ライフサイエンスコーパス: renal tubule

1 the innate immune response to the distressed renal tubule.

2 be active urea secretion somewhere along the renal tubule.

3 he paracellular cation barrier of the distal renal tubule.

4 home specifically to injured regions of the renal tubule.

5 xpressed by L. kirschneri that colonized the renal tubule.

6 channel involved in NaCl reabsorption in the renal tubule.

7 ubject to an active secretory process by the renal tubule.

8 on of calcium transport processes within the renal tubule.

9 vity of different nephron segments along the renal tubule.

10 thelial ion flux and fluid generation by the renal tubule.

11 hesis by a genetic approach along the entire renal tubule.

12 of the proximal and the distal parts of the renal tubule.

13 ion and antiapoptosis during regeneration of renal tubules.

14 opportunity to pursue experiments on single renal tubules.

15 in which fluid-filled cysts displace normal renal tubules.

16 F by increasing local delivery of BNP to the renal tubules.

17 of stem cells and augmenting repopulation of renal tubules.

18 require polarization of epithelia that line renal tubules.

19 or to detect fluid flow through the lumen of renal tubules.

20 is found in greatest abundance in the distal renal tubules.

21 normal G alpha(s) expression in the proximal renal tubules.

22 ejecting kidney biopsies and co-expressed in renal tubules.

23 stitial cells, and macrophages in the distal renal tubules.

24 n rats, where infection is restricted to the renal tubules.

25 ateral membranes of hepatocytes and proximal renal tubules.

26 adult mice, the expression is restricted to renal tubules.

27 d the structural and functional integrity of renal tubules.

28 r of CaOx crystal formation and retention in renal tubules.

29 he nascent nephron that is the progenitor of renal tubules.

30 ystal formation and crystal retention in the renal tubules.

31 ron model revealed hot spots in the proximal renal tubules.

32 alamin and selective protein reabsorption in renal tubules.

33 suggesting defect(s) in Cl- reabsorption in renal tubules.

34 ossum kidney (OK) cells, a model of proximal renal tubules.

35 suggesting a Na+ reabsorption deficiency in renal tubules.

36 to several important transport functions in renal tubules.

37 Ig light chain deposition was evident within renal tubules.

38 nger in isolated membrane vesicles or intact renal tubules.

39 re distinguishable in the tissue surrounding renal tubules.

40 tes, GLUT2 transporters are overexpressed in renal tubules.

41 alcium oxalate monohydrate (COM) crystals in renal tubules.

42 of ribosomal protein S6 (rpS6) in activated renal tubules.

43 he preconditioning dose of endotoxin and the renal tubules.

44 e epithelial cells of distal segments of the renal tubules.

45 IHC of kidneys localized FAM20A in the renal tubules.

46 , stellate cells, in Drosophila melanogaster renal tubules.

47 induces phosphaturia through its effects on renal tubules.

48 in SCC diagnosis, we found p53+ cells in the renal tubules.

49 proliferating cell nuclear antigen-positive renal tubules.

50 luid transport by the Drosophila Malpighian (renal) tubule.

51 ed fluid transport by Drosophila Malpighian (renal) tubules.

52 al fluid transport by Drosophila Malpighian (renal) tubules.

53 oxcarbazepine can enhance the sensitivity of renal tubules, a reduction in desmopressin dose might be

54 dney, characterized by cystic enlargement of renal tubules, aberrant epithelial proliferation, and io

55 east 10 mutations that cause severe proximal renal tubule acidosis in humans.

56 omerulus, the site of ultrafiltration, and a renal tubule, along which the filtrate is modified.

57 At the level of renal tubules, ambrisentan treatment prevented the incre

58 membrane protein that is expressed along the renal tubule and exposed to a wide range of concentratio

59 olarity, found that many dividing pre-cystic renal tubule and hepatic bile duct cells from Tsc1, Tsc2

60 ng transcription factor expression along the renal tubule and mapping metabolic pathways.

61 effects of acid on calcium transport in the renal tubule and then discuss why not all gene defects t

62 The cysts arise from renal tubules and are lined by abnormally functioning an

63 ized to epithelial cells, including proximal renal tubules and biliary epithelial cells.

64 atopoietic cell niche in proximal and distal renal tubules and collecting ducts.

65 Animals that overexpress soluble Crry in renal tubules and elsewhere are protected from the acute

66 ic kidney disease (ADPKD) cysts develop from renal tubules and enlarge independently, in a process th

67 Detection of viral gene products in renal tubules and excretion of JC virions in the urine s

68 rfamily of cytokines, is highly expressed in renal tubules and generally promotes maintenance of epit

69 itin to visualize the interleaved pattern of renal tubules and glomeruli.

