ライフサイエンスコーパス: repair

1 intestinal inflammation and impaired tissue repair.

2 LB2-BRCA2 interaction, thereby inhibiting HR repair.

3 for efficient HR-mediated chromosome damage repair.

4 NTMT1 regulates cell mitosis and DNA damage repair.

5 are required during normal shell growth, and repair.

6 e domain of HELLS is required to promote DSB repair.

7 ancer that regulates PI3K activation and DNA repair.

8 al deficit even after advanced microsurgical repair.

9 scan) were randomized to PFC versus bridged repair.

10 otein for general chromosome maintenance and repair.

11 en transportation to host defense, to injury repair.

12 potentially other mutagenic pathways of DSB repair.

13 ed switch region in cells ablated for uracil repair.

14 , activating antioxidants, and enhancing DNA repair.

15 hat is essential for host defense and tissue repair.

16 s homologous recombination (HR)-mediated DNA repair.

17 -17~92 cluster, are upregulated during wound repair.

18 as an understudied therapeutic for fracture repair.

19 mitment to nucleotide incorporation and thus repair.

20 lantation option for lower eyelid retraction repair.

21 uated XRCC1-LIG3 recruitment and delayed DNA repair.

22 ntrol of self-renewal during skeletal muscle repair.

23 ing the brain in health and assisting in its repair.

24 of the RAD50 hook properly functions in DNA repair.

25 r mechanisms hold great potential for tissue repair.

26 T cells using CRISPR-based homology-directed repair.

27 mismatch repair, and DNA double-strand break repair.

28 f SSCs that mediate skeletal maintenance and repair.

29 ) controls histone degradation to assist DNA repair.

30 ing the protein-basis of GBM maintenance and repair.

31 ons in 31 genes involved in DSB response and repair.

32 ovel Mmp12 (+) macrophage subset acts during repair.

33 re widely used in cellular therapy for joint repair.

34 and outcomes during retinal detachment (RD) repair.

35 sure and inflammation during cutaneous wound repair.

36 MJ) reinnervation following nerve injury and repair.

37 y of DNA replication, transcription, and DNA repair.

38 gent requirements for Ino80-dependent HR DNA repair.

39 in end target muscles after nerve injury and repair.

40 id cohesion, chromosome segregation, and DNA repair.

41 s (DMM) and after acute cartilage injury and repair.

42 ical step in skeletal muscle development and repair.

43 to the role of mechanosensing in spinal cord repair.

44 e potential targets of transcription-coupled repair.

45 oping applications for human tracheal tissue repair.

46 genome structure integrity during DNA damage repair.

47 , affects ATP production, and attenuates DNA repair.

48 ce and contributed to airway homeostasis and repair.

49 CD8 T cell activation, as well as epithelial repair.

50 pyrimidine dimer crosslinks to govern their repair.

51 n AAA repairs, and total open juxtarenal AAA repairs.

52 After undergoing inguinal hernia repair, 1.5% of patients developed new persistent opioid

53 ound complications, whereas recurrent hernia repair (2.69, 1.14-6.35), biologic mesh (3.1, 1.67-5.75)

54 To repair a DNA double-strand break by homologous recombina

55 nd 2-oxoglutarate-dependent dioxygenase that repairs a wide range of alkylated nucleobases in DNA and

56 y bypass grafting, abdominal aortic aneurysm repair, abdominal aortic aneurysm repair, total hip arth

57 macrophage differentiation, self-renewal and repairing ability, as evidenced by the downregulation of

58 To accomplish these repair activities, APE1 must recognize and accommodate s

59 of acute kidney injury, to incomplete kidney repair after acute kidney injury and to chronic kidney d

60 2); Dsc2 (fl/fl)) exhibited impaired mucosal repair after biopsy-induced colonic wounding and recover

61 R), but HR can also perform post-replicative repair after bypass of the obstacle.

62 se a role for Gdf5 in tissue remodelling and repair after injury, which may partly underpin its assoc

63 n maintenance of the vascular system and the repair after injury.

64 opment of therapies for enhancing intestinal repair after injury.

