ライフサイエンスコーパス: replacement of @2 by

1 Replacement of Ile(1624) by 13 other amino acids produce

2 ass spectrometry in order to demonstrate the replacement of 14N by 15N under the growth conditions us

3 Finally, replacement of adenine by 2-aminopurine (AG --> 2-APG) h

4 step we have investigated the possibility of replacement of T by 2'-deoxy-5-(hydroxymethyl)uridine (5

5 effects of hydroxylation are stereospecific; replacement of ProB28 by (4R)-hydroxyproline (Hyp) cause

6 esis enabled us to achieve approximately 75% replacement of T by 5hmU in the E. coli genome and in pl

7 Replacement of GTP by 7-deaza-GTP completely abolishes t

8 Moreover, replacement of guanine by 8azaG does not alter the melti

9 Replacement of G by 8OG in telomeric DNA can affect the

10 As shown here, replacement of Ala(245) by a threonine enables the oxida

11 rent substrate specificity can be related to replacement of an arginine by a glutamine in the active

12 subtle structural modification on the diene (replacement of an H by a trans-CH3 group) leads to a com

13 The replacement of Arg104 by a smaller residue allows L-dT t

14 male Wistar rats were exteriorized, allowing replacement of endogenous bile by a model bile.

15 The replacement of fossil fuels by a clean and renewable ene

16 Previously, replacement of G8 by a series of nucleobase variants sho

17 a major defect in CD4 binding induced by the replacement of H375 by a serine.

18 Conversely, the replacement of His 375 by a serine residue (H375S) withi

19 Our findings indicate that replacement of L-IGR by a nonviral Ssyn could serve as a

20 entally friendly synthesis strategies to the replacement of petrochemical feedstocks by abundant smal

21 The replacement of aryl halides by acyl halides provides acc

22 Previous studies have shown that replacement of the guanine by adenine in the AG (AG -->

23 to only a 10-fold decrease in activity upon replacement of Asp(176) by Ala, substitutions of Asp(204

24 responding monomeric cyclic hexapeptide with replacement of Cys by Ala.

25 The replacement of Gln137 by Ala also has a dramatic effect

26 Replacement of Glu(377) by Ala and Gln decreased V(max)

27 We further demonstrate that replacement of His-212 by Ala disrupts the interaction o

28 Replacement of Ile152 by Ala had a similar but less mark

29 By contrast, replacement of Pro85 by Ala abolishes the observable slo

30 The replacement of Ser(187) by Ala, eliminating the only pho

31 The replacement of Ser-43 by Ala ablates the PKA phosphoryla

32 Site-directed replacement of Ser176 by Ala abolishes glutaminase and G

33 Replacement of Ser2 by Ala does not substantially alter

34 In contrast to isozyme II, the replacement of Trp 5 by Ala in HCA III abolished chemica

35 Replacement of Trp 5 by Ala, Leu, or Phe in H64A HCA II

36 Replacement of alpha4Arg185 by alanine, glutamate, and l

37 We show here that replacement of Arg(72) by alanine strongly alters fideli

38 osphate is linked to Cys(119) of BVP because replacement of Cys(119) by alanine or serine abrogates p

39 Surprisingly, in AOX1A, replacement of CysI by alanine, which cannot form a (thi

40 each of these positions shows that while the replacement of Gln173 by alanine does not affect the ini

41 2 by valine, and 1298A>C, which leads to the replacement of Glu-429 by alanine; the former polymorphi

42 Replacement of Gly794 by alanine causes the apoenzyme to

43 Replacement of lysine 267 by alanine, histidine, or argi

44 Replacement of Ser(429) by alanine or valine elicited a

45 Replacement of Ser128 by alanine has no effects on BAD p

46 Replacement of serine 61 by alanine within the minimal t

47 upstream of their dileucine-like motif, and replacement of these residues by alanine conversely redu

48 es BAD phosphorylation at threonine 201, and replacement of threonine 201 by alanine generates a BAD

49 Replacement of tryptophan 142 by alanine or serine resul

50 In contrast, replacement of Tyr194 by aliphatic amino acids had no si

51 on-dependent shift from Neu5Gc to Neu5Ac and replacement of alpha2,6 by alpha2,3 linkages may regulat

52 ical and biological elements involved in the replacement of Neanderthals by AMHs.