70 xperiments were conducted in isolated canine renal tubules and in a canine autotransplant model of hy

71 cialized epithelia of the choroid plexus and renal tubules and in connective tissues of the eye, ovar

72 AC3 and G(olf) colocalize in renal tubules and in macula densa (MD) cells which modul

73 tion, uPAR mRNA transcripts were detected in renal tubules and interstitial cells of the obstructed u

74 Morphometric analysis of renal tubules and interstitium revealed a marked attenua

75 f an increase in sympathetic activity on the renal tubules and is insufficient to produce these effec

76 iation that are essential for the control of renal tubules and kidney morphogenesis.

77 es derived from it, one of which deposits in renal tubules and one of which displays no renal pathoge

78 y intravital microscopy revealed dilation of renal tubules and peritubular capillaries within 20 minu

79 ost animals that harbor leptospires in their renal tubules and shed the bacteria in their urine.

80 e can lead to PTH resistance in the proximal renal tubules and thus lead to impaired regulation of mi

81 s during cold storage preservation injury in renal tubules and to determine whether these changes con

82 tically attenuated CD8 infiltration into the renal tubules and tubular injury.

83 show that BMDC can respond by engrafting the renal tubules and undergo DNA synthesis after acute rena

84 cell types, including endothelial, neuronal, renal tubule, and cardiac cells.

85 omarker of increased oxidative stress in the renal tubule, and demonstrate that antioxidants can atte

86 ng step of sodium reabsorption in the distal renal tubule, and thus may play a key role in the mainte

87 d microcephaly, decreased convolution of the renal tubules, and abnormal craniofacial morphology.

88 munoglobulin peak, immunoglobulin deposit in renal tubules, and highly characteristic bone lytic lesi

89 ntetate dimeglumine enabled visualization of renal tubules, and hypointensity from cationic ferritin

90 Epac1 is expressed in heart, renal tubules, and in the HK-2 cell line.

91 hemistry, UbA52 was exclusively localized to renal tubules, and its expression was markedly increased

92 tor expression was specifically increased in renal tubules, and myofibroblastically phenotypic transi

93 , miRNAs are essential for the maturation of renal tubules, and Pkd1 is a target of miR-200.

94 se in the branching ureteric bud, developing renal tubules, and sex ducts.

95 ss were obtained within 3.2 minutes to image renal tubules, and T2*-weighted images of the same resol

96 eactive nitrogen species (RNS) generation by renal tubules, and the inducible nitric oxide synthase i

97 d convergent extension (CE) shape developing renal tubules, and their disruption has been associated

98 uptake of the fusion protein in the proximal renal tubules, and, therefore, could significantly reduc

99 ic beta-cells, small intestine, and proximal renal tubule are encoded by the 12 exons of the PKLR gen

100 c permeabilities in the Ildr1 knockout mouse renal tubules are not affected.

101 appear in PKD kidneys and that PKD-deficient renal tubules are predisposed to abnormally increased cy

102 crystal adhesion to the luminal membrane of renal tubules as a fundamental initiating mechanism of o

103 ciated with increased delivery of BNP to the renal tubules as evident by a greater urinary BNP excret

104 sis directly causes synchronized necrosis of renal tubules, as demonstrated by intravital microscopy

105 al hemofiltration cartridge in series with a renal tubule assist device (RAD) containing 10(9) porcin

106 al hemofiltration cartridge in series with a renal tubule assist device (RAD) containing 109 renal pr

107 The renal tubule assist device (RAD) is composed of a conven

108 colonizing the lumen of proximal convoluted renal tubules at both 10 and 28 days postinfection.

109 In the renal tubule, ATP is an important regulator of salt and

110 nsgene recapitulated Gata3 expression in the renal tubules but failed to direct sufficient GATA3 acti

111 on in the parathyroid, the placenta, and the renal tubule, but its overall physiological and patholog

112 e kidney glomerulus and is reabsorbed in the renal tubule by the action of the apical sodium-dependen

113 uired for efficient destruction of the graft renal tubules by CD8 effectors directed to donor MHC I a

114 absorbed from the lumen of the intestine and renal tubules by, respectively, enterocytes and renal ep

115 of the renal Ca receptor (CaR) may decrease renal tubule Ca reabsorption and cause hypercalciuria th

116 (GHS) rats is due, in part, to a decrease in renal tubule Ca reabsorption.

117 ts demonstrate that loss of NEDD4-2 in adult renal tubules causes a new form of mild, salt-sensitive

118 dent amino acid transporters in the proximal renal tubule, causing a reduction in amino acid resorpti

119 90 may play a role as an adapter molecule in renal tubule cell death.