65 xhaustive Search) error-correcting code that repairs all three basic types of DNA errors: insertions,

66 1 and SETD2), DNA methylation and DNA damage repair, all of which have been associated with clinical

67 , vericiguat, and transcatheter mitral valve repair, all of which incrementally improve prognosis bey

68 pelin as a key mediator of coronary vascular repair and a pharmacotherapeutic target for immune-media

69 APE2 plays essential roles in base excision repair and ATR-Chk1 DNA damage response (DDR) pathways,

70 responses including ESCRT-dependent membrane repair and autophagic removal of damaged organelles.

71 w that Pavarotti also functions during wound repair and confirm that while Pavarotti, Tumbleweed, and

72 Tailored decision making for elective repair and considering the aforementioned risk factors f

73 ammalian cells involves post-replicative gap repair and define a role for PrimPol in HR-mediated DNA

74 t identified the double-stranded break (DSB) repair and Fanconi anemia (FA) factors active in the S/G

75 tudies demonstrate that EGF promotes HSC DNA repair and hematopoietic regeneration in vivo via augmen

76 uncovers important roles for HDAC1 in 8-oxoG repair and highlights the therapeutic potential of HDAC1

77 implicated in DNA double strand break (DSB) repair and in resolving replication stress.

78 ation of A3B expression by activation of DNA repair and NF-kappaB pathways could promote cancer mutat

79 tions to maintain tissue homeostasis, tissue repair and organismal health.

80 d used immunohistochemistry to analyze their repair and phagocytic properties.

81 rates (Drosophila) offer insights into brain repair and quiescence regulation that are difficult to o

82 -maintenance for their functions, and tissue repair and regeneration in renal diseases.

83 ses to injury, and new methods to study lung repair and regeneration.

84 obust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once

85 ntributes to oligodendrocyte development and repair and reveal a new role for Nedd4 in glial biology.

86 eal that ATRX has an effect on telomeric DSB repair and that this role involves both telomere cohesio

87 hat interfere with transcription, DNA damage repair and the cell cycle.

88 PC-derived exosome dysfunction in myocardial repair and to investigate if modification of specific ex

89 (PARP-1) is a nuclear enzyme involved in DNA repair and transcription regulation, among other process

90 and slipped hairpins during DNA replication, repair and/or recombination may contribute to TR expansi

91 ted thymidine lesions are known to be poorly repaired and persist in mammalian tissues.

92 extrusion, drug degradation, and DNA damage repair) and using rate constants of these reactions to e

93 ation process involved in transcription, DNA repair, and cell division.

94 egulated gene expression, recombination, DNA repair, and chromosome segregation during mitosis.

95 at involve ssDNA, including DNA replication, repair, and damage signaling.

96 ision repair, base excision repair, mismatch repair, and DNA double-strand break repair.

97 A access for transcription, replication, DNA repair, and epigenetic modification, chromatin forms the

98 throughout the biosphere in DNA restriction, repair, and homing.

99 e entry is essential for development, tissue repair, and immune defences.

100 r the IL-33-ST2 axis in bronchial epithelial repair, and implicate ST2 in myeloid cell differentiatio

101 imely resolution of inflammation, successful repair, and kidney homeostasis during aging.

102 ome inactivation, imprinting, and DNA damage repair, and mutations in SMCHD1 can cause facioscapulohu

103 (PCNA) and functions in genome replication, repair, and recombination.

104 c hotspots, impaired DNA double-strand-break repair, and reduced crossover number.

105 l's average annual volume for total open AAA repairs, and total open juxtarenal AAA repairs.

106 olution of intestinal inflammation and wound repair are active processes that mediate epithelial heal

107 le, defects in homologous recombination (HR) repair arise in cancer cells through inherited or acquir

108 red myocardium and are essential for cardiac repair as they can adopt both pro-inflammatory or repara

109 irtually all MM subgroups have activated DNA repair-associated signature as a prominent late mutation

110 ites and will be valuable tools to study DSB repair at a local and genome-wide scale.