53 dependent protein kinase inhibitor KT5823 or replacement of ATP by AMP-PNP reduced NP(o), while activ

54 The replacement of Cys-199 by an Ala residue in the enzyme s

55 reversal potential (Er) that was altered by replacement of external Na+ by an impermeant cation, but

56 Replacement of Phe138 by an aliphatic amino acid also ca

57 The replacement of Thr(705) by an alanine or glutamic acid a

58 Replacement of Trp 185 by an Arg residue caused displace

59 to the neurons by the cycle may derive from replacement of oxidized glutamate by anaplerosis.

60 etc.), similar to those that accompanied the replacement of "archaic" Neanderthal by anatomically mod

61 The nature of the replacement of Neanderthal by anatomically and behaviora

62 The large-scale replacement of gymnosperms by angiosperms in many ecolog

63 criptional switching between VSPs results in replacement of one VSP by another.

64 Replacement of cribellate silk by aqueous silk glue may

65 ur atoms is absent from onconase, due to the replacement of Tyr92 by Arg73, which is situated away fr

66 Replacement of Lys(188) by arginine reversed the step 3

67 of an RXL motif can be partially restored by replacement of S643 by arginine.

68 We determined that replacement of these residues by arginine enhances polyQ

69 rowth of GFAJ-1 in arsenate without invoking replacement of phosphorus by arsenic in biological macro

70 l,ATP) was Cl(-) selective, and inhibited by replacement of extracellular Cl(-) by Asp(-); both curre

71 Our prediction was that a replacement of Asp128 by asparagine would preferentially

72 e efficient at dephosphorylating the latter, replacement of Asp608 by asparagine enhanced activity to

73 ural distortions required to accommodate the replacement of leucine by asparagine in the N-terminal c

74 Replacement of 0'Arg by aspartate, glutamate (alpha7 nAC

75 self was investigated through the systematic replacement of Glu59 by aspartate, asparagine, and alani

76 The replacement of tyrosine by aspartic acid at position M21

77 In contrast, replacement of AUG by AUU leads to a dramatic reduction

78 and the changes in properties resulting from replacement of Sr by Ba are supported by ab initio calcu

79 and the impact of 20% (B20) and 100% (B100) replacement of fossil diesel by biodiesel.

80 Initiation of vascularization and replacement of cartilage by bone were delayed in c-Cbl(-

81 ng endochondral bone formation, which allows replacement of cartilage by bone.

82 This phenotype is associated to delayed replacement of cartilage by bone.

83 We tested if replacement of CTCF by BORIS on regulatory DNA occurs in

84 Replacement of beef by buffalo and vice versa is frequen

85 ning 30 patients, eight (27%) demonstrated a replacement of C. albicans by C. dubliniensis when a com

86 ation of miR-34a, up-regulation miR-210, and replacement of Mnt by c-Myc in binding to cyclin D1.

87 Insertion of UGU and replacement of U by C immediately 5' to the deletion sit

88 Contrary to that, replacement of Mg2+ by Ca2+ in the EF-hand 4 moved Trp-9

89 The replacement of Mg2+ by Ca2+ in the EF-hands 2 and 3 furt

90 Total replacement of Na+ by Ca2+ also completely blocked the c

91 Our studies show that replacement of thiol by carbodithioate not only enhances

92 ralization resulting from recent sub-surface replacement of supergene oxyhydroxides by carbonate and

93 nd detection of Cd in the monomers suggested replacement of magnesium (Mg) by Cd in the Chl molecules

94 akened this correlation, possibly because of replacement of CD8(+) CTL by CD8(+) suppressor cells in

95 Replacement of Na(+) by choline(+) also inhibited the ca

96 sibly by fetal applications of amiloride and replacement of Na+ by choline in the Ringer solution, an

97 es of base pairs and duplexes as a result of replacement of T by ClU, we determined four crystal stru

98 zation energy of 4.74 eV, and the successive replacement of PEt3 by CO ligands ends with Co6Te8(CO)6

99 pacemaking was also consistently silenced by replacement of external calcium by cobalt and was slowed

