ライフサイエンスコーパス: renew

1 hase II acute optic neuritis clinical trial (RENEW).

2 er stem-like cells is their capacity to self-renew.

3 te protocol takes 1-4 weeks to generate self-renewing 3D organoids and to perform genetic manipulatio

4 p53 status and reduced the viability of self-renewing, 5-fluorouracil-resistant Aldefluor positive [A

5 The pny pnf restoration correlates with renewed accumulation of transcripts conferring floral me

6 of DUSP6 in combination with elevated c-Src renews activation of the Ras/MAPK pathway, which enhance

7 Long-lived and self-renewing adult stem cells (SCs) are essential for homeos

8 G12D/+)p53(-/-) MEPs are transformed to self-renewing AML-initiating cells and are capable of inducin

9 s) are tumour initiating cells that can self-renew and are highly tumorigenic and chemoresistant.

10 al stem cells (MSC) have the ability to self-renew and differentiate into multiple cell types valuabl

11 Adult stem cells across diverse organs self-renew and differentiate to maintain tissue homeostasis.

12 s, which is dependent on the ability to self-renew and differentiation.

13 al mitochondrial respiration) failed to self-renew and displayed lymphoid differentiation defects.

14 throughout life due to their ability to self-renew and exist as quiescent neural progenitors (QNPs) b

15 oma cells reprogram their metabolism to self-renew and fuel the tumor hierarchy, revealing potential

16 roblasts (NBs) divide asymmetrically to self-renew and generate differentiated neurons or glia.

17 l stem cells (aNSCs) in the hippocampus self-renew and generate neurons throughout life.

18 OCR stem cells self-renew and generate osteoblasts, chondrocytes, and reticu

19 Stem cells self-renew and generate specialized progeny through different

20 e defined by their inherent capacity to self-renew and give rise to neurons, astrocytes, and oligoden

21 A fraction of these cells self-renew and persist as a minor B1 B cell subset throughout

22 esident macrophages have the ability to self-renew and persist in the body for months to years.

23 op from meristems-cell populations that self-renew and produce cells that undergo differentiation-loc

24 Airway stem cells slowly self-renew and produce differentiated progeny to maintain hom

25 cells (SCs) that possess the ability to self-renew and produce differentiating progeny.

26 Stem cells self-renew and produce progenitors with limited proliferative

27 stem cells (LSCs) have the capacity to self-renew and propagate disease upon serial transplantation

28 replaced when lost, in fish they constantly renew and regenerate after injury.

29 sed HSCs lacking Hif-1alpha efficiently self-renew and sustain long-term multilineage hematopoiesis u

30 owed with the stem cell-like ability to self-renew and the multipotent capacity to reconstitute the e

31 (NSCs) are defined by their ability to self-renew and to differentiate into mature neuronal and glia

32 he xenograft assay by their capacity to self-renew and to generate non-LICs in vivo The xenotransplan

33 d extrinsic factors that enable PSCs to self-renew and to transition between different pluripotent st

34 elopment have the unlimited capacity to self-renew and undergo differentiation into all of the cell t

35 To provide renewed and improved access to eupalinilide E, a laborat

36 ng NSCs isolated from the mouse SGZ are self-renewing and capable of differentiating into neurons, as

37 in-dependent transcriptional programs in the renewing and differentiating populations of the nephron

38 renewal as they transit into short-term self-renewing and multipotent progenitor states, with the fir

39 mbryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pa

40 nograft models, reflecting a stem-like, self-renewing and tumor-propagating phenotype.

41 g is a multipotent progenitor pool that self-renews and produces differentiating descendants.

42 There has been a renewed appreciation for the dynamic nature of ribonucle

43 This renewed appreciation for, and need to better understand,

44 In this work, we present a renewed approach to calculate the impact of gene mutatio

45 GBM cell stemness and their capacity to self-renew as spheres and propagate glioma xenografts in vivo

46 nce of neurocompetent stem cells, which self-renew as well as generating all of the cell types found

47 dditional studies to provide appropriate and renewed assessments of the risks of feeding modes for th

48 ge arouse greater fears of obesity, spurring renewed attempts to restrict intake severely.