111 paper evaluated historical changes of ATAAD repair at Stanford University since the establishment of

112 ding an association with nucleotide excision repair, base excision repair, mismatch repair, and DNA d

113 sensitive to inhibitors of the base excision repair (BER) protein poly (ADP-ribose) polymerase (PARP)

114 (DSBs) by perturbing canonical base excision repair (BER).

115 ially preventing DNA incision by Bax1 during repair bubble extension.

116 SB-adjacent DNA is a key step in meiotic DSB repair, but this process has remained understudied.

117 in an allele-specific manner, leading to DNA repair by gene conversion or NHEJ.

118 ise to DSBs indirectly, but also promote DSB repair by inducing R-loops, revealing an unexpected inte

119 s KAT5 depletion rewires double strand break repair by promoting 53BP1 binding to double-strand break

120 atomical outcomes of retinal detachment (RD) repair by vitrectomy and perfluorocarbon liquid (PFCL) t

121 alled replication forks can be restarted and repaired by RAD51-mediated homologous recombination (HR)

122 oliferation of tubular epithelial cells, but repair can also lead to fibrosis and progressive kidney

123 tion stress, however successful fragile site repair cannot be calculated using existing techniques.

124 NAD(+) levels also affect DNA repair capacity as NAD(+) is a substrate for PARP-enzyme

125 inducing genome instability and changing DNA repair capacity in prostate cancer cells.

126 these same serum samples rescues sarcolemmal repair capacity.

127 ular NAD(+) content and NAD(+)-dependent DNA repair capacity.

128 om Syndrome (BS) are disorders of DNA damage repair caused by biallelic disruption of the WRN or BLM

129 Injury and repair caused by the oxygen-induced retinopathy model re

130 normal levels, decreases cDC1 apoptosis, and repairs cDC1 maturation to drive superior control of tum

131 e find that genes related to cell cycle, DNA repair, cell death, the IGF1 pathway, and immunity are u

132 involved in regulating gene expression, DNA repair, chromatin remodeling, apoptosis, and cell prolif

133 d UVSSA and the manner in which the core DNA repair complex, including transcription factor IIH (TFII

134 AR procedures per pathology varied, with TAA repair constituting from 40% of TEVARs in the US to 72%

135 models, whether and how grafts functionally repair damaged neural circuitry in the adult brain is no

136 lyse 2,717 genomes from wild-type and 53 DNA repair defective backgrounds, exposed to 11 genotoxins,

137 ibute to genetic instability in DNA mismatch repair-defective human tumors.

138 hese patient cell lines displayed DNA damage repair defects that were comparable to previously observ

139 nograft models that carry certain DNA damage repair deficiencies.

140 cellular and genetic context nominates a DNA repair dependency in KRAS-mutant cells, mediated by a ne

141 which allows for labeling of replicating or repaired DNA.

142 ife, including transcribing, replicating and repairing DNA.

143 tem plays critical roles in promoting tissue repair during recovery from neurotrauma but is also resp

144 and Pebble are all used during this cellular repair, each has a unique localization pattern and knock

145 type TTK rescued both radioresistance and HR repair efficiency after TTK knockdown; however, reintrod

146 uanine glycosylase (OGG1) is a base excision repair enzyme responsible for the recognition and remova

147 inflammation, cellular infiltration, tissue repair enzymes, pathways of oxidative stress, and altere

148 development, but it also mediates DNA damage repair essential to proliferating neural progenitor cell

149 Among RRD patients who underwent repair, estimated variance coefficients were 0.07 for ge

150 on missense variants in the key DNA mismatch repair factor MSH2.

151 amage and promotes the accrual of downstream repair factors at damaged chromatin.

152 DSB) repair pathways in human cells, how DNA repair failures can lead to human disease, and how PARP

153 e biological processes, including DNA damage repair (Fanconi anemia), telomere maintenance (dyskerato

154 Cs) may promote cognitive recovery and brain repair, focusing on the drug metformin, in parallel rode

155 nal stem cell differentiation and epithelial repair following injury, which depends on peroxisomes an

156 cell-cycle progression delay and slowed DNA repair following radiation, enhancing colony and sphere

157 rwent vitrectomy using PFCL tamponade for RD repair from causes such as giant tear, chronic RD, or RD

158 els and tested the impact of ATM loss on DNA repair function and therapeutic sensitivities.

