ライフサイエンスコーパス: replacement of

1 for 5 wk every 4 mo for 3 y or to daily meal replacements of 1-2 meals for 3 y [regular (RE) group].

2 We show that replacement of 10 SNAP-23 residues with their SNAP-25 co

3 high risk, with an STS PROM for mitral valve replacement of 11%.

4 eriophage genes to achieve approximately 63% replacement of 2'-deoxycytidine (dC) with 5-hydroxymethy

5 Replacement of 3' UTR by non-UTR sequence had surprising

6 stem cells (MSCs) appeared to contribute in replacement of 40% and 13% host hepatocytes, respectivel

7 and active enzymatic processes resulting in replacement of 5meCs with unmethylated cytosines is a ha

8 PEO composite electrolytes by monitoring the replacement of (7) Li in the composite electrolyte by (6

9 The replacement of 75% of fat, for both types of mucilage, h

10 The replacement of a carboxylic acid with a surrogate struct

11 The replacement of a CH group with a N atom in aromatic and

12 motifs, and unusual interactions (e.g., the replacement of a conserved water molecule).

13 major challenge facing the discipline is the replacement of a generation of clinical microbiologists.

14 ed identification of an indirect promiscuous replacement of a key metabolic enzyme, which would have

15 The ongoing efforts dedicated to the replacement of a lab-based detector by a cellphone with

16 l cells and only few result in the effective replacement of a neighbour to effect expansion to the en

17 Through careful SAR, the successful replacement of a polar pyrazole group by a simple chloro

18 e report a comprehensive study of systematic replacement of a single phosphate with an amide linkage

19 brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat

20 Evidence of the replacement of active workers by inactive workers has be

21 orm stable complexes due to the evolutionary replacement of Ala(241) with Gly.

22 ing products, however, were not generated by replacement of AlCl3 with a protonic acid.

23 Immunoprecipitation assays revealed that replacement of all four tyrosines with alanines substant

24 wave at 60,000 years ago and the subsequent replacement of all indigenous populations, is in need of

25 to explore the impact of broadly distributed replacement of alpha-amino acid residues with beta-amino

26 We also validate a related approach whereby replacement of alphabeta TCR domains with corresponding

27 Replacement of amide functionality in RN-18 (IC50 = 6 mu

28 represents the first example of bioisosteric replacement of an acetate group by a spirobutyrolactone

29 yl-1-oxa-4,8,12-triazacyclotetradecane) upon replacement of an NMe donor in the TMC and TMCN ligands

30 In particular, the hypothesized replacement of ancient rainforest-dwelling extinct linea

31 Replacement of antibody on immune complexes by antibody

32 A final step consists of partial replacement of aragonite by dolomite, possibly in neutra

33 Replacement of Arg-1005, also located in the vicinity of

34 With the hypothesis that replacement of Arg-213 and Asp-143 with the correspondin

35 Replacement of Arg8 of inotocin by D-Arg8 led to a poten

36 generally applicable methods for the direct replacement of aryl hydrogens with NH2/NH(alkyl) moietie

37 olding conformation triggered by the Glu-145 replacement of Asp.

38 A plausible 30% replacement of banana flour in the formulation of layer

39 Replacement of BDNF selectively in the mOFC in Bdnf(+/-)

40 Replacement of beef by buffalo and vice versa is frequen

41 ch closest to clinical implementation is the replacement of beta cells with human pluripotent stem ce

42 lacial cycles, likely causing rapid regional replacement of biota.

43 h their combined role in hydrophobic gating, replacement of both Leu residues with the isosteric but

44 osylation factors (Arfs) by accelerating the replacement of bound GDP with GTP.

45 ion from ATP was observed for C932R, whereas replacement of C932 with leucine or phenylalanine, the l

46 Replacement of canonical histones with specialized histo

47 , fully restored receptor function; however, replacement of CAR-D2 with domains from CD155 or CD80 re

48 The replacement of carbon atoms in bioactive substances with

49 The replacement of CH with N increases Diels-Alder reactivit

50 ains unclear, however, and it is likely that replacement of colonized water reservoirs may be require

51 ptix knockouts in four species show complete replacement of color pigments with melanins, with corres

52 Replacement of conserved SC35M NP residues by those of H

53 The results indicate that replacement of conventional milk by organic or UHT milk

54 Metasurfaces have facilitated the replacement of conventional optical elements with ultrat

55 s that this is due to a gradual topochemical replacement of coordinated solvent molecules.

