ライフサイエンスコーパス: repair mechanism

1 es are side-byproducts unassociated with the repair mechanism.

2 es place by a highly efficient base excision repair mechanism.

3 ronment subsequent to compromised injury and repair mechanism.

4 entially connected to a replicative mismatch repair mechanism.

5 ium sensor involved in the lysosome-mediated repair mechanism.

6 mutations is not because of defects in this repair mechanism.

7 rivative, was also employed to probe the ICL repair mechanism.

8 through an EGCG-induced IL-12-dependent DNA repair mechanism.

9 arcinogenesis through an IL-12-dependent DNA repair mechanism.

10 observed role of Ca(2+) is to engage a wound repair mechanism.

11 hese interactions contribute to the mismatch repair mechanism.

12 lap endonuclease processing via a long patch repair mechanism.

13 air and may represent a new 3' mispaired DNA repair mechanism.

14 ough a single-nucleotide patch base excision repair mechanism.

15 the primary participants in the predominant repair mechanism.

16 n-tunneling pathway that is critical for the repair mechanism.

17 EJ) is a major DNA double-strand break (DSB) repair mechanism.

18 chemokine receptor CXCR4 promote epithelial repair mechanisms.

19 ocus in the genome and invoke endogenous DNA repair mechanisms.

20 eted as a therapeutic approach for enhancing repair mechanisms.

21 tresses, bacteria induce both resistance and repair mechanisms.

22 could be involved in the MRL/MpJ spinal cord repair mechanisms.

23 ould be core components of the mitochondrial repair mechanisms.

24 el, mainly through stimulation of endogenous repair mechanisms.

25 gions of chromatin that are deficient in DNA repair mechanisms.

26 onal function, cilia, epithelial growth, and repair mechanisms.

27 n) are often considered to reflect different repair mechanisms.

28 s, which in turn signal downstream epidermal repair mechanisms.

29 ry responses, while sparing host defense and repair mechanisms.

30 nsitivity to promotional stimuli, like wound repair mechanisms.

31 posed roles in DNA pairing and recombination/repair mechanisms.

32 nds designed to enhance barrier function and repair mechanisms.

33 reatment and are central regulators of renal repair mechanisms.

34 DNA, which are then substrates for cellular repair mechanisms.

35 is completed by competing recombination and repair mechanisms.

36 ole-genome sequencing analysis to define DNA repair mechanisms.

37 vulnerability to DNA damage and inefficient repair mechanisms.

38 Smicro segments differ, suggesting different repair mechanisms.

39 nt spermatocytes have intact recombinational repair mechanisms.

40 bly reflect biases intrinsic to mutation and repair mechanisms.

41 e neurogenesis, synaptic plasticity and self-repair mechanisms.

42 links can be used as substrates to study DNA repair mechanisms.

43 es the concerted action of several DNA break-repair mechanisms.

44 ubject to injury and therefore need membrane repair mechanisms.

45 by driving initial symptoms, but by altering repair mechanisms.

46 matory signals and enhance endogenous tissue repair mechanisms.

47 he expression of genes that act in different repair mechanisms.

48 elivery and the overlap of cancer and neural repair mechanisms.

49 what extent their formation depends upon DSB repair mechanisms.

50 scular disease and dysfunctional endothelial repair mechanisms.

51 modulation of cellular stress responses and repair mechanisms.

52 oliferation in an attempt to initiate innate repair mechanisms.

53 ptations of membranes, proton pumps, and DNA repair mechanisms.

54 ly-ADP ribose polymerase (PARP)-mediated DNA repair mechanisms.

55 ic, as has its relationship to canonical DNA repair mechanisms.

56 ic sex development from existing prokaryotic repair mechanisms.

57 on, damage that is not amenable to the usual repair mechanisms.

58 ng in fixed mutations via host-dependent DNA repair mechanisms.

59 suppression of inflammation and promotion of repair mechanisms.

60 that are crucial in coordinating DNA damage repair mechanisms.

61 m the DNA lesion and activates intrinsic DNA repair mechanisms.

62 st likely reflecting the role of PNKP in DNA-repair mechanisms.

