ライフサイエンスコーパス: renal clearance

1 ropriate prescribing, in view of compromised renal clearance.

2 by its short biological half-life and rapid renal clearance.

3 onsidered when measuring Hcy plasma flux and renal clearance.

4 es (carboxylates) on the chelator, promoting renal clearance.

5 dney and liver uptake with equal biliary and renal clearance.

6 atively high kidney uptake and predominantly renal clearance.

7 (PF-4) and a lysine-rich sequence for rapid renal clearance.

8 axel using a dose formula based on projected renal clearance.

9 esult from increased formation and decreased renal clearance.

10 n protects against enzymatic degradation and renal clearance.

11 tion by dipeptidyl peptidase-IV (DPP-IV) and renal clearance.

12 tion by dipeptidyl peptidase-IV (DPP-IV) and renal clearance.

13 al accumulation in normal tissues, and rapid renal clearance.

14 ave low kidney retention and relatively fast renal clearance.

15 ed the highest tumor accumulation and little renal clearance.

16 all tracers, and they all showed predominant renal clearance.

17 y dipeptidyl peptidase-4 (DPP-4) and through renal clearance.

18 l imaging may increase the size too much for renal clearance.

19 ted fast in vivo pharmacokinetics with major renal clearance.

20 albumin-binding peptide to prevent its rapid renal clearance.

21 s a dangling carboxylate to facilitate rapid renal clearance.

22 er limit of 5-10 ligands per quantum dot for renal clearance.

23 escriptors show a positive relationship with renal clearance.

24 nd to be the physicochemical determinants of renal clearance.

25 nother serum protein that protects RBP4 from renal clearance.

26 rse cholesterol transport or, alternatively, renal clearance.

27 a-BBN(7-14) exhibited both hepatobiliary and renal clearance.

28 le gastrointestinal absorption and nonlinear renal clearance act additively to produce the ceiling ef

29 Rosuvastatin renal clearance, although still minor, was increased app

30 can be valuable in early prediction of human renal clearance and can aid the chemist in structural mo

31 Renal clearance and enzymatic inactivation control the e

32 predicts that a GCSF analog that eliminates renal clearance and has reduced endosomal binding affini

33 The efficient renal clearance and high compatibility can be translated

34 labeled C2Am derivative showed predominantly renal clearance and high specificity and sensitivity for

35 biodistribution profiles, with predominantly renal clearance and low nonspecific retention in the liv

36 n mouse blood for 5 h and demonstrated rapid renal clearance and lower blood levels in vivo compared

37 However, slow renal clearance and persistent activity predominately in

38 Renal clearance and recollection micro-puncture experime

39 d antibody recycling, thereby evading ligand renal clearance and requiring increasingly high antibody

40 With renal clearance and tubule perfusion techniques, we show

41 rating near infrared emission with efficient renal clearance and ultralow background interference, th

42 Evaluation in vivo demonstrated primarily renal clearance and uptake of approximately 8 percentage

43 Measured renal clearance and whole body total clearance data for

44 s reduction may be attributable to defective renal clearance and/or extrarenal clearance and metaboli

45 antly decreased urinary carnitine excretion, renal clearance, and fractional clearance of NEC.

46 CKD and determined by intestinal uptake and renal clearance, and it is not fully accounted for by di

47 Renal clearance appeared to be the major route of elimin

48 Augmented renal clearance appears to be a common finding in this p

49 (IRDye 800CW) in physiological stability and renal clearance but exhibit a much longer tumor retentio

50 le fluorescence in xenograft MCF7 tumors and renal clearance by MR imaging.

