ライフサイエンスコーパス: replication complex

1 ed following stress, it redistributes to the replication complex.

2 idylinositol 4-phosphate (PI4P) lipid to the replication complex.

3 ion and retargeting of the PI4P lipid to its replication complex.

4 component of the bacteriophage T4-coded DNA replication complex.

5 otency and cancer, and as a component of the replication complex.

6 er in the absence of other components of the replication complex.

7 lar interactions that occur within the viral replication complex.

8 ion, including the formation of a functional replication complex.

9 s a central role in the formation of the HCV replication complex.

10 s-acting function that may occur outside the replication complex.

11 mpair the function of the EBOV transcription/replication complex.

12 ant component of the hepatitis C virus (HCV) replication complex.

13 est that this may represent a coxsackievirus replication complex.

14 is an integral component of viral lytic DNA replication complex.

15 ting the expression of components of the pre-replication complex.

16 ructural proteins (nsps) that form the viral replication complex.

17 imicking the form that would be present in a replication complex.

18 eeps the primer in physical proximity to the replication complex.

19 oteins recruited to the origins form the pre-replication complex.

20 recise roles of 3AB and VPg in the viral RNA replication complex.

21 the primer, caused termination of the T7 DNA replication complex.

22 utilized by the virus to form its membranous replication complex.

23 interaction in the formation of the HCV RNA replication complex.

24 gging strand polymerases are together in the replication complex.

25 protein with the membranes of the viral RNA replication complex.

26 e nsP4 is an integral part of the alphavirus replication complex.

27 vity against DENV, and localizes to the DENV replication complex.

28 erative binding of gp32 molecules within the replication complex.

29 lymerase (RdRp) 3D are involved in the viral replication complex.

30 y active 3D molecules and those that build a replication complex.

31 ment synthesis behind and independent of the replication complex.

32 is a member of, and can regulate, the HPV16 replication complex.

33 targeting a cellular component of the viral replication complex.

34 interact with other components of the T4 DNA replication complex.

35 sDNA sequences within the functioning T4 DNA replication complex.

36 pology of the Beet black scorch virus (BBSV) replication complex.

37 nality of specific proteins within the virus replication complex.

38 ay regulate the assembly of an active genome replication complex.

39 in cultured cells, and may be present in the replication complex.

40 lication as well as real-time measurement of replication complexes.

41 ltimately becomes associated with functional replication complexes.

42 ate with or assist in the formation of viral replication complexes.

43 ing events downstream of the assembly of pre-replication complexes.

44 pparent role in promoting progression of DNA replication complexes.

45 y acid biosynthetic pathway to establish its replication complexes.

46 uctural protein 3 (nsp3), a marker for virus replication complexes.

47 he majority of the dsRNA was associated with replication complexes.

48 for genome replication, perhaps formation of replication complexes.

49 embrane anchors during assembly of the viral replication complexes.

50 alterations leading to the formation of HCV replication complexes.

51 y involve release of replicated genomes from replication complexes.

52 r sites, consistent with membrane-associated replication complexes.

53 owing to loss of functional connection with replication complexes.

54 ic RNA and associates with transcription and replication complexes.

55 mal cellular pathways to assemble functional replication complexes.

56 nization of membranes used to form viral RNA replication complexes.

57 recruitment element targeting viral RNAs to replication complexes.

58 n and microenvironment of plant (+)RNA virus replication complexes.

59 l DNA replication, and failure to form viral replication complexes.

60 lar machinery to form and operate membranous replication complexes.

61 entry, with incoming virions failing to form replication complexes.

62 The largest viral protein in the replication complex, 2C, is thought to have multiple rol

63 ndicated that XCdc7/Drf1 is required for pre-replication complex activation but not their assembly.

64 bly and the second step was dependent on pre-replication complex activation.

65 en envelope proteins and NS3 and NS5A within replication complexes adjacent to lipid droplets, where

66 n uninfected cells and with the dengue virus replication complex after infection.

67 not only an essential component of the viral replication complex and a prime target for antiviral int

68 nction that likely occurs as part of the HCV replication complex and a trans-acting function that may

69 endent RNA polymerase form part of the viral replication complex and are involved in viral RNA genome

70 tent with the tight juxtaposition of the HCV replication complex and assembly site at the LD surface.