159 DNA repair GAs are relatively frequent in GBC and associated

160 an analog-sensitive CDK12 reduces DNA damage repair gene expression, but selective inhibition of endo

161 ed Pol II CTD phosphorylation and DNA damage repair gene expression.

162 Direct DNA repair gene GAs were identified in 109 patients (14.2%),

163 pathogenic germline variants in DNA mismatch repair genes.

164 is protein pool to protect exposed ssDNA and repair genomic loci affected by DNA damage.

165 ever its incidence following inguinal hernia repair has not been described.

166 that RNF8 is important for homology-directed repair (HDR) independently of KU, which appears linked t

167 ) added at the ends of the homology-directed repair (HDR) template interact with Cas9 ribonucleoprote

168 te into embryos to trigger homology directed repair (HDR).

169 ntrol, while ablation results in altered ECM repair/homeostasis and conventional outflow physiology.

170 omote parasitic immunity and initiate tissue repair; however, they can also result in immunopathologi

171 , cell cycle, cell death, cell motility, DNA repair, immune response, two phosphorylation pathways, a

172 gastroplasty in 4 (3.1%), and primary suture repair in 20 (15.6%).

173 Increased intersister repair in absence of Mph1 triggers a shift among remaini

174 Our data show that endogenous DNA gap repair in E coli supports efficient multiplex site-direc

175 ntial enzyme involved in DNA replication and repair in eukaryotes.

176 G, and that current models for etheno lesion repair in humans should be revised.

177 tails identifies a distinct pattern of wound repair in mammals while exhibiting features in common wi

178 ed to examine mechanisms of regeneration and repair in organs.

179 Cartilage repair in osteoarthritic patients remains a challenge.

180 elling activities are required for efficient repair in specific genomic contexts.

181 es or the balance of inflammation and tissue repair in the resolution of infection.

182 lays a crucial role in organ development and repair, in wound healing and in numerous pathological pr

183 is not required for single-strand annealing repair involving extensive end resection.

184 The Fanconi anaemia pathway of ICL repair is activated when a replication fork stalls at an

185 Efficient wound repair is critical to reestablish the mucosal barrier an

186 show that WDR26-mediated inhibition of wound repair is mediated through the inhibition of Rac family

187 he concept that homologous recombination DNA repair is not an all-or-nothing concept, but a spectrum,

188 ge response, but its mechanistic function in repair is not well understood.

189 py and chemotherapy by inhibiting DNA damage repair is proposed as a therapeutic strategy to improve

190 The repair is sufficient to support fertility and maintain h

191 y and in the limited ability of the organ to repair itself.

192 A interstrand crosslinks and determine their repair mechanism in Xenopus egg extracts.

193 excision repair (TC-NER) is an important DNA repair mechanism that removes RNA polymerase (RNAP)-stal

194 Approaches that enable innate repair mechanisms hold great potential for tissue repair

195 pproaches to restore the impaired epithelial repair mechanisms in COPD, which is still a high medical

196 onuclease, followed by mending of the DNA by repair mechanisms inherent in cells.

197 We show that although end-joining repair mechanisms may cause the system to break down, un

198 cular control, including integrity check and repair mechanisms.

199 th nucleotide excision repair, base excision repair, mismatch repair, and DNA double-strand break rep

200 ns, most notably BRCA1/2 mutations, mismatch repair (MMR) deficiencies or NTRK1-3 fusions, have shown

201 LE tumor variants, with and without mismatch repair (MMR).

202 f cellular functions, including roles in DNA repair, mRNA processing, and regulation of RNA polymeras

203 ing rapid assays to quantify DNA damage, DNA repair, mutations, and cytotoxicity is broadly relevant

204 Nucleotide excision repair (NER) in eukaryotes is orchestrated by the core f

205 Nucleotide excision repair (NER) is a major DNA repair pathway for a variety

206 women were included, of whom 2113 underwent repair of a primary ventral hernia.