56 Replacement of critical amino acid residues within the F

57 The replacement of current petroleum-based plastics with sus

58 responding monomeric cyclic hexapeptide with replacement of Cys by Ala.

59 Furthermore, replacement of Cys-575 in the IgM tail piece of multimer

60 Surprisingly, in AOX1A, replacement of CysI by alanine, which cannot form a (thi

61 EMR2), which was predicted to result in the replacement of cysteine with tyrosine at amino acid posi

62 Replacement of D2 with the homologous D2 domain from chi

63 ion of growth factors that can stimulate the replacement of dead cells to the promotion of tissue rep

64 P1 levels are decreased in SMA mice and that replacement of deficient MCP1 increases differentiation

65 The main reason cited for the replacement of dental composite restorations is the recu

66 minating nutrient budgets despite continuous replacement of depleted soils with fresh bedrock via ero

67 nd IHD mortality for theoretical, isocaloric replacement of dietary fatty acids (FAs) in quintiles (1

68 itive detection of dsDNA based on the strand replacement of dsDNA by peptide nucleic acid (PNA) and t

69 Due to the strand replacement of dsDNA by PNA, dsDNA can be directly detec

70 inks) as a better, economic and eco-friendly replacement of dyes.

71 , chronic muscle inflammation and adipogenic replacement of dysferlinopathic muscle.

72 se, insulin, and triglyceride concentrations.Replacement of either glucose or sucrose by fructose res

73 and insulinemic responses after isoenergetic replacement of either glucose or sucrose in foods or bev

74 male Wistar rats were exteriorized, allowing replacement of endogenous bile by a model bile.

75 Moreover, molecular replacement of endogenous PSD-95 with the S561A mutant b

76 ifference is significantly reduced by either replacement of extracellular Ca(2+) with Mg(2+) or the a

77 is is supported by further observations that replacement of extracellular Cl(-) with gluconate(-) dim

78 (Glu) uptake in neighboring astrocytes evoke replacement of extracellular Glu for GABA, driving neuro

79 ocked by the SGLT1 inhibitor phlorizin or by replacement of extracellular Na(+) with N-methyl-d-gluca

80 The replacement of F-75 with unfortified rice porridge is as

81 The replacement of F-75 with unfortified rice porridge to am

82 nerate free holes (p-type doping), while the replacement of Fe(2+) by Ga(3+) cations, taking place in

83 The replacement of fossil resources that currently provide m

84 ), and GA3 (0.3%), with predominant genotype replacement of GA5 by GA2 and then GA2 by ON1.

85 li with a system for efficient, programmable replacement of genomic DNA with long (>100-kb) synthetic

86 her insertion of exogenous DNA (knock-in) or replacement of genomic segments is very poor.

87 ( approximately 7 years) there is sequential replacement of genotypes, whereas on shorter time scales

88 ulinemic markers after chronic, isoenergetic replacement of glucose or sucrose in foods or beverages

89 ddressed the effect of isoenergetic fructose replacement of glucose or sucrose on peak postprandial g

90 randomized controlled trials of isoenergetic replacement of glucose, sucrose, or both by fructose in

91 eak postprandial glycemia after isoenergetic replacement of glucose, sucrose, or both with fructose i

92 Replacement of Gly residues C-terminal to GFPGER did not

93 igand to the heme iron, Met80, such that the replacement of glycine by serine promotes the dissociati

94 provided by aza-glycine allows for complete replacement of glycine residues in collagen peptides and

95 Replacement of glycine with an l-amino acid, while reduc

96 nt starch and dietary fiber content with the replacement of green banana flour (up to a fivefold impr

97 Replacement of H2Q with the higher-potential EPTM, 2-chl

98 a major defect in CD4 binding induced by the replacement of H375 by a serine.