71 g with MOV10 and Xrn1, localizes to the DENV replication complex and associates with DENV proteins.

72 PI4KIIIalpha results in a breakdown of this replication complex and cessation of HCV replication in

73 NS3 is intimately associated with the viral replication complex and dsRNA.

74 lication licensing factor is part of the pre-replication complex and essential for the maintenance of

75 ecursor asymmetry could cause pausing of the replication complex and hence exacerbate the propensity

76 raction abolishes the formation of the HPV16 replication complex and impairs HPV16 DNA replication in

77 ular enzyme, SIRT1, is part of the HPV16 DNA replication complex and is brought to the viral genome b

78 SIRT1 is part of the E1-E2 DNA replication complex and is recruited to the viral origin

79 pid-binding protein, is recruited to the HCV replication complex and is required for HCV genome repli

80 nsistent with the tight juxtaposition of the replication complex and the assembly site at the surface

81 ously shown to contain elements of the viral replication complex and the TGN resident endoprotease Ke

82 (MNV), is intimately associated with the MNV replication complex and the viral replication intermedia

83 FMDV protein 2C is part of the replication complex and thought to have multiple roles d

84 C) complex, may interact with incoming HIV-1 replication complexes and affect key steps of infection.

85 ion disrupts the integrity of membranous HCV replication complexes and renders HCV RNA susceptible to

86 ique lipid blueprints on which they assemble replication complexes and synthesize viral RNA.

87 onment that supports the formation of active replication complexes and the initiation of RNA synthesi

88 are two important components of the HCV RNA replication complex, and nascent HCV RNA to autophagosom

89 ropagation of the viral genome occurs within replication complexes, and understanding this process ca

90 if impaired polymerase activity, assembly of replication complexes, and viral replication.

91 ractions with other components of the T4 DNA replication complex are discussed.

92 a bulge through a polymerase binding site or replication complex are important components of frameshi

93 ngs indicate that components of the reovirus replication complex are mediators of cell-selective vira

94 t factors in the hepatitis C virus (HCV) RNA replication complex are not well understood.

95 tical interactions within the poliovirus RNA replication complex are those of the RNA-dependent RNA p

96 For poliovirus, these replication complexes are anchored to the membrane via t

97 Our results showed that Nodamura virus replication complexes are targeted to mitochondria, as e

98 These vesicles, which contain the HCV replication complex, are highly enriched in proteins req

99 parate localization of NS1 and the viral RNA replication complex, as the latter is present on the cyt

100 proteins, which promotes the assembly of the replication complexes, as well as cellular poly(A) bindi

101 al membrane-specific host factor for FHV RNA replication complex assembly and function in S. cerevisi

102 Hsp90 and Hsp70 chaperone systems in FHV RNA replication complex assembly and function in Saccharomyc

103 steps: the first step was independent of pre-replication complex assembly and the second step was dep

104 level of redundancy in using host factors in replication complex assembly and virus replication.

105 leating center for ORC assembly and then pre-replication complex assembly by binding to mitotic chrom

106 in P bodies may be an important step in RNA replication complex assembly for BMV, and possibly for o

107 To study viral replication complex assembly we use the established mode

108 enomic replicon offers a unique way to study replication complex assembly, as it enables improved com

109 In addition to replication complex assembly, the results have implicati

110 ane interactions, an initial step of FHV RNA replication complex assembly, we established an in vitro

111 To better understand replication complex assembly, we studied the mechanisms

112 Drf1 complexes was entirely dependent on pre-replication complex assembly.

113 in, is thought to function as a scaffold for replication complex assembly; however, functional intera

114 -strand RNA genomes amplify their genomes in replication complexes associated with cellular membranes

115 is that K-Rta facilitates the formation of a replication complex at oriLyt.

116 exact mechanism for de novo assembly of the replication complex at the replication origin is, or how

117 ulates viral gene transcription, nucleates a replication complex at the viral origin of lytic replica

118 uired in vitro for pol eta to gain access to replication complexes at forks stalled by T (wedge)T and

119 n 6 (Cdc6) is essential for formation of pre-replication complexes at origins of DNA replication.