49 talities emphasise that the disease warrants renewed attention from public health officials and polic

50 talities emphasize that the disease warrants renewed attention from public health officials and polic

51 Insurance Program (CHIP) beyond 2017, merits renewed attention on the quality of these options for ch

52 antiretroviral therapy (ART) has resulted in renewed attention to non-HIV-related diseases exacerbate

53 anticoagulant drug heparin in 2007 has drawn renewed attention to the challenges that are associated

54 optical properties has received, since 2009, renewed attention, triggered notably by low-bandgap ferr

55 metal dichalcogenides have recently received renewed attention.

56 minescence upconversion has begun to receive renewed attention.

57 ells, because the autoreactive T cells could renew autoimmunity in the reconstituted B cell compartme

58 control of stem cell activity, whereby self-renewing behavior emerges from the lack of cell displace

59 Molecular mechanisms preventing self-renewing brain stem cells from oncogenic transformation

60 quiescent and slowly-cycling stem cells self-renew but replenish an active-cycling population, is wel

61 ns than other Tmem subsets and not only self-renewed, but also contributed to the expanding CX3CR1(-)

62 The disk membranes are continually renewed, but how new disks are formed remains poorly und

63 s a squamous epithelium that is continuously renewed by a population of basal layer stem/progenitor c

64 The skin epidermis is constantly renewed by epidermal stem cells.

65 The intestinal epithelium is continuously renewed by intestinal epithelial stem cells (IESCs) posi

66 xists a subpopulation of highly plastic self-renewing cancer cells that retain the ability to expand

67 We report that self-renewing cancer stem cells (CSCs) in glioblastoma have l

68 Elimination of self-renewing cancer stem cells (CSCs) is necessary to perman

69 over, PAF expression endows MECs with a self-renewing capacity and cell heterogeneity generation via

70 promote the generation of HT-resistant, self-renewing CD133(hi)/ER(lo)/IL6(hi) cancer stem cells (CSC

71 The self-renewing cell lines stain weakly for CDX2 and strongly f

72 lencing of H1.0 promotes maintenance of self-renewing cells by inducing derepression of megabase-size

73 bust homeostatic mechanisms mediated by self-renewing cells capable of generating all resident cell t

74 ogenic emissions did not resume to cause the renewed [CH4] rise after 2006, which contradicts emissio

75 Superficial cells are self-renewing chondrocyte progenitors, which form the articul

76 rizing medical marijuana programs, there are renewed clinical and policy concerns regarding the menta

77 ing stem cell population with long-term self-renewing, clonal expanding and differentiating abilities

78 s from later divisions in the DLN could self-renew, clonally yielding a TCF1-silenced daughter cell a

79 Although China and India have both shown renewed commitment through national programmes for commu

80 A renewed commitment to a more forward-looking, flexible y

81 A renewed convergence between neurobiology and cognition i

82 sms that maintain stable proportions of self-renewing CSC within heterogeneous tumors under homeostat

83 l of HCV direct-acting antivirals (DAAs) has renewed discussions as to whether these therapies could

84 lls (ISCs) by promoting their symmetric self-renewing division in Drosophila adult midgut.

85 dicated that deleting p18 gene favoured self-renewing division of HSC in vitro.

86 Plants constantly renew during their life cycle and thus require to shed s

87 We suggest that a renewed effort be made into understanding whether basal

88 The renewed effort to eliminate malaria and permanently remo

89 rus [SIV]) are of intense interest given the renewed effort to identify potential cures for HIV.

90 or allergic diseases in children have led to renewed efforts aimed at prevention.

91 Over the last fifteen years renewed efforts at control have reduced the prevalence o

92 egative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery.

93 For women who are already obese, renewed efforts should be made towards improved manageme

94 Furthermore, it calls for renewed efforts to delineate fermentation pathways bioch

95 elopment of allosteric modulators encourages renewed efforts to exploit their potential as therapeuti

96 nt age gap in survival, suggest the need for renewed efforts to improve cancer outcomes.