63 The repair mechanisms acting on DNA interstrand crosslinks (

64 t transplanted stem cells enhance endogenous repair mechanisms activated after cerebral ischaemia.

65 ing properties of NK314, to evaluate the DNA repair mechanisms activated in cells that may lead to re

66 further, indicating that HR is the major DNA repair mechanism after G2/M phase arrest.

67 se to physiological stress and an endogenous repair mechanism after ischemic injury.

68 could bridge a major gap in knowledge of the repair mechanism after myocardial injury.

69 Mismatch correction occurs by an excision-repair mechanism and has been shown to depend on the 5'

70 modeling, as they enhance endogenous cardiac repair mechanisms and decrease cardiomyocyte apoptosis.

71 mediated by polymorphisms in genes governing repair mechanisms and inflammation in the peripheral ner

72 suggesting a trade-off between highly active repair mechanisms and late-life pathology in females.

73 ely relies on the mobilization of endogenous repair mechanisms and local factors that control them.

74 one of the most frequently used cellular DNA repair mechanisms and modulates many human pathophysiolo

75 carcinogenesis, possibly by interfering with repair mechanisms and natural regression of early lesion

76 In this review, we discuss DNA repair mechanisms and strategies used to target them in

77 vitamin D can positively modify endothelial repair mechanisms and thus endothelial function in a pop

78 tions in this process, the co-option of DNA 'repair' mechanisms and AID evolution.

79 esource useful for studying DNA breakage and repair mechanisms, and for analyzing the genetic basis o

80 l of the cell cycle, response to stress, DNA repair mechanisms, and more.

81 DNA methylation, various DNA repair mechanisms, and possibly early events in the open

82 tical cell cycle events are halted while DNA repair mechanisms are activated to restore genome integr

83 normal in patients with SLE, and endothelial repair mechanisms are also impaired.

84 We hypothesize that recombination-based DNA-repair mechanisms are at least partially responsible for

85 ective neuroprotection and enhance intrinsic repair mechanisms are central goals for future therapy o

86 DNA repair mechanisms are essential for the maintenance of g

87 rates in vivo or in cell lines where all DNA repair mechanisms are functional.

88 DNA repair mechanisms are fundamental for B cell development

89 We propose that gap repair mechanisms are important in DNA damage-associated

90 DNA repair mechanisms are less able to repair DSBs compared

91 Because endogenous cardiac repair mechanisms are not sufficient for meaningful tiss

92 ing this procatabolic stimulus such that the repair mechanisms are ultimately overwhelmed by degradat

93 of stem cells and their progeny, though the repair mechanisms are unclear.

94 DNA efficiently or degraded by cellular DNA repair mechanisms as damaged DNA.

95 se activity in synthesis associated with DNA repair mechanisms as the cause of local increase in poin

96 snake toxins to cope with different membrane repair mechanisms at the cellular levels.

97 , stress/senescence marker proteins, and DNA repair mechanisms at the gene expression level.

98 hich take advantage of homology-directed DNA repair mechanisms at the site of nuclease action.

99 Damage repair mechanisms at transcriptionally active sites duri

100 DNA ICLs present a complex challenge to DNA repair mechanisms because of the involvement of both DNA

101 It is well established that cardiovascular repair mechanisms become progressively impaired with age

102 ssODN, demonstrating the specificity of the repair mechanism being recruited.

103 overexpression of caveolin-1 inhibits muscle repair mechanisms both in vitro and in vivo.

104 Ruxolitinib inhibited 2 major DSB repair mechanisms, BRCA-mediated homologous recombinatio

105 HR is the most accurate DSB repair mechanism but is generally restricted to the S an

106 important discoveries about DNA breakage and repair mechanisms, but also offer important clues about

107 nism was used so that the cell's "choice" of repair mechanism can have profound genetic consequences.

108 hila, to show that the relative usage of DSB repair mechanisms can change substantially as an organis

109 nd react to DNA damage; the induction of DNA repair mechanisms can lead to genomic restoration or, if

110 ts a relatively rare but very unfaithful DSB repair mechanism causing chromosomal aberrations.