207 es in both replication of the genome and the repair of a wide range of lesions.

208 However, the repair of acetaldehyde-induced crosslinks results in inc

209 ne the transient kinetics of recognition and repair of alkylated DNA by AlkB.

210 sistent with this, PNKP is implicated in the repair of both DNA single-strand breaks (SSBs) and DNA d

211 ltered mutational spectrum compared with the repair of cisplatin-induced crosslinks.

212 mechanisms that facilitate stabilization and repair of damaged sarcolemmal membranes following myocar

213 fficacy in BRCA1-deficient cells and altered repair of damaged telomeres, can be explained from this

214 ted during the homologous recombination (HR) repair of DNA double strand breaks (DSBs).

215 tic crossovers result from homology-directed repair of DNA double-strand breaks (DSBs).

216 e tumor suppressor BRCA1, is crucial for the repair of DNA interstrand crosslinks (ICL), a highly tox

217 monoubiquitination, an essential step in the repair of DNA interstrand crosslinks.

218 nse to injury, but they are also involved in repair of injury.

219 of the viral genome, which is formed by the repair of lesion-bearing HBV relaxed circular DNA delive

220 tric acid (CA) and tetracycline (TCN) on the repair of onlay bone grafts.

221 these LMC progenitors during maintenance and repair of PLVs, along with their function in other lymph

222 damage is thought to arise from the aberrant repair of spontaneous replication stress, however succes

223 Here we show that repair of the inactivated C16L/B22R gene of MVA enhances

224 e negative pressure device immediately after repair of the surgical incision (n = 816), or receive st

225 Upon repair of this polymorphism to the sequence present in Y

226 showed omega-3 fatty acid (omega-3)-mediated repair of unfolded protein response and here we show muc

227 tigate the impact of DNA damage response and repair on 3D genome folding using Hi-C experiments on wi

228 Surgical valve repair or replacement has been the standard of care for

229 ected medical therapy, surgical mitral valve repair or replacement, and, in the setting of advanced h

230 extracellular proteins required for growing, repairing or remodelling the nacreous shell layer, where

231 integrity and may, more broadly, predict DNA repair outcome in malignant cells.

232 We show that the most common repair outcome is microhomology-mediated end joining, wh

233 se that 53BP1 has evolved to avoid mutagenic repair outcomes and does so by controlling the processin

234 Here, we evaluate repair outcomes of a Cas9-induced double-strand break (D

235 of ZNF281 impairs the efficiency of the NHEJ repair pathway and decreases cell viability upon DNA dam

236 e strand breaks repair via homology-directed repair pathway and prostate tumorigenesis.

237 ole in the non-homologous end joining (NHEJ) repair pathway and the DNA damage response (DDR).

238 leotide excision repair (NER) is a major DNA repair pathway for a variety of DNA lesions.

239 y, either a DPC tolerance mechanism or a DPC repair pathway is essential for C. albicans to maintain

240 enic drivers and the DNA damage response and repair pathway warrant further prospective evaluation.

241 will highlight DNA double-strand break (DSB) repair pathways in human cells, how DNA repair failures

242 These results define the repair pathways of DNA interstrand crosslinks caused by

243 reatments that target RNA processing and DNA repair pathways simultaneously as effective cancer thera

244 remodelling enzymes facilitate different DNA repair pathways, during different stages of the cell cyc

245 etions differ in their dependencies on these repair pathways.

246 in disease-related spending on EVR and open repair patients 5 years after surgery.

247 After hip fracture repair, patients in hospitals with major decreases in LO

248 ed strong production of periostin during the repair phase of ischemia reperfusion.

249 , muscarinic receptors (mAChRs) regulate the repair phenotype of PSCs and are overactivated at diseas

250 The endogenous repair process can result in recovery after acute kidney

251 pyrimidinic (AP) site that initiates the DNA repair process.

