently been shown to be involved in lipid remodeling and scavenging during replication.

84 ibutions during Drosophila epithelial tissue remodeling and show that Rab35 is dynamically planar pol

85 critical role of adult stem cells in tissue remodeling and unravel the complexity of stem cell fate

86 atin (CalpTG) are protected against vascular remodelling and angiotensin II-dependent inflammation.

87 by transmission electron microscopy revealed remodelling and degradation of core extracellular matrix

88 6583 or Cicaprost induced rapid cytoskeleton remodelling and inhibited proliferation and migration in

89 e had preserved kidney tissue, less vascular remodelling and less markers of senescence than wild-typ

90 ypertensive effects, (2) attenuating cardiac remodeling, and (3) increasing angiogenesis and cell sur

91 or flow-dependent vasodilation, blood vessel remodeling, and atherosclerosis.

92 ted with the initial STEMI severity, adverse remodeling, and long-term health outcome.

93 Mical-mediated F-actin disassembly, cellular remodeling, and repulsive axon guidance.

94 n HF are primed to induce cardiac injury and remodeling, and retain this memory on adoptive transfer.

95 oteases have diverse roles in the formation, remodeling, and the destruction of extracellular matrix.

96 for osteoporosis, which act by reducing bone remodelling, and are thought to prevent perforations and

97 signaling (PIK3R1, VAV1), RHOA/cytoskeleton remodeling (ARHGEF3), RNA splicing (U2AF1), T-cell recep

98 on and chromosomal breakage, suggesting fork remodeling as a global fork slowing and protection mecha

99 es, loss of proliferative control, chromatin remodeling as well as extensive morphological alteration

100 ion and arrythmia, SMOC2, involved in matrix remodeling, as well as enkephalin and RUNX3, potentially

101 e expression profiles, among which catabolic remodeling, associated with high expression of metallope

102 Favorable cardiac remodeling at 6 months included decreases in end-diastol

103 ty volumes at day 3, followed by ventricular remodeling at day 30, and recovery at day 60 (P < 0.05,

104 egulated by SOX10 and MITF and for chromatin remodeling at distal and proximal regulatory sites.

105 y assess the functional impact of structural remodelling at the cellular scale.

106 Through a process called perilacunar remodeling, bone-embedded osteocytes dynamically resorb

107 more, NFLG patients experienced less reverse remodeling but the same symptomatic benefit.

108 process requires actomyosin-driven membrane remodeling, but not microtubules.

109 is associated with global pulmonary vascular remodeling, but the severity of PH correlates most stron

110 ix (ECM), are significantly and irreversibly remodeled by cellular traction forces, as well as by mac

111 ochondria form extensive networks constantly remodeled by fission and fusion.

112 soform interactome reveals extensive network remodeling by alternative splicing.

113 ated with less likelihood of adverse cardiac remodeling by cardiac magnetic resonance.

114 ains in mediating HFD-induced adipose tissue remodeling by influencing multiple functions including a

115 r matrix, are significantly and irreversibly remodelled by cellular traction forces and by macroscopi

116 umans, molecular imaging of inflammation and remodeling can potentially help early diagnosis and moni

117 essential actions for ESCRT-III in membrane remodeling, cargo selection, and cargo retention, which

118 t size, LV ejection fraction, and adverse LV remodeling, changes associated with decreased neutrophil

119 edominantly in genes that regulate chromatin remodeling, chromosome alignment, and stability.

120 Injury of CNS nerve tracts remodels circuitry through dendritic spine loss and hype

121 rculation, the ancestral heart may have been remodelled coincidently with, or accompanied by, the pro

122 role of the SWI/SNF ATP-dependent nucleosome-remodeling complex in the repair of a defined DNA DSB.

123 Here we show that the INO80 chromatin remodeling complex is required for oncogenic transcripti

124 emodeling and deacetylation (NuRD) chromatin remodeling complex opposes this transcriptional pioneeri

125 genes encoding subunits of the BAF chromatin remodeling complex that exhibited Ras-mediated dependenc

126 cooperates with a tissue-specific chromatin remodeling complex to activate brown fat identity genes.

127 and recruits a tissue-specific BAF chromatin remodeling complex to brown fat gene enhancers, thereby

128 actor (NURF), a member of the ISWI chromatin-remodeling complex.

129 is Swi1, a subunit of the SWI/SNF chromatin-remodeling complex.

130 tial ATPase subunit of the SWI/SNF chromatin-remodelling complex, is required for expression of Wilms

131 Among them, the ATP-dependent chromatin remodeling complexes control the chromatin architecture

132 witch for other PTMs, and connects chromatin remodeling complexes into gene transcription and gene ac

133 on factors that recruit activating chromatin remodeling complexes.