97 This has placed a renewed emphasis on detailed GSL headgroup structural an

98 tics and vaccine probe studies, as well as a renewed emphasis on lung aspirates from radiologically c

99 current emphasis on novelty be replaced by a renewed emphasis on predictive power as a characteristic

100 global health problem by 2025, there is now renewed emphasis on snail control.

101 mmunotherapy trials in lung cancer, there is renewed enthusiasm in targeting the immune component of

102 nd ribosome occupancy at the genome level, a renewed enthusiasm toward studying translation regulatio

103 stem cells (hPSCs) differentiation into self-renewing epicardial cells in a completely defined, xeno-

104 Self-renewing epigenetic states are not stable, and reexpress

105 ity of Lgr5-positive cell divisions serve to renew epithelial cells and only few result in the effect

106 aced by langerin(high) LCs arising from self-renewing epithelial precursors of hematopoietic origin.

107 ation/activation of PKCalpha is seen in self-renewing epithelium of the intestine, cervix, and skin.

108 has little effect on gene expression in self-renewing ESC culture.

109 eocilia F-actin cores are either continually renewed every 24-48 h via a treadmill or are stable, exc

110 es and directions, the field is experiencing renewed excitement that mutant RAS may finally be conque

111 ested that curing HIV infection is possible, renewing excitement about research efforts.

112 itochondria, plays an essential role in self-renewing expansion of Tie2(+) HSCs.

113 Now, its genome has been sequenced, enabling renewed experimental study and revealing unexpected surp

114 ereas others retain potency, preserving self-renewing features established early while progressively

115 A reminder can temporarily renew flexibility of consolidated memories, referred to

116 rd lists or stories find that a reminder can renew flexibility of episodic memory.

117 itioning studies suggest that a reminder can renew flexibility of threat responses but that episodic

118 These findings are timely given the renewed focus of regulatory agencies on reproductive saf

119 This study provides a renewed focus on infected erythrocyte debris as the caus

120 Renewed focus on large (1-50 ha) permanent plots and on

121 We suggest that a renewed focus on LTCCs as targets, and the development o

122 low levels of metal impurities has brought a renewed focus on metal-free coupling processes.

123 sion are noted in high burden settings and a renewed focus on reducing person-to-person transmission

124 he future for these enzymes is bright, but a renewed focus on studying them will be critical to the s

125 goal of universal health coverage provides a renewed focus on taking a system perspective in designin

126 of physiological thermogenesis and support a renewed focus on targeting UCP3 in metabolic physiology.

127 ion inherent to cancer relates directly to a renewed focus on the voluminous next-generation sequenci

128 transitory' myeloid cells that originate and renew from bone marrow hematopoietic stem cells, and to

129 nravel the extent of H pylori control on the renewing gastric epithelium.

130 nt in yields in various species will require renewed genetic interventions and dramatic improvement o

131 entation is oncogenic, not by promoting self-renewing germ cell divisions within the niche, but by pr

132 Renewed glacier resurgence in the fjords between c. 15,1

133 g LF elimination by 2020 in the light of the renewed global action against NTDs and the global effort

134 thematically most likely explanation for the renewed growth in atmospheric methane, counterintuitivel

135 stent with other proposed hypotheses for the renewed growth of atmospheric methane since 2007.

136 d death are tightly regulated in the rapidly renewing gut epithelium, with proliferation confined to

137 rain tumor and contains a population of self-renewing, highly tumorigenic glioma stem cells (GSCs), w

138 Self-renewing, highly tumorigenic glioma-initiating cells (GI

139 cling as well as RAS signaling networks have renewed hope for developing strategies to selectively bl

140 These findings offer renewed hope for development of IL-12-based treatments f

141 With this new understanding has emerged renewed hope for engineering these assembly lines to pro

142 transplantation in the past 5 years provide renewed hope for prevention and treatment of liver graft

143 advent of cancer immunotherapy has generated renewed hope for the treatment of many malignancies by i

144 d on the surface of the virus envelope--thus renewing hope of developing carbohydrate-based HIV vacci

145 In this model, self-renewing HSCs progressively lose the capacity for self-r

146 This development has provided renewed impetus toward an HIV vaccine and led directly t

147 sation of treatment to limit toxicity are of renewed importance in the context of human papilloma vir

148 Hematopoietic stem cells (HSCs) self-renew in bone marrow niches formed by mesenchymal progen

149 rent markers, reside in different locations, renew in different ways, and show little or no interconv

150 HSPCs differentiate and renew in other locations, ensuring homeostatic maintenan

151 ha-deficient HSCs lost their ability to self-renew in serial transplantation assays.