252 hanism by which an enteric pathogen subverts repair processes by targeting stem cells during infectio

253 uclear and mitochondrial DNA replication and repair processes, preferentially unwinding RNA:DNA hybri

254 d-type and homologous recombination (HR) DNA repair-proficient cancers, including central nervous sys

255 transcriptional regulators regulating these repair programs.

256 reveal how lncRNA effectively replaces a DNA repair protein for efficient NHEJ with implications for

257 n be detected by MutS homolog (MSH) mismatch repair protein heterodimers.

258 Importantly, the NEIL3 pathway repairs psoralen-ICLs without generating double-strand b

259 DNA clamp that can coordinate the subsequent repair reactions.

260 pha-1-antitrypsin, lactulose, mannitol), and repair (regenerating gene 1beta) at median ages 3, 14, a

261 es of processes such as transcription or DNA repair remain an open question.

262 nctions in peripheral myelination and myelin repair remain elusive.

263 tput of motor neurons, but its impact on NMJ repair remains unknown.

264 coronary artery bypass surgery; heart valve repair/replacement; percutaneous coronary intervention;

265 specific nuclease family are crucial for DNA repair, replication, and recombination.

266 The bladder epithelial repair response is cumulative and aberrant as, after mul

267 gated by a poorly characterized, maladaptive repair response.

268 odulatory actions, while abnormal epithelial repair responses may contribute to remodelling of the ai

269 nappropriately activating the DNA damage and repair responses.

270 racterized by excellent DNA surveillance and repair, resulting in one of the lowest spontaneous mutat

271 The need for reoperation to repair RRD within 90 days was independently associated w

272 ecise prediction of post-treatment cartilage repair scores with coefficient of determination of 0.637

273 By contrast, adult zebrafish are able to repair spinal cord tissue and restore motor function aft

274 In contrast, the rate of SSB repair (SSBR) is markedly reduced.

275 of cells that support tissue homeostasis and repair, such as innate lymphoid cells.

276 n periostin during the late stages of tendon repair, suggesting that persistent NF-kappaB signaling m

277 often encoded adjacent to components of RNA repair systems.

278 Transcription-coupled nucleotide excision repair (TC-NER) is an important DNA repair mechanism tha

279 Thoracic endovascular aortic repair (TEVAR) has become the primary surgical treatment

280 tly in isolates with defects in DNA mismatch repair that confer an elevated mutation rate.

281 ingrowth, and promote neovascularisation to repair the defects.

282 326), while reducing the ability of cells to repair their plasma membrane makes them more sensitive t

283 egurgitation with transcatheter mitral valve repair (TMVr) using the MitraClip plus guideline-directe

284 wn to be necessary in the early steps of ICL repair to prevent aberrant nuclease resection, the role

285 ious HBV relaxed-circular-DNA substrates are repaired to form cccDNA by both cell extracts and purifi

286 c aneurysm repair, abdominal aortic aneurysm repair, total hip arthroplasty, total knee arthroplasty,

287 with respect to RD configuration or other RD repair types (PPV only vs PPV with SB).

288 ence and absence of the germ line on somatic repair under benign and stressful conditions.

289 enesis, suggesting a dual effect on vascular repair upon FECH inhibition, without ocular toxicity.

290 ated rhegmatogenous retinal detachment (RRD) repair using pars plana vitrectomy (PPV) alone versus co

291 e and breakage-fusion-bridge cycles that are repaired using multiple distinct long inverted repeat se

292 Ventral hernia repair(VHR) is one of the most commonly performed proced

293 ene in androgen-induced double strand breaks repair via homology-directed repair pathway and prostate

294 The VA at baseline and 12 months post-RRD repair was recorded.

295 ost strongly correlated with facile cellular repair was the ability of the A analogues to H-bond with

296 on and also hindered DNA double-strand break repair, which both led to improved radiosensitivity.

297 mediators involved in resolution and tissue repair, whose intracellular signaling remains of interes

298 bloat symptoms which were more common after repair with absorbable mesh.

299 anatomical and histological evidence of tail repair with regrowth in an archosaur, the American allig

300 ation at two-ended breaks and contributes to repair within heterochromatic regions during G2.