120 n, in which MPs function to compartmentalize replication complexes at PD for localized RNA synthesis

121 nto the microscopic details of DDR factor/LT replication complexes at the MCPyV origin but also provi

122 In addition to inhibiting replication complex biogenesis, daclatasvir prevents vir

123 mage induces assembly and execution of a DNA replication complex (break-induced replisome) at telomer

124 sets of nonstructural proteins that form the replication complex but expresses either only capsid or

125 l ORF1a protein nsp10 colocalizes with viral replication complexes, but its role in transcription/rep

126 Subsequently, NS3 is recruited to the replication complex by NS5BDelta21, resulting in RNA syn

127 Hsc70 associates with the HCV replication complex by primarily binding to the poly U/U

128 d membranes facilitate the assembly of viral replication complexes by sequestering viral and co-opted

129 Our data lead to a model wherein the replication complex can be assembled with a minimally ac

130 y the APC/C-dependent oscillation of the pre-replication complex component Orc1.

131 ocalization of TIAR and TIA-1 with the viral replication complex components dsRNA and NS3 was observe

132 The picornavirus replication complex comprises a coordinated network of p

133 tis C virus (HCV) occurs in a membrane-bound replication complex consisting of viral and cellular pro

134 te marker of the rate of intracellular viral replication complex decay.

135 se that phosphorylates components of the pre-replication complex during DNA replication initiation.

136 eractions of the other sub-assemblies of the replication complex during the replication cycle.

137 eplication requires the recruitment of a pre-replication complex facilitated by Origin Recognition Co

138 tructure to remain in close proximity to the replication complex followed by reassembly on nascent DN

139 Assembly of virus replication complexes for all known positive-strand RNA

140 using cells lacking D-type cyclins, in which replication complexes form normally, and correspondingly

141 phila cells, Flock House nodavirus (FHV) RNA replication complexes form on outer mitochondrial membra

142 cruit FHV genomic RNA to membranes where RNA replication complexes form.

143 oteins that play multiple roles in viral RNA replication complex formation and function.

144 will help us to understand the mechanism of replication complex formation and the pathogenesis of No

145 fore provides the first link between NoV RNA replication complex formation and the pathogenesis of th

146 -replicase fusions can be used to quantitate replication complex formation and virus replication.

147 ts establish RNA recruitment to the sites of replication complex formation as an essential, distinct,

148 Little is known about the mechanism of replication complex formation in cells infected with Nod

149 Our data indicate that Sindbis virus replication complex formation in mosquito cells activate

150 basic patch residues are likely critical for replication complex formation through interactions with

151 o a region of VP35 IID that is important for replication complex formation through interactions with

152 er-235 phosphorylation probably promotes the replication complex formation via increasing NS5A intera

153 ganization but show important differences in replication complex formation, cell entry, host tropism,

154 d is required for HCV genome replication and replication complex formation.

155 f PI4KA-dependent PI4P production influences replication complex formation.

156 he outer mitochondrial membrane sites of RNA replication complex formation.

157 modify host cytoplasmic membranes for viral replication complex formation.

158 nting an early stage in the steps leading to replication complex formation.

159 e interface can explain potent inhibition of replication-complex formation, resistance, effects on li

160 be fully functional in replication; (ii) the replication complex formed during PV replication in vivo

161 cycle, some of which can be supplied to the replication complex from a separate genome (i.e., in tra

162 , and the autophagy pathway facilitates IBDV replication complex function and virus assembly, which i

163 r of the host proteins involved in the viral replication complex have been identified, including oxys

164 that E7(2) reduced the amount of GBF1 on the replication complexes; however, the level of PI4KIIIbeta

165 of these genes encode components of the pre-replication complex, implicating defects in replication

166 lication and the subcellular localization of replication complexes.IMPORTANCE Hepatitis C virus is an

167 A, we demonstrated the role of the viral RNA replication complex in efficient replication of viruses

168 gest that (i) VPg has to be delivered to the replication complex in the form of a large protein precu

169 It forms a replication complex in the presence of replication facto

170 tein (G3BP) and sequesters it into viral RNA replication complexes in a manner that inhibits the form

171 sly established system for visualizing MCPyV replication complexes in cells.