ライフサイエンスコーパス: renewal

1 ext after extinction in another context (ABA renewal).

2 aling, a key governor of satellite cell self-renewal.

3 tween AURKA and FOXM1, crucial for BCSC self-renewal.

4 ubpopulations of cells that support CSC self-renewal.

5 nic stem cells (mESCs) does not disrupt self-renewal.

6 source of sonic hedgehog (Shh) for taste bud renewal.

7 l expansion and differentiation during organ renewal.

8 for alveolar epithelial cell growth and self-renewal.

9 cell cycle progression, as well as stem cell renewal.

10 tion of the prelimbic cortex (PL) attenuates renewal.

11 uated RAS-ERK-dependent BTIC growth and self-renewal.

12 H activity rescued AMPKalpha1(-/-) MuSC self-renewal.

13 population for extended periods through self-renewal.

14 ner to promote ES cell pluripotency and self-renewal.

15 on for this pathway of hypoxia-mediated self-renewal.

16 integumentary organs form and undergo cyclic renewal.

17 aintenance of embryonic stem cell (ESC) self-renewal.

18 noma cells and has been linked to their self-renewal.

19 axis and enhances tumor stem-like cell self-renewal.

20 rase to promote p53 degradation and MPC self-renewal.

21 nd the adult heart is capable of modest self-renewal.

22 ng, a key determinant of satellite cell self-renewal.

23 SCs depend on Tcf1 and Lef1 factors for self-renewal.

24 ls plays a central role in tissue growth and renewal.

25 Like PHB, HIRA is required for hESC self-renewal.

26 al activator of genes that regulate CSC self-renewal.

27 of epidermal function, differentiation, and renewal.

28 zation, longevity, and the capacity for self-renewal.

29 99 as a critical regulator of stem cell self-renewal.

30 efficiency of mouse embryonic stem cell self-renewal.

31 dult mammalian bone marrow ensure blood cell renewal.

32 ependent of its catalytic domain in ESC self-renewal.

33 d river water), including a successive water renewal.

34 m by which T-UCR uc.173 regulates epithelial renewal.

35 ons producing daughter cells capable of self-renewal.

36 tenin/Hoxa9/Prmt1 in governing leukemic self-renewal.

37 es in apoptosis and impaired ability of self-renewal.

38 MB-HSCs to promote their quiescence and self-renewal.

39 e capacity involving more than cardiomyocyte renewal.

40 d signalling requirements for long-term self-renewal.

41 s dispensable for ESC proliferation and self-renewal.

42 cell, controls muscle stem cell (MuSC) self-renewal.

43 ved MLL-CSCs and helps sustain leukemic self-renewal.

44 DNA damage response (DDR) and inhibits self-renewal.

45 reased SCP/neurofibroma-initiating cell self-renewal, a surrogate for tumour initiation, and activate

46 Our data suggest that defective self-renewal ability and leukemogenesis of MLL-Af4 myeloid ce

47 counteracts H19-mediated glycolysis and self-renewal ability in vitro and in vivo.

48 ve inhibition of the tumorigenicity and self-renewal ability of BCSCs.

49 opic overexpression of p62 enhanced the self-renewal ability of breast cancer cells in vitro.

50 duces sphere formation and inhibits the self-renewal ability of breast cancer cells, resulting in an

51 al for maintaining the stemness and the self-renewal ability of CSCs, resulting in the reduction of h

52 l human epidermal cells differ in their self-renewal ability.

53 s, and impairs haematopoietic stem-cell self-renewal activity and regenerative potential.

54 POT1a protein prevents DDR, maintained self-renewal activity and rejuvenated aged HSCs upon ex vivo

55 merization, Sox2 heterodimerization and self-renewal activity.

56 ed to the hematopoietic stem cell (HSC) self-renewal agonist UM171.

57 ) pathway transcriptional activator and self-renewal agonist, and promotes immunomodulatory drug resi

58 pathway is crucial for intestinal stem cell renewal and aberrant WNT signaling is an early event in

59 eterogeneous and whether differences in self-renewal and activation reflected differential kinetics a

60 cells (CSCs) requires neutralization of self-renewal and chemoresistance, but these phenotypes are of

61 dge of the population structure and how self-renewal and de novo influx contribute to the maintenance

62 quires establishing the rules underlying the renewal and death of peripheral T cells.