100 Replacement of exon 4 by combinations of the new exons y

101 munoprecipitation in Ewing sarcoma we report replacement of E2F3/pRB by constitutively expressed repr

102 (v) The replacement of His48 by Cys, which does not bind copper,

103 The replacement of alphaSer254 by cysteine by site-directed

104 Thus, replacement of proline 77 by cysteine, isoleucine, leuci

105 Replacement of G243 by D in the afsB+ strain M145 reprod

106 and homeostasis can be achieved through the replacement of dying cells by differentiating precursors

107 A final step consists of partial replacement of aragonite by dolomite, possibly in neutra

108 Results from earlier studies have shown that replacement of Asp-132 by, e.g., Asn, slows proton uptak

109 occurs during GTP hydrolysis and subsequent replacement of GDP by EF-Ts which is then displaced by G

110 Instead, replacement of CBC by eIF4E is promoted by importin beta

111 Remarkably, translation does not affect replacement of CBC by eIF4E.

112 In summary, in LDLRKO mice the replacement of dietary SFA by either MUFA or CARB causes

113 n outgrowth was rescued in vivo by selective replacement of R-cadherin by electroporation into cultur

114 The replacement of CVs by EVs in 2012 could have mitigated t

115 To demonstrate these effects brought by the replacement of CVs by EVs, we take Beijing, China, as an

116 The resulting replacement of muscle by fatty and fibrous tissue leaves

117 AC is characterized by the replacement of cardiac myocytes by fibro-adipocytes, car

118 nerate free holes (p-type doping), while the replacement of Fe(2+) by Ga(3+) cations, taking place in

119 ), and GA3 (0.3%), with predominant genotype replacement of GA5 by GA2 and then GA2 by ON1.

120 Particularly important is the replacement of Glu by Gln at position 132, which has bee

121 In addition, the replacement of Trp-48 by Gln-48 yields an FRC variant fo

122 Replacement of Cl(-) by gluconate or 2-(N-morpholino)eth

123 During postnatal development, the replacement of GluN2B- by GluN2A-containing NMDARs at SC

124 Replacement of Ser-480 by glutamate, to mimic the phosph

125 In addition, replacement of the serines by glutamate to mimic phospho

126 Replacement of serine 53 by glutamic acid, mimicking pho

127 of K13Q CooC was generated by site-specific replacement of lysine by glutamine and was purified acco

128 other mycobacteria, other than the reported replacement of l-alanine by glycine in the peptide side

129 argely conferred by a single cysteine (C19), replacement of which by glycine removes the ability to f

130 is unable to form a stable triple helix, and replacement of GAA by GPO or VM by PO within the GAAVM b

131 Reperfused mouse infarcts show accelerated replacement of cardiomyocytes by granulation tissue lead

132 Replacement of the TL by Gre factor occurs only in backt

133 ing alleles revealed an identical phenotype: replacement of multinucleated myofibers by groups of sin

134 osylation factors (ARF1-3) by catalyzing the replacement of bound GDP by GTP, an action critical for

135 ne nucleotide-exchange factors that catalyze replacement of GDP by GTP.

136 vation of these G-proteins through catalytic replacement of GDP by GTP.

137 Replacement of adenine by guanine at positions -8 and -1

138 thern Hemisphere countries, and a pattern of replacement of strain H1N1pre by H1N1pdm between the 200

139 Our results show that replacement of mCD1d by hCD1d can select a population of

140 composed of small hepatocytes, and eventual replacement of damaged parenchyma by healthy hepatocytes

141 ORF50/Rta protein, mutagenesis of the LR, or replacement of the LR by heterologous multimerization do

142 Thus, replacement of Cd(2+) by Hg(2+) in CdTe nanocrystals doe

143 4, Wi-Phy, and the iRFP series, initially by replacement of Asp-207 by His.

144 , a point mutation in sigA, resulting in the replacement of arginine 522 by histidine, was found resp

145 tion found frequently in human cancer is the replacement of R273 by histidine or cysteine residues re

146 marked preference for H2S generation by beta-replacement of cysteine by homocysteine.

147 safener can undergo stepwise hydrogenolysis (replacement of chlorine by hydrogen) in each system at n

148 Replacement of external Cl- by I- shifted the reversal p

149 was perturbed by internal mismatches or the replacement of G.C by I.C base-pairs.