99 lands isolated by millions of years reflects replacement of hemosporidian lineages infecting similar

100 rophic level pattern is explained by trophic replacement of herbivorous fish by sea urchins at low bi

101 Conversely, the replacement of His 375 by a serine residue (H375S) withi

102 in a replication-dependent manner to promote replacement of histone H2A.Z by H2A.

103 ariants, H3.1 and H3.3, differ by only 5 aa, replacement of histone H3.1 with H3.3 can modulate the t

104 This is achieved by replacement of histones with protamines.

105 investigate whether the repeated removal and replacement of individuals in experimental groups (a key

106 oteobacterial symbionts result from multiple replacements of inferred different ages from related but

107 Replacement of intermediate by lateral mesoderm recapitu

108 Here we report the formal replacement of iron in Fe-porphyrin IX (Fe-PIX) proteins

109 ough careful synthesis and characterization, replacement of KBe2 BO3 F2 (KBBF) by a Be-free DUV NLO m

110 Replacement of KCl by KGlu stabilizes protein-nucleic ac

111 Our findings indicate that replacement of L-IGR by a nonviral Ssyn could serve as a

112 Replacement of land plant Rubisco by faster bacterial va

113 ream across the region, as well as continued replacement of large-stream fishes by small-stream fishe

114 Partial replacement of lead service lines (LSLs) often results i

115 The replacement of lead with nontoxic alternatives such as t

116 still help prioritize both leak repairs and replacement of leak-prone sections of distribution lines

117 Strikingly, replacement of leucine(973) in the juxtamembrane region

118 s building blocks for redox species, and the replacement of Li metal with graphite anode can circumve

119 Moreover, the replacement of lithium metal anode impedes unwanted side

120 armers from western Africa involved complete replacement of local hunter-gatherers in some regions, a

121 Replacement of lost beta cells in patients with diabetes

122 An example of such a barrier is that replacement of lost neurons may be insufficient because

123 Cell replacement of lost neurons using enteric neural stem ce

124 therapy offer a cure, but despite successful replacement of lymphoid immune lineages, a long-term ris

125 nd detection of Cd in the monomers suggested replacement of magnesium (Mg) by Cd in the Chl molecules

126 , the majority of reports are limited to the replacement of metallic nanoparticles or metal surfaces.

127 Replacement of mitochondria through nuclear transfer bet

128 Gene replacement of MoGSK1 caused significant delay in myceli

129 candidates for energy-efficient and scalable replacements of MOSFETs.

130 and valve repair or replacement surgery, the replacement of multiple valves, aortic root reconstructi

131 muscle weakness and wasting, significant fat replacement of muscles on imaging, myopathic changes on

132 mice reduced muscle inflammation, adipogenic replacement of myofibers, and improved muscle function.

133 This indicates that replacement of native crabs by invasive crayfish likely

134 The replacement of native forests by tree plantations is inc

135 ngineering of mechanically robust biological replacements of native tissue.

136 his leads to clogging, malodor, and possible replacement of nonwater urinals with flush urinals.

137 To determine whether replacement of NPY could ameliorate some of the neurodeg

138 /SWR-C chromatin remodeling enzymes catalyze replacement of nucleosomal H2A.Z with H2A when the subst

139 osition one obtains ultimately upon complete replacement of O(2-) ions.

140 This suggests that the natural replacement of older vehicles with newer ones that meet

141 hese derivatives result from iodine-mediated replacement of one BH3 hydride of a boranephosphonate li

142 Moreover, the replacement of one Calpha-stereogenic center by a nitrog

143 The replacement of one Gly in the essential repeating tripep

144 Replacement of one of the triazolate linkers with a more

145 Five subjects required removal/replacement of one or more valves.

146 e-modified porphyrins that resulted from the replacement of one or two pyrrole rings with other five-

147 e in the hominids that created the tools, or replacement of one species or population by another.

148 -to-child mtDNA disease transmission involve replacement of oocyte maternal mtDNA.