111 c drugs and irradiation by modulation of DNA repair mechanisms, cell cycle checkpoints and Bcl-2 prot

112 show that MYCC (c-Myc) expression alters DNA repair mechanisms, cell cycle checkpoints, and karyotypi

113 control of genomic stability, including DNA repair mechanisms, cell-cycle checkpoints, apoptosis and

114 likely participates in a viral base excision repair mechanism, characterized by low fidelity.

115 gh the LINC complex may serve as an input to repair mechanism choice and efficiency.

116 xin sensitivity, indicating that back-up DSB repair mechanisms compensate for Rad18 deficiency.

117 As such, cells have a robust wound repair mechanism comprised of dynamic membrane resealing

118 Whether additional general DNA repair mechanisms contribute to ribonucleotide removal f

119 ls (BMCs) are critically involved in cardiac repair mechanisms contributing to preserved cardiac func

120 Many DNA repair mechanisms cooperate in cells to fight DNA damage

121 Understanding mtDNA repair mechanisms could facilitate the development of no

122 DNA double-strand break (DSB) repair mechanisms differ in their requirements for a hom

123 te differences in DNA-replication processes, repair mechanisms, DNA-modification systems, and mutatio

124 regeneration for injuries for which natural repair mechanisms do not deliver functional recovery and

125 Such DNA repair mechanisms either stall the cell cycle to allow r

126 y, and the robust and flexible nature of DNA repair mechanisms elicited by telomere dysfunction.

127 Restoration of DNA repair mechanisms emerges as an important therapeutic ta

128 ost physiologically predominant forms of DNA repair mechanisms, emerging lines of evidence suggest th

129 show that folic acid can enhance growth and repair mechanisms even in the adult CNS.

130 A (mtDNA) is prone to mutation and few mtDNA repair mechanisms exist, crippling mitochondrial mutatio

131 multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia pathway is

132 effects can also result from activating DNA repair mechanisms following damage.

133 by perturbing cell cycle progression and DNA repair mechanisms following DNA damage, we examined the

134 provides a model for a replication-dependent repair mechanism for double-strand breaks (DSBs) at rear

135 In humans, the only known cellular repair mechanism for eliminating the dimer from DNA is n

136 port suggests a role for a non-base excision repair mechanism for the removal of 8-oxo-7,8-dihydrogua

137 Repair mechanisms for chromium and other DNA phosphate-b

138 merous complex and redundant replication and repair mechanisms function in tandem with the core repli

139 terial cells, indicating that this important repair mechanism has been conserved through evolution.

140 unprecedented quantitative insight into DNA repair mechanisms has come from the new-found ability to

141 esion synthesis (TLS, a post-replication DNA repair mechanism) has been suggested, but the basis for

142 Two scenarios for the repair mechanism have been suggested that differ in the

143 DNA damage repair mechanisms have been most thoroughly explored in

144 Nonhomologous repair mechanisms have been relatively less well studied

145 One such DNA repair mechanism, homologous recombination, has the capa

146 ction between checkpoint proteins and damage repair mechanisms, how cells recover from an arrest resp

147 promotes unfaithful recombination-dependent repair mechanisms HRR and SSA, and enhances the loss of

148 Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms.

149 Renal mesangial cell apoptosis is a crucial repair mechanism in glomerular nephritis (GN).

150 membrane lesions, which could be part of the repair mechanism in hair cells after noise damage.

151 The most common DSB repair mechanism in human cells, non-homologous end join

152 ghlight the significance of the abnormal DNA repair mechanism in male infertility.

153 provide evidence for a homology-directed DNA repair mechanism in mitochondria that is directly linked

154 ascularization is an important physiological repair mechanism in response to ischemic injury, and its

155 -NHEJ) was originally identified as a backup repair mechanism in the absence of classical NHEJ (c-NHE

156 Our results show a self-repair mechanism in the mammalian brain and may have imp

157 transposition, and may hint at a common gap-repair mechanism in these diverse transposons.