150 where a putative "pump site" was modified by replacement of Asp372 by Ile.

151 Evidence of the replacement of active workers by inactive workers has be

152 Upon replacement of water by increasing amounts of the larger

153 promising adipocyte viability and preventing replacement of lost adipocytes by inhibiting preadipocyt

154 Adhesion was restored by replacement of TSP2 and by inhibitors of MMP2 activity.

155 sticizer and water loss, and the progressive replacement of unordered structures by intermolecular hy

156 This indicates that replacement of native crabs by invasive crayfish likely

157 Replacement of either region by itself was ineffective.

158 We demonstrate here that replacement of Na(+) by K(+), Rb(+) or Cs(+) and precise

159 s opening of the channels, and extracellular replacement of Na+ ions by K+ ions promotes closing of t

160 Replacement of KCl by KGlu stabilizes protein-nucleic ac

161 The replacement of c-Myc by L-Myc in immature DCs may provid

162 Acute pharmacological replacement of NA by L-threo-DOPS partially restored pho

163 The rate constant of replacement of unlabeled by labeled DNA strands (labelin

164 Replacement of Ser by large residues such as His and Trp

165 Replacement of intermediate by lateral mesoderm recapitu

166 letion of short consensus repeat 3 domain or replacement of Ser(165) by Leu in this domain, or the us

167 upon substitution of 2B1 Ile-114 by Val, and replacement of Val-363 by Leu or Ile selectively suppres

168 The replacement of His(86) by leucine (H86L) weakened pyrido

169 the experiments with slow calcium infusion, replacement of KCl by LiCl in the incubation medium incr

170 h suspension of isolated brain mitochondria, replacement of KCl by LiCl suppressed mitochondrial swel

171 Mice carrying a targeted replacement of Igh by LMP2A leading to high or low expre

172 Replacement of Arg-735 by Lys gives a V-ATPase that, alt

173 7 of the E2 envelope glycoprotein, involving replacement of Glu by Lys, resulted in a small-plaque ph

174 ring epithelial transformation suggests that replacement of gelsolin by M-severin may function to ach

175 oltage-dependent calcium entry by cadmium or replacement of external calcium by magnesium enhanced bu

176 uch as indomethacin and flurbiprofen, and by replacement of heme by manganese protoporphyrin IX (form

177 tics is now under way that may result in the replacement of traditional keys by matrix-based computer

178 ea cytosolic ascorbate peroxidase (rpAPX) by replacement of Ser160 by Met (S160M variant).

179 for catechol-O-methyltransferase results in replacement of Val-108 by Met in the soluble form of the

180 on of MMAS-3 from MTB resulted in a complete replacement of ketomycolate by methoxymycolate in both B

181 However, replacement of these cells by mineralized bone is delaye

182 ) to Upper Paleolithic (UP) is marked by the replacement of late Neandertals by modern humans in Euro

183 years before the present led to the eventual replacement of the Neanderthals by modern humans approxi

184 With the replacement of ionizing CT by MR imaging, integrated PET

185 ution (TTX-resistant current measured by the replacement of extracellular sodium by N-methyl-D-glucam

186 Replacement of K+ by Na+ fails to induce a similar pheno

187 Replacement of acidic by neutral residues at positions 9

188 Replacement of phosphates by neutral methylphosphonates

189 binds to the same site in ABH2 as iron, and replacement of the iron by nickel does not prevent the b

190 Remarkably, replacement of one carbon by nitrogen alters the reactio

191 tively inhibited by Gd(3+) and Zn(2+), or by replacement of extracellular NaCl by NMDG; I(Cl,ATP) was

192 Replacement of Na+ by NMDG depressed basal (normoxic) ef

193 gnetic complexes deriving from isoelectronic replacement of CO by NO(+), {(mu-SRS)[Fe(CO)2PMe3] [Fe(C

194 Replacement of 3' UTR by non-UTR sequence had surprising

195 In cells expressing DeltaF508-CFTR, replacement of PC by noncharged analogues results in an

196 rom vascular occlusive events results in the replacement of contractile myocardium by nonfunctional s

