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1 be reprogrammed; the device was subsequently replaced.
2 T2 when two of the conserved amino acids are replaced.
4 Gene drives have the potential to rapidly replace a harmful wild-type allele with a gene drive all
7 e health and prevent disease, through safely replacing a large amount of daily sedentary time with ph
12 mary aim in tissue engineering is to repair, replace, and regenerate dysfunctional tissues to restore
15 nvolved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000.
18 ared, and that visual communication may have replaced auditory in these colourful, diurnal frogs.
20 , in silico designed catalyst emerged, where replacing Bpin with Beg (eg = ethylene glycolate) was pr
21 mococcal conjugate vaccine (PCV7) from 2005, replaced by 13-valent PCV (PCV13) in 2011, uniquely amon
24 with the pendant Mn horizontal lineO moiety replaced by a hydrogen abstracted from the organic subst
27 k that currently characterizes DoC should be replaced by a multidimensional framework that better cap
29 ding that our current emphasis on novelty be replaced by a renewed emphasis on predictive power as a
32 g interactions with the ribosomal target, is replaced by an apramycin-like dioxabicyclo[4.4.0]octane
34 ivated domain wall dynamics is progressively replaced by an intense thermally activated relaxational
35 ode catalytic layer of the DMFC is partially replaced by an ionomer with molecular recognition capabi
36 re the complex borohydride anion, BH4(-), is replaced by another anion, i.e. a halide or amide ion; a
37 ent on its MAP subunit EDE1, which cannot be replaced by AUG8, and that the cell-cycle-dependent func
38 lary-lymph-node dissection can be omitted or replaced by axillary radiotherapy, reducing morbidity.
40 nylenes, in which one or more aryl units are replaced by borazine rings, is reported for the first ti
43 -based P -value estimation methods have been replaced by exact methods, providing faster and more acc
45 and 3, while in Jam 4 sucrose was completely replaced by fructose and stevioside, making this formula
48 stability, notably Gln264 of E, which, when replaced by His264 strengthens a hydrogen-bonding networ
50 ) evoked by steady depolarization at rest is replaced by irregular firing during functional network a
51 nt's role in regulating Mmp2 and Oamb can be replaced by its human homolog Ras-responsive element-bin
53 T p.Val804Met (protein valine at residue 804 replaced by methionine) genetic mutation, with 2 of the
55 vealed that the pyridinyl ring of 2 could be replaced by other aromatic rings and the pyrrolidinyl ri
57 he XND1 C-terminal domain could be partially replaced by RBR fused to the N-terminal domain of XND1.
58 mph-node dissection for staging has now been replaced by sentinel-lymph-node biopsy for patients with
59 Pegylated interferon plus ribavirin has been replaced by sofosbuvir plus pegylated interferon and rib
60 em cells (ISCs) in the Drosophila midgut are replaced by spindle-independent ploidy reduction of cell
61 skeletons, which were subsequently lost and replaced by spongin later in the evolutionary history of
63 tional nonchemical methods were subsequently replaced by synthetic chemicals, other traditional metho
64 l mammographic images are increasingly being replaced by synthetic mammograms in DBT screening in an
66 ction of the original coumarin dyes has been replaced by the cyano(4-nitrophenyl)methylene moiety.
70 f the charges on the proteins is in this way replaced by the magnitudes and orientations of the multi
71 that the first 40 amino acids of gp120 were replaced by the signal sequence and the first 27 amino a
72 on proteins (IFPs) with the cytoplasmic tail replaced by the signaling domain of the costimulatory re
74 ttom-dwelling benthivores, are being rapidly replaced by traits of incoming boreal species, particula
77 WT and Ccr2(-/-) mice, and that neutrophils replace CCR2(+) macrophages as the primary phagocytic ce
80 lla flgM gene, the effects on translation of replacing codons Thr6 and Pro8 of flgM with synonymous a
81 rge scale MFC applications and are likely to replace conventional anodes for the development of next
82 sis of immunosuppressants and creatinine can replace conventional venous sampling in daily routine.