63 ional changes associated with stem cell self-renewal and differentiation and followed the maturation

64 xerts control over the decision between self-renewal and differentiation at the transcriptional, post

65 CSCs), a subset of tumor cells with the self-renewal and differentiation capabilities, in therapeutic

66 orphology, gene expression and in vitro self-renewal and differentiation capacity of human tips.

67 The balance between self-renewal and differentiation ensures long-term maintenanc

68 progeny, which promotes translation of self-renewal and differentiation factors by directly binding

69 show that Aub binds the mRNAs encoding self-renewal and differentiation factors in cultured GSCs.

70 hematopoietic stress changes the balance of renewal and differentiation in these homeostatic cells.

71 The balance between HSC self-renewal and differentiation is maintained by various int

72 heir proper size, the processes of stem cell renewal and differentiation must be tightly regulated.

73 Although the mechanisms that balance self-renewal and differentiation of a stem cell lineage have

74 Controlling self-renewal and differentiation of SSCs could apply to treat

75 enables quantitative assessment of the self-renewal and differentiation patterns of these cells in a

76 ult mouse airway basal cells results in self-renewal and differentiation phenotypes.

77 Given their unique function in self-renewal and differentiation potential, stem cells might

78 e target cells, resulting in defects in cell renewal and differentiation processes which lead to mali

79 rs tightly regulate the balance between self-renewal and differentiation to give rise to all nephron

80 /progenitor cells (MSPCs) undergo rapid self-renewal and differentiation, contributing to fast skelet

81 mice revealed that ZFP521 regulates HSC self-renewal and differentiation.

82 ogonial stem cells (hSSCs) must balance self-renewal and differentiation.

83 trol transcription of genes involved in self-renewal and differentiation.

84 d balance between renal progenitor cell self-renewal and differentiation.

85 the transcription of genes involved in self-renewal and differentiation.

86 our ability to control pluripotent cell self-renewal and differentiation.

87 ion of Ngn3 governs the switch between their renewal and differentiation.

88 are mediated by programs of adult stem cell renewal and differentiation.

89 AP-ROS-TGF-beta-p38(MAPK) balances HSPC self-renewal and differentiation.

90 s tissues with efficient capability for self-renewal and differentiation.

91 key transcription factor for basal cell self-renewal and differentiation: SOX2.

92 motes a preleukemic state with enhanced self-renewal and dysregulated differentiation.

93 Prostaglandin E2 (PGE2) stimulates HSC renewal and engraftment through, for example, induction

94 Wnt/beta-catenin signalling to enhance self-renewal and expand the ISC compartment.

95 Methods for maintaining self-renewal and expansion in vivo of PGCs and controlling fo

96 cells in vitro, indicating reduction of self-renewal and expansion of neural progenitors by IE2.

97 The vascular niche drives a robust self-renewal and expansion phase of rEC-HSCs (days 20-28).

98 genes were implicated in ESC and cancer self-renewal and fell into two distinct groups: those depende

99 Cs lacking Oct1 show normal appearance, self-renewal and growth but manifest defects upon differentia

100 Here we report that Aub promotes GSC self-renewal and GSC progeny differentiation.

101 findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression analysis o

102 role is nonredundant in regulating HSC self-renewal and in myeloid transformation.

103 ed LIF induction commensurate with GCSC self-renewal and inhibition of differentiation.

104 with a high glycolytic flux supporting self-renewal and inhibition of glycolysis stimulating differe

105 idermal PRMT1 loss abolished progenitor self-renewal and led to premature differentiation.

106 expressed in GSCs and is essential for self-renewal and lineage commitment in vitro.

107 key master regulator for hematopoietic self-renewal and lineage specification-requires HDAC activity

108 These cells were also capable of self-renewal and maintained their phenotypic and functional c

109 stem cell fate ensuring adequate NSPCs self-renewal and maintenance during development.

