ライフサイエンスコーパス: remodelling

1 ng Se transference during metamorphic tissue remodelling.

2 how endothelial activation-mediated vascular remodelling.

3 ype and intensity of airway inflammation and remodelling.

4 ting, and mechano-sensitive dynamic vascular remodelling.

5 ced maximal force development due to disease remodelling.

6 sed immune response and extracellular matrix remodelling.

7 atch may be generally required for chromatin remodelling.

8 Asthmatic airways are inflamed and undergo remodelling.

9 assembly and fibrillogenesis during vascular remodelling.

10 ial-venous differentiation, angiogenesis and remodelling.

11 idases, which plays an important role in ECM remodelling.

12 ate cell activation and extracellular matrix remodelling.

13 gy and the effects of progressive AF-induced remodelling.

14 in part at least through promotion of tissue remodelling.

15 getic adaptation during cardiac pathological remodelling.

16 kely through a mechanism involving chromatin remodelling.

17 ing airway hyperreactivity, inflammation and remodelling.

18 ostasis, glycogen biosynthesis and chromatin remodelling.

19 es and chemokines leads to tissue damage and remodelling.

20 development and progression of pathological remodelling.

21 geneity and APD reduction due to progressive remodelling.

22 d to processes relevant to cancer and tissue remodelling.

23 erreactivity, airway inflammation and airway remodelling.

24 ressive inflammation and pathological tissue remodelling.

25 ate cell activation and extracellular matrix remodelling.

26 ndent tissue that undergoes dynamic cyclical remodelling.

27 ast prevents COPD-like lung inflammation and remodelling.

28 potential source of macrophages in vascular remodelling.

29 endothelial cell (EC) polarity and vascular remodelling.

30 ls with key roles in host defense and tissue remodelling.

31 iation, nascent transcription, and chromatin remodelling.

32 ates, supporting involvement of cytoskeletal remodelling.

33 ieu linking the metabolic state to chromatin remodelling.

34 phosphodiesterase 3 (SMPD3) and cytoskeletal remodelling.

35 ulator of hypoxia-induced pulmonary vascular remodelling.

36 ommonly associated with extracellular matrix remodelling.

37 imicrobial peptides to facilitate microbiota remodelling.

38 is characterized by inflammation and airway remodelling.

39 lates FN assembly and flow-mediated vascular remodelling.

40 onal programs with adhesive and cytoskeletal remodelling.

41 pines by triggering MMP-9 activation and ECM remodelling.

42 ally reverse peripheral airway smooth muscle remodelling.

43 ions of the heart lead to cardiac structural remodelling.

44 regulates mitotic progression and chromatin remodelling.

45 tone deacetylase and ATP-dependent chromatin remodelling activities.

46 Critically, remodelling activity can be regulated by modifications n

47 fferentially modified nucleosomes, directing remodelling activity towards specific nucleosome substra

48 e commitment through the regulation of SRCAP remodelling activity.

49 py decreased peripheral airway smooth muscle remodelling after 12 weeks (p = 0.007 and p = 0.02, resp

50 one/salmeterol reversed extracellular matrix remodelling after 12 weeks, both within the lamina propr

51 egarding the fate of MSCs in arterial repair/remodelling after injury.

52 ed heart function and decreased pathological remodelling after myocardial infarction, suggesting that

53 but the extent to which this form of axonal remodelling alters brain functional structure remains un

54 r p38 inhibition, prevents atrial structural remodelling and AF vulnerability in response to exercise

55 PLG and P4HA2 are involved in vascular remodelling and angiogenesis, suggesting a high relevanc

56 e phosphatase known to regulate blood vessel remodelling and angiogenesis.

57 atin (CalpTG) are protected against vascular remodelling and angiotensin II-dependent inflammation.

58 e in Ca(2+) /cation signalling, cytoskeletal remodelling and barrier function in retinal microvascula

59 hypertrophy, diastolic dysfunction, cellular remodelling and compromised calcium dynamics.

60 the fission/fusion balance, promotes network remodelling and content mixing, and thus may serve as an

61 nt for actin cytoskeleton and focal adhesion remodelling and contraction.

