ライフサイエンスコーパス: replication checkpoint

1 on on DnaA through activation of the Sda DNA replication checkpoint.

2 e that regulates the DNA damage response and replication checkpoint.

3 at its deficiency activates a SOG1-dependent replication checkpoint.

4 racting protein that participates in the DNA replication checkpoint.

5 efficient and timely termination of the DNA replication checkpoint.

6 ondensation in cells, indicating a defect in replication checkpoint.

7 Here we describe the roles of Sap1 in the replication checkpoint.

8 ckpoint kinase 2) is a major effector of the replication checkpoint.

9 the Chk1 damage checkpoint but not the Cds1 replication checkpoint.

10 es regulation of late origins by the intra-S replication checkpoint.

11 by an entirely distinct checkpoint, the DNA replication checkpoint.

12 lled by both Cyclin B limitation and the DNA-replication checkpoint.

13 lting from stalled forks that escape the ATR replication checkpoint.

14 indicating that ATR is required for the DNA replication checkpoint.

15 both leads to synergistic disruption of the replication checkpoint.

16 kd expression there was a marked loss of the replication checkpoint.

17 een chromatin structure and induction of the replication checkpoint.

18 t component of the signal that activates the replication checkpoint.

19 ells, it was unable to restore fully the DNA replication checkpoint.

20 ds1, serves an essential function in the DNA replication checkpoint.

21 of DNA damage and may play a role in the DNA replication checkpoint.

22 ibuted to a mitotic delay imposed by the S-M replication checkpoint.

23 er of Cdc25p (OPcdc25(+)), which lacks a DNA replication checkpoint.

24 Cds1 and Chk1 appear to jointly enforce the replication checkpoint.

25 onsequently, for activation of a meiotic DNA replication checkpoint.

26 sly been believed to be involved only in the replication checkpoint.

27 hat phosphorylate Cdc2, are regulated by the replication checkpoint.

28 ive in the DNA damage checkpoint but not the replication checkpoint.

29 bundance of Cdc25 are unconnected to the DNA replication checkpoint.

30 is also maintained in cells arrested at the replication checkpoint.

31 aintained in wild-type cells arrested at the replication checkpoint.

32 se to stimulate Mec1 kinase and initiate the replication checkpoint.

33 ells, Cds1 is the effector kinase of the DNA replication checkpoint.

34 replication fork stalling and activated the replication checkpoint.

35 ge accumulation caused by defects in the DNA replication checkpoint.

36 the minimal signal required to activate the replication checkpoint.

37 uppressed by ATR, a central regulator of the replication checkpoint.

38 oth cellular DNA damage response and the DNA replication checkpoint.

39 is a major player in the control of the DNA replication checkpoint.

40 el that Dpb11 couples DNA replication to the replication checkpoint.

41 plays a critical role in the control of DNA replication checkpoint.

42 rerequisite for the subsequent activation of replication checkpoint.

43 oteins, leading to the activation of the DNA replication checkpoint.

44 te switching-depend on the activation of the replication checkpoint.

45 and Chk1 are two key protein kinases in the replication checkpoint.

46 noise immunity, properties required for the replication checkpoint.

47 protein Mrc1 in activating Rad53 in the DNA replication checkpoint.

48 rks stalled by hydroxyurea that activate the replication checkpoint.

49 nal transducers in eukaryotic DNA damage and replication checkpoints.

50 use damage that activates the DNA-damage and replication checkpoints.

51 ng the activation of both the DNA damage and replication checkpoints.

52 solvases, with intriguing connections to DNA replication checkpoints.

53 cells and in cells subject to DNA damage or replication checkpoints.

54 cks S-phase completion but not activation of replication checkpoints.

55 ial component of both the DNA damage and DNA replication checkpoints.

56 tein kinases required for the DNA damage and replication checkpoints.

57 logenetic conservation of the DNA damage and replication checkpoints.

58 nuclear-to-cytoplasmic ratio and on the DNA replication checkpoints.

59 ich normally activate the DNA damage and DNA replication checkpoints.

60 cytoplasmic ratio, but not requiring the DNA replication checkpoints.

61 equired for activation of the DNA damage and replication checkpoints.

62 Fission yeast Mrc1 (mediator of replication checkpoint 1) is an adaptor checkpoint prote

63 stress results in the activation of the DNA replication checkpoint, a signaling cascade whose centra

64 ed mitosis, Hsl7 overexpression overrode the replication checkpoint, accelerating Wee1 destruction.