110 ys an important role in regulating aNSC self-renewal and maintenance in the adult brain, which may ha

111 ation, indicating that JNK promotes CSC self-renewal and maintenance in TNBC.

112 of their activity is necessary for the self-renewal and maintenance of muscle stem cells (satellite

113 itional Jak1 loss in HSCs reduces their self-renewal and markedly alters lymphoid/myeloid differentia

114 well established regulator of stem cell self-renewal and neurogenesis.

115 bd3/NuRD axis-mediated control of NPCs' self-renewal and neuronal differentiation during mammalian co

116 nd the complex plays a critical role in self-renewal and neuronal differentiation of NPCs.

117 nding proteins act to promote stem cell self-renewal and oppose cell differentiation predominantly th

118 hesized to account for the 'stemness' - self-renewal and pluripotency - shared between embryonic stem

119 in controlling embryonic stem (ES) cell self-renewal and pluripotency.

120 that Twist overexpression augments CSC self-renewal and population and that Skp2 inhibition reverts

121 OX1 over-expression moderately promotes self-renewal and proliferation in GSCs.

122 more tumorigenic, had a higher rate of self-renewal and proliferation, and were more sensitive to a

123 s and conventional cell lines decreases self-renewal and proliferative capacity in vitro and tumor in

124 one deacetylation in stem cells enables self-renewal and rapid restriction of developmental potential

125 A high demand is placed on renewal and regeneration of the skin's barrier in order

126 es a model for the study of ectodermal organ renewal and regeneration.

127 aged muscles, decreased satellite cell self-renewal and regenerative potential, and increased neurom

128 As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas the occurren

129 ells (ECs) from young mice promoted HSC self-renewal and restored immune cell content in aged mice.

130 regulating ESC differentiation but not self-renewal and suggests the existence of context-specific H

131 addition, the RB family is required for self-renewal and survival of human embryonic stem cells (hESC

132 tasis depends on a balance between stem cell renewal and terminal differentiation.

133 lear role in hESCs that is required for self-renewal and that it acts with HIRA in chromatin organiza

134 he homeostatic process of colonic epithelium renewal and the epithelial barrier function.

135 as a unique signaling node that drives self-renewal and therapeutic resistance through a bifurcating

136 been shown to significantly promote GSC self-renewal and tumor progression.

137 xpressed and participated in stem cells self-renewal and tumorigenesis initiating of prostate cancer.

138 regulation plays key roles in stem cell self-renewal and tumorigenesis.

139 , the Wnt pathway can promote stem cell self-renewal and/or direct lineage commitment.

140 ng (FC) paradigms (signaled, unsignaled, and renewal) and two context-guided object recognition tasks

141 tem cells whose quiescence, activation, self-renewal, and differentiation are influenced by oxygen su

142 homeostatic balance between quiescence, self-renewal, and differentiation of HSCs is strongly depende

143 ven by BCL-XL modulation of RAS-induced self-renewal, and during which apoptotic resistance is not ne

144 actors, is necessary and sufficient for self-renewal, and is suppressed by TLR4 overexpression in CSC

145 og signaling specifies tissue patterning and renewal, and pathway components are commonly mutated in

146 order to specify survival, DNA repair, self-renewal, and proliferation.

147 ar requirements for genome stability, tissue renewal, and tumorigenesis as well as new perspectives o

148 study, we show that differentiation and self-renewal arise as opposing outcomes of sibling CD4(+) T c

149 red for normal haematopoietic stem cell self-renewal, Asxl2 loss promoted AML1-ETO leukemogenesis.

150 acquired mucosal immune systems, epithelial renewal, barrier integrity, and mucosal vascularisation

151 We quantified intestinal epithelial renewal based on BrdU incorporation, villus height and c

152 ha/2alpha dKO myoblasts exhibit reduced self-renewal but more pronounced differentiation under hypoxi

153 ranscriptional memory in regulating CSC self-renewal, but also reveal a novel molecular network media

154 oteins are unable to induce Lgr5(+) ISC self-renewal, but instead confer a basal competency by mainta

155 Aub controls GSC self-renewal by preventing DNA-damage-induced Chk2 activation

156 mucosa and stimulates intestinal epithelial renewal by reducing levels of miRNA195.