152 Differentiated macrophages can self-renew in tissues and expand long term in culture, but th

153 s can self-organize into organoids that self-renew in vitro while retaining their tissue-of-origin co

154 ustain effector T-cell production while self-renewing in reaction to persistent antigen; yet, excessi

155 Langerhans cells (LCs) are self-renewing in the steady state but repopulated by myeloid

156 stabilize the landforms and may even promote renewed incision.

157 of relapsed prostate cancer in patients with renewed increase in the prostate-specific antigen (PSA),

158 Characterized by their ability to self-renew indefinitely and differentiate into all cell linea

159 tem cells (TSCs) retain the capacity to self-renew indefinitely and harbour the potential to differen

160 stem cells are known to have the capacity to renew indefinitely, being intrinsically able to differen

161 pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an attractive source for

162 attention in recent years, in part driven by renewed interest and opportunities for antibody-based st

163 ecombinant proteins, have recently attracted renewed interest as an efficient strategy for drug disco

164 ly termed "Ly-1" and now "B-1," has received renewed interest as an innate-like B cell population of

165 state of the art review on SCR will create a renewed interest at all levels including transplant clin

166 ors, especially those using NbO2, is gaining renewed interest because of its potential utility in neu

167 brane anion transport modality is enjoying a renewed interest because of recent advances toward antic

168 These wall polysaccharides are attracting renewed interest because of their central roles as sourc

169 energy conversion has attracted substantial renewed interest due to its applications in industrial h

170 Although lipid droplets are attracting renewed interest from the standpoint of normal physiolog

171 With the renewed interest in anti-TH2 biologics, we propose a rat

172 heter aortic valve replacement (TAVR) led to renewed interest in balloon aortic valvuloplasty (BAV).

173 cent progress in artificial intelligence has renewed interest in building systems that learn and thin

174 l demand for fossil resources has prompted a renewed interest in catalyst technologies that increase

175 1R negative allosteric modulators (NAMs) has renewed interest in CB1R by offering a potentially safer

176 In recent years there has been renewed interest in combating these diseases not only by

177 mergence of multidrug-resistant bacteria has renewed interest in developing antimicrobial biomaterial

178 s to liver injury and fibrosis have led to a renewed interest in developing therapies beyond ursodeox

179 nt advances in X-ray detection have led to a renewed interest in diffuse scattering analysis as a way

180 There has been renewed interest in environmental releases of engineered

181 Although having limitations, this study has renewed interest in evaluating CoQ10 supplementation in

182 andic eruption of Eyjafjallajokull generated renewed interest in finding ways to identify airborne vo

183 348 348 References 348 There is renewed interest in how transgenerational environmental

184 on peaks, we argue that the time is ripe for renewed interest in inmate society and its connections t

185 ifically the motor neurons, have triggered a renewed interest in insulin-like growth factor-1 (IGF-1)

186 n, given the availability of ruxolitinib and renewed interest in interferons.

187 Renewed interest in malaria eradication has placed great

188 be following similar trends as DENV and have renewed interest in monitoring and modeling arboviruses

189 t is believed the present study could spur a renewed interest in open-tubular LC.

190 lted in an urgent need for new therapies and renewed interest in other classes such as aminocyclitols

191 er uranium for more than six decades, with a renewed interest in particular since 2010.

192 new drugs brought to the market has fostered renewed interest in plant-based drug discovery.

193 However, in recent years, there has been renewed interest in Plasmodium vivax, with CHMI models d

194 ions in measles incidence and mortality have renewed interest in regional elimination and global erad

195 of commonly used antibiotics, which spurs a renewed interest in revisiting older and poorly studied

196 a theory and computational power have led to renewed interest in stellarators.