158 ICLs in various DNA structures via a genuine repair mechanism in which complex DNA lesions can be rem

159 existence of endogenous cardiac renewal and repair mechanisms in adult mammalian hearts that could c

160 integrity of DSB recognition, signaling, and repair mechanisms in B lymphoblastoid cell lines derived

161 are not subject to p53-mediated DNA excision repair mechanisms in B-CLL cells.

162 initial airway inflammatory, remodeling, and repair mechanisms in CF lung disease.

163 des a foundation for further explorations of repair mechanisms in different chromatin domains.

164 metabolite damages not only DNA but also DNA repair mechanisms in human cells.

165 pplications and facilitates the study of DNA repair mechanisms in mammalian cells.

166 Although DSB repair in nDNA is well studied, repair mechanisms in mitochondria are not characterized.

167 These results may implicate 8-oxoG repair mechanisms in mitochondria of certain breast canc

168 nge, indicating that there are two different repair mechanisms in mitotic cells.

169 The reasons for the eventual failure of repair mechanisms in multiple sclerosis are unknown.

170 ions on nanoparticle-mediated DNA damage and repair mechanisms in plants.

171 ys in which the cell differentially utilizes repair mechanisms in response to both changes in the gen

172 , E or E+P increased gene expression for DNA repair mechanisms in serotonin neurons, thereby renderin

173 e dysregulation of endogenous cardiovascular repair mechanisms in the aging heart and vasculature.

174 to the NSCs, which may have implications for repair mechanisms in the central nervous system.

175 y may have important implications for injury/repair mechanisms in the CF airway.

176 enzymes that are involved in both injury and repair mechanisms in the CNS.

177 mplicates both major DNA double-strand break repair mechanisms in the generation of 8p alterations.

178 We explored DSB repair mechanisms in the yeast Saccharomyces cerevisiae

179 Understanding cellular repair mechanisms in vivo has been advanced through the

180 ctions as a potent hormonal inducer of wound repair mechanisms in vivo.

181 s of this review is on the comparison of DNA repair mechanisms in young versus old.

182 models for the mammalian NER-independent ICL repair mechanism, in which a DNA endonuclease(s) unhooks

183 DNA repair mechanisms include direct repair, base excision r

184 Repair mechanisms include the participation of endogenou

185 It coincides with activation of repair mechanisms, including accumulation of extracellul

186 t during HR with the unique aspects of these repair mechanisms, including mutagenesis and template sw

187 are essential for structural and functional repair mechanisms, including regeneration of cerebral wh

188 ic and found that the oxidative stress-break repair mechanism increased the emergence of antibiotic-r

189 to characterize DNA double strand breaks and repair mechanisms induced by this type of drugs using a

190 The complexity of DNA repair mechanisms infers that xenobiotics, derived from

191 sized that glucocorticoids may influence the repair mechanisms initiated after extended cold preserva

192 type of ssODN used and by modulation of the repair mechanism involved in the correction process.

193 nd theory it is demonstrated that the acting repair mechanism involves proton transfer from the proto

194 ICLs, possibly in a transcription-associated repair mechanism involving SNM1A, and that defects in th

195 however, the recent discovery of endogenous repair mechanisms involving hematopoietic stem and other

196 Our study shows that the choice of repair mechanism is continuously adjusted throughout the

197 tion of damaged cells may mend DNA until the repair mechanism is exceeded and then revert to apoptosi

198 lls, indicating that the nucleotide excision repair mechanism is involved in EGCG-mediated DNA repair

199 The damage repair mechanism is modeled by an expanded reaction-rate

200 Our ribose-protonated repair mechanism is not only energetically more preferab

201 The disruption repair mechanism is now well understood at the cellular

202 Redundancy of TOP1-mediated repair mechanisms is a major challenge facing the effici

203 Because a decline in cellular repair mechanisms is hypothesized to contribute to senes

204 described here is that the character of the repair-mechanisms is reflected by the secondarily built

205 ecombination (HR), although an important DNA repair mechanism, is dangerous to the cell if improperly

206 a DSB; and as a functional component of DNA repair mechanism itself.