157 ly, PL inactivation specifically affects ABA renewal by reducing responding in the conditioning conte

158 ts suggest that Icaritin enhances mESCs self-renewal by regulating cell cycle machinery and core plur

159 bryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues.

160 Hence, invasion and self-renewal capabilities were strongly decreased.

161 ery significant role for PRMT5 in GBMNS self-renewal capacity and proliferation.

162 ly EVP cells and not TA and D cells had self-renewal capacity as demonstrated by colony-forming capac

163 We also demonstrate functional self-renewal capacity for CD34(+) cells to drive the developm

164 , decreased bone mass, and impaired MSC self-renewal capacity in mice.

165 SCs proliferation while maintains their self-renewal capacity in vitro and pluripotency in vivo.

166 self-sustained clocks, compromises the self-renewal capacity of mammary epithelia.

167 have shown that Hh inhibitors block the self-renewal capacity of SCLC cells, the lack of activating p

168 f epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compa

169 HSCs have a transcriptome and long-term self-renewal capacity similar to those of adult haematopoieti

170 e need for mesenchymal support, exhibit self-renewal capacity, and display additional AEC2 functional

171 decreased hematopoietic stem cell (HSC) self-renewal capacity, myeloid skewing, and immune cell deple

172 ipotency-associated gene expression and self-renewal capacity.

173 Grp78 double mutant stem cells had lost self-renewal capacity.

174 rug imatinib mesylate, and differential self-renewal capacity.

175 s the disease, exhibiting properties of self-renewal, cell cycle quiescence, and chemoresistance.

176 rine mediators of glioma stem-like cell self-renewal could potentially contribute to the treatment of

177 potency '2i' media, suggesting that the self-renewal defect is mediated through pluripotency network

178 he expression of genes critical for HSC self-renewal, differentiation and apoptosis in Lin(-)cKit(+)

179 interactions with their niche influence self-renewal, differentiation and drug resistance, although t

180 nto how these networks control potency, self-renewal, differentiation, and aging of highly proliferat

181 chy, from EVP to TA to D, as defined by self-renewal, differentiation, and molecular profiling of an

182 aberrant hematopoietic stem cell (HSC) self-renewal/differentiation, implicating TET2 as a master re

183 ion, differentiation, localization, and self-renewal during homeostasis.

184 ssential for CML stem cell survival and self-renewal during imatinib mesylate (IM) treatment.

185 ated that PL inactivation attenuated the ABA renewal effect in the same animals, replicating earlier

186 the level of proliferation, cell cycle, self-renewal, epithelial-mesenchymal transition, invasion, an

187 as the intestinal epithelium undergoes self-renewal every 4-7 days through a continuous process of c

188 ures: Hox gene overexpression, enhanced self-renewal, expansion of hematopoietic progenitors, and mye

189 these regulations, the initial and periodic renewal expenses for the registration of diagnostic alle

190 lian stem cells by distinct priming and self-renewal factors, with broad implications for precise con

191 ationally controlling the expression of self-renewal factors.

192 t depend on a balance between stem cell self-renewal for continuity and the formation of progenitors

193 Disrupting Lgr5(+) ISCs triggers epithelial renewal from Bmi1(+) cells, from secretory or absorptive

194 phan residues ablating dimerization and self-renewal function completely.

195 esults suggest that, rather than attenuating renewal generally, PL inactivation specifically affects

196 whereby FOXO1 binds to multiple crucial self-renewal genes and is required for their activation.

197 ly updated and upgraded since its last major renewal in 2007.

198 ion of anchorage-independent growth and self-renewal in 3D-spheroid conditions.

199 tion acquisition or memory, but blocked fear renewal in a novel context.

200 mice, and furthermore protected against fear renewal in BL6 mice.

201 (Hh) signaling regulates cell fate and self-renewal in development and cancer.

202 ut distinct roles to fuel unconstrained self-renewal in GBM stem cells via transcriptional control of

203 required for maintaining satellite cell self-renewal in hypoxic environments.

