ライフサイエンスコーパス: reparative

1 ses, more delayed inflammatory events may be reparative.

2 macrophage subpopulations, including RM3/1 (reparative), 25F9 (resident), and 27E10 (inflammatory).

3 n the infarct area and exhibits strengthened reparative abilities after MI.

4 The myocardial reparative abilities of EVs derived from induced pluripo

5 Reactivating primitive reparative ability in the mature mammalian heart require

6 The reparative ability of the central nervous system varies

7 ibition in CD34(+) cells would improve their reparative ability.

8 on, NO release, and in vivo retinal vascular reparative ability.

9 distinct immune cells drive inflammatory and reparative activities after injury.

10 rophages that are proinflammatory and lacked reparative activities.

11 in in transgenic (TG) mice would provide any reparative advantage in response to DDC.

12 2-mC mice and cells identified injurious and reparative agents that affect kidney damage.

13 presents with (a) EC shape and proliferative-reparative alterations: ongoing cycles of cellular injur

14 Recent research has shown that reparative (alternatively activated or M2) macrophages p

15 disequilibrium between 2 opposing processes: reparative and cytoprotective mechanisms vs. inflammatio

16 However, these reparative and homeostatic functions can be subverted by

17 ent mesenchymal stromal cells (MSCs) possess reparative and immunoregulatory properties, making them

18 tivates macrophages, endowing them with both reparative and pathological functions.

19 Understanding the mechanisms governing the reparative and pathological properties of activated macr

20 d neuron survival, suggest that LIF has both reparative and protective activities that make it a prom

21 ion of lymphocyte proliferation, delivery of reparative and protective signals after reperfusion inju

22 The reparative and regenerative capacity of multiple mammali

23 rts the paradigm that stem cells exert their reparative and regenerative effects, in large part, thro

24 ment of human cardiac progenitor cell (hCPC) reparative and regenerative potential by genetic modific

25 ental signaling pathways that regulate their reparative and regenerative potential, and the surroundi

26 VX lesions contain primarily reparative and resident foam cells, with limited numbers

27 can be modulated to mediate cytoprotective, reparative, and even regenerative functions in the infar

28 el therapeutic target for the improvement of reparative angiogenesis after stroke in diabetes.

29 richment for PC that express NK1 and promote reparative angiogenesis after transplantation in a mouse

30 ntly, pharmacologic Nrf2 activation promotes reparative angiogenesis and suppresses pathologic neovas

31 guidance cue netrin-1 activates a program of reparative angiogenesis in microglia within the ischemic

32 al cells in the ischemic hindlimb; that such reparative angiogenesis is indeed dependent upon VEGF up

33 pensity to impact tissue vascularization and reparative angiogenesis.

34 , which are resident stem cells committed to reparative angiomyogenesis.

35 myocardial damage, and suppression of cardio-reparative Angiotensin II receptor 2 (Agtr2).

36 ardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple ce

37 ombocytopenic mice exhibited no delay in the reparative aspects of wound healing.

38 tal role for osteoblast dedifferentiation in reparative bone formation in fish and indicate that adul

39 study characterized mobilization of vascular reparative bone marrow progenitor cells in mouse models

40 esponses (and their potential protective and reparative capabilities) following WNV infection have no

41 on of endogenous stem cells to enhance their reparative capabilities, and transplantation of oligoden

42 To compare the cardiac reparative capacities in vivo, vehicle, iPSCs, and iPSC-

43 ) production in diabetic BMCs improves their reparative capacities.

44 We investigated aging of human endogenous reparative capacity and aimed to clarify whether it is a

45 uced pluripotent-derived cells have the same reparative capacity as physiologically committed CNS-der

46 rs of older patients have significantly less reparative capacity following ischemia and reperfusion (

47 ts indicate that the heart has a substantial reparative capacity if the molecular signals responsible

48 failing heart has a previously unrecognized reparative capacity involving more than cardiomyocyte re

49 To investigate the reparative capacity of BM in inflammatory bowel disease

50 ising therapeutic strategy for restoring the reparative capacity of dysfunctional diabetic CD34(+) ce

51 Moreover, NK cells limited the reparative capacity of NSCs following brain inflammation

52 pidermis and control both the functional and reparative capacity of the skin.