207 the rate of replication and functionality of repair mechanisms; little is known, however, about the c

208 turn, DNA damage activates a variety of DNA repair mechanisms, many of which are activated in vascul

209 Elucidation of the PSII repair mechanism may reveal the occurrence of hitherto u

210 n, the exploitation of endogenous brain self-repair mechanisms may also yield therapeutic strategies.

211 Thus, maintenance of in-house DNA-repair mechanisms may provide an alternate approach for

212 modulating sprouting, a naturally occurring repair mechanism, may be a more attainable therapeutic g

213 A differential DNA repair mechanism might protect certain non-Ig loci such

214 Given the central role of translation, such repair mechanisms might be widespread in nature.

215 Thus, we studied cardiac mtDNA repair mechanisms, mtDNA damage, and mitochondrial struc

216 Recently, a third, less characterized repair mechanism, named microhomology-mediated end joini

217 the inverse dependence of anions in the self-repair mechanism of Co-OECs.

218 ons and deletions consistent with a hAT-type repair mechanism of hairpin formation and non-homologous

219 not, thanks to the presence of an efficient repair mechanism of PSII.

220 ifferent efficiencies of photoprotection and repair mechanisms of algal food sources play a role in t

221 ng an essential role in oxidative DNA damage repair mechanisms of GAS, dual functions predicted to co

222 To study the repair mechanisms of interstrand cross-links in mammalia

223 crucial in order to understand the intrinsic repair mechanisms of the brain, and key to designing the

224 These mutations arise by different repair mechanisms of the double-strand break produced by

225 to understand aspects of the robust pattern repair mechanisms of the Drosophila embryonic epidermal

226 ntegrity, organisms have evolved several DSB repair mechanisms, of which nonhomologous end-joining (N

227 h the activation of pathways responsible for repair mechanisms, often resulting in a delay/arrest in

228 cted only as part of a methyltransferase DNA repair mechanism or at trace amounts in hemoglobin.

229 altered DNA repair, either through defective repair mechanisms or drug-mediated inhibition, may contr

230 ormation may reflect an endogeneous neuronal repair mechanism, or it could be a by-product of radiati

231 s recognized by sensor proteins that trigger repair mechanisms, or, if repair is unsuccessful, initia

232 lular damage is beyond the capability of the repair mechanisms, p53 induces apoptosis or cell cycle a

233 flammation, demyelination, axonal damage and repair mechanisms) participate in the disease process.

234 It can be expected that DNA repair mechanisms play important roles in cpDNA survival

235 de excision repair is a highly conserved DNA repair mechanism present in all kingdoms of life.

236 ision repair (NER) is a highly conserved DNA repair mechanism present in all kingdoms of life.

237 high mutation rate of the mtDNA and limited repair mechanisms present in the mitochondrion.

238 In summary, HO-1 modulates muscle repair mechanisms preventing its uncontrolled accelerati

239 ethality and that in its absence alternative repair mechanisms promote cell survival.

240 We have found that the repair mechanisms propagated in the literature to this d

241 PARP in the context of defects in other DNA repair mechanisms provide a tumor specific way to kill c

242 tory profile that can accelerate deleterious repair mechanisms rather than support proper vascular re

243 ses RecA action and participates in some DNA repair mechanisms, RecBCD exonuclease, which degrades do

244 DNA damage repair mechanisms remained defective in these BRCA1 K898

245 cy of standard chemotherapy by targeting DNA repair mechanisms remains an important area of research.

246 FA), for example, has elucidated a novel DNA repair mechanism required for maintaining genomic stabil

247 role for MTDH in male fertility and the DNA repair mechanisms required for normal spermatogenesis.

248 ) has been proposed to be critical in tissue repair mechanisms resulting from radiation injury.

249 ion of N(6)-CMdA, suggesting the presence of repair mechanism(s) for the rapid clearance of this lesi

250 sites which have been shown to challenge the repair mechanism(s) of the cell.

251 Repair mechanisms such as ingrowth of RPE/drusenoid mate

252 ystematically faster compensation and damage repair mechanisms than individual tolerance.