65 The DNA damage/replication checkpoints act by sensing the presence of d

66 gest an antagonistic interaction between DNA replication checkpoint activation and Cdk1-CycB activity

67 Replication checkpoint activation disrupted Hsl7-Wee1 in

68 egulation of both normal DNA replication and replication checkpoint activation through the novel phos

69 The replisome is important for DNA replication checkpoint activation, but how specific comp

70 tial blastoderm stage cell-cycle delays, DNA replication checkpoint activation, cellularization, and

71 Chk1 and cell-cycle arrest, consistent with replication checkpoint activation.

72 lian DNA helicase and has been implicated in replication checkpoint activation.

73 lation and allowed late-origin firing during replication checkpoint activation.

74 We conclude that normal S phase and replication checkpoint activities are important timers o

75 This replication checkpoint acts by down-regulating the activ

76 n yeast Schizosaccharomyces pombe, Mrc1 is a replication checkpoint adaptor protein that allows the s

77 This two-stage activation mechanism for the replication checkpoint allows for rapid activation with

78 ditions that activate the DNA damage and DNA replication checkpoints also activated the spindle check

79 are required for both the DNA damage and the replication checkpoints, an exception being chk1 .

80 Rad53 kinase is a central effector of the replication checkpoint and both binds to and phosphoryla

81 man TopBP1 participates in the activation of replication checkpoint and DNA damage checkpoints, follo

82 Chk1 plays a key role in regulating the replication checkpoint and DNA damage response.

83 mechanism of how the replisome regulates the replication checkpoint and genomic stability.

84 SpCds1 functions in the DNA replication checkpoint and in the S phase DNA damage che

85 arrest appeared not to be related to the DNA replication checkpoint and not to be mediated through in

86 cts have demonstrated that activation of the replication checkpoint and phosphorylation of the Chk1 k

87 se data establish Hsl7 as a component of the replication checkpoint and reveal that similar cell cycl

88 optotic sensitivity to inhibitors of the DNA replication checkpoint and suggesting it as a candidate

89 phorylation of Cdc2 is essential for the DNA replication checkpoint and suggests that Cdc25, and/or o

90 ions redundantly with the kinase Cds1 at the replication checkpoint and that both kinases phosphoryla

91 y network integrating NF-kappaB with the DNA-replication checkpoint and the expression of critical re

92 hereby contributing to the activation of the replication checkpoint and the stabilization of replicat

93 lay important roles in the activation of the replication checkpoint and the stabilization of stalled

94 heckpoint response, but not DNA replication, replication checkpoint, and cell cycle progression.

95 essential roles in DNA metabolism, including replication, checkpoint, and repair.

96 DNA replication machinery interact with the replication checkpoint apparatus.

97 Mechanisms controlling DNA replication and replication checkpoint are critical for the maintenance

98 lowed replication fork restart, although DNA replication checkpoints are functional.

99 These mutations also impair the replication checkpoint arrest.

100 Furthermore, Cdc2 isolated from replication checkpoint-arrested cells can be activated i

101 ivity, CHES1 had no measurable effect on the replication checkpoint as assayed by hydroxyurea sensiti

102 DPB11, cut5, has been implicated in the DNA replication checkpoint as has the POL2 gene with which D

103 The DNA damage and DNA replication checkpoints block anaphase in response to DN

104 Further, replication checkpoint blockade via small-molecule inhib

105 ncy does not alter the activation of the DNA replication checkpoint but rather affects the execution

106 activity and cell survival in the endogenous replication checkpoint but that Ddc1 is absolutely requi

107 lity to activate Mec1 are proficient for the replication checkpoint, but they are compromised for the

108 replication ensemble and plays a role in the replication checkpoint by directly associating with repl

109 Therefore, the DNA replication checkpoint can prevent mitosis by suppressin

110 d postreplicative repair, and DNA damage and replication checkpoints caused growth defects or lethali

111 S. pombe Ddb1 is functionally linked to the replication checkpoint control gene cds1.

112 y a potentially critical role for Claspin in replication checkpoint control in mammalian cells.

113 ternal cell-cycle programme, and disrupt DNA-replication checkpoint control of cell-cycle progression

114 Here, we show that a DNA replication checkpoint control operates during meiosis i

115 for DNA replication and have been linked to replication checkpoint control.

