ライフサイエンスコーパス: repetitive

1 Inhibitory responses that diminished after repetitive ACh application at RMPs were immediately resc

2 cent [Ca(2+)] indicator revealed that during repetitive action potential stimulation, [Ca(2+)] elevat

3 Afterhyperpolarizations (AHPs) generated by repetitive action potentials in supraoptic magnocellular

4 Repetitive activation of glutamatergic inputs onto HIPP

5 ve interneurons to study the effects of such repetitive activation on epileptiform discharges induced

6 lay extensive short-term facilitation during repetitive activity, with a large several fold postsynap

7 ther, our results point to the potential for repetitive AD-MSC administration in improving outcomes a

8 nt of persistently infected mice for 4 wk by repetitive administration of neutralizing anti-PD-1 Ab s

9 heterochromatin, and is encoded, in part, by repetitive alpha-satellite sequences, which are retained

10 attenuated lung inflammation in response to repetitive Alternaria inhalation challenges.

11 er airways may act as persistent stimuli for repetitive alveolar injury in IPF.

12 underlying poor control over stereotyped and repetitive and compulsive behaviors, respectively.

13 until 3 years of age and allergic symptoms (repetitive and continuous for at least 6 months) were no

14 sis causes a high burden for patients, since repetitive and long-term parenteral administration is re

15 to monitor the position and dynamics of both repetitive and non-repetitive genomic regions in live ce

16 ates challenges related to the large, highly repetitive and polyploid switchgrass genome, to perform

17 n communication and social skills as well as repetitive and stereotypical behaviors.

18 s sufficient to generate ASD-related social, repetitive, and restricted behaviors, while stimulation

19 ts in multiple behaviors, including anxiety, repetitive, and social behaviors.

20 esponses and the acoustic signals confirms a repetitive appearance of acoustic distinctions of phonem

21 to other species, primarily associated with repetitive AT-rich sequences, in addition to larger-scal

22 secondary IgE Ab responses can be boosted by repetitive B cell epitopes without allergen-specific T c

23 ay disruption might play a causative role in repetitive behavior of Shank3B mutant mice.

24 tween compulsive behavior (measured with the Repetitive Behavior Scale) and ACC glutamate (rho=0.24,

25 zed by impairments in social interaction and repetitive behavior, and is also associated with cogniti

26 e for 2-AG deficiency in social deficits and repetitive behavior, and they demonstrate a key role for

27 everity of impaired social communication and repetitive behavior, immune dysregulation and gastrointe

28 ction, aberrant communication, and increased repetitive behavior.

29 Often, restricted and repetitive behaviors (RRBs) accompany this disorder.

30 sorder (ASD) is characterized by ritualistic-repetitive behaviors and impaired verbal/non-verbal comm

31 displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment

32 n these strategies is relevant to inflexible repetitive behaviors in psychiatric disorders.

33 al functioning, with no observed decrease in repetitive behaviors or anxiety.

34 eraction, cognitive/executive functions, and repetitive behaviors reflective of ASD-like phenotypes.

35 vironmentally driven, but not self-directed, repetitive behaviors were exacerbated in lesioned mice.

36 o an increase in other spontaneously emitted repetitive behaviors without alteration of motor coordin

37 (ASD) include impaired social communication, repetitive behaviors, and restricted interests.

38 ia dysfunction has been proposed to underlie repetitive behaviors, few studies have provided direct e

39 its of ASD, that are, social, cognitive, and repetitive behaviors, we report that a systemic administ

40 ether with exacerbated spontaneously emitted repetitive behaviors.

41 luding intrusive thoughts and time-consuming repetitive behaviors.

42 reating disorders characterized by excessive repetitive behaviors.

43 , social interaction deficits, and increased repetitive behaviors.

44 g adverse scores in Social Communication and Repetitive Behaviour measures that are independently pre

45 meliorates autism-related symptoms including repetitive behaviour, defective social interaction and a

46 Sociability and repetitive behavioural phenotypes could be selectively m

47 01), loss of sympathy and empathy (p=0.008), repetitive behaviours (p<0.001) and dietary changes (p<0

48 We found that after exposure to repetitive blast-induced TBI, phosphoinositol biphosphat

49 egative outcomes associated with exposure to repetitive brain trauma (RBT) continues to strengthen.

50 Following each pulse during repetitive Ca(2+) elevations, CaMKII activity increased

51 n from the endoplasmic reticulum to generate repetitive Ca(2+) puffs.

52 n Meg-01 cells and enhanced the frequency of repetitive Ca(2+) transients by 80% in platelets.

53 as ineffective at reducing halothane-induced repetitive Ca(2+) waves in the presence of resting level

54 bility of research and minimize the need for repetitive calibration.

55 eated coding motif variants and higher-order repetitive cassette structures unique to specific spidro

56 d chimerism (4 weeks), most pronounced after repetitive cell administration (12.92% vs 5.03% [POD 1]

57 opic recombination event mediated by similar repetitive centromeric DNA elements shared between chrom

58 We attribute this phenomenon to repetitive changes in the electronic structure of superl

59 ich lymphocyte entry and exit is governed by repetitive circadian rhythms.

60 We show that editing levels in non-repetitive coding regions vary more between tissues than

61 sites and ADAR2 is the primary editor of non-repetitive coding sites, whereas the catalytically inact

62 However, the repetitive composition of genomes challenges the identif

63 Here we report spontaneous and repetitive constriction of mitochondrial inner compartme

64 oids, genomic locations showing differential repetitive contents were genetically mapped, which displ

65 During extinction training with repetitive CS presentations, the CS representation becam

66 Surprisingly, we find that the repetitive CTD is structurally heterogeneous.

67 Cells employing amoeboid motility exhibit repetitive cycles of rapid expansion and contraction and

68 maintenance of genome stability by silencing repetitive DNA elements and transposons.

69 LTR retrotransposons are repetitive DNA elements comprising approximately 10% of

70 and derepression of endogenous LTR- and LINE-repetitive DNA elements during differentiation of mouse

71 ng heterochromatin and repressing endogenous repetitive DNA elements during differentiation.

72 iched with species-specific transposable and repetitive DNA elements.

73 diate repeat-induced point mutation (RIP) of repetitive DNA in N. crassa.

74 yotic genomes contain substantial amounts of repetitive DNA organized in the form of constitutive het

75 Recently, understudied repetitive DNA regions called microsatellites have been

76 Because of its dense packaging and repetitive DNA sequence, heterochromatin is a challengin

77 hyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability.

78 Repetitive DNA sequences are ubiquitous in life, and cha

79 eport here the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and rel

80 yeast is prone to trigger deletions between repetitive DNA sequences via a mechanism we call Inter-F

81 CAG/CTG repeats are structure-forming repetitive DNA sequences, and expansion beyond a thresho

82 ha satellite is a tandemly organized type of repetitive DNA that comprises 5% of the genome and is fo

83 Regions of highly repetitive DNA, such as those found in the nucleolus, sh

84 by abundant gene-loss and an accumulation of repetitive DNA, yet the nature of the gene repertoire of

85 rochromatin, usually characterized by highly repetitive DNA.

86 because of unequal recombination mediated by repetitive DNA.

87 with a significantly higher mutation rate in repetitive DNA.

88 e also conducted a genome-wide survey of the repetitive DNAs in S. spontaneum following a similarity-

89 er perspective on how structural variants in repetitive DNAs may contribute to human disease.

90 on-effect variegation (PEV), organization of repetitive DNAs, and DNA repair.

91 combination in wheat and contained an extra repetitive-domain cysteine residue in 1Dx5 that was impo

92 es were exposed to either a single dose or 5 repetitive doses of ssUVR.

93 lightly better than wild type animals during repetitive downhill running.

94 voked potential studies were performed after repetitive electrical stimulation of the ictal onset zon

95 suggest an important link between TDP-43 and repetitive element biology, our data indicate that TDP-4

96 ripheral blood mononuclear cells by >75% and repetitive element CpG methylation by approximately 10%,

97 ssociated with toxicity and, while increased repetitive element expression has been observed in sever

98 lation of RNA polymerase II activity altered repetitive element expression in vitro.

99 Instead, we found that repetitive element expression positively correlated with

100 These analyses confirmed that repetitive element expression was significantly increase

101 To assess whether aberrant expression of repetitive element sequences are observed in ALS, we ana

102 I activity in ALS/FTLD may lead to increased repetitive element transcript expression, a novel pathol

103 Recently, the expression of repetitive element transcripts has been associated with

104 , was used to validate the levels of several repetitive element transcripts.

105 ipts from multiple classes and subclasses of repetitive elements (LINEs, endogenous retroviruses, DNA

106 DNA methylation in repetitive elements (RE) suppresses their mobility and m

107 that most enhancers and several families of repetitive elements act as autonomous transcription init

108 nomes are characterized by a high content of repetitive elements and large pericentromeric regions th

109 e piRNA and nuclear RNAi pathways to silence repetitive elements and prevent genotoxic stress in the

110 Repetitive elements are often found in heterochromatin;

111 The composition of genes and repetitive elements differs between distal and proximal

112 cient to account for the observed changes in repetitive elements in ALS/FTLD.

113 The functional role of repetitive elements in mammalian genomes is still largel

114 Increasing evidence suggests that repetitive elements may play a role in host gene regulat

115 and reveals the significant contribution of repetitive elements to the RNA regulatory landscape of t

116 Repetitive elements, including LINE-1 (L1), comprise app

117 ely half of the mammalian genome consists of repetitive elements, including retrotransposons, some of

118 oncoding, and intergenic regions, as well as repetitive elements, telomeres, etc.

119 The major component of complex genomes is repetitive elements, which remain recalcitrant to charac

120 id assembly of oligosaccharides, built up of repetitive elements.

121 recombination rates and in the proximity of repetitive elements.

122 on suggesting a rapid turnover of W-specific repetitive elements.

123 Our genomes are dominated by repetitive elements.

124 g within 1 to 4 hours of food ingestion with repetitive emesis and lethargy.

125 In comparison with repetitive Env immunizations, sequential Env administrat

126 e granular layer may provide a reference for repetitive EPSP/AP phase coupling.

127 Several cycles of repetitive exposure of cells to 0.1 g/L nZVI induced a p

128 ered significantly from those that underwent repetitive exposures.

129 d 1, the major cat allergen, displayed in a repetitive fashion on virus-like particles (VLPs) may fu

130 tivity in ten patients with PD who performed repetitive feet or hand movements while undergoing impla

131 (lorcaserin) to septic rats greatly improved repetitive firing and motor unit force generation.

132 in supraoptic magnocellular neurons regulate repetitive firing and spike frequency adaptation but rel

133 We recently identified a defect in repetitive firing of lower motor neurons as a novel cont

134 apitulated the elevated action potential and repetitive firing phenotype.

135 re potential mechanisms underlying defective repetitive firing.

136 rmine the mechanism underlying the defect in repetitive firing.

137 ing cytosolic Ca(2+) except during prolonged repetitive firing.

138 might be the mechanism underlying defective repetitive firing.

139 slowed repolarization of late spikes during repetitive firing; (ii) enhanced the after-depolarizatio

140 (50 ms) visual stimulus re-exposure during a repetitive foil task enhanced the stability of cued vers

141 We compared the effects of single versus repetitive follow-up 24-hour urine samples on the relati

142 to colocalize with telomeres, which contain repetitive G4-forming sequences.

143 con resequencing with maize, one of the most repetitive genomes sequenced to date ( approximately 85%

144 tion and dynamics of both repetitive and non-repetitive genomic regions in live cells.

145 ic parts are iteratively integrated into the repetitive genomic sequences in a modular manner using r

146 cause of autism, and Shank3 mutant mice show repetitive grooming and social interaction deficits.

147 um spiny neurons (MSNs) and its relevance to repetitive grooming behavior in Shank3B mutant mice.

148 Importantly, the repetitive grooming behavior was rescued by selectively

149 g activity in this pathway reduced excessive repetitive grooming in the mutant mice.

150 letion from the ventral striatum resulted in repetitive grooming.

151 between gene-rich euchromatin and the highly repetitive heterochromatin domain, which is enriched for

152 During repetitive high-frequency motoneuron drive, PMn synapses

153 ed as adjunctive therapy to treat or prevent repetitive ICD therapies when antiarrhythmic drugs are i

154 ed as adjunctive therapy to treat or prevent repetitive ICD therapies.

155 l neurons by providing calcium influx during repetitive inputs.

156 neous coronary intervention (PCI) induced by repetitive interruptions of blood flow to the ischemic m

157 PF was induced by repetitive intraperitoneal injections of chlorhexidine g

158 RNA polymerase II contains a repetitive, intrinsically disordered, C-terminal domain

159 c disorder characterized by the execution of repetitive involuntary movements.

160 a-affected and remote myocardial areas after repetitive ischemia/reperfusion (r-I/R) injury without e

161 us plasma coherent emission is maintained by repetitive Langmuir collapse driven by the nonlinear evo

162 ns that concentrated shear stresses, and (3) repetitive, localized biting.

163 nd it is essential to validate assemblies of repetitive loci.

164 8 million years in response to selection for repetitive, low-cost contractile behavior.

165 In a repetitive, low-dose challenge study, we observe robust

166 cterization of gene regulation in the highly repetitive maize genome.

167 The robotic approach is best suited to repetitive measurements of sample series, with academic

168 on can also be compressed using CRIMP by the repetitive merging of ions distributed over multiple TW

169 alternative explanations, for example, that repetitive motor performance or personality traits in si

170 al social approach, social interactions, and repetitive motor stereotypies that are relevant to ASD.

171 The caudate nucleus may be involved in the repetitive movements and limbic changes of autism.

172 disorder that forces the body into twisting, repetitive movements or sometimes painful abnormal postu

173 2+) ions from the extracellular space during repetitive muscle activity.

174 ar range) and provide a good reusability for repetitive NADH detection.

175 The large size and highly repetitive nature of the Ae. tauschii genome has until n

176 Their repetitive nature poses a challenge for genome assembly

177 Evidence suggests that repetitive neonatal procedural pain precedes long-term a

178 oxidative stress, telomeres are segments of repetitive nucleotide sequence at each end of a chromoso

179 l a highly nonrandom, statistical pattern of repetitive nucleotide triplets that correlates with the

180 ermore, it is not known whether the combined repetitive oligopeptide (CROP) domain is involved in or

181 o distinct epitopes within the TcdB combined repetitive oligopeptide (CROP) domain, preventing toxin

182 ltiple sites on the TcdA C-terminal combined repetitive oligopeptides (CROPs) domain.

183 ts in social interaction, communication, and repetitive or restrictive behavior.

184 external detail production (i.e., semantic, repetitive, or off-topic information), reflected by a si

185 essenger inositol trisphosphate often evokes repetitive oscillations in cytosolic Ca(2+) .

186 s procedure and the known adverse effects of repetitive pain in neonates should encourage the search

187 n the prevention of adverse effects of early repetitive pain on brain development.

188 Repetitive pairing caused strong augmentation of cortica

189 ommunication and interaction and restricted, repetitive patterns of behavior, interests, and activiti

190 ocial communication deficits and restricted, repetitive patterns of behavior.

191 with a scarcity of ancient clades exhibiting repetitive patterns of phenotypic evolution [5, 6].

192 e nuclease-deactivated Cas9 protein fused to repetitive peptide epitopes (SunTag) recruiting multiple

193 Repetitive place-contingent pairing of activation caused

194 ies Aegilops tauschii, a large and extremely repetitive plant genome that has resisted previous attem

195 se this data alone, particularly with highly repetitive plant genomes.

196 Characterization of the repetitive portion of the genome revealed more than 130,

197 Repetitive prenatal exposure to identical or similar dos

198 ent.SIGNIFICANCE STATEMENT Early exposure to repetitive procedural pain in very preterm neonates may

199 w tool reduces user input time by automating repetitive processes and facilitates access to GPU clust

200 ing methods by eliminating the necessity for repetitive purification steps and increasing throughput

201 We used a repetitive (r)TBI mouse model and harvested the injured

202 majority of intermediates follow simple and repetitive reaction patterns.

203 s included 23 families with mutations in the repetitive region of RPGR exon 15 that would have been m

204 otein fibronectin (Fn) via an N-terminal non-repetitive region, and this protein-protein interaction

205 ssociated capsule transport genes flanked by repetitive Regions D and D'.

206 aracterized 36 previously unidentified large repetitive regions in the proximity of sequence assembly

207 Megabase-sized, complex, repetitive regions of genomes are poorly studied, due to

208 ng differences in the epigenome occurring at repetitive regions of the Arabidopsis genome.

209 ng because many variants have breakpoints in repetitive regions of the genome and thus are difficult

210 quencing because they tend to integrate into repetitive regions of the genome.

211 ely, the weakening of replication origins in repetitive regions suppresses these gaps.

212 ning regions using a single sgRNA and of non-repetitive regions with as few as four unique sgRNAs.

213 Delta reveals copy number changes flanked by repetitive regions with high R-loop-forming potential.

214 some, which are known to contain GC-rich and repetitive regions, but at the distal tip of the largest

215 n of replication resources to origins within repetitive regions, induced by SIR2 deletion, leads to p

216 hese methods are mostly applicable to highly repetitive regions, whereas imaging regions with low or

217 are able to extend paths into problematic or repetitive regions.

218 more between tissues than editing levels in repetitive regions.

219 mediated silencing, combined with the use of repetitive regulatory elements, led to aggressive transp

220 region within Xist exon 7-namely, the highly repetitive Repeat E motif.

221 Additionally, these sensors show a repetitive response for several days and are reusable af

222 te that frameshifting takes place during the repetitive ribosomal conformational changes associated w

223 Means to target these repetitive RNAs are required for diagnostic and therapeu

224 Repetitive runs of NSVT were also associated with ICD-tr

225 0 beats per minutes), longer (>7 beats), and repetitive runs of NSVT were more highly predictive of I

226 uirement is not necessarily fulfilled, since repetitive sampling can remove a significant fraction of

227 Highly repetitive satellite DNA (satDNA) repeats are found in m

228 ar how transcription is linked to underlying repetitive satellite sequences.

229 Furthermore, rapid, repetitive scanning was done, which allowed measurement

230 OB plasticity may act to filter sustained or repetitive sensory signals.

231 s uniform gene density over chromosomes, low repetitive sequence content ( approximately 6%), and a h

232 2 Mb due to a more accurate determination of repetitive sequence elements and assembled the complete

233 ed-coil domain and associates densely on the repetitive sequence of the phosphorylated CTD via its N-

234 he genuine leptin gene with a GC-rich ( 70%) repetitive-sequence content was identified in the chicke

235 DNA elimination reveals that in all species, repetitive sequences (that differ among the genera) and

236 Repetitive sequences accounted for 46.1% of the assemble

237 We propose that amplified repetitive sequences act as selfish elements by promotin

238 mosome genetic degeneration, accumulation of repetitive sequences and heteromorphism.

239 Centromeres and other repetitive sequences can drive in meiosis by cheating th

240 Repetitive sequences derived from transposons make up a

241 ents (TEs) contribute to the large amount of repetitive sequences in mammalian genomes and have been

242 (MSI) refers to the hypermutability of short repetitive sequences in the genome caused by impaired DN

243 h displayed different organization of highly repetitive sequences in the two genomes.

244 Selected repetitive sequences termed short inverted repeats (SIRs

245 sites of long interspersed nuclear element-1 repetitive sequences was assessed in a group of 63 patie

246 Heterochromatin is highly enriched for repetitive sequences, and is defined epigenetically by m

247 ficant differences were identified in highly repetitive sequences, including centromere, 45S ribosoma

248 ciated changes in chromatin accessibility at repetitive sequences, we suggest that replication gaps r

249 ric deletions and large insertions of middle repetitive sequences.

250 mber variation of paralogous genes, and long repetitive sequences.

251 ively bind and enrich hypervariable, long or repetitive sequences.

252 east and mammalian CTD are hampered by their repetitive sequences.

253 The intestinal epithelium is a repetitive sheet of crypt and villus units with stem cel

254 Globally, ADAR1 is the primary editor of repetitive sites and ADAR2 is the primary editor of non-

255 urst of beta-actin synthesis at multiple non-repetitive sites, particularly in the periphery.

256 e, has been proposed to limit fatigue during repetitive skeletal muscle activity.

257 inje neuron morphology that help to preserve repetitive spiking can also therefore have deleterious c

258 annel mediated afterhyperpolarization (AHP), repetitive spiking is maintained, through the increased

259 tion with prominent Purkinje neuron atrophy, repetitive spiking is restored, although at a greatly re

260 urkinje neurons early in disease to maintain repetitive spiking.

261 ally G2/M checkpoint and mitotic regulation, repetitive ssUVR led to extensive changes in genes relat

262 ay activity-dependent slowing (ADS), whereby repetitive stimulation (>/=1 Hz) results in a progressiv

263 lity of maintaining contractile force during repetitive stimulation in the presence of 2.5 mM extrace

264 ferent synapses drives greater LTP following repetitive stimulation.

265 ious reduced responsiveness to continuous or repetitive stimulation.

266 l biphasic decline in contractile force with repetitive stimuli of hind-limb muscle, both in vivo and

267 tart their speedy elongation, resulting in a repetitive stop-and-go growth dynamics.

268 Repetitive strain from eye movements over decades might

269 in the native antigenic conformation and the repetitive structure of the original virus particle, but

270 shed C. hircus assembly, and better resolves repetitive structures longer than 1 kb, representing the

271 mation of DNA double-strand breaks (DSBs) in repetitive switch region elements followed by ligation b

272 Using mouse models of severe or repetitive TBI, we showed that cis P-tau elimination wit

273 ing CTE-like pathology and dysfunction after repetitive TBI.

274 e-dependent binding of mossy fiber spikes to repetitive theta-frequency cycles of granule cell activi

275 o subject to double-strand breaks within the repetitive tract followed by DNA repair.

276 Although several strategies of repetitive transcranial magnetic stimulation (rTMS) have

277 To investigate the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) of t

278 efrontal cortex for treating depression with repetitive transcranial magnetic stimulation (rTMS) rema

279 Repetitive transcranial magnetic stimulation (TMS) thera

280 brain stimulation, and non-invasive such as repetitive transcranial magnetic stimulation and transcr

281 nce imaging data, a robotic arm positioned a repetitive transcranial magnetic stimulation coil over a

282 female and male human participants, whether repetitive transcranial magnetic stimulation of a fronta

283 sal lateral prefrontal cortex target, and 50 repetitive transcranial magnetic stimulation pulses were

284 ds, and by applying excitatory or inhibitory repetitive transcranial magnetic stimulation to a subjec

285 in intestine, hypodermis, or neurons using a repetitive transgene can enable silencing also in unresc

286 an be inhibited wihin tissues that express a repetitive transgene.

287 ecause muscle-specific rescue of rde-4 using repetitive transgenes enables silencing in other tissues

288 al promoters, report an inhibitory effect of repetitive transgenes, and discover conditions for cell-

289 Repetitive transorbital alternating current stimulation

290 ), spoligotyping, mycobacterial interspersed repetitive units - variable number tandem repeats (MIRU-

291 break via routine mycobacterial interspersed repetitive units-variable number of tandem repeats typin

292 veness to restore the membrane permeance for repetitive usage.

293 ed an association between 'the degree of the repetitive use of objects or interest in parts of object

294 Patients with repetitive ventricular tachycardia/ventricular fibrillat

295 FICANCE STATEMENT We use a novel paradigm of repetitive whisker stimulation and in vivo calcium imagi

296 pronounced deficit in neuronal adaptation to repetitive whisker stimulation in both young and adult F

297 The spinach genome is highly repetitive with 74.4% of its content in the form of tran

298 ng, counting, writing-rewriting compulsions, repetitive writing tics) and disinhibition (uttering syl

299 Indeed, haploid and repetitive Y chromosomes in species with male heterogame

300 Both fern mitogenomes are highly repetitive, yet they show extremely low levels of active