84 arch, we here investigate the possibility of replacing conventional enzymatic digestion methods with
86 es, particularly in systems subject to stand-replacing crown fires, such as most Mediterranean-type e
87 n of these two methods, there is a chance to replace culture-based methods in the future for the moni
90 PORB plants, caused more severe effects than replacing Cys276 by an Ala residue in the active site of
91 superoxide ions, but NRAMP2 can functionally replace cytosolic superoxide dismutase in yeast, indicat
93 stem cells in adult tissues are tasked with replacing decaying cells and regenerating tissue after i
96 is indicates that M1 and M2 can functionally replace each other in some, but not all, aspects of viru
97 an GLUT5 sequence into 26 fragments and then replaced each fragment with the corresponding region in
99 antibodies and identify antibodies that can replace either Sox2 and Myc (c-Myc) or Oct4 during repro
100 ined as the candidate ontology to import and replace eligible EFO cell line classes thereby supportin
101 phosphorylation of other mitotic substrates; replacing endogenous Gwl with a phosphomimetic S883E mut
104 The approach is sufficiently general to replace existing unsupervised clustering approaches outs
106 mucilage proved to be a new alternative for replacing fat in food products, preserving the quality a
107 binoxylans (AX) from wheat bran to partially replace flour during baking, were investigated to identi
108 The radical possesses four mPEG-3 groups replacing four methyl groups in the tert-butyl groups at
109 ults suggest that the qSOFA score should not replace general early warning scores when risk-stratifyi
111 n Failure 1 (EFF-1) somatic cell fusogen can replace HAP2/GCS1 in one of the fusing membranes, indica
116 iration rates and short leaf lifespans, were replaced in the Early Jurassic by forests dominated by h
118 ilence the endogenous allele of ataxin 7 and replace it with an exogenous copy of the gene, highlight
119 xide from a carboxylic acid and economically replace it with an organozinc-derived olefin on a molar
120 collections is unsatisfactory and propose to replace it with an unspecific mechanism capturing approx
122 lowered intake of dietary saturated fat and replaced it with polyunsaturated vegetable oil reduced C
124 ted organophosphate insecticide use by 2001, replacing it with pest monitoring systems, threshold-bas
125 nile loss in a young man are devastating and replacing it with the same organ is likely to produce th
126 he function of HEV ORF3 can be maintained by replacing it with the well-characterized viroporin influ
127 ly that lowering intake of saturated fat and replacing it with unsaturated fats, especially polyunsat
128 ost's adaptive immune response by repeatedly replacing its dense variant surface glycoprotein (VSG) c
129 ously immortalised DF-1 cell line is rapidly replacing its progenitor primary chicken embryo fibrobla
133 s cutoffs as a test replacement strategy (to replace liver biopsy) in making key decisions in the man
134 s of multiple tetrahydrofuranyl abasic sites replacing loop adenines (A/AP) and tetrad guanines (G/AP
143 ponding to maximized conventional MV, and to replace MV and minimize/abolish the harmful effects of v
145 se ligand exchange methods, which completely replace native ligands with functionalized cinnamate lig
146 orporate modifications to the PIV5 backbone, replace native RSV F with a prefusion-stabilized RSV F m
148 erived from stem cells have the potential to replace neurons that have already been lost and thereby
149 onal hot spots, and segments that are always replaced, never replaced, or linked to pathogenesis or h
150 catalysts have been extensively developed to replace noble metal Pt and RuO2 catalysts for the oxygen
156 New vaccine virus strains are selected, replacing older strains to better match the currently ci
157 with a biphenyl lead, bioisosteres formed by replacing one phenyl by pyridine or pyrimidine showed im
159 ransplantation and gene therapy may serve to replace or resurrect dead or injured retinal neurons.