116 ensure the proper cell cycle progression and replication checkpoint control.

117 t Drc1 is required for DNA synthesis and S-M replication checkpoint control.

118 P1 is a key mediator protein involved in DNA replication checkpoint control.

119 hat ETAA1 is a new ATR activator involved in replication checkpoint control.

120 PA2 functionally interact and participate in replication checkpoint control.

121 t that BACH1 has an unexpected early role in replication checkpoint control.

122 es, TopBP1 may be involved in DNA damage and replication checkpoint controls.

123 of which are required for DNA damage and/or replication checkpoint controls.

124 The DNA replication checkpoint couples the onset of mitosis with

125 encodes Checkpoint kinase 1 (Chk1), are DNA-replication-checkpoint defective and fail to cellularize

126 show that mnk grp double-mutant embryos are replication-checkpoint defective but cellularize, gastru

127 These data suggest that replication checkpoint defects may result indirectly fro

128 We have found that a DNA replication checkpoint dependent on the ATM homolog MEC1

129 pin is phosphorylated at the MBT at both DNA replication checkpoint-dependent and -independent sites.

130 Finally, the DNA replication checkpoint did not contribute to the arrests

131 The DNA replication checkpoint (DRC) monitors and responds to st

132 es or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative st

133 Cds1 protein kinase are required for the DNA replication checkpoint during meiosis, with Cds1 playing

134 in preventing spontaneous activation of the replication checkpoint during normal cell cycles.

135 The DNA replication checkpoint ensures that mitosis is not initi

136 The ATR replication checkpoint ensures that stalled forks remain

137 Effectors of the replication checkpoint evoked by hydroxyurea (HU) are un

138 nction of checkpoint regulators, such as the replication checkpoint factors Tof1 and Rad53.

139 This study suggests that inhibition of replication checkpoint function can suppress skin carcin

140 This defect in replication checkpoint function was reversed after the a

141 show that, contrary to current models of DNA replication checkpoint function, replication proteins re

142 Tel1, the ortholog of human ATM, has a minor replication checkpoint function.

143 romosomal fragile sites in cells lacking the replication checkpoint gene ATR.

144 In addition, vegetative replication checkpoint genes are not required for the ar

145 syncytial cell-cycle timing or the embryonic replication checkpoint, however, suggesting that Mei-41-

146 We identified a Mec1/ATR- and Dbf4-dependent replication checkpoint in budding yeast that prevents th

147 ll cycle transcriptional program and the DNA replication checkpoint in fission yeast.

148 the role of human Claspin in the DNA damage/replication checkpoint in mammalian cells.

149 We report that the DNA replication checkpoint in S. pombe is abrogated in cells

150 The DNA replication checkpoint in Schizosaccharomyces pombe cont

151 og of Chk2 and the major effector of the DNA replication checkpoint in Schizosaccharomyces pombe.

152 have implicated the Saccharomyces cerevisiae replication checkpoint in the suppression of spontaneous

153 proteins to Cdc25 in vitro and disrupts the replication checkpoint in vivo.

154 Pin1 was found to be required for the DNA replication checkpoint in Xenopus laevis.

155 Initiation of the DNA replication checkpoint in yeast is mainly mediated by Me

156 1, a checkpoint protein required for the DNA replication checkpoint in yeast.

157 The G(2) DNA damage and DNA replication checkpoints in many organisms act through th

158 an essential component of the DNA damage and replication checkpoints in the fission yeast Schizosacch

159 1 plays a crucial role in the DNA damage and replication checkpoints in vertebrates and may therefore

160 resence of unreplicated DNA (that is, in the replication checkpoint) in fission yeast.