134 matory drugs or components of the nucleosome remodeling deacetylase (NuRD) complex, which associate w

135 tions and their association with right heart remodeling differ between AF-TR and left-sided heart dis

136 namic organ that undergoes continuous tissue remodeling during adulthood.

137 he potential role of tissue degeneration and remodeling during anuran metamorphosis as a mechanism fo

138 tokines, including TNF, interferes with bone remodeling during inflammation through Ca(2+)-dependent

139 ing are widely used to profile transcriptome remodeling during myocardial ischemia.

140 MPC-dependent ECM remodeling during the first week of a growth stimulus is

141 g-range resection, indicating that chromatin remodelling during resection is underlying DSB repair pa

142 nuation of IRE1 activity is important for ER remodelling dynamics and cell survival in the face of re

143 the surrounding extracellular matrix (ECM), remodeling ECM fiber network structure by condensing, de

144 This remodeling effect is mediated by the ubiquitination and

145 Human ALC1 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses

146 Furthermore, the Fun30 remodeling enzyme, which has been implicated in DNA repa

147 decreased expression of extracellular matrix remodeling-enzyme coding genes and increased levels of s

148 ISWI-family nucleosome remodeling enzymes need the histone H4 N-terminal tail t

149 regulation is modulated in part by chromatin-remodeling enzymes that control gene accessibility by al

150 c subunit of the mammalian SWI/SNF chromatin-remodeling enzymes, is required for both myoblast prolif

151 trates that hepatic scar in NASH is actively remodeled even in advanced fibrosis, a disease that is g

152 e discuss the transcriptional and epigenomic remodeling events associated with cell fate transitions

153 e histone modification profile and chromatin-remodeling events leading to Sp7 gene expression.

154 of epithelial cells underlies diverse tissue-remodeling events, but the mechanisms that coordinate in

155 ous outflow homeostasis in their capacity to remodel extracellular matrices, which has a direct impac

156 e interface and illustrate how integrins can remodel extracellular matrix.

157 (BPTF) is the largest subunit of nucleosome remodeling factor (NURF), a member of the ISWI chromatin

158 Chromatin remodeling factor metastatic tumor protein 1 (MTA1), one

159 distributed to radial actin stress fibres of remodelling focal AJs.

160 tentials in normal hearts and during cardiac remodeling following myocardial infarction (MI).

161 distinguish exercise-induced arrhythmogenic remodeling from ARVC and post-inflammatory cardiomyopath

162 increased expression of extracellular matrix remodeling genes, while single-cell RNA-seq analyses sho

163 g to full-length GP, bound a proteolytically remodeled GP with picomolar affinity, suggesting that en

164 P<0.0001), more concentric left ventricular remodeling, greater right ventricular dilatation (base,

165 Remodelling has been long identified in the lower airway

166 The concept of upper airway remodelling has only recently been introduced, and data

167 ocrine stress axis coordinates developmental remodelling, immune function and energy allocation in la

168 hy, was the commonest pattern of ventricular remodeling in ATTR.

169 e that participates in ATP-dependent protein remodeling in both eukaryotes and prokaryotes.

170 Zbtb7b impaired cold-induced transcriptional remodeling in brown fat, rendering mice sensitive to col

171 this study was: 1) to compare LA structural remodeling in experimental MI swine models recapitulatin

172 e conclude that the pathogenesis of vascular remodeling in hypoxic PH involves an early compartment-i

173 and time-lapse imaging to visualize cochlear remodeling in mouse.

174 nce of AF, partly related to electroanatomic remodeling in obese patients.

175 implicating changes in extracellular matrix remodeling in other, related optic nerve pathological st

176 nflammation by several mechanisms: chromatin remodeling in promoter regions of specific genes, blocka

177 lation has been linked to occlusive vascular remodeling in pulmonary arterial hypertension (PAH) that

178 lopment when the brain undergoes substantial remodeling in response to the environment.

179 it is a strong predictor of left ventricular remodeling in ST-segment-elevation myocardial infarction

180 Exercise promotes metabolic remodeling in the heart, which is associated with physio

181 pecific actions of Smad3 regulate repair and remodeling in the infarcted myocardium.

182 itro Mechanistically, TRPV4 modulated matrix remodeling in the lung via 2 distinct but dependent path

183 nchial fibroblasts play a key role in airway remodelling in asthma.

184 nockout mice attenuated airway smooth muscle remodelling in mouse asthma models.

185 of ASMCs and attenuated airway smooth muscle remodelling in mouse asthma models.

186 ngs reveal essential functions for chromatin-remodelling in the activation of EPDCs during cardiovasc

187 on of the treatment and did not induce glial remodelling in the brain.