53 ociated with transplantation has limited the reparative capacity of these cells in vivo.

54 repair by continued proliferation overwhelm reparative capacity, causing loss of specialised cell fu

55 cadian peak of EPC release led to diminished reparative capacity, resulting in the development of the

56 mbranes and biogenic cellular membranes with reparative capacity.

57 ential, which contributes to their decreased reparative capacity.

58 ntified a novel population of c-kit-negative reparative cardiac cells (SA CMCs) that can be isolated

59 The long-term sequelae of many reparative cardiac surgical procedures are not yet fully

60 t and a prolonged effect on inflammatory and reparative cell functions leading to delayed healing and

61 ndings could have important implications for reparative cell therapies for brain disorders.

62 Among the candidates for the reparative cells are the adult stem cells from bone marr

63 at the hierarchical organization of tracheal reparative cells be revised to include a facultative bas

64 application it would be preferable to obtain reparative cells from an olfactory mucosal biopsy via in

65 P12 administration mediated proliferation of reparative cells in the AMI hearts.

66 be readily extended to the delivery of other reparative cells of interest and used in quantitative st

67 n to all, guides the behavior of potentially reparative cells.

68 ry response is associated with activation of reparative cells.

69 rodamage (fissuring) as well as vascular and reparative changes were evaluated.

70 out c-kit sorting, was sufficient to isolate reparative CMCs.

71 oid response, including higher levels of the reparative cytokine interleukin-22.

72 earance and release of anti-inflammatory and reparative cytokines such as transforming growth factor-

73 This reparative cytotype was characterized by high expression

74 tors was strongly inferred from the profound reparative defect in livers of mice lacking tPA and uPA

75 toward an odontoblastic phenotype to produce reparative dentin beneath caries lesions.

76 putation site healing was characterized by a reparative dentin bridge produced by odontoid cells.

77 nds that can potently stimulate and expedite reparative dentin formation is still underexplored.

78 ereas molars exhibit increased attrition and reparative dentin formation.

79 sed from these materials is known to mediate reparative dentin formation.

80 ORAI1 may be a therapeutic target to enhance reparative dentin formation.

81 tion in injured teeth; (3) it does not block reparative dentin formation; and (4) it does not block s

82 greatest in immature teeth, and formation of reparative dentin impeded it.

83 lammation were reduced by DEX treatment, but reparative dentin was formed just as well in the DEX rat

84 al pulp and have the ability to regenerate a reparative dentin-like complex.

85 ver, DPSCs were found to be able to generate reparative dentin-like tissue on the surface of human de

86 s a dental procedure that aims to regenerate reparative dentin.

87 lphaSMA-tdTomato(+) cells to cells secreting reparative dentin.

88 ies removal to stimulate the regeneration of reparative dentin.

89 te into odontoblast-like cells and produce a reparative dentin.

90 onists that promote the natural processes of reparative dentine formation to completely restore denti

91 n of reactionary dentine, but in common with reparative dentine formation, exogenous elevation of Wnt

92 ule GSK-3 antagonists, resulting in enhanced reparative dentine formation.

93 ion that stimulates the natural formation of reparative dentine via the mobilisation of resident stem

94 into new odontoblast-like cells that secrete reparative dentine.

95 ole of Wnt/beta-catenin signaling pathway in reparative dentinogenesis using an in vivo mouse tooth d

96 ntal pulp exposure model in molars to induce reparative dentinogenesis, we demonstrate the contributi

97 essential and important roles in primary and reparative dentinogenesis, with conflicting results rega

98 that acts in an autocrine manner to modulate reparative dentinogenesis.