120 Renal tubule cell injury occurs early in septic shock bu

121 ), a major physiologic regulator of proximal renal tubule cell sodium-phosphate cotransport, stimulat

122 Earlier work identified renal tubule cell synthesis of C3, rather than hepatic s

123 n of a synthetic hemofiltration device and a renal tubule cell therapy device containing porcine rena

124 abnormal pattern of L-fucose on postischemic renal tubule cells and activates a destructive inflammat

125 nt injuries induce cholesterol increments in renal tubule cells and that statins sensitize these cell

126 Since renal tubule cells appear to play a critical role in the

127 ubule cell therapy device containing porcine renal tubule cells in an extracorporeal perfusion circui

128 ve effector on the fate of cisplatin-exposed renal tubule cells in vivo and in vitro; adenoviral tran

129 Renal tubule cells produce BNP.

130 Ex vivo renal tubule cells showed a marked capacity for CL-11 bi

131 its sodium-phosphate cotransport in proximal renal tubule cells through activation of several kinases

132 eins to the same subcellular regions such as renal tubule cells where the proteins are associated wit

133 hat cisplatin causes apoptotic cell death in renal tubule cells, but the underlying molecular mechani

134 rs of dUTP-biotin nick end labeling-positive renal tubule cells, suggesting that increased lethality

135 docrine, and immunologic functions of normal renal tubule cells.

136 cially in bile duct epithelial cells, and in renal tubule cells.

137 n the inherited germline mutation within the renal tubule cells.

138 nterferon-gamma up-regulate C3 production in renal tubule cells.

139 uppressor) and present in lower abundance in renal tubule cells.

140 her pyruvate-to-lactate flux than the normal renal tubule cells.

141 In renal tubules, cilium-associated PKD2 appears to mediate

142 Haufen originated from renal tubules containing virally lysed cells, and the de

143 ng manba expression in zebrafish resulted in renal tubule defects and pericardial edema, phenotypes t

144 including glomerular crescent formation and renal tubule defects in early disease, which progressed

145 Isolated renal tubules demonstrated progressive loss of membrane

146 eotypic positioning of outgrowing Drosophila renal tubules depends on signaling in a subset of tubule

147 inositide 3-kinase-C2alpha (PI3K-C2alpha) in renal tubule-derived inner medullary collecting duct 3 c

148 cAMP can stimulate fluid secretion early in renal tubule development during the time when renal cyst

149 PKD1 gene product, plays a critical role in renal tubule diameter control and disruption of its func

150 Renal tubules did not demonstrate any evidence of peroxy

151 riptional target, MIM, resulted in extensive renal tubule dilation and cysts, whereas Hdac5 heterozyg

152 disease, including biliary epithelial cysts, renal tubule dilation, organ fibrosis, and basement memb

153 of active morphogenesis and, except for some renal tubules, disappeared from the adult kidney.

154 Here, we demonstrate that renal tubules do not undergo sensitization to necroptosi

155 Infiltrating lymphocytes and the renal tubules drove the miRNA tissue pertubations in rej

156 Hypertension and renal tubule dysfunction, including hyperkalemia, hyperc

157 a skin cancer and nonprogressive, reversible renal tubule effects were observed with avagacestat.

158 r1.1, encoded by KCNJ1) critically regulates renal tubule electrolyte and water transport and hence b

159 Renal tubule epithelia represent the primary site of dam

160 implicated in hyperproliferative diseases of renal tubule epithelia.

161 Renal tubule epithelial cells express the insulin recept

162 ed along the entire nephron, its function in renal tubule epithelial cells remains unclear, as no spe

163 In primary renal tubule epithelial cells, overexpression of AATF me

164 ally involved in cold preservation injury in renal tubule epithelial cells.

165 mal tubule (HK-2) cells and in mouse primary renal tubule epithelial cells.

166 ey; increases proliferation and apoptosis of renal tubule epithelial cells; elevates protein kinase A

167 ic cells is an important mechanism mediating renal tubule epithelial regeneration after AKI.

168 lium, hepatocytes, thymocytes, plasma cells, renal tubule epithelium, spermatogonia, prostatic secret

169 NRP could mediate attachment of CaOx to the renal tubule epithelium, thereby causing retention of cr

170 transgenic mice expressed Cre recombinase in renal tubules, especially collecting ducts and thick asc

171 helial resistance than other segments of the renal tubule exhibit.

