ライフサイエンスコーパス: renalase

1 tumor mass, suggesting a pathogenic role for renalase.

2 mmon single nucleotide polymorphism in human renalase 3'-UTR (C/T; rs10749571) creates a binding site

3 -29a/b/c and miR-146a/b with mouse and human renalase 3'-UTR (untranslated region) in cultured cells.

4 consistently, miR-146a down-regulated human renalase 3'-UTR/luciferase activity in case of the T all

5 Renalase, a recently discovered secreted flavoprotein, p

6 Renalase, a recently identified oxidoreductase, is emerg

7 We previously identified renalase, a secreted novel amine oxidase that specifical

8 rge of epinephrine lasting <2 minutes causes renalase activity to increase from 48+/-18 to 2246+/-98

9 Renalase, an amine oxidase secreted by the proximal tubu

10 ase signaling using siRNA or inhibitory anti-renalase antibodies decreased the viability of cultured

11 We have identified the catalytic activity of renalase as an alpha-NAD(P)H oxidase/anomerase, whereby

12 These results identify renalase as what we believe to be a novel amine oxidase

13 Inhibition of renalase caused tumor cell apoptosis and cell cycle arre

14 also leads to a 2.8-fold increase in plasma renalase concentration.

15 It is not known whether endogenous renalase contributes to the regulation of catecholamines

16 d plasma catecholamine levels were higher in renalase-deficient mice subjected to renal ischemia repe

17 erall survival was inversely correlated with renalase expression in the tumor mass, suggesting a path

18 Here we show that renalase expression is increased in pancreatic cancer ti

19 e estimated miR-29b and miR-146a, as well as renalase expression, in genetically hypertensive blood p

20 terleukin-2 (IL-2), IL2/4q27 (rs2069763) and renalase, FAD-dependent amine oxidase (RNLS)/10q23.31 (r

21 DPH and NADH initiate rapid reduction of the renalase flavin cofactor.

22 dence for post-transcriptional regulation of renalase gene by miR-29 and miR-146 and has implications

23 exposed to dopamine upregulate steady-state renalase gene expression by >10-fold.

24 In humans, renalase gene expression is highest in the kidney but is

25 possible role of microRNAs in regulation of renalase gene in this study.

26 The mechanism of regulation of renalase gene, especially at the post-transcriptional le

27 Since its discovery in 2005, renalase has been the subject of conjecture pertaining t

28 eveal a previously unrecognized role for the renalase in cancer: its expression may serve as a progno

29 ggesting its potential role in regulation of renalase in humans.

30 ion injury had significantly lower levels of renalase in the plasma and kidney compared with sham-ope

31 Renalase infusion in rats caused a decrease in cardiac c

32 onal antibody m28-RNLS or shRNA knockdown of renalase inhibited pancreatic ductal adenocarcinoma grow

33 Renalase is a flavoprotein whose structural topology is

34 Renalase is a protein hormone secreted into the blood by

35 The plasma concentration of renalase is markedly reduced in patients with end-stage

36 While it has been widely reported that renalase is the third monoamine oxidase (monoamine oxida

37 We show here that circulating renalase lacks significant amine oxidase activity under

38 ministration of either native or recombinant renalase lowers blood pressure, heart rate, and cardiac

39 ney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed

40 apoptosis, and inflammation, and that plasma renalase might be a biomarker for AKI.

41 In two xenograft mouse models, either the renalase monoclonal antibody m28-RNLS or shRNA knockdown

42 h mice showed diminished (~1.6- to 1.8-fold) renalase mRNA/protein levels and elevated (~2.2-fold) mi

43 In the renalase pathway, excess catecholamine facilitates the c

44 Renalase plasma levels are markedly reduced in patients

45 Taken together, these data suggest that renalase protects against ischemic AKI by reducing renal

46 Administration of recombinant human renalase reduced plasma catecholamine levels and amelior

47 vels, cardiac hypertrophy, and hypertension, renalase replacement is an attractive therapeutic modali

48 Renalase (RNLS) is a secreted flavoprotein that function

49 Inhibition of renalase signaling using siRNA or inhibitory anti-renala

50 denine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney

51 Recombinant renalase therapy may have potential for the prevention a

52 nalase, an inactive plasma amine oxidase, to renalase, which can degrade catecholamines.