99 o a second generation of odontoblasts during reparative dentinogenesis.

100 essential and important roles in primary and reparative dentinogenesis.

101 y phenotype and restricts their survival and reparative effects in a mechanism mediated by TLR4.

102 The mechanism(s) underlying cardiac reparative effects of bone marrow-derived mesenchymal st

103 The reparative effects of exogenous GFP-BMSCs were investiga

104 re used in early clinical trails to evaluate reparative effects on recent or record infarcts.

105 two sources do not differ in terms of their reparative effects or functional efficacy after transpla

106 ti-inflammatory and possibly neuroprotective/reparative effects, may contribute to its efficacy in MS

107 h monocyte infiltration and loss of resident reparative embryonic-derived cardiac macrophages.

108 immune response and the generation of a pro-reparative environment.

109 ucts (AGEs) contributes to impairment of EPC reparative function after diabetes-related endothelial i

110 abetic patients demonstrate reduced vascular reparative function due to decreased proliferation and d

111 r inhibiting NADPH oxidase would restore the reparative function in diabetic EPCs.

112 Reparative function was evaluated in a mouse model of re

113 that the late inflammatory response serves a reparative function.

114 and restoration of the cells' natural robust reparative function.

115 pathy but may be preempted from carrying out reparative functions if the molecular abnormalities comp

116 cell to mediate both tissue-destructive and -reparative functions.

117 mal cells (ADSCs) that have regenerative and reparative functions; however, whether DWAT atrophy in f

118 ailure after myocardial infarction induces a reparative genetic program with increased scar border va

119 agen or ePTFE membranes revealed substantial reparative healing.

120 aging abnormalities among infants undergoing reparative heart surgery.

121 nd the phased transition from destructive to reparative inflammation.

122 r testing the effects of neuroprotective and reparative interventions.

123 This suggests that reparative K14+ progenitor cells may be tumor-initiating

124 Autophagy is a reparative, life-sustaining process by which cytoplasmic

125 e identified suppressed formation of a novel reparative lipid mediator 14S,21R-dihydroxydocosa-4Z,7Z,

126 on Day 1 to Day 4 and digest damaged tissue; reparative Ly-6C(lo) monocytes dominate on Day 5 to Day

127 cumulated Ly-6C(high) monocytes give rise to reparative Ly-6C(low) F4/80(high) macrophages that proli

128 accumulation of inflammatory Ly-6C(high) and reparative Ly-6C(low) monocytes/macrophages.

129 motes cardiac healing after MI by activating reparative Ly6C(low) Mos/Mps, indicating that Ep3 recept

130 (sVegfr-2), that inhibits developmental and reparative lymphangiogenesis by blocking Vegf-c function

131 py significantly increased the percentage of reparative M2 macrophages (F4/80(+)CD206(+)) in the infa

132 ediator Fas, whereas there was a decrease in reparative M2-like CD11b(+) microglia and phosphorylatio

133 ssue injury and promoting the development of reparative macrophage responses.

134 The reparative mechanisms that operate following carious and

135 g hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/

136 mediators as the emerging factor for post-MI reparative mechanisms-translational leukocyte modifiers,

137 cement after injury via stem cells and other reparative mechanisms.

138 al signals required to activate these innate reparative mechanisms.

139 helial cells, antagonizing NO production and reparative mechanisms.

140 These events serve to erect a reparative membrane patch and then anneal it to the defe

141 the potential and value of this therapy as a reparative modality.

142 pathways that drive oligodendrocytes into a reparative mode contributing to remyelination following

143 s used to explore the regenerative effect of reparative monocyte recruitment.