149 Efficient replacement of oocyte mutant mtDNA was performed by spin

150 The progressive replacement of organic solvent-based coatings by waterbo

151 ddressed the effect of isoenergetic fructose replacement of other sugars and its effect on glycated h

152 Replacement of pancreatic beta-cells through deceased do

153 ycin-resistant enterococci (VRE) through the replacement of peptidoglycan (PG) stem terminal d-Ala-d-

154 zation energy of 4.74 eV, and the successive replacement of PEt3 by CO ligands ends with Co6Te8(CO)6

155 ach to manufacturing chemicals, enabling the replacement of petroleum-based raw materials with renewa

156 The replacement of PFOA with short-chain substitutes is thus

157 plete structural understanding and potential replacement of pharmaceutically relevant PEGs by alterna

158 rogen (or piperazine), biaryl extension, and replacement of phenyl rings by pyridine.

159 The replacement of phosphorescent metal complexes with inexp

160 These findings are ameliorated by replacement of PLXNC1 on bone marrow-derived cells or by

161 Immediate replacement of pneumococcal vaccine serotypes with non-v

162 cused on questions related to the repeal and replacement of portions of the Affordable Care Act (ACA)

163 Moreover, the replacement of pQBR57 by nontransferable chromosomal Hg(

164 e findings presented herein are relevant for replacement of precious metals in dye-sensitized solar c

165 Theory predicts that the replacement of private with public goods may reverse sel

166 effects of hydroxylation are stereospecific; replacement of ProB28 by (4R)-hydroxyproline (Hyp) cause

167 -reactivity but is occluded by alpha subunit replacement of pTalpha upon alphabetaTCR formation.

168 vestigation was conducted, with the eventual replacement of radiotracers with stable isotopically lab

169 Our results suggest that the damage and replacement of red blood cells during infection could be

170 tween stability and plasticity, facilitating replacement of replisomal components dependent on their

171 Further, the replacement of residues 28 to 39 of huNHE1 with the corr

172 ures include loss of myocytes and fibrofatty replacement of right ventricular myocardium; biventricul

173 mechanisms, plant transformation strategies, replacement of Rubisco in a model C3 plant with cyanobac

174 We found that knockin alanine replacement of ryanodine receptor PKA (S2808) or CaMKII

175 n (sediment accretion, subsidence), mangrove replacement of salt marsh, with or without disturbance,

176 In contrast, replacement of saturated fat with mostly refined carbohy

177 Replacement of saturated fatty acids (SFAs) with unsatur

178 Replacement of saturated with unsaturated fats lowers lo

179 This method has been used as a replacement of SDS-PAGE for purity analysis of adeno-ass

180 The replacement of semolina with carob flour from 1% to 5% h

181 Replacement of serine 61 by alanine within the minimal t

182 In vivo evidence further supported the replacement of serum proteins by salivary proteins.

183 In continuous analyses, replacement of SFAs plus TFAs with total UFAs, PUFAs, or

184 heterozygosity (LOH) events that lead to the replacement of single, functional tumor suppressor genes

185 sence of central nuclei, inflammation, fatty replacement of skeletal muscle, and muscle fiber degener

186 trans-splicing, and indicate that continuous replacement of SL ribonucleoproteins consumed during tra

187 The objective was to evaluate replacement of sodium erythorbate with a natural antioxi

188 Therefore, the replacement of sodium from a technological standpoint is

189 Replacement of SYTL1 in MEIS1-deficent cells restored bo

190 step we have investigated the possibility of replacement of T by 2'-deoxy-5-(hydroxymethyl)uridine (5

191 esis enabled us to achieve approximately 75% replacement of T by 5hmU in the E. coli genome and in pl

192 nslocase in which substrate binding triggers replacement of TatB by TatA at the polar cluster site.

193 the albumin bound PTX, represents a superior replacement of Taxol(R) that mitigates the side effects

194 ting vascular invasion, which is crucial for replacement of terminally differentiated hypertrophic ch

195 Replacement of tethered mucus with untethered mucus rest

196 Instead, replacement of tetralinoleoyl-CL with tetradocosahexaeno

197 A butyl substituent at N(4) was optimal, and replacement of the 5-iodo group with chloro, bromo, or f

198 he PIG-L deacetylases is an alanine in GalB; replacement of the alanine with aspartate decreased the

199 Further optimization through replacement of the amide with a variety of five- and six

200 structural changes to 1 include bioisosteric replacement of the amide with oxadiazole and alpha,alpha

201 recommend 3 months of anticoagulation after replacement of the aortic valve with a bioprosthesis.