197 Indeed, there has been renewed interest in sulfur-based reactions in just the p

198 Our findings call for renewed interest in the biological causes and cognitive

199 f pathways inside living cells has triggered renewed interest in the bottom-up development of CRNs.

200 Therefore, a renewed interest in the development of neuraminidase (NA

201 to the growing literature stemming from the renewed interest in the discovery and development of nov

202 ve source in the terahertz range triggered a renewed interest in the Dynamic Nuclear Polarization (DN

203 ynn Sagan) is widely regarded as stimulating renewed interest in the long-dormant endosymbiont hypoth

204 th controlled size and shape, there has been renewed interest in the mechanical properties of polymer

205 ll-optical helicity dependent switching, has renewed interest in the physics that governs the interac

206 This has renewed interest in the physiological roles of this inte

207 umina that was recently reported has created renewed interest in the potential of core-shell structur

208 One significant change is a renewed interest in the right ventricle-to-pulmonary art

209 These findings have renewed interest in the search for new AR inhibitors (AR

210 ti-drug-resistant (MDR) bacteria has spurred renewed interest in the use of bacteriophages in therapy

211 were discovered in the 1950s, there has been renewed interest in their therapeutic potential, particu

212 Recent work has renewed interest in therapies targeting the renin-angiot

213 tpy synthesis, consequently giving rise to a renewed interest in this class of compounds.

214 It is hoped that this review will lead to a renewed interest in this truly enlightening technology,

215 The renewed interest of mechanochemistry as an ecofriendly s

216 mizes water usage efficiency - has attracted renewed interest worldwide in recent years.

217 Science outreach via social media demands a renewed interest, and Facebook may be an overlooked high

218 rmance information processing have attracted renewed interest.

219 With the recent renewed interests in chemical manufacturing and process

220 We anticipate that our results will spark renewed investigation in modulating the function of thes

221 nually shift into the rapidly dividing, self-renewing ISC pool.

222 s also challenge the nephrology community to renew its attention and efforts on hypertension clinical

223 terminally differentiated effector cells and renews itself for continued defense.

224 gram non-stem bulk leukaemia cells into self-renewing, leukaemia-initiating stem cells.

225 cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essential for the mainten

226 e terminally differentiated effector or self-renewing memory lineages, with cell-intrinsic and -extri

227 That renewed method comprises the output of an a Er:YAG laser

228 aris Conference of Parties (COP21) agreement renewed momentum for action against climate change, crea

229 ansition to form clonogenic, long-term, self-renewing MSC-like cells.

230 Hematopoietic stem cells (HSCs) are self-renewing multipotent stem cells that generate mature blo

231 Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can tri

232 offer researchers studying complex diseases renewed opportunities to discover new or repurpose exist

233 ics is a means of segmenting time to provide renewing opportunity windows for decision.

234 A number of recent advances have spurred renewed optimism toward initiating clinical trials and d

235 ell fate decisions to remain quiescent, self-renew or differentiate are largely governed by the inter

236 SSCs self-renew or differentiate into spermatogonia that prolifera

237 mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis of gen

238 een reported in both rapidly and slowly self-renewing organs and follow conserved mechanisms.

239 Vaccine refusal can lead to renewed outbreaks of previously eliminated diseases and

240 stem-like cells that are totipotent and self-renew over the long term, 2) Ascl1(+) transit-amplifying

241 The pharmaceutical industry is entering a renewed period of productivity as a result of advances i

242 We have thus identified a self-renewing perivascular progenitor cell line that lacks os

243 e to GMP quality protocols for deriving self-renewing perivascular progenitors from the human embryon

244 The live observations give renewed perspective on the mechanisms of axonal guidance

245 stem cell division, which enhances the self-renewing population and diminishes the differentiation p

246 areas of the neocortex and supports the self-renewing potential of mouse NPCs.

247 pplement some of the provider workload: they renew prescriptions, address patient questions, and prov

248 y resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeosta

249 Thus, superficial cells are self-renewing progenitors that are capable of maintaining the

250 ys, most individual tip cells behave as self-renewing progenitors, some of whose progeny remain at th

251 nce requires stem cell populations that self-renew, proliferate, and differentiate.