144 that a low number of CD34+KDR+ cells favors reparative neovascularization and possibly myogenesis in

145 othelial cell (EC) function and postischemic reparative neovascularization by molecular mechanisms th

146 us ECs-derived H2O2 plays a critical role in reparative neovascularization in response to ischemia by

147 erproduction of O2-, which may contribute to reparative neovascularization in response to ischemic in

148 +) progenitors to ischemic muscles, impaired reparative neovascularization, and delayed perfusion rec

149 Our data highlight the role of SP in reparative neovascularization.

150 Diabetes impairs endothelial function and reparative neovascularization.

151 pport a model in which IL-6, produced in the reparative niche, functions to enhance the differentiati

152 wever, it is unclear whether these potential reparative niches remain functional during chronic injur

153 Although these reparative options have proven successful, they are tech

154 Great variability in reparative outcomes was found, attributed to patient fac

155 ad cells and matrix debris, while activating reparative pathways necessary for scar formation.

156 ased cardiomyocytes by using the classic and reparative pathways.

157 In the second, reparative phase, accumulated Ly-6C(high) monocytes give

158 During the later, reparative phase, infarcts of bmLp-PLA2 (-/-) mice conta

159 iferative cytokines IL-6 and IFNgamma at the reparative phase.

160 f bone morphogenetic protein 2 at a critical reparative phase.

161 on and migration during the inflammatory and reparative phases and limit these responses during the r

162 monocytes orchestrate both inflammatory and reparative phases during myocardial infarction and depen

163 3CR1(-/-)) microglia and macrophages adopt a reparative phenotype and increase expression of genes th

164 This reparative phenotype in Vim(-/-) corneas is strikingly r

165 eting GM-CSF, leading to a unique macrophage reparative phenotype that supports tubular proliferation

166 duced a shift in macrophage profile toward a reparative phenotype, which secondarily stimulated colla

167 orresponding to an "M2"-like homeostatic and reparative phenotype.

168 phage activation from a proinflammatory to a reparative phenotype.

169 d injury in two mouse strains with different reparative phenotypes following virus-induced demyelinat

170 the cytosol either through these pores or by reparative pinocytosis.

171 Rather than representing "reparative plasticity," increased ipsilateral projection

172 migratory capabilities, which impair overall reparative potential for injured myocardium.

173 This model system demonstrates the robust reparative potential of myelin in the central nervous sy

174 Compare the reparative potential of saphenous vein-derived pericytes

175 hCPCeP exhibited augmentation of reparative potential relative to hCPCe control cells, as

176 duced pluripotent stem (iPS) cells harbour a reparative potential, and were here bioengineered from s

177 ration of progenitor cells with vasculogenic/reparative potential.

178 agnosis to maximize opportunity to perform a reparative procedure.

179 ld be taken into account during mitral valve reparative procedures.

180 keletal development, the extent to which the reparative process actually recapitulates the fetal prog

181 iodontitis and through TNF limits the normal reparative process by negatively modulating factors that

182 mediator of inflammation and may impede the reparative process for neurovascular damage in AD.

183 ositive effect on MSCs in conditions where a reparative process has been initiated.

184 Inappropriate activation of this reparative process leads to scarring and fibrosis.

185 on of GSH-Px and depletion of GSH indicate a reparative process of accelerated elimination of reactiv

186 or a key role of neuroendocrine cells in the reparative process of airway epithelial cell renewal aft

187 Additionally, CTS augments the reparative process via abrogation of TNFalpha-induced su

188 Additionally, CTS augments the reparative process via hyperinduction of aggrecan mRNA e

189 Vascular injury is characterized by a local reparative process with inflammatory components, indicat

190 portant contributor to this inflammatory and reparative process, mainly through TNF-alpha receptor 1.

191 damage but is also essential for the tissue reparative process.

192 of macrophages is critical for activation of reparative processes during the midstage of cutaneous re

193 regulates the balance between pathogenic and reparative processes from early in the disease course.

194 At present, understanding existing reparative processes in humans and exploring the latent

195 ults show that propofol may prevent or limit reparative processes in the early-phase postinjury.

196 heart has been tempered by realizations that reparative processes in the heart are insufficient to re

197 that anesthetics may enhance the endogenous reparative processes in the injured brain.