51 showed 64Cu-DOTA-knottin 2.5F to have a fast renal clearance combined with low nonspecific accumulati

52 ibutions were also assayed in the absence of renal clearance (e.g., in mice rendered surgically aneph

53 ze result in four- to ninefold reductions in renal clearance efficiency in the early elimination stag

54 y but different densities, we found that the renal-clearance efficiency exponentially increased in th

55 h solute/regimen combination, the equivalent renal clearance (EKR: ml/min) was calculated as a dimens

56 lysis and hemodialysis? (2) Are dialytic and renal clearances equivalent? and (3) Will survival impro

57 odified Brenner method, in which (99m)Tc-MDP renal clearance estimated from the whole-body counts was

58 First, renal clearance experiments were used to assess the impa

59 Unbound tracer underwent rapid renal clearance followed by high renal reabsorption.

60 ion, urinary fluoride excretion and fluoride renal clearance following no exercise and three exercise

61 of physicochemical properties and the human renal clearance for a data set of 391 drugs or compounds

62 c residues with smaller dimensions to ensure renal clearance for better biocompatibility of the funct

63 y large size, can be efficiently excreted by renal clearance from the host after systemic injection.

64 en the scFv were evaluated in the absence of renal clearance in anephric mice, indicating that the ra

65 y the deleterious systemic effects of absent renal clearance in ARF without the confounding effects t

66 clearance (29-min half-life) and predominant renal clearance in nonhuman primates.

67 redox properties, hypertensive response, and renal clearance in rats.

68 d pharmaceuticals in patients with augmented renal clearance, in addition to the potential impact on

69 y, increased blood circulation time, reduced renal clearance, increased tumor biodistribution, and gr

70 Renal clearance is a major pathway for regulating the le

71 ghtly longer than that of ShK, implying that renal clearance is the major determinant of its plasma l

72 Optimized for efficient renal clearance, it concurrently achieved specific tumor

73 ent was subtracted from the total (bone plus renal) clearance (K(total)) measured from the free (99m)

74 iopharmaceuticals; however, both agents have renal clearances less than that of (131)I-orthoiodohippu

75 all excellent renal imaging agents but have renal clearances lower than that of (131)I-orthoiodohipp

76 Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-base

77 Renal clearance measurements and histologic assessments

78 Renal clearance measurements showed that uroguanylin def

79 ands and small bowel, with hepatobiliary and renal clearance noted, whereas (68)Ga-RM2 had the highes

80 est physiologic uptake in the pancreas, with renal clearance noted.

81 Renal clearance of (11)C-metformin was approximately 3 t

82 metformin PET/CT in 6 anesthetized pigs, and renal clearance of (11)C-metformin was compared with ren

83 ation in the kidneys, indicating substantial renal clearance of (18)F-FCP.

84 11)C-metformin was approximately 3 times the renal clearance of (51)Cr-EDTA.

85 earance of (11)C-metformin was compared with renal clearance of (51)Cr-ethylenediaminetetraacetic aci

86 No appreciable renal clearance of (64)Cu-DOTA-VEGF(121) was observed, a

87 These methods were compared with renal clearance of 125I-iothalamate GFR (GFR1) in 193 hy

88 idneys and urinary bladder, indicating rapid renal clearance of 18F-annexin V metabolites.

89 Renal clearance of 4-pyridoxic acid was 232 +/- 94 mL/mi

90 Hepatobiliary and renal clearance of 99mTc-sestamibi are Pgp-mediated, and

91 modal imaging studies in mice to investigate renal clearance of a single-walled carbon nanotube (SWCN

92 Alterations in renal clearance of anticancer drugs can affect the occur

93 This analysis is based on the renal clearance of ascorbic acid, which rises sharply wi

94 her transplacental transfer efficiencies and renal clearance of branched PFOS and PFOA isomers, compa

95 The renal clearance of cobalt increased with the serum conce

96 Renal clearance of creatinine was found significantly be

97 Renal clearance of DMSO was 14.1 +/- 3.4 mL/min.

98 'bandpass' filter to significantly slow down renal clearance of few-atom gold nanoclusters (AuNCs) wi

99 he indocyanine-green or both, methods and by renal clearance of inulin and para-aminohippurate (PAH),