62 optosis as genetic interference with cristae remodelling and cytochrome c release.

63 and aLac on IAPP amyloid aggregation, fibril remodelling and cytotoxicity, pointing to the role of pr

64 in physically associates with the Nucleosome Remodelling and Deacetylase (NuRD) complex, Sall4 neithe

65 by transmission electron microscopy revealed remodelling and degradation of core extracellular matrix

66 , metabolic remodelling, and beta-adrenergic remodelling and discusses promising new technologies for

67 roteinases and TIMPs regulate adipose tissue remodelling and distribution.

68 DSB-induced histone modification, chromatin remodelling and DSB-repair via HRR; effectively phenocop

69 Progressive airway wall remodelling and emphysema in pIgR(-/-) mice are associat

70 microbiota, driving progressive small airway remodelling and emphysema.

71 lar disease but its contribution to vascular remodelling and even its existence have recently been qu

72 surfaces that would be optimal for both bone remodelling and for reducing risk of bacterial infection

73 ts, which can lead to scarring, pathological remodelling and functional deficit, but can also promote

74 cRNA required for tissues-specific chromatin remodelling and gene expression.

75 PDAC invasion through regulation of stromal remodelling and highlights the SerpinB2/uPA axis for fur

76 ion of the 17q21 gene ORMDL3 leads to airway remodelling and hyperresponsiveness.

77 se exacerbations, but their effect on airway remodelling and inflammation remains ill-defined.

78 ne or combined, to the reversal of bronchial remodelling and inflammation.

79 6583 or Cicaprost induced rapid cytoskeleton remodelling and inhibited proliferation and migration in

80 e had preserved kidney tissue, less vascular remodelling and less markers of senescence than wild-typ

81 R-beta/MLC-2 pathway in peritumoural stromal remodelling and mechanosensory-driven activation of PSCs

82 al analysis of AVNFH bone revealed increased remodelling and reduced bone mineral density portrayed b

83 lity and micro-architecture, normalised bone remodelling and reduced TNFalpha and TGFbeta sigalling.

84 ging photoreceptor activation with chromatin remodelling and regulation of gene expression have been

85 nd effects as it may lead to cerebrovascular remodelling and result in memory reduction.

86 molecular pathways associated with chromatin remodelling and RNA transcription, indicative of an epig

87 neutral lipids, as well as serving in lipid remodelling and signalling.

88 nzyme involved in extracellular matrix (ECM) remodelling and synaptic plasticity.

89 tension alone, or in combination with matrix remodelling and synthesis agents, leads to neocartilage

90 pic modulation may not occur during vascular remodelling and that plaque macrophages may not be of ha

91 s is required for stress to induce lymphatic remodelling and that this depends on COX2 inflammatory s

92 K, which are genes involved in cytoskeleton remodelling and transcription factor NFkappaB signaling,

93 tion of genes that are involved in chromatin remodelling and translation.

94 Defects in remodelling and trophoblast differentiation are associat

95 By orchestrating the remodelling and turnover of K16, and uncoupling it from

96 Migration into these vessels promotes remodelling and, as a consequence, adaption of blood flo

97 a beta-oligomer population that, via further remodelling and/or elongation steps, ultimately generate

98 for osteoporosis, which act by reducing bone remodelling, and are thought to prevent perforations and

99 of electrophysiology remodelling, metabolic remodelling, and beta-adrenergic remodelling and discuss

100 Lung function, central and peripheral airway remodelling, and bronchoalveolar inflammation were asses

101 perfibrinogenaemia (HFg) results in vascular remodelling, and fibrinogen (Fg) and amyloid beta (Abeta

102 iciency results in electrical and structural remodelling, and impaired repair of the heart in murine

103 ing in hydrogel matrices, and allows growth, remodelling, and proliferation of cells.

104 f a multigene family involved in erythrocyte remodelling, and show that a short region on chromosome

105 Therefore, lipid remodelling appears limited at the highest temperatures

106 Progressive remodelling appears to be gradual, but not universal, an

107 nate immunity as macrophages (MACs) and bone remodelling as osteoclasts (OCs).

108 gate the role of calpain in asthmatic airway remodelling as well as the underlying mechanism.