252 ong-lived basal cell population able to self-renew, proliferate, and generate differentiated cells, c

253 it into a leukemic stem cell (LSC) that self-renews, proliferates, and differentiates to give rise to

254 A concurrent increase in self-renewing proliferation leading to a twofold to fourfold

255 Revaccination may renew protection.

256 eir opinions on the promises and pitfalls of renewed psychedelic research, with a focus on the develo

257 MS: The mammalian intestinal epithelium self-renews rapidly and homeostasis is preserved via tightly

258 proliferate and are therefore unable to self-renew, replacement of these cells depends on stem/progen

259 stem cell potential that allows them to self-renew, repopulate a damaged tissue, and then undergo dif

260 erent basic emotions has recently come under renewed scrutiny.

261 In self-renewing SCs, Foxc1 activates Nfatc1 and bone morphogene

262 for the first time a reproducible method for renewing solid electrodes whenever their morphology or c

263 the production of functional sperm from self-renewing spermatogonial stem cells (SSCs) in cell cultur

264 leukemic myeloblasts at an immature and self-renewing stage of development.

265 Multiple cell fates, including renewed stem cells and committed differentiating progeni

266 ry can be established and maintained in self-renewing stem cell compartments.

267 ence of WNT10A, and identify Wnt-active self-renewing stem cells in affected tissues including hair f

268 demic became an imperative for mobilization, renewed strategies for vector control, and biomedical re

269 rmacological landscape of NMDARs and offer a renewed structural framework for designing next-generati

270 ically, DYRK1A inhibition insulates the self-renewing subpopulation of human pluripotent stem cells f

271 ncer stem cells (CRCSC) comprise a rare self-renewing subpopulation that contributes to tumor mainten

272 ed that HCMV replicates in continuously self-renewing TBPC lines derived from the chorion and alters

273 f limbal stem cells (LSCs) that continuously renew the corneal epithelium.

274 etric division and neutral drift dynamics to renew the intestinal epithelium.

275 rns about water use for petroleum extraction renew the need to inventory water use for oil production

276 Here, we first renew the theory with a simple model based on the assump

277 n subjects with acute coronary syndromes has renewed the enthusiasm for the cholesterol hypothesis an

278 imaging, and neurophysiological studies have renewed the idea that the information processing within

279 ess in the field of cancer immunotherapy has renewed the urgency of the need for basic studies of imm

280 were then easily removed by the fluid flow, renewing the sensing surface for the next test.

281 s to ensure patient safety while continually renewing the surgical workforce.

282 stochemistry revealed that superficial cells renew their number by symmetric division, express mesenc

283 In contrast, extant mammals can either renew their teeth once (diphyodont dentition, as found i

284 measuring supramolecular interactions - have renewed their interest in water-mediated non-covalent in

285 nonical, Wnt pathway-dependent, rapidly self-renewing tissue, the regeneration of which is fueled by

286 ressed following cell division, more-rapidly renewing tissues could be at higher risk because of the

287 Cairns suggested that renewing tissues may reduce cancer risk by partitioning

288 omes in adult mouse intestine and other self-renewing tissues show fewer and distinct bivalent promot

289 lation, is well established in other rapidly renewing tissues such as the haematopoietic system.

290 icity and long-term complications in rapidly renewing tissues, including the gastrointestinal tract.

291 servations from the intestine and other self-renewing tissues.

292 roliferate to repair muscle tissue, and self-renew to replenish the satellite cell population.

293 witch between Mll2 and Set1A during the self-renewing-to-differentiation transition.

294 f p62 impaired breast cancer cells from self-renewing under anchorage-independent conditions, whereas

295 With the recent renewed understanding of glutamine metabolism involvemen

296 rodegenerative disorders promises to provide renewed understanding of the aetiology and pathogenesis

297 Moreover, while their ability to self-renew was resistant to SHH inhibitors, as has been previ

298 le-blind, placebo-controlled, phase 2 study (RENEW) was done at 33 sites in Australia, Canada, and Eu

299 Extinguished operant behavior can recover ("renew") when tested outside the extinction context.

300 od resources are quickly depleted and slowly renewed, yielding an uncertain spatial distribution of r