202 zard ratio: 2.7; p = 0.002), and concomitant replacement of the ascending aorta (hazard ratio: 7.7; p

203 Replacement of the Asp f3 cysteines with serine residues

204 Moreover, replacement of the beta'-COP propeller domain with unrel

205 ls of enantioselectivity are maintained upon replacement of the bulky tert-butyl substituents on the

206 By replacement of the C-terminal Leu(13)-Met(14)-NH2 dipept

207 ized from riboflavin in a reaction involving replacement of the C8 methyl with a dimethylamino group.

208 hetic collagen is difficult and requires the replacement of the canonical amino acids (4R)-hydroxypro

209 In particular, replacement of the canonical H2A histone with the varian

210 Replacement of the canonical TFIID-TBP complex with TRF3

211 boxylates (16) were designed by bioisosteric replacement of the carbonyl group at position 2 in a ser

212 s Cd(II) inhibition of hUNG which was due to replacement of the catalytic water by binding the active

213 Moreover, replacement of the central nucleosome with a nucleosome

214 te closure of the B-tubule, and occlusion or replacement of the central pair complex by accumulated e

215 change much its cyclic delocalization, while replacement of the CH ortho to B leads to smaller cyclic

216 Replacement of the CH ortho to N in 1,4-azaborine does n

217 Further replacement of the charged Lys-5 by neutral Gln to resem

218 Interestingly, replacement of the conserved Cys at the metal binding po

219 cement with lamellar bone; in another, total replacement of the crystalline lens by adipose tissue; a

220 Replacement of the cysteine C932 in transmembrane helix

221 Replacement of the diseased cells with a healthy donor e

222 the key features of the G57 genotype is the replacement of the earlier A/chicken/Beijing/1/1994 (BJ/

223 Replacement of the endogenous DHODH gene with catalytica

224 n but can satisfactorily avoid the expensive replacement of the entire membrane module after irrevers

225 absence of methods that enable the stepwise replacement of the Escherichia coli genome with long syn

226 to conventional maraging steels owing to the replacement of the essential but high-cost alloying elem

227 y gradually switching from FPP to GPP, until replacement of the final alpha-helix, whereupon cyclopro

228 s the density of transport channels, and the replacement of the fine CNT tips with their cylindrical

229 tion and branching activities were lost upon replacement of the first helix in the six-helix bundle.

230 ich we observed mass mortality and wholesale replacement of the former community.

231 combination of these events resulted in the replacement of the formerly stratified water column in t

232 ation based on the nonclassical bioisosteric replacement of the guanidine group in arginine by a func

233 er disease (PCLD) is characterized by cystic replacement of the hepatic parenchyma, leading to hepati

234 egment crossing forming the activation gate, replacement of the homologous Met residues in human Slo2

235 Chronic GVHD is fundamentally caused by replacement of the host's immune system with donor cells

236 A chimera with replacement of the human NTD by the bovine NTD resembled

237 bundle formation was affected by systematic replacement of the hydrophobic surface of the oligourea

238 However, outcomes after replacement of the ICD generator in patients with recove

239 Replacement of the imidazo[1,2-a]pyridine group of the p

240 Replacement of the iminium motif by a cyano group is wel

241 nt infection (PJI) usually requires surgical replacement of the infected joint and weeks of antibioti

242 In contrast, replacement of the ketoreductase domain of the upstream

243 nal issues can sometimes interfere with full replacement of the lead line.

244 cative of a change in the binding motif upon replacement of the ligand (GDP versus GDPnP).

245 s elegant approach and describe the galvanic replacement of the liquid metal alloy galinstan with Ag

246 Replacement of the LIZ with alanine resulted in dramatic

247 a Monte Carlo simulation framework, partial replacement of the LSL was predicted to result in releas

248 ased on native context or using a "cassette" replacement of the mature miRNA sequence.