161 emonstrated that in Saccharomyces cerevisiae replication, checkpoint inactivation via a mec1 mutation

162 cycle 7 and cycle 10, this extension is DNA-replication checkpoint independent, but correlates with

163 prevented double-strand break formation in a replication-checkpoint-independent manner, and delaying

164 from the Ppp5-deficient mice maintain normal replication checkpoint induced by hydroxyurea, Ppp5-defi

165 To determine the effect of replication checkpoint inhibition on carcinogenesis, we

166 The DNA replication checkpoint inhibits mitosis in cells that ar

167 The DNA replication checkpoint is a complex signal transduction

168 The replication checkpoint is a dedicated sensor-response sy

169 evel zygotic transcription is initiated, the replication checkpoint is activated and the cell cycle s

170 We report that the replication checkpoint is activated in two stages.

171 The replication checkpoint is activated when replication for

172 We previously showed that when the DNA replication checkpoint is activated, the repressor Yox1

173 As a result, the replication checkpoint is activated.

174 In fission yeast, the replication checkpoint is enforced by the kinase Cds1 (h

175 tely replicated DNA, indicating that the DNA replication checkpoint is inactive under these condition

176 1-1 and for the activation of XChk1 when the replication checkpoint is induced by aphidicolin.

177 We conclude that the Sda replication checkpoint is required to delay the initiati

178 accharomyces pombe the major effector of the replication checkpoint is the protein kinase Cds1.

179 We propose that while the DNA replication checkpoint is unlikely to regulate the assem

180 a telangiectasia and Rad3-related (ATR) is a replication checkpoint kinase activated by DNA stresses

181 We demonstrate that the replication checkpoint kinase ATR, but not ATM, is criti

182 at Sap1 is involved in the activation of the replication checkpoint kinase Cds1 and that sap1 mutant

183 The replication checkpoint kinase Cds1 preserves genome inte

184 val of fork arrest and for activation of the replication checkpoint kinase Cds1.

185 ddb1 strain to an increased activity of the replication checkpoint kinase Cds1.

186 s on the 14-3-3 chaperone Rad24p and the DNA replication checkpoint kinase Cds1p.

187 But activation of the replication checkpoint kinase Chk2 is unaffected, defini

188 tion of the Cdc10 subunit of MBF by the Cds1 replication-checkpoint kinase.

189 We conclude that the DNA-replication checkpoint maintains genome integrity during

190 stress in Saccharomyces cerevisiae, the DNA replication checkpoint maintains replication fork stabil

191 In the endogenous replication checkpoint, Mec1 phosphorylation of Rad53 re

192 on of Cdc2 on tyrosine-15 is not part of the replication checkpoint mechanism.

193 provide some insight into the DNA damage and replication checkpoint mechanisms of HRad17.

194 strate for the first time a link between the replication checkpoint mediated by ATR/Chk1 and the tran

195 yeast carrying deletions of both ISC1 and a replication checkpoint mediator gene including MRC1, TOF

196 f DNA chain elongation and activation of the replication checkpoint might be responsible for the UVC-

197 The replication-checkpoint mimic requires colocalization of

198 Therefore we constructed an in vivo replication-checkpoint mimic that recapitulates Mec1-dep

199 d lethality, because it not only impairs DNA replication checkpoint more profoundly than inhibition o

200 cells tolerate deletions of mediator of the replication checkpoint (MRC) 1 (mrc1Delta) and radiation

201 Replication checkpoint mutant cds1Delta shows increased

202 Yeast replication checkpoint mutants lose viability following

203 We show that CtrA also mediates a DNA replication checkpoint of cell division by regulating th

204 activation of the sensor kinase Rad3 in the replication checkpoint of fission yeast may involve a di

205 genes that function specifically in the DNA replication checkpoint pathway, we searched for high-cop

206 lex and Exo1 contribute to activation of the replication checkpoint pathway.

207 T1 gene as an effector of the DNA damage and replication checkpoint pathway.

208 h is required for activation of Chk1 and the replication checkpoint pathway.

209 oteins participate in the DNA damage and DNA replication checkpoint pathways and are critical to main

210 is a signal transducer in the DNA damage and replication checkpoint pathways and functions downstream

211 red for the activation of DNA damage and DNA replication checkpoint pathways, and that is implicated

212 sential protein kinase in DNA damage and DNA replication checkpoint pathways.

213 Our data reveal how the replication checkpoint preserves genome integrity, provi

214 rom the fork stalled at the lesion site, the replication checkpoint presumably coordinates the action

215 In eukaryotes, the DNA replication checkpoint prevents entry into mitosis when

216 In yeast, Mec1 protein kinase-mediated replication checkpoint prevents the breakdown of replica

217 that Chk1, a component of the DNA damage and replication checkpoints, protects vertebrate cells again

218 Here, we show that Rad17, a replication checkpoint protein, is required for the earl

219 ndicate that, like TopBP1, Treslin is a dual replication/checkpoint protein that directly participate

220 somerase IIbeta-binding protein 1) is a dual replication/checkpoint protein.