204 ate that light contributes to visual-pigment renewal in mammalian rods and cones through a non-enzyma

205 d S100A4 as a critical regulator of GSC self-renewal in mouse and patient-derived glioma tumorspheres

206 advance our understanding of progenitor cell renewal in other cell types/organ systems in which Myc a

207 s a critical mechanism driving aberrant self-renewal in preleukemic cells expressing the t(8;21)-asso

208 Growth Factor (FGF) signaling promotes self-renewal in progenitor cells by encouraging proliferation

209 an important role in the regulation of self-renewal in stem cells.

210 amined the effects of PL inactivation on ABC renewal in the same rats.

211 d the hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be

212 poietic stem and progenitor cell (HSPC) self-renewal in vitro and in vivo.

213 s of p38(MAPK) activity and loss of HSC self-renewal in vivo.

214 Aberrant proliferation, symmetric self-renewal, increased survival, and defective differentiati

215 bit VEGF secretion, decreased stem cell self-renewal, inhibited tumor growth, and increased the survi

216 ll molecules in modulation of stem cell self-renewal is a promising approach to expand stem cells for

217 The enhancement of mESCs self-renewal is characterized by increased population in S-ph

218 tiation versus returning to quiescence (self-renewal) is crucial for tissue repair.

219 Upon isolation and culture in NPC renewal medium, younger NPCs displayed a higher glycolys

220 e similar signaling cascades that drive self-renewal, migration, differentiation or a combination of

221 d owing to persistent activation of the self-renewal network and a lack of termination cytokines that

222 ucible Irf8 and beta-catenin progenitor self-renewal network control the transient formation of regen

223 Furthermore, we found that cartilage renewal occurs as the progeny of superficial cells fully

224 In both of these scenarios, cardiomyocyte renewal occurs via the proliferation of pre-existing car

225 Rapid epithelial renewal occurs, but the specific cell of origin that sup

226 tional pathways that mediate growth and self-renewal of alveolar type 2 progenitor cells, including I

227 Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell ty

228 can undergo a low level of new cardiomyocyte renewal of approximately 1% per year, which is primarily

229 nal IR-induced injury by regulating the self-renewal of B1a cells.

230 breast and other cancers, and promotes self-renewal of cancer stem-like cells.

231 espan, the mammalian heart undergoes limited renewal of cardiomyocytes.

232 form tumorspheres, indicating a reduced self-renewal of CCSC due to reduced levels of O-GlcNAc.

233 factor CNOT3, which is known to control self-renewal of embryonic stem cells (ESC).

234 CT4) supports long-term LIF-independent self-renewal of ES cells cultured in media containing fetal b

235 ladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulating pr

236 of Transcription 3) axis to enhance the self-renewal of glioma stem-like cells.

237 oid malignancies by conferring enhanced self-renewal of hematopoietic stem and progenitor cells but t

238 hibitin (PHB) as an essential factor in self-renewal of human embryonic stem cells (hESCs).

239 tainability leaders rests upon a fundamental renewal of humans' connection to the natural world.

240 and environmental chemistry have promoted a renewal of interest in the role of vitamins in governing

241 le for AC in maintaining malignancy and self-renewal of invasive melanoma cells.

242 development and maintenance of AML and self-renewal of leukemia stem/initiation cells (LSCs/LICs).

243 fferent materials have been investigated for renewal of lost supporting periodontal structures and te

244 itin, a phytoestrogen molecule enhances self-renewal of mouse embryonic stem cells (mESCs).

245 uggesting that betaENaC plays a role in cell renewal of mouse MG.

246 ation of specific factors that regulate self-renewal of normal and cancer stem cells remains limited.

247 follicle regeneration where it controls the renewal of rapidly proliferating epithelial (matrix) pro

248 nents from natural plant to improve the self-renewal of SSCs.

249 s that account for the joint maintenance and renewal of stem and transit cells, also competing proces

250 oliferation and differentiation and the self-renewal of stem cells by inducing beta-catenin-dependent

251 understanding the mechanisms that drive self-renewal of stem cells.

252 nting cell (APC) types that sustain the self-renewal of TH17 cells.

253 73 levels by LNA-anti-uc.173 in mice reduced renewal of the intestinal epithelium.