197 Moreover, the replacement of pQBR57 by nontransferable chromosomal Hg(

198 We previously proposed that replacement of fibrillarin by Nop52 (RRP1/NNP-1) for the

199 lerate significant in vivo deviation, making replacement of adult neurons by NSCs during pathology a

200 However, replacement of BDNF by NT4 rescued these gene expression

201 Replacement of FFA by OCT can be justified if there is a

202 ke systems in the plankton and of widespread replacement of metals by one another for various biochem

203 The results indicate that replacement of conventional milk by organic or UHT milk

204 The results indicate that replacement of conventional milk by organic or UHT milk

205 y than p21(SNFT) with Jun and NF-AT, and the replacement of Fos by p21(SNFT) in the trimolecular comp

206 y p50-p50 in a novel way, represses, whereas replacement of OCT-1 by p50-p65 induces CRP transcriptio

207 nts, including the eIF4AIII anchor, but also replacement of PABPN1 by PABPC1.

208 The replacement of native vegetation by pastures or tree pla

209 itive detection of dsDNA based on the strand replacement of dsDNA by peptide nucleic acid (PNA) and t

210 tude of decrease in k(cat) obtained with the replacement of Tyr(34) by Phe, suggesting that interrupt

211 By contrast, replacement of 0'Arg by phenylalanine (alpha4 subunit MA

212 Replacement of the tryptophan by phenylalanine gave rise

213 first position of codon 12, with consequent replacement of valine by phenylalanine in the deduced am

214 Replacement of Lhx3 by Phox2a led to specification of cr

215 This was almost exclusively due to the replacement of phycocyanobilin by phycoerythrobilin on t

216 iant 1 GNA1870 expression (either by allelic replacement of gna1870 or by plasmid-driven high-level e

217 X) cores, and P700-A(1) cores shows that the replacement of phylloquinone by plastoquinone-9 induces

218 Due to the strand replacement of dsDNA by PNA, dsDNA can be directly detec

219 Despite the replacement of MAdCAM-1 by PNAd in HEV endothelia, lymph

220 Replacement of saturated fat by polyunsaturated or monou

221 In particular, replacement of Glu84 by positively charged residues such

222 monophasic without an intermediate, but the replacement of PPh3 by PPhMe2 is biphasic (proceeds by a

223 The replacement of typical products by products that are in

224 Replacement of Ala-21 by proline in an alpha AB/beta CD-

225 cleotide position 215, which resulted in the replacement of arginine by proline at position 48 of the

226 Replacement of gene fragments by promoter-derived sequen

227 sed functions range from facilitation of the replacement of somatic histones by protamines to epigene

228 Early replacement of PTBP1 by PTBP2 during neuronal differenti

229 rogen (or piperazine), biaryl extension, and replacement of phenyl rings by pyridine.

230 Replacement of His(309) by Q or F yields enzyme with no

231 With the replacement of wheat flour by QL (1-5%), a linear increa

232 CaFe(2)As(2) via electron-doping by partial replacement of Ca by rare-earth.

233 Replacement of Rbpj by Rbpjl in the PTF1 complex drives

234 The replacement of bioassays by real-time PCR for the isolat

235 Replacement of peanut extracts by recombinant peanut com

236 s in multicellular organisms could be due to replacement of damaged cells by regeneration through inc

237 Replacement of Asp 145 by residues such as alanine or se

238 Replacement of RFC1 by rfc1-DeltaN in yeast shows essent

239 Conversely, replacement of hIAPP sequence by rIAPP sequence causes a

240 Furthermore, replacement of Tctex-1 by RP3 selectively disrupts the t

241 at 77 K of the radical, which is formed upon replacement of S-adenosylmethionine by S-3',4'-anhydroad

242 Strain associated with the replacement of aspirin molecules by salicylic acid molec

243 In vivo evidence further supported the replacement of serum proteins by salivary proteins.

244 librium potential (E(Cl)) and was shifted by replacement of external Cl- by SCN- or isethionate.