249 Finally, we show that replacement of the Mek1/2 inhibitor with a Src inhibitor

250 Thus, although functional replacement of the mitochondrial genome is possible, eve

251 We studied functional replacement of the mutated gene encoding survival motor

252 result in chronic inflammation or adipogenic replacement of the myofibers.

253 t chronic muscle inflammation and adipogenic replacement of the myofibers.

254 Replacement of the n-butyl group with cyclic bioisostere

255 isted design was focused on the bioisosteric replacement of the N1 atom by a CH group in a previous s

256 Neanderthals and modern humans, the eventual replacement of the Neanderthals was determined by the re

257 Replacement of the noncanonical methionine residue M584

258 We also report the impact of prosthetic replacement of the ocular surface ecosystem (PROSE) trea

259 Replacement of the P4-P3' reactive center loop residues

260 The present report documents the replacement of the potentially genotoxic 3-nitro group b

261 be a dynamic process of successive waves of replacement of the previously dominant clone.

262 of noncanonical amino acid mutagenesis, that replacement of the proline residue at position 28 of the

263 l on top of calcite surfaces followed by the replacement of the remaining calcite core.

264 Replacement of the residues His-936 and His-917 in the a

265 la wax (CDW) containing oleogels for partial replacement of the shortening in cookies.

266 The IFNAR1*557Gluext*46 resulted in replacement of the stop codon with 46 additional codons

267 Previously, we have demonstrated that replacement of the strictly conserved glycine in collage

268 Herein, we demonstrate that replacement of the strictly conserved glycine in collage

269 domestication or agricultural traits, drives replacement of the tandem centromere repeats in maize an

270 rmine a large kinetic isotope effect for the replacement of the transferring hydrogen atom by deuteri

271 Replacement of the transmembrane domain of CD74 or the a

272 Replacement of the trivalent oral poliovirus vaccine (tO

273 mall hydrophobic protein (DeltaSH) gene, and replacement of the wild-type fusion (F) protein gene wit

274 for cell viability but that loss of NreA (or replacement of the wild-type protein with a truncated ve

275 mework for how to rationally apply isosteric replacements of the carboxylic acid functional group.

276 rnover throughout life, causing the constant replacement of their synaptic contacts.

277 uences for the soil microbiome, inducing the replacement of thermosensitive bacterial species with mo

278 rate and are therefore unable to self-renew, replacement of these cells depends on stem/progenitor ce

279 on studies in Rag-5xfAD mice, revealing that replacement of these missing adaptive immune populations

280 Replacement of these residues with equally conserved Glu

281 anti-athero-miR suggest that the therapeutic replacement of this microRNA could be a potential strate

282 Replacement of thymidine with AHP dU increases duplex st

283 However, replacement of TM2 by the transmembrane domain of CD4, t

284 intramembrane proteolysis is insensitive to replacement of TM2 by the transmembrane domain of CD74 o

285 2013-2018 began with the synchronized global replacement of trivalent OPV (tOPV) with bivalent OPV (b

286 chemical and genetic tools, we show that the replacement of tryptophan 237 with phenylalanine imparts

287 It is reported that replacement of two OH groups in curcumin with less polar

288 Complementation analysis revealed that replacement of tyrosines 474 and 480 with alanine failed

289 response to inhibition of proliferation and replacement of ubiquitylated lysine residues reduced the

290 sticizer and water loss, and the progressive replacement of unordered structures by intermolecular hy

291 The Deconvoluter method uses these for replacement of untagged mutations in the genome using a

292 two valve migration events requiring removal/replacement of valves.

293 e by utilizing nanoliter-sized droplets as a replacement of wells.

294 Replacement of WFI with G5 significantly reduces the nee

295 The replacement of wheat flour with the potato powders reduc

296 -binding motif is identified in this domain, replacement of which abrogates liposome-binding and rend

297 strated that streaming is reduced by genomic replacement of wild-type Khc with this sliding-deficient

298 tent reservoir in chronic infection, and the replacement of wild-type virus by CTL escape mutants wit

299 kinase inhibition, and CRISPR-Cas9-mediated replacement of WT KRAS with a mutant allele sensitized h

300 inine-to-serine change (R764S) in ZF9 and by replacement of ZF11 with two other fingers, yielding 14