254 Renewal of the medium resulted in linear sorption isothe

255 responsible for the dependence of taste cell renewal on gustatory innervation, neurotrophic support o

256 hes receptors essential for maintaining self-renewal on the cytoplasmic membrane to cope with low lig

257 oss does not contribute to enhanced HSC self-renewal or cooperate with Flt3-ITD to induce myeloid tra

258 xogenous molecules to control stem cell self-renewal or differentiation has arrived at natural produc

259 In renewal paradigms, extinguished behavior recovers when t

260 Understanding and blocking the self-renewal pathway of preleukemia stem cells could prevent

261 self-renewal versus amniogenesis under self-renewal-permissive biochemical conditions.

262 utophagy; augmentation of GBM stem cell self-renewal; possible implications of GBM-endothelial cell t

263 ACF significantly inhibited growth and self-renewal potential of several glioblastoma neurosphere li

264 akness, we propose the Cascading Alternating Renewal Process (CARP) to forecast interconnected global

265 MLL-Af4 activated a self-renewal program in a lineage-dependent manner, showing t

266 t tumor-initiating cells can co-opt the self-renewal program of endogenous stem cells as a means of e

267 iption factor Myc to activate the progenitor renewal program.

268 ction of deregulated genes that perturb self-renewal, proliferation, and differentiation.

269 ion of cancer cells that are capable of self-renewal, proliferation, differentiation, plastic adaptat

270 domains are required to drive increased self-renewal properties.

271 hematopoietic stem cells with improved self-renewal properties.

272 We use a mean-field quasi-renewal (QR) approximation that decomposes spike history

273 atopoietic stem cells (HSCs), including self-renewal, quiescence, differentiation, and migration.

274 we show that cyclin D2-induced cardiomyocyte renewal reduced myocardial remodeling and dysfunction af

275 The rats exhibited ACD renewal regardless of PL inactivation.

276 ck differentiation and promote aberrant self-renewal remain unclear.

277 While the exact mechanism for this renewal remains unclear, two possibilities have been pro

278 f the phosphatidylinositol 3-kinase/Akt self-renewal signaling pathway or stimulation of differentiat

279 nt-derived survival, proliferation, and self-renewal signals for engraftment of normal and malignant

280 coordination of colonic epithelial cell self-renewal, suggesting this factor as a new biomarker for m

281 ssion of every Wnt9b/beta-catenin progenitor renewal target assessed as well as for proper nephron en

282 enable Nanog to confer LIF-independent self-renewal, the mechanism of dimerization and the effect of

283 al stem cell differentiation as well as self-renewal, thus specifying a regenerating epithelial patte

284 on and their consequences for stem cell self-renewal, tissue homeostasis, and regeneration.

285 Asymmetric division enables self-renewal to be coupled to production of differentiated CD

286 esenchymal transition (EMT) program and self-renewal traits (CSCs) via various signaling pathways.

287 lase Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm i

288 esis and neuroprotection, levels of pro-self-renewal transcripts in hematopoietic and patient-derived

289 Microglial self-renewal under steady state conditions constitutes a stoc

290 of developmental pathways in promoting self-renewal versus a pathological response to tissue injury.

291 factors act as a switch to toggle hPSC self-renewal versus amniogenesis under self-renewal-permissiv

292 as has been previously suggested, this self-renewal was instead WNT-dependent.

293 incisor as a model of stem cell-based tissue renewal, we found that the transcriptional cofactors YAP

294 fen/muscimol (B/M) during testing attenuates renewal when tested in the original acquisition context

295 A similar inactivation has no impact on renewal when testing occurs in a new, rather than the or

296 eta is sufficient to maintain mouse ESC self-renewal, whereas GSK3alpha inhibition promotes mouse ESC

297 cancer-initiating cells and to undergo self-renewal, which is suggestive of a key role for AC in mai

298 s, allowing for tissue turnover, repair, and renewal while simultaneously inhibiting the release of s

299 Somatic progenitors sustain tissue self-renewal while suppressing premature differentiation.

300 ow an age-dependent capacity to balance self-renewal with differentiation.