100 Reduced renal clearance of inulin, resulting from gentamicin or

101 e, were examined against GFR measured by the renal clearance of iothalamate in 1286 individuals with

102 on exchange (ionic etching), and facilitates renal clearance of metal ions released from the quantum

103 can be employed to evaluate the mechanism of renal clearance of organic anions, to assess potential d

104 Impaired renal clearance of parathyroid hormone may contribute to

105 We determined the single-pass renal clearance of parathyroid hormone, fibroblast growt

106 a surrogate of intestinal uptake as well as renal clearance of phenylacetylglutamine.

107 pport a role of the intestine in stimulating renal clearance of Pi.

108 Since lowering TTR levels increases renal clearance of RBP4, we determined whether decreasin

109 Dynamic gamma imaging demonstrated rapid renal clearance of RP748.

110 Because the rapid renal clearance of scFv may blunt the impact of improved

111 Baseline levels as well as renal clearance of the NNK metabolites correlated with n

112 in anephric mice, indicating that the rapid renal clearance of the scFv was not responsible for thes

113 take in the kidneys and bladder due to rapid renal clearance of the tracer.

114 r of QD-Cys ( approximately 6 nm) allows for renal clearance of these nanoparticles in rat models.

115 modifier to improve the water solubility and renal clearance of three hydrophilic analogues of 1.

116 In two patients, the renal clearance of thymidine was approximately 20% that

117 serve immune defenses and the breakdown and renal clearance of toxic substances.

118 ive, better tolerated agents to increase the renal clearance of uric acid and thereby control hyperur

119 The renal clearances of (99m)Tc(CO)(3)(rac-ASMA) and (131)I-

120 The renal clearances of inulin and para-aminohippurate were

121 Overall, 65.1% manifested augmented renal clearance on at least one occasion during the firs

122 xed-effects model, the presence of augmented renal clearance on study day 1 strongly predicted (p = 0

123 that predonation GFR as measured by isotopic renal clearance or any of the creatinine-based estimatio

124 ficantly to its enhanced tumor-targeting and renal clearance properties and makes DOTAReCCMSH an exce

125 The renal clearance property was assessed using the correspo

126 G6 dendrimers also showed decreased renal clearance rate, slightly increased liver and splee

127 Renal clearance represented only a small portion of tota

128 es demonstrated conjugate safety profile and renal clearance route of the selected PGA-doxy candidate

129 h a modification that effectively eliminates renal clearance should have a significantly longer half-

130 3-fold, tumor retention of CGT prolonged and renal clearance significantly reduced when compared with

131 Renal clearance studies were conducted in normal rats wi

132 A range of techniques were used including renal clearance studies, in situ microperfusion, RT-PCR

133 and 36(17) mug/h; and iii) rate of fluoride renal clearance was 26.5(9.0), 27.2(30.4), 13.1(20.4) an

134 Augmented renal clearance was defined by a creatinine clearance mo

135 safe systemic administration and systematic renal clearance was demonstrated in both tested species.

136 oxaban, an oral factor Xa inhibitor with 50% renal clearance, was noninferior to well-managed warfari

137 The physicochemical space and renal clearance were also statistically analyzed by ther

138 stance to degradation and presumably reduced renal clearance were obtained by introducing a 1,4-disub

139 egree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted

140 oncentration and decline in rate of fluoride renal clearance with increasing exercise intensity needs

141 t decline in urinary carnitine excretion and renal clearance with nonesterfied carnitine (NEC) declin

142 a blood half-life of 25.8 +/- 4.6 min, rapid renal clearance with only 26.2 +/- 6.1 percentage inject

143 bited high kidney-to-blood contrast and slow renal clearance, with an SUV of 14.1 +/- 6.2.

144 The tracer exhibited predominantly renal clearance, with some activity in the liver and spl

145 melanoma show receptor-specific imaging and renal clearance within 4 h post-injection.