188 strate that NO plays a key role in cell wall remodelling in trichoblasts and suggest that it also par

189 Our findings have identified matrix remodelling, in the absence of cytoskeletal tension gene

190 RV end-systolic remodeling index (RVESRI) was defined by lateral length

191 omoting chronic lung inflammation and tissue remodeling induced by cigarette smoke and highlight anot

192 activation, we demonstrate that cytoskeleton remodeling, induced by okadaic acid, restores lymphocyte

193 l infarction (LAI); and 2) to analyze how LA remodeling influences ischemic MR development.

194 In this study, we show that K6a network remodeling is a host defense response that directly up-r

195 Post-MI cardiac remodeling is a multifaceted process that includes activ

196 lowing transplantation, appropriate vascular remodeling is crucial to ensure the survival and functio

197 This vascular remodeling is reversible, and hydrogen sulfide donors ar

198 Localized extracellular matrix (ECM) remodeling is thought to stabilize the cleavage furrow a

199 meric ATP-dependent molecular chaperone that remodels its substrate 'client' proteins, facilitating t

200 Perturbation of CL remodeling leads to the rare X-linked genetic disorder B

201 HCN remodeling likely occurs in human athletes, as well as i

202 idase-7, -9, and -12, diverged from anabolic remodeling linked to maximal thrombospondin and platelet

203 AAA+ proteases and remodeling machines couple hydrolysis of ATP to mechanic

204 ponent of the BM-was capable of inducing BTB remodeling, making the BTB leaky in studies in vivo Furt

205 While chromatin remodeling mediated by post-translational modification o

206 tiated cells utilize conserved strategies to remodel microtubules, there is considerable diversity in

207 SCs retain their plasticity to myelinate and remodel myelin via mTORC1 throughout life.

208 Activity-dependent synaptic remodeling occurs during early-use critical periods, whe

209 Here we show that large-scale chromatin remodelling occurs during Drosophila neural development.

210 chloride dysregulation is important for the remodeling of aberrant glutamatergic neuronal circuits.

211 ermore, we found that tafazzin catalyzes the remodeling of cardiolipin by combinations of forward and

212 are mechano-chemical GTPases involved in the remodeling of cellular membranes.

213 tions and demonstrate that global structural remodeling of chromatin underpins heart failure.

214 The E6AP-dependent remodeling of dendritic arborization results from retrac

215 tatus could uniquely regulate the continuous remodeling of ECM in the normal TM.

216 ., GnTI, GnTII, and GnTIV) involved in early remodeling of glycans in the mammalian glycosylation pat

217 irus replication is known to cause extensive remodeling of Golgi and endoplasmic reticulum membranes,

218 otogenic drug challenge, in conjunction with remodeling of local connectivity.

219 ther interdisciplinary impacts for catalytic remodeling of natural products, including contributions

220 epressant properties of ketamine, structural remodeling of prefrontal and hippocampal neurons has bee

221 ith LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by modulating Fe homeost

222 to self-associate and initiate Rac-mediated remodeling of the actin cytoskeleton.

223 been shown to induce structural and electric remodeling of the atria.

224 rophages was associated with almost complete remodeling of the chromatin landscape, as well as altera

225 Our studies provide evidence that remodeling of the fibronectin matrix in injured or disea

226 contribute to such long-lived changes is the remodeling of the ionotropic AMPA-type glutamate recepto

227 Remodeling of the left ventricle (LV) in response to pre

228 a signaling cascade that provokes structural remodeling of the RMS through recruitment of MMP-2 by a

229 IUGR is associated with vascular remodeling of the stem villus arteries.

230 The remodeling of the stromal extracellular matrix (ECM) has

231 d that AML progression leads to differential remodeling of vasculature in central and endosteal bone

232 solution by increasing inflammatory vascular remodeling of venous thrombi in vivo, and the potential

233 Remodelling of electrostatic interactions near the Cbeta

234 However, little is known about remodelling of intracellular Ca(2+) homeostasis in the h

235 cs between epithelial cells and sustains the remodelling of the adherens junction in response to mech

236 Catabolic remodelling of the cell surface trehalose mycolates of M

237 esulted in increased tumour growth, aberrant remodelling of the extracellular matrix (ECM) and increa

238 n both Abeta(1-40) oligomers and EGCG during remodeling offer a foundation for understanding the mole

239 superior to MCT in changing left ventricular remodeling or aerobic capacity, and its feasibility rema

240 Arterial remodeling participates pivotally in many diseases inclu

241 and MLT families, which resemble mobile gene-remodeling platforms that supply promoters and first exo

242 derail the experience-driven neural circuit remodeling process important for executive control of re

243 Pathological cardiac hypertrophy, a dynamic remodeling process, is a major risk factor for heart fai

244 glycosyltransferase, able to exert a "glycan remodelling" process, even at distal compartments.