253 Thus, BRCA1/SETX complexes support a DNA repair mechanism that addresses R-loop-based DNA damage

254 process lead to activation of an alternative repair mechanism that depends on MUS81-catalyzed cleavag

255 steps of base excision repair, the principal repair mechanism that identifies and removes endogenous

256 that these signalling events form part of a repair mechanism that is activated when the migrating sl

257 ting chromosome breakage and elucidate a DNA repair mechanism that is critical to maintain chromosome

258 ir-proficient cells, suggesting a cross-link repair mechanism that is independent of homologous recom

259 G repeats may be mediated by a recombination-repair mechanism that is influenced by DNA structure.

260 Organisms have evolved with a DNA repair mechanism that largely ameliorates the deleteriou

261 t pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic

262 lication (BIR), a genome rearrangement-prone repair mechanism that requires the Pol32/POLD3 subunit o

263 Revascularization is an adaptive repair mechanism that restores blood flow to undersuppli

264 A stem that may be difficult to recognize by repair mechanisms that are not transcription- or replica

265 metazoans possess robust homology-dependent repair mechanisms that can be harnessed for recombineeri

266 otentially deleterious homology-directed DSB repair mechanisms that can impair genome integrity.

267 and increases utilization of error-prone DNA repair mechanisms that could contribute to disease progr

268 Focal cerebral ischemia initiates self-repair mechanisms that include the production of neurotr

269 n important component of double-stranded DNA-repair mechanisms that interacts with both BRCA1 and BRC

270 Maladaptive repair mechanisms that persist following the acute phase

271 type 2 ILCs (ILC2s) have been implicated in repair mechanisms that restore tissue integrity after in

272 ) coordinate cell cycle checkpoints with DNA repair mechanisms that together maintain genome stabilit

273 In combination with DNA repair mechanisms, the system produces targeted mutation

274 in mussels suggesting that ACC is used as a repair mechanism to combat shell damage under OA.

275 ondria lack a functional nucleotide excision repair mechanism to repair DNA adducts and are sensitive

276 a model for testing the contribution of DNA repair mechanisms to cisplatin ototoxicity.

277 tes the efficiency and fidelity of major DSB repair mechanisms to protect leukemia cells from apoptos

278 inst ribonucleotides, and by the capacity of repair mechanisms to remove incorporated ribonucleotides

279 tely, hematopoietic cells have sophisticated repair mechanisms to suppress such translocations.

280 Little was known about DPC-specific repair mechanisms until the recent identification of a D

281 toenzymatic repair (PER) is an important DNA repair mechanism used by marine microorganisms occupying

282 Lack of this repair mechanism very likely increases aging-related dis

283 gene conversion; however, an alternative DSB repair mechanism was used in an rhp55Delta background in

284 model, the impact of hyperglycemia on brain repair mechanisms was investigated.

285 TOPO-II-alpha), which is associated with DNA repair mechanisms, was also overexpressed by these cells

286 Despite differences in the replication and repair mechanism, we show that the human polymerase effi

287 and for proteins involved in DNA damage and repair mechanisms, we conclude that the lack of PTIP res

288 n to photoreactivation, three other putative repair mechanisms were identified including d(CTAG) meth

289 Telomeric repair mechanisms were intact in HLA-DRB1*04+ donors.

290 h sufficient rapidity that cellular membrane repair mechanisms were not activated during cytoplasmic

291 hin a genome is crucial to understanding the repair mechanisms which protect this integrity.

292 ed an ever more detailed dissection of these repair mechanisms, which are described here.

293 unately, FTKs compromise the fidelity of DNA repair mechanisms, which contribute to the accumulation

294 the genomes of cancer cells may enhance DNA repair mechanisms, which in turn limit the accumulation

295 argeting this complex thanks to an efficient repair mechanisms, while if PSI is affected, there are d

296 ions by activating cell cycle checkpoint and repair mechanisms, while multicellular animals have acqu

297 e our understanding of stem cell biology and repair mechanisms will provide a platform for therapeuti

298 air is an important and highly conserved DNA repair mechanism with an exceptionally large range of ch

299 e functional interplay between SIRT6 and DNA repair mechanisms, with implications for both tumorigene

300 ite expansion, and describe an inherent self-repairing mechanism working against expansion.