198 importance in understanding regenerative and reparative processes in the myocardium.

199 This may be related to reparative processes of viable myocytes or to a higher o

200 ribute replacement muscle through endogenous reparative processes or via cell transplantation in prec

201 man skin injected with PDGF-BB and in tissue reparative processes PDGF beta-receptors colocalize with

202 ptualizing osteoarthritis and spondylosis as reparative processes provides a pathologic model consist

203 he genes that mediate these pathological and reparative processes remain largely unknown.

204 Reparative processes such as gliosis and fibrosis also c

205 ell-mediated matrix contraction in anomalous reparative processes such as proliferative vitreoretinop

206 odeling of extracellular matrix and controls reparative processes such as wound healing and liver reg

207 Emerging understanding of reparative processes suggest several possible therapeuti

208 lls and pathways during acute injury and the reparative processes that are subsequently activated.

209 oduce matrix, regulate inflammation, mediate reparative processes, and serve as pluripotent mesenchym

210 Through efficient anti-inflammatory and reparative processes, inflammation may resolve without a

211 Cerebral ischemia can activate endogenous reparative processes, such as proliferation of endogenou

212 phin receptor expression, probably to foster reparative processes, which in turn could render the bra

213 endothelial dysfunction and promote vascular reparative processes.

214 car formation, in the course of reactive and reparative processes.

215 keys, suggesting ongoing, albeit inadequate, reparative processes.

216 text of ongoing destructive, protective, and reparative processes.

217 (ECM) and drive important developmental and reparative processes.

218 herapy was endorsed as a means of bolstering reparative processes.

219 to contribute to either neurodegeneration or reparative processes.

220 ucing inflammatory, adaptive, injurious, and reparative processes.

221 P expression and secretion may influence the reparative proficiency of APC therapy.

222 rminant of initial tubular cell survival and reparative proliferation after ischemic injury.

223 activity to restrain cell growth during the reparative, proliferative state induced by vascular inju

224 sue, there was a significant increase in the reparative/proliferative macrophage phenotype.

225 c monoclonal antibodies for inflammatory and reparative/proliferative phenotypes.

226 SA CMCs exhibited robust reparative properties and offered numerous advantages, a

227 zed, the components that regulate macrophage reparative properties are less well understood.

228 type of skin fibroblasts by augmenting their reparative properties in skin-like HSEs.

229 EK1/2 inhibition is capable of promoting the reparative properties of murine and human macrophages.

230 r, parallel advances in understanding of the reparative properties of stem cells--including their dis

231 le of endogenous AnxA1 in the protective and reparative properties of the intestinal mucosal epitheli

232 d in the cardiac tissue and maintained their reparative properties, reduced infarct size, increased s

233 1/2 pathway as a key regulator of macrophage reparative properties.

234 damental questions about the universality of reparative regeneration and whether mammals share any pr

235 Impaired CPC-dependent reparative remodeling ultimately leads to continuous dec

236 eep cerebellar stimulation may guide plastic reparative reorganization after nonprogressive brain inj

237 bles execution of the acute inflammatory and reparative response after epithelial injury and leads to

238 sociated alterations in the inflammatory and reparative response after myocardial infarction (MI) and

239 ular signals regulating the inflammatory and reparative response after myocardial infarction.

240 e of IP-10 resulted in a hypercellular early reparative response and delayed contraction of the scar.

241 the regulation of the acute inflammatory and reparative response by using HO-2-null mice and well-est

242 to male atherosclerotic apoE(-/-) mice; this reparative response correlated with the upregulation of

243 liverdin, rescued the acute inflammatory and reparative response in HO-2-null mice.

244 flammatory signaling affects this endogenous reparative response is unclear.

245 erapeutic modulation of the inflammatory and reparative response may hold promise for the prevention

246 e propose that CTGF is a part of the limited reparative response of the degenerated disc.

247 on during a dynamic and complex inflammatory/reparative response remain to be clearly defined.