245 ABSTARCT: Electrical and structural remodeling processes are contributors to the self-perpet

246 To study this process, we simulated membrane remodeling processes in the presence and absence of memb

247 In summary, these remodeling processes tuned photosynthesis according to t

248 CLEAN will further enlighten the ECC-couplon-remodelling processes that underlie cardiac diseases.

249 This remodeling produces a distinct gene signature and new vu

250 roader role in biology, including organellar remodeling, protein and organelle quality control, preve

251 n in vivo function of CHD Type III chromatin remodeling proteins in this process, and reveal the deta

252 ogel systems, permitting NPC-mediated matrix remodelling proved to be a generalizable strategy for st

253 d a strong positive correlation between bone remodeling rates, mitotic activity, and osteotomy site h

254 riments show that poly(dA:dT) tracts perturb remodeling reactions if within one and a half helical tu

255 ined fibroblast proliferation, impaired scar remodeling, reduced fibroblast-derived collagen synthesi

256 budding yeast Saccharomyces cerevisiae, ECM remodeling refers to sequential formations of the primar

257 ting preterm birth (PTB)-associated cervical remodeling remain unclear.

258 n myocardial infarction (MI)-induced cardiac remodeling remains unclear.

259 the role of calpain in airway smooth muscle remodelling remains unknown.

260 rdiac ischemic injury induces a pathological remodeling response, which can ultimately lead to heart

261 Pulmonary vascular remodeling severity was associated with reductions in th

262 We find that acute and pathological tubular remodeling significantly affect TATS electrical conducti

263 Hypertension induces considerable cardiac remodelling, such as hypertrophy, interstitial fibrosis,

264 on and allowing natural uninterrupted tissue remodeling suggests new therapeutic opportunities in the

265 The multi-subunit chromatin-remodeling SWI/SNF complex determines gene expression pr

266 terplay of p300-HDAC2-Sin3A in the chromatin remodeling system is involved in HIF-1alpha degradation

267 xtensive data suggest that TRF2 in shelterin remodels telomeres into the t-loop structure, thereby hi

268 Patients with NFLG had less severe AS and LV remodeling than patients with normal-flow high-gradient.

269 he different steps of CSB-mediated chromatin remodeling that can be regulated by NAP1L1.

270 asticity in VTA GABA cells, and the synaptic remodeling that can occur after Delta(9)-tetrahydrocanna

271 ta argue that TBI elicits pathological spine remodeling that contributes to behavioral deficits by al

272 GF) is implicated in the peritoneal membrane remodeling that limits ultrafiltration in patients on pe

273 this analysis to predict that magnesium ions remodel the landscape, shifting the equilibrium away fro

274 ms of the HCN4 isoform, reflecting how S672R remodels the free energy landscape for the modulation of

275 ways have been implicated in stretch-induced remodeling, the control structures by which signals from

276 ges responsible for adverse left ventricular remodeling, the relationship between inflammation and pr

277 Gram-negative bacteria remodel their surfaces to interact with the environment,

278 to counteract the effects of adverse cardiac remodeling, thereby improving survival and quality of li

279 ical regulator of extracellular matrix (ECM) remodeling through its availability and stepwise polymer

280 d C. elegans embryos to demonstrate that BBs remodel to support ciliogenesis in a subset of sensory n

281 ted mode in which the Ras effector domain is remodeled to expose an extended pocket that connects two

282 imals, heterochromatin undergoes large-scale remodeling to create a compartment with low chromatin de

283 eft ventricular assist device (LVAD)-induced remodeling to identify mechanisms impeding recovery.

284 expenditure, and fat depot-specific cellular remodeling toward lowered energy storage capacity and br

285 NA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis.

286 But how local remodeling tunes stress production and dissipation, and

287 Pase motor, which selectively activates ALC1 remodeling upon recruitment to sites of DNA damage.

288 d purification scheme followed by structural remodeling using commercially available and recombinantl

289 f2) in regulating myocardial necroptosis and remodeling using genetic mouse models.

290 ventricular dysfunction, pulmonary vascular remodeling was not more severe.

291 This remodelling was prevented in AC3I mice, with cardiac-tar

292 nflammation, hyperresponsiveness, and airway remodeling were analyzed in allergen-sensitized and airw

293 e gene program linked to CREM-induced atrial remodeling were identified in the expression of genes re

294 ulmonary hypertension and pulmonary vascular remodeling were not or only slightly affected by Cox4i2

295 antitative analysis of sacculus architecture remodeling), which measures subcellular peptidoglycan dy

296 emergence are both accompanied by cell-wall remodeling, which involves the INFLORESCENCE DEFICIENT I

297 namic consequences and extent of ventricular remodeling, which is an important predictor of future ou

298 es matrix-based therapies that may attenuate remodeling while promoting repair and regeneration.

299 Mucosal immunity remodeled with increased in anti-inflammatory cytokines

300 directed response strategies, linking neural remodeling with outcome-based decision making.