221 eplication forks that are then stabilized by replication checkpoint proteins, whereas CAF-I defects l

222 n asf1 mutants have a strong requirement for replication checkpoint proteins, whereas normal S-phase

223 fission yeast Schizosaccharomyces pombe, the replication checkpoint regulates the entire G(1)/S trans

224 is resistance does not rely on the essential replication checkpoint regulator WEE1 but could be block

225 The DNA replication checkpoint remains intact in ATR knockout ce

226 er, whether mutp53 directly perturbs the DNA replication checkpoint remains unclear.

227 has previously shown that activation of the replication checkpoint requires the initiation of DNA sy

228 ulation of Rad60 is an important part of the replication checkpoint response controlled by Cds1.

229 iotic response to DNA damage due to a failed replication checkpoint response differs substantially fr

230 e transcriptional program is part of the DNA replication checkpoint response in human cells and estab

231 for the ATR-dependent activation of the DNA replication checkpoint response in Xenopus and human cel

232 that ObgE defines a pathway analogous to the replication checkpoint response of eukaryotes and acts i

233 We found that during recovery from the DNA replication checkpoint response, Claspin is degraded in

234 ts suggest that WRN and ATM participate in a replication checkpoint response, in which WRN facilitate

235 contributes to two key functions of the DNA replication checkpoint response, namely, preventing geno

236 mp functioning in the S phase DNA damage and replication checkpoint response, upon treatment with DNA

237 n of Claspin results in termination of a DNA replication checkpoint response.

238 are involved in a common pathway in the DNA replication checkpoint response.

239 ning multiprotein complexes participate in a replication checkpoint response.

240 his distinct class of G1/S genes for the DNA replication checkpoint response.

241 tion protein Mcm2 during both DNA damage and replication checkpoint responses in Xenopus egg extracts

242 s a replisome component that participates in replication checkpoint responses to genotoxic stress, it

243 ATM and ATR, are required for DNA damage and replication checkpoint responses.

244 damage-induced G(2)/M arrest and a subset of replication checkpoint responses.

245 During the replication checkpoint, Saccharomyces cerevisiae Dbf4 is

246 rks in a configuration that is recognized by replication checkpoint sensors.

247 nopus ATR (XATR) and Hus1 (Xhus1) as the DNA replication checkpoint sensors.

248 S1 branches of the intra-S checkpoint or the replication checkpoint showed synergistic interactions w

249 thought to act as a specific mediator of the replication checkpoint signal that activates the effecto

250 ication initiation is required to induce the replication checkpoint signal.

251 that Cdc2 is in an activated state during a replication checkpoint, suggesting that phosphorylation

252 epair and recover normally from the G2/M and replication checkpoints, suggesting a specific function

253 icating MBF as a target of the budding yeast replication checkpoint, suggests that checkpoint regulat

254 kpoint-specific transcriptional program, the replication checkpoint targets MBF to maintain the norma

255 Swi1 is also needed for the replication checkpoint that arrests division in response

256 within the yxcC gene and at or near the left replication checkpoint that is activated under stringent

257 cell cycle checkpoint responses and the DNA replication checkpoint that prevents mitosis before the

258 protein kinase Cds1 is activated by the S-M replication checkpoint that prevents mitosis when DNA is

259 lls lacking either the DNA damage or the DNA replication checkpoints, the spindle checkpoint contribu

260 clb6 are unable to activate the meiotic DNA replication checkpoint, they do possess an intact DNA da

261 after activation of either the DNA damage or replication checkpoints; this is accompanied by a slight

262 (MBT) is a requirement for a functional DNA replication checkpoint to coordinate cell-cycle remodeli

263 However, the role and mechanism of the replication checkpoint transcriptional response in human

264 The DNA replication checkpoint transcriptionally upregulates gen

265 Loss of both the DNA damage and replication checkpoints was observed in fission yeast ce

266 se results demonstrate that a Chk1-dependent replication checkpoint which slows S phase progression c

267 what role these Mec1 activators play in the replication checkpoint, which recognizes stalled replica

268 ction pathway involved in the DNA damage and replication checkpoints, while Cdc7-Dbf4 kinase (DDK) is

269 Dna2 shows partial redundancy for the replication checkpoint with checkpoint initiators 9-1-1