248 Wound healing represents a well orchestrated reparative response that is induced by injuries.

249 like 1 gene, as a critical component of this reparative response that serves to limit tubular cell ap

250 tion plays a fundamental role in the hepatic reparative response to injury.

251 Neovascularization is a reparative response to ischemia, and includes 3 processe

252 robial infections and may be involved in the reparative response to nerve injury.

253 This reparative response univariately correlated with increas

254 ntrinsic activity capable of initiating this reparative response was found to reside within bone itse

255 degree of injury, a critical mediator of the reparative response, and a possible biomarker to identif

256 ime a sex-specific difference in the corneal reparative response, which is mediated by ERbeta and ERa

257 the execution of an ordered inflammatory and reparative response.

258 the ordered execution of an inflammatory and reparative response.

259 periodontal attachment and stimulation of a reparative response.

260 jury leads to suppression of an NGF-mediated reparative response.

261 o the spatial and temporal regulation of the reparative response.

262 t studies suggest that diabetes also impairs reparative responses after cell therapy.

263 ate a critical role for LXA4 in inflammatory/reparative responses and provide the first evidence that

264 the role of estradiol in ocular inflammatory-reparative responses are not well understood.

265 bioligands can be harnessed to direct tissue reparative responses associated with implanted biomateri

266 nner that initiates both inflammatory and/or reparative responses in the host.

267 related receptor can dramatically change the reparative responses of multiple cellular constituents i

268 and how the sum of initial inflammatory and reparative responses only sets the trajectory for diseas

269 ding of mechanisms that balance inflammatory/reparative responses to provide effective host defense w

270 of therapeutic approaches to activate innate reparative responses.

271 inducer of neoangiogenesis that can promote reparative revascularization.

272 stroke brains and suggests that CD36 plays a reparative role during the resolution of inflammation in

273 This unexpected reparative role for TNF alpha in the CNS is important fo

274 fic macrophage functions that underlie their reparative role in injured tissues, including the regula

275 acute period but serves a protective and/or reparative role in the post-acute phase of SCI.

276 g chambers to determine the inflammatory and reparative role of IL-6.

277 Given the numerous reparative roles glia may play after spinal cord injury

278 cts as both an antiinflammatory signal and a reparative signal.

279 and acts as both an anti-inflammatory and a reparative signal.

280 niches harboring local transiently expressed reparative signals.

281 ng hemodynamics have given way to long-term, reparative strategies, including beta-adrenergic recepto

282 issue is critical for the rational design of reparative strategies.

283 rategies that modulate the fate/phenotype of reparative structural cells, including epithelial, endot

284 mes and survival to next-stage palliative or reparative surgery between patients undergoing a modifie

285 hycardia in patients who had undergone prior reparative surgery for congenital heart disease could be

286 Early reparative surgery in neonates and infants with congenit

287 The success of this strategy of early reparative surgery now has been extended to the prematur

288 leaflet remodeling needs to be considered in reparative surgical techniques.

289 led knowledge of the disease process and the reparative techniques.

290 owledge is important to improve mitral valve reparative techniques.

291 n into account in the design of mitral valve reparative techniques.

292 yocardial infarction seems to be a promising reparative therapeutic approach, (2) HGF and VEGF are ca

293 trials, spurred by the immense need to find reparative therapeutics for central nervous system (CNS)

294 of our implantable device for cellular-based reparative therapies.

295 , double immunostaining showed that cells in reparative tissue expressed both myogenin and embryonic

296 y mediates the expression of the endothelial reparative transcription factor Forkhead box M1 (FoxM1).

297 as CPC exosomes from older children were not reparative unless subjected to hypoxic conditions.

298 overview of some commonly used techniques in reparative valve surgery in children.

299 the recruitment of hematopoietic stem cells, reparative vascularization, and reperfusion of the ische

300 flammation in either hindering or supporting reparative wound healing and regeneration, this inverteb