109 a response circuit that mediates epithelial remodelling associated with type 2 immunity in the small

110 y assess the functional impact of structural remodelling at the cellular scale.

111 matics' fibroblasts can contribute to airway remodelling, at least in part, by modulating epithelial

112 elicase, suggesting a plausible mechanism of remodelling before exon ligation.

113 nd disease-specific pathogenic mechanisms of remodelling between the sinonasal system and the lung ma

114 iae spliceosome stalled after Prp16-mediated remodelling but before exon ligation.

115 al in chondrocytes promotes TMJ degenerative remodelling by chondrocyte-mediated pro-catabolic activi

116 ased expression of genes that drive synaptic remodelling by microglia via complement.

117 n the mesentery during induction of vascular remodelling by over-expression of endothelial nitric oxi

118 The suppression of cardiac remodelling by SIKE is further validated in rats and mon

119 thma, lung function abnormalities and airway remodelling can already be seen early in life and can in

120 Whilst remodelling changes in AR are limited, CRS phenotypes de

121 nifesting their critical roles in structural remodelling checkpoints and nuclear export.

122 tions targeting a neuron-specific nucleosome remodelling complex subunit, BAF53b.

123 pathway interacts with the SWI/SNF chromatin-remodelling complex, an interaction that we show is cons

124 l components of the BAF (mSWI/SNF) chromatin remodelling complex, are critical in chromatin structure

125 tial ATPase subunit of the SWI/SNF chromatin-remodelling complex, is required for expression of Wilms

126 encoding subunits of SWI/SNF (BAF) chromatin remodelling complexes are collectively altered in over 2

127 iptional machinery is dependent on chromatin remodelling complexes such as the SWI\SNF (BAF) complex.

128 ulated by pluripotency factor and nucleosome remodelling deacetylase (NuRD), we illustrate how the de

129 of cardiac arrhythmias, adverse ventricular remodelling, decline of cardiac performance and prematur

130 es involved in four main pathways: chromatin remodelling, DNA damage repair, activation of mTOR signa

131 ti-layered cell wall that requires extensive remodelling during cell division.

132 rganelles that exchange contents and undergo remodelling during cyclic fusion and fission.

133 tic cells and has beneficial roles in tissue remodelling during embryogenesis and wound healing.

134 biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA).

135 g-range resection, indicating that chromatin remodelling during resection is underlying DSB repair pa

136 nuation of IRE1 activity is important for ER remodelling dynamics and cell survival in the face of re

137 However, the atypical remodelling elicited by exercise in the autophagy defici

138 ylmuramyl-L-alanine amidase, a peptidoglycan remodelling enzyme implicated in cell division.

139 , together with greater loading of chromatin remodelling enzymes and lower nucleosome occupancy.

140 This indicates that the chromatin remodelling enzymes responsible for spacing nucleosomes

141 in a position predicted to exclude chromatin remodelling enzymes.

142 ssential mechanistic details for three major remodelling events before nuclear export: rotation of th

143 ata, ER-PM contact sites undergo substantial remodelling events during cell differentiation.

144 rotein (r-protein) binding and ribosomal RNA remodelling events in the nucleolus, nucleoplasm and cyt

145 lational feedback loops as well as chromatin remodelling events.

146 contrast, concomitant loss of the chromatin remodelling factor PBRM1 (mutated in 40% of ccRCC) rescu

147 ssion, and our study demonstrates how airway remodelling/fibrosis is associated with a defective muco

148 distributed to radial actin stress fibres of remodelling focal AJs.

149 dly reduces neointima formation and vascular remodelling following carotid artery ligation.

150 ation-related cytokine, chemokine and tissue-remodelling genes that are activated via NF-kappaB signa

151 Importantly, ES-62 can act even after airway remodelling has been established, arresting pathogenesis

152 Remodelling has been long identified in the lower airway

153 The concept of upper airway remodelling has only recently been introduced, and data

154 hmogenicity that stems primarily from tissue remodelling (hypertrophy, fibrosis) rather than cellular

155 ocrine stress axis coordinates developmental remodelling, immune function and energy allocation in la

156 g and capturing dColl, understanding how ECM remodelling impacts disease progression, and development

157 r learning task induced substantial synaptic remodelling in a small subset of neurons.