245 rophic level pattern is explained by trophic replacement of herbivorous fish by sea urchins at low bi

246 therapy are regeneration of damaged tissue, replacement of function by secretion of biologically act

247 exchanged with alkaneselenols from solution, replacement of thiolates by selenols is rapid and comple

248 However, extensive replacement of methionine by selenomethionine for anomal

249 ng growth in selenomethionine, and efficient replacement of methionine by selenomethionine, based on

250 ed into a fully folded triple helix, whereas replacement of Gly by Ser or Arg resulted in the presenc

251 ransporters in this C-terminal domain showed replacements of Thr294 by Ser and Val295 by Ile to be re

252 lic attack by reduced thioredoxin, mutagenic replacement of Cys-256 by serine has no effect on thiore

253 Replacement of cysteine 470 by serine does not restore a

254 igand to the heme iron, Met80, such that the replacement of glycine by serine promotes the dissociati

255 in C(4) Amaranthaceae with multiple parallel replacements of alanine by serine at position 281 and me

256 With replacement of M231 by site-directed mutagenesis, no tra

257 n transgenic mice (TG) with cardiac-specific replacement of cTnI by slow skeletal TnI (ssTnI, which l

258 A common effect was the replacement of tumor by small scar.

259 The replacement of Ge by Sn should reduce the raw material c

260 2 signal was reduced immediately, suggesting replacement of SRC-2 by SRC-1.

261 ne potential treatment strategy involves the replacement of dead neurons by stimulating the prolifera

262 st 2 months of breastfeeding without regular replacement of any meal by supplemental feeding.

263 The replacement of G by T at position -216 increases the pro

264 nslocase in which substrate binding triggers replacement of TatB by TatA at the polar cluster site.

265 The replacement of a CH by the isolobal analogue Os(PH3)3H r

266 methoxide as the base used to accomplish the replacement of active hydrogens by the diazeniumdiolate

267 atin in early spermiogenesis before eventual replacement of histones by the protamines.

268 Replacement of ND10-ES by the corresponding region from

269 Displacement/replacement of one by the other as a result of their hig

270 that in two species of bluebirds, cycles of replacement of one by the other emerge as an indirect co

271 Replacement of Rev-RRE by the CTE provides a novel appro

272 ffords tertiary amides, which arise from the replacement of the halogen by the N,N-dimethylcarbamoyl

273 Replacement of the SGS by the strong gyrase sites from p

274 However, replacement of TM2 by the transmembrane domain of CD4, t

275 intramembrane proteolysis is insensitive to replacement of TM2 by the transmembrane domain of CD74 o

276 In contrast, replacement of water by the similarly sized deuterium ox

277 Here we show that replacement of ureas by thioureas yields substantial fur

278 Replacement of Ser(429) by threonine partially suppresse

279 e current therapy aims at exogenous cellular replacement of dopaminergic function by transplanting fe

280 The replacement of native forests by tree plantations is inc

281 Replacement of the levulinate by triflate enables introd

282 We predict that the replacement of methyl groups by trifluoromethyl groups o

283 However, in three mutants, which shared a replacement of Phe181 by Trp, the F(V) yield was dramati

284 not as a sorting receptor but as a protease: replacement of Kex2p by truncated secretory Kex2p (which

285 ined include amidated and free peptides, and replacements of tyrosine by tryptophan.

286 The replacement of B subunits by tumor antigens inhibits PP2

287 n two of these five patients showed complete replacement of the marrow by tumor.

288 Replacement of Phe13 by Tyr, Leu, Lys, and Ala showed th

289 Results from the estimated rate constant of replacement of labeled by unlabeled DNA (delabeling kine

290 Replacement of A310 by Val in the BjPutA mutant A310V ra

291 Consequently, replacement of Gln by Val was probably a key step in the

292 The free-energy change due to the replacement of Gly35 by valine was also determined to as

293 ed a 137 G>T transition that resulted in the replacement of glycine by valine at position 46 of the c

294 Specifically, replacement of the epoxyketone by vinyl sulfone moieties

295 The effect on texture by replacement of pork backfat by W1/O/W2 emulsions general

296 The replacement of histidine by water in the five-coordinate

297 e depot of dipicolinic acid and cations, and replacement of these components by water.

298 Replacement of mutant by wild-type troponin in TNNT2mut

299 bone marrow is a reverse process of natural replacement of red marrow by yellow marrow.

300 Replacement of ZF3 by ZF1 creating a ZF1/4 chimera was f