172 with conditional inactivation of Xpr1 in the renal tubule exhibited generalized proximal tubular dysf

173 ells and cooperate to enhance and accelerate renal tubule formation in uninduced rat metanephric mese

174 The paradigm for recovery of the renal tubule from acute tubular necrosis is that survivi

175 ) expression has been shown to be altered in renal tubules from diabetic mice.

176 formoterol restored renal function, rescued renal tubules from injury, and diminished necrosis after

177 Furthermore, compared with renal tubules from kidney samples of normal controls, cy

178 -smooth muscle actin (SMA) were increased in renal tubules from kidney transplant recipients on calci

179 ring the looped morphology characteristic of renal tubules from worms to humans.

180 layers in mammalian microvessels of choroid, renal tubules, glomerulus, and psoas muscle all showed s

181 lateral Na+/H+ exchange in the regulation of renal tubule HCO3- absorption.

182 to interstitial fibrosis and atrophy of the renal tubules if not appropriately treated.

183 long the basolateral surface of the proximal renal tubule in association with L-fucose, the potential

184 that conditional inactivation of Xpr1 in the renal tubule in mice resulted in impaired renal Pi reabs

185 of gestation, and it was confined mainly to renal tubules in 1-week-old mice.

186 fic expression of cadherin-6 in the proximal renal tubules in normal human kidney and suggest that al

187 increasing the cold storage time of isolated renal tubules in University of Wisconsin solution caused

188 e nitric oxide (NO) is cytotoxic to isolated renal tubules, inhibition of NO production in vivo invar

189 to assess whether vitamin Ds directly affect renal tubule injury responses.

190 tion of miRNAs in CDs spontaneously evokes a renal tubule injury-like response, which culminates in p

191 e of cleaving hBD1, a component of the human renal tubule innate immune response.

192 the human sickle kidney, HO-1 is induced in renal tubules, interstitial cells, and in the vasculatur

193 hether mTOR contributes to the regulation of renal tubule ion transport.

194 The renal tubule is a major route of clearance of uric acid,

195 neuroendocrine stimulation of the Drosophila renal tubule is an extensive remodeling of the mitochond

196 Chloride transport by the renal tubule is critical for blood pressure (BP), acid-b

197 communication between different parts of the renal tubule is increasingly recognized as an important

198 dium-retaining factor acting directly on the renal tubule is responsible for sodium retention.

199 Immune destruction of the graft renal tubules is an important barrier to the long-term f

200 widely studied; however, mTORC2 function in renal tubules is poorly characterized.

201 alcium oxalate monohydrate (COM) crystals to renal tubules is thought to be one of the critical steps

202 PTHrP, and PTHrP expression in rat proximal renal tubules is upregulated in response to ischemic inj

203 peptide signaling in the insect Malpighian (renal) tubules is a key physiological mechanism during r

204 Diabetic kidneys contained renal tubules laden with communities of E. coli UTI89 ba

205 rized by the growth of fluid-filled cysts in renal tubules leading to end-stage renal disease.

206 ajor role is played by the kidney, where the renal tubule matches the urinary magnesium excretion and

207 pment, but their role during later stages of renal tubule maturation is not well understood.

208 sgenic progeny expressed lacZ exclusively in renal tubules, mesonephric tubules, ureteric bud, develo

209 Here, we used RNA-seq coupled with classic renal tubule microdissection to comprehensively profile

210 Through live analysis of Drosophila renal tubule morphogenesis we show that tissue elongatio

211 Renal tubules normally show no lymphocyte infiltration,

212 rk demonstrates that repopulation of damaged renal tubules occurs primarily from proliferation of tub

213 sured intraluminal ATP concentrations in the renal tubules of anesthetized rats.

214 Cell proliferation in the developing renal tubules of Drosophila is strikingly patterned, occ

215 Using the renal tubules of Drosophila, we show that a specific dis

216 is essential to brush border maintenance in renal tubules of Drosophila.

217 ed expression of TLR4 but not of TLR2 in the renal tubules of human kidneys with diabetic nephropathy

218 o epithelial cell surfaces under flow in the renal tubules of the kidney.

219 in many cell types in the kidney, including renal tubules of the outer stripe of the medulla, glomer

220 alactosidase-positive cells were detected in renal tubules of the recipients by X-Gal staining.

221 ssion via freshwater and colonization of the renal tubules of their reservoir hosts.

222 long with greater cell proliferation, in the renal tubules of Tsc1 and rpS6 double-mutant mice.

223 In the Malpighian (renal) tubule of Drosophila melanogaster, TA activates a

224 helial ion and water flux in the Malpighian (renal) tubules of the fly, which are in direct contact w

225 tered gadopentetate dimeglumine to visualize renal tubules on T1-weighted gradient-refocused echo (GR

226 the sodium transporters expressed along the renal tubule, only the 70 kDa form of the y-subunit of t

227 within the tight junction of cultured canine renal tubule or human intestinal epithelial monolayers.

228 ach combining two-photon imaging of isolated renal tubules, physiological studies, and genetically en

229 omponents of salt reabsorption in the distal renal tubule), possibly through adenylate cyclase and cy

230 In renal tubules, preconditioning prevented peroxisomal dam

231 lized to the basolateral membranes of normal renal tubules, predominantly thick ascending limbs of He

232 in Solution and reperfused in vitro to model renal tubule preservation injury, which was assessed by

233 ynitrite (1 mM) directly to freshly isolated renal tubules produced strong nitrotyrosine signals but

234 miRNA-processing enzyme Dicer from maturing renal tubules produces tubular and glomerular cysts in m

235 produce a nitrotyrosine signal in extracted renal tubule proteins but significantly impaired transpo

236 ine renal tubular cells and freshly isolated renal tubules rapidly absorbed RCM, plasma membrane inte

237 ithelium is key to renal physiology, but how renal tubules regulate capillary development remains unc

238 red in vivo for a Wnt response to injury and renal tubule repair, the absence of which triggers cysto

239 cient method for the genetic manipulation of renal tubules, representing a quick and versatile altern

240 Excision of Vegfa from renal tubules resulted in the formation of a smaller kid

241 roximal tubular cells or in freshly isolated renal tubules revealed that this Xpr1 deficiency signifi

242 median depth of 8261 genes in microdissected renal tubule samples (105 replicates in total) and glome

243 Fly renal tubules secrete a KCl-rich fluid.

244 The function of each renal tubule segment depends on the genes expressed ther

245 sively profile gene expression in each of 14 renal tubule segments from the proximal tubule through t

246 Global miRNA profiling of microdissected renal tubules showed that miRNAs exhibit segmental distr

247 endogenous SLC41A1 specifically localized to renal tubules situated at the corticomedullary boundary,

248 e that parathyroid hormone inhibits proximal renal tubule sodium-phosphate cotransport through a sign

249 unction of these noncoding RNAs in postnatal renal tubules still remains unclear.

250 VHL mRNA was differentially expressed within renal tubules suggesting that the VHL gene product may h

251 rfaces of lipids and proteins that may mimic renal tubule surfaces while allowing direct visualizatio

252 produces a specific pattern of injury to the renal tubule that alters uptake of DMSA.

253 accumulation of hemoglobin and lipofuscin in renal tubules that account for the pigmentation.

254 an kidney is composed of roughly 1.2-million renal tubules that must maintain their tubular structure

255 required for lumen continuity in developing renal tubules, though its mechanism of action remains un

256 we show that selective activation of HIF in renal tubules, through Pax8-rtTA-based inducible knockou

257 Renal tubules thus represent a tissue that is not sensit

258 roliferative stages, PCP signaling polarizes renal tubules to control OCD.

259 transgene, a predominant isoform of PHDs in renal tubules, to reduce HIF-1alpha level significantly

260 ing a simulated (1)H NMR data set to emulate renal tubule toxicity and further exemplified this metho

261 iltration rate (eGFR) owing to inhibition of renal tubule transport of creatinine.

262 Developmental changes in the renal tubule transport systems and their regulation have

263 ncludes characterization of a urate-specific renal tubule transporter explaining many aspects of rena

264 In fly embryonic renal tubules, Tsh is expressed in mesodermally derived

265 that endotoxin toxicity to nonpreconditioned renal tubules was direct and independent of immune cells

266 g content of HTL in chronically infected rat renal tubules was indistinguishable from that of IVCL.

267 Of interest, C3 deposition around renal tubules was significantly less in animals with IRI

268 ehind the ability of BMP-7 to repair damaged renal tubules, we hypothesized that systemic treatment w

269 was induced 6 h after nephrotoxic serum and renal tubules were identified as the site of expression

270 The cells can differentiate into renal tubules when injected under the capsule of an unin

271 -MAG3) is excreted almost exclusively by the renal tubules, whereas (99m)Tc-diethylenetriamine pentaa

272 The arcades are long, branched renal tubules which connect deep and mid-cortical nephro

273 Claudin-8 is expressed in the distal renal tubule, which has a characteristically low passive

274 tably, albumin overload induced apoptosis in renal tubules, which was less severe in PKC-delta-knocko

275 teomics' approach, which profiles the entire renal tubule with regard to changes in Na+ transporter a

276 It also limits diameters of differentiating renal tubules, with mutation of certain components of th

277 mice, demonstrating the utility of the Kim-1 renal tubule zebrafish models.