158 nchial fibroblasts play a key role in airway remodelling in asthma.

159 way, thereby regulating airway smooth muscle remodelling in asthma.

160 n the mature system, and during pathological remodelling in cardiovascular disease.

161 l combination decreases extracellular matrix remodelling in central airways and intraluminal neutroph

162 , BORT and AAL(S) +BORT also reduced airway remodelling in chronic AAD.

163 ffer a practical method for investigation of remodelling in disease, and thus, virtual pathology and

164 well as apoptosis, cell clearance and tissue remodelling in diverse organs and species.

165 (HMGB1) which triggered airway smooth muscle remodelling in early-life.

166 ollowing embryo injection were distinct from remodelling in fertilization and the resulting 2-cell em

167 gh muscle, undergoes extensive neuromuscular remodelling in healthy ageing, as characterized by a los

168 nockout mice attenuated airway smooth muscle remodelling in mouse asthma models.

169 of ASMCs and attenuated airway smooth muscle remodelling in mouse asthma models.

170 cate a novel role of BAF-dependent chromatin remodelling in mouse development via regulation of linea

171 generation and longevity and promote airway remodelling in mouse models of asthma, but the mechanism

172 tify SIKE as a negative regulator of cardiac remodelling in multiple animal species due to its inhibi

173 ing important roles for this circuit in bone remodelling in normal and disease contexts.

174 force development through secondary disease remodelling in patients suffering from dilated cardiomyo

175 pendent predictors of diastolic function and remodelling in patients with type 2 diabetes.

176 gs also reveal that GOS induces cytoskeleton remodelling in RAW264.7 cells and promotes macrophage pr

177 let tethering from adverse right ventricular remodelling in response to any of several disease proces

178 stem progenitor cell (HSPC) activity and LV remodelling in response to myocardial ischaemia in vivo.

179 thods may be used to characterise structural remodelling in soft (non-calcified) tissues and to condu

180 ngs reveal essential functions for chromatin-remodelling in the activation of EPDCs during cardiovasc

181 on of the treatment and did not induce glial remodelling in the brain.

182 pha2A-adrenoreceptor attenuated degenerative remodelling in the condylar cartilage and subchondral bo

183 for miR-93 in high glucose-induced chromatin remodelling in the kidney, and provide evidence for a pr

184 us condition, characterized by abnormal bone remodelling in the otic capsule leading to fixation of t

185 matory and immune responses and cytoskeleton remodelling in the suboptimal Se status group.

186 proliferation and extracellular matrix (ECM) remodelling in the underlying dermis.

187 l protein vimentin, implicating hypothalamic remodelling in this response.

188 strate that NO plays a key role in cell wall remodelling in trichoblasts and suggest that it also par

189 equired by stromal cells for normal collagen remodelling in vitro, regulating fibroblast interaction

190 ks the effect of chronic stress on lymphatic remodelling in vivo and reduces lymphatic metastasis in

191 r one major epigenetic mechanism, nucleosome remodelling, in drug-associated memories remains largely

192 Our findings have identified matrix remodelling, in the absence of cytoskeletal tension gene

193 2 expression occurs in physiological cardiac remodelling induced by endurance training in mice.

194 ata argue that DNA methylation and chromatin remodelling induced by HR may be a source of permanent v

195 Bone remodelling is a constant process requiring specific cue

196 bly supporting the notion that mitochondrial remodelling is a core feature of acclimatisation to extr

197 It has been suggested that this remodelling is associated with impairment of neuromuscul

198 Airway remodelling is the term used to describe tissue structur

199 ro-tumor stroma, characterized by angiogenic remodelling, is associated with an accelerated transitio

200 RNA helicase DHX34 was found to promote mRNP remodelling, leading to activation of NMD.

201 he cellular level cardiac hypertrophy causes remodelling, leading to changes in ionic channel, pump a

202 fatal disease characterized by interstitial remodelling, leading to compromised lung function.

203 Remarkably, VEGF caused extensive NSC remodelling manifested in transition of the enigmatic NS

204 designed to improve cardiovascular and bone remodelling markers in post-menopausal women.

205 th FR and EX normalized extracellular matrix remodelling markers to levels similar to L-WD (P > 0.05)

206 vidence for nasal priming and whether or not remodelling may be a feature of allergic rhinitis will b

207 and the positive or negative impact of each remodelling mechanism are not fully understood.

208 Remodelling membrane lipids, via homeoviscous adaptation

209 human HF investigations of electrophysiology remodelling, metabolic remodelling, and beta-adrenergic

210 vessel sprouting by regulating cytoskeleton remodelling, migration and tip cell competitiveness.

211 chromatin state in the Arabidopsis chromatin remodelling mutant ddm1, unique lincRNAs including TE-li

212 gulation by recruiting activating factors or remodelling nucleosomes.

213 over a range of transmural pressures, inward remodelling occurred after T3-SCI with a 40% reduction i

214 Here we show that large-scale chromatin remodelling occurs during Drosophila neural development.

215 response is excessive, pathological cardiac remodelling occurs, which can progress to heart failure,

216 in, downregulated expression of occludin and remodelling of adherens contacts consisting of vascular

217 During epithelial cytokinesis, the remodelling of adhesive cell-cell contacts between the d

218 A similarly radical remodelling of central metabolism could greatly accelera

219 e alteration of afferent neural signals, and remodelling of convergent neurons, represents a 'neural

220 Remodelling of electrostatic interactions near the Cbeta

221 lular fragment of ODZ1 promotes cytoskeletal remodelling of GBM cells and invasion of the surrounding

222 Remodelling of histones and genomic 5'-methylcytosine an

223 However, little is known about remodelling of intracellular Ca(2+) homeostasis in the h

224 Here we report the assembly, arrangement and remodelling of liposomes with designer geometry: all of

225 stem cells (MSCs) participate in the repair/remodelling of many tissues, where MSCs commit to differ

226 ural challenge that requires the substantial remodelling of membrane morphology.

227 mprovements in autonomic balance, functional remodelling of post-ganglionic neurons and reduced infla

228 h is Ca(2+)-dependent and accompanied by the remodelling of postsynaptic gephyrin scaffolds.

229 rs in chondrocytes has roles in degenerative remodelling of temporomandibular joint (TMJ) and to dete

230 cs between epithelial cells and sustains the remodelling of the adherens junction in response to mech

231 h persistent lung inflammation and long-term remodelling of the airways that have proved refractory t

232 Catabolic remodelling of the cell surface trehalose mycolates of M

233 tial and temporal heterogeneity, with marked remodelling of the clonal landscape in response to NAI.

234 ted disease burden leads to rapid, selective remodelling of the endosteal space, resulting in a compl

235 esulted in increased tumour growth, aberrant remodelling of the extracellular matrix (ECM) and increa

236 Dynamic remodelling of the extracellular matrix (ECM) is a key f

237 ve that observed on Earth, which may explain remodelling of the eye in astronauts.

238 Y1 inhibits Smad3/4 binding to and chromatin remodelling of the Foxp3 locus.

239 the native fold by kinetic and thermodynamic remodelling of the gating energetics towards that of wil

240 Our data show that NLRP3(R258W)-induced remodelling of the gut microbiota, induces local Tregs t

241 rticipates in physiological and pathological remodelling of the heart.

242 re to characterize structural and functional remodelling of the ICNS post-MI in a porcine model (cont

243 e need for tuft cells in the epithelial cell remodelling of the intestine.

244 At the cellular scale this remodelling of the ionic channels, pumps and exchangers

245 Intricate remodelling of the outer membrane proteome is critical f

246 n disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known coll

247 ls secrete exosomes that are involved in the remodelling of the tumour-stromal environment and promot

248 ity are inherently linked to the slow-active remodelling of the underlying cortical actin network.

249 R vs. OZR, although there was no evidence of remodelling of the venular wall.

250 ct rapidly with oocysts and engulfed them by remodelling of their actin cytoskeleton.

251 for the execution of pluripotency, entailing remodelling of transcriptional, epigenetic, signalling a

252 ling or IFNgamma-mediated, pregnancy-induced remodelling of uterine arteries.

253 ted the effects of cAMP-induced cytoskeletal remodelling on the serum response factor (SRF) co-factor

254 e atria, can arise as a result of electrical remodelling or alterations in Ca(2+) homeostasis.

255 During bone remodelling, osteoclasts induce chemotaxis of osteoblast

256 regulating inner membrane dynamics, cristae remodelling, oxidative phosphorylation, was post-transla

257 -diastolic volume ratio, a marker of cardiac remodelling (P < 0.050 for all linear models).

258 Therapeutic vascular remodelling paradigms may therefore require treatments t

259 glycosyltransferase, able to exert a "glycan remodelling" process, even at distal compartments.

260 rrent rather limited understanding of airway remodelling processes in AR, CRS and asthma and presents

261 CLEAN will further enlighten the ECC-couplon-remodelling processes that underlie cardiac diseases.

262 enues for a deeper understanding of vascular remodelling processes.

263 , where ATP is rapidly consumed during actin remodelling processes.

264 g the interaction between Rac1 and the actin-remodelling protein flightless-1 homologue, to modulate

265 High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cel

266 Many chromatin remodelling proteins possess conserved protein domains t

267 ogel systems, permitting NPC-mediated matrix remodelling proved to be a generalizable strategy for st

268 is finally applied to the study of arterial remodelling, proving its potential for the non-destructi

269 R programming in baboons produces myocardial remodelling, reduces systolic and diastolic function, an

270 Extracellular matrix remodelling regulated by matrix-metalloproteinase (MMP)

271 and molecular mechanisms involved in airway remodelling remain incompletely defined.

272 the role of calpain in airway smooth muscle remodelling remains unknown.

273 eparations, it is hypothesised that synaptic remodelling required for threat learning involves the ex

274 ltative pathogens, such as the physiological remodelling required to colonize hosts from environmenta

275 In both vertebrates and invertebrates, this remodelling requires the activity of non-muscle myosin I

276 However, bisphosphonates may oversuppress remodelling resulting in accumulation of microcracks.

277 These data reveal a novel tissue remodelling signature and identify endogenous alarmins a

278 Hypertension induces considerable cardiac remodelling, such as hypertrophy, interstitial fibrosis,

279 rve before cardiac structural and functional remodelling, suggesting that early intervention in the i

280 sive understanding of how actin cytoskeleton remodelling supports stable junctions remains to be esta

281 ntestinal Bap180 (a subunit of the chromatin-remodelling switch/sucrose non-fermentable (SWI/SNF) com

282 Components of the chromatin remodelling switch/sucrose nonfermentable (SWI/SNF) comp

283 dergo continuous activity-dependent synaptic remodelling that persists into adulthood.

284 go differential morphological and phenotypic remodelling that reflects the site of myocardial infarct

285 ation of a ROCK-dependent regulator of actin remodelling, the formin FHOD1, largely rescued morpholog

286 play important roles in extracellular matrix remodelling; they are usually found to significantly inc

287 maged Drosophila epithelia allows epithelial remodelling, thus facilitating wound repair.

288 c process, mobilizing diverse cell types and remodelling tissues over long time periods.

289 onally, this results in extracellular matrix remodelling to create a permissive environment for tumou

290 adhesive ligands, instead relying on matrix remodelling to facilitate cadherin-mediated cell-cell co

291 oautophagy requires membrane trafficking and remodelling to form the autophagosome and deliver its co

292 e on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceosome's catalytic centre.

293 ppresses force-mediated extracellular matrix remodelling to inhibit local cancer cell invasion in 3D

294 NA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis.

295 ion, the left ventricle undergoes structural remodelling under the influence of changing haemodynamic

296 This remodelling was prevented in AC3I mice, with cardiac-tar

297 Here we reveal a new form of structural remodelling where mature spines of adult-born but not ea

298 ological thermogenic activation enhances HDL remodelling, which is associated with specific lipidomic

299 Airway remodelling with excessive deposition of extracellular m

300 nstrates profibrosis and hypertrophic inward remodelling within the largest cerebral artery after hig