162 red, selective C5a receptor inhibitor, could replace oral glucocorticoids without compromising effica
164 rting seed densities showed that seeds could replace other more labour intensive and costly methods,
166 immunomodulatory approach being developed to replace our current clinical immunosuppression therapies
167 revealed that all Mf subsets were completely replaced over time; Mf1 and Mf2, phenotypically similar
170 radable polyesters have a large potential to replace persistent polymers in numerous applications and
177 methacrylate) appears to enhance activity by replacing protein-water interactions, thereby preserving
182 ized to the plasma membrane and functionally replaced RhoA with respect to invasion, clonogenic growt
183 boundaries where mangroves are expanding and replacing salt marsh, wetland capacity to respond to sea
185 This single comprehensive WGS assay has replaced seven molecular assays and has resulted in resi
186 -sized CdSe quantum dot (3.0 +/- 0.2 nm) can replace several different dye catalysts needed for five
187 nificantly lower risks of CVD mortality when replacing SFAs plus TFAs with total UFAs [HR in quintile
189 f developing DM and the potential benefit of replacing SSBs with ASBs or water.The national Women's H
190 or safety profile, we suggest that Rtx might replace St-Cp as first-line immunosuppressive therapy in
191 of sodium-ion battery electrodes obtained by replacing stepwise the oxygen atoms with sulfur atoms in
194 l of Dixon T2-weighted fat-only sequences to replace T1-weighted sequences for the detection of bone
195 n tomography scans for MIBG-nonavid disease, replace technetium-99m diphosphonate bone scintigraphy f
198 risk of bias in observational studies, none replace the balance of both known and unknown prognostic
200 ired to develop a practical process that can replace the current energy and capital intensive natural
201 blocks, which could partially or even fully replace the currently utilized fossil-based ones in well
202 eded to determine if en face OCT imaging can replace the evaluation of individual B-scans for the det
205 ioArtificial Liver machine could temporarily replace the functions of the liver, buying time for the
206 sion that the HTLV-1 CA NTD can functionally replace the HIV-1 CA CTD, but the HIV-1 CA NTD cannot re
207 he HIV-1 CA CTD, but the HIV-1 CA NTD cannot replace the HTLV-1 CA CTD, indicating that the HTLV-1 CA
208 CopyCat elements) can efficiently delete and replace the L2-CRM with orthologous sequences from other
210 thermore, bioengineered artificial ducts can replace the native CBD, with no evidence of cholestasis
212 free of a disabling stroke or reoperation to replace the pump for malfunction), driven by a reduced n
213 portable and shows significant potential to replace the reliance on more expensive and laborious PCR
215 motif exchange (SME) reaction to selectively replace the surface motifs of parent [Ag44(SR)30](4-) (S
216 e-embedded osteocytes dynamically resorb and replace the surrounding perilacunar bone matrix to maint
217 taposed, and single detached nodal complexes replace the symmetrical heminodes found in both the CNS
218 This conductance trend is reversed when we replace the thiols with amines, highlighting the impact
219 niques studied could be successfully used to replace the time-consuming spectrophotometric method and
220 lated by universal Gre factors, which should replace the TL to get access to the RNAP active site.
222 ally introduced gene drive allele spreads to replace the wild-type allele, although it possesses a se
223 ole of the gag sequence in RNA packaging, we replaced the 5' gag sequence in the HIV-1 genome with tw
224 His-DPhe-Arg-Trp or tripeptide DPhe-Arg-Trp replaced the Arg-Phe-Phe sequence in the AGRP active loo
226 cumvent these potentially harmful events, we replaced the C-terminal region of DENV NS1 with the corr
227 reference for Cenozoic dispersal origins has replaced the classical view of Mesozoic vicariance in th
229 nd absent protein, while the second mutation replaced the highly conserved cysteine 107 with a serine
230 rmers of Anatolian origin [1-3], who largely replaced the local Mesolithic hunter-gatherers [1, 4-6].
232 ansgenic Drosophila, in which the mouse OPN4 replaced the native Rh1 photopigment of Drosophila R1-6
233 arrier sponge is degraded over time, dentine replaces the degraded sponge leading to a complete, effe
234 ich acetate:succinate CoA-transferase (ASCT) replaces the enzymatic step typically performed by succi
236 f cardiopulmonary resuscitation science that replaces the previous 5-year cyclic batch-and-queue appr
238 A-specific chimeric dinucleotide (DIAL) that replaces the pyrophosphate leaving group of the native s
239 Electrochemical studies indicate that by replacing the BIPY(2+) units in homo[2]catenane HC(*7+)-
243 ionotropic AMPA 2 (GRIA2), modifies a codon, replacing the genomically encoded glutamine (Q) with arg
244 itical first step in solving this problem is replacing the Journal Impact Factor with an article-leve
245 tamorphosed into one another by sequentially replacing the loops and helices of the six-helix bundle
246 ical cure for type 1 diabetes (T1D) involves replacing the lost insulin-producing cells with new ones
248 y minor differences in channel function, and replacing the nmrASIC3 sequence with that of rASIC3 did
249 ion of biotinylated nuclei was redesigned by replacing the outer nuclear-envelope-targeting domain of
252 single-component Cas9 variant engineered by replacing the protein's REC2 domain with the BCL-xL prot
254 ween the classes is artificially degraded by replacing the SVM model with an ad hoc k-means classifie
255 e the trapping of the captodative radical by replacing the vinylic carboxylic acid with an amide.
259 we evaluated the functional consequences of replacing this residue in two CRF01_AE Envs (CM244 and 9
261 regimen for HER2-positive breast cancer that replaces traditional systemic chemotherapy with targeted
262 y and has been increasingly supplementing or replacing traditional approaches based on P values.
264 es, including 2,4-dinitroanisole (DNAN), are replacing traditional explosive compounds to protect sol
266 we mimic phosphorylation of cytochrome c by replacing tyrosine 48 with p-carboxy-methyl-l-phenylalan
267 chocolate cakes made with chia mucilage can replace up to 50% of fat without affecting the technolog
271 es were kept outside for 45 seconds and then replaced, whereas left testicles were twisted by 360 deg
272 constructs in which specific G residues are replaced with (th) G, an emissive isomorphic G surrogate
273 When the amount of powder reached 1g, it was replaced with 8g of scrambled egg, after then subsequent
275 be stabilized if one of the pyrrole rings is replaced with a furan ring to afford stable oxasmaragdyr
277 ing between H(+) and sugar translocation, is replaced with a neutral side chain, the pH effect is abo
278 variant in which the proximal tryptophan was replaced with a non-oxidizable phenylalanine exhibited h
280 in which an inverted Cys-Pro motif had been replaced with Ala residues fails to bind hemin with high
281 iddle Pro residue within the tripeptides was replaced with analogues of varying ring sizes (azetidine
282 decomposition in the manual pipeline can be replaced with any NMF algorithm, for further generalizat
283 alent residue to K305 in human NHA2 has been replaced with arginine, which is a mutation that makes N
285 ed that a recombinant VSV where G protein is replaced with EBOV GP (rVSV-EBOV) is safe and highly eff
286 P. berghei csp gene coding sequence has been replaced with either full-length P. vivax VK210 or the a
287 seful in deciding whether orchiectomy can be replaced with follow-up or less invasive organ-sparing s
288 ative Rh-based system having acetate ligands replaced with MeCN indicates that C-H bond activation is
289 ly altered when one of the cytosine bases is replaced with methyl-, hydroxymethyl-, formyl-, or carbo
291 3 active site, the Zn(2+) chelating unit was replaced with nonchelating polar residues that bridged o
292 tudy indicated that the allyl group could be replaced with other substituents, with the most active b
293 irical parameters in existing models must be replaced with physics- and biology-based terms anchored
296 hila atonal coding sequence was endogenously replaced with that of atonal homologues (ATHs) at key ph
297 tocompatibility complex class II antigen was replaced with the human leukocyte antigen DR4 (HLA-DR4).
298 nd extracellular loops of CD81 and OCLN were replaced with the respective human sequences, which cont
299 ane and cytoplasmic tail (TMCT) domains were replaced with those of the HPIV1 F protein in an effort
300 pheral blood monocytes (PBMos), were largely replaced within 3 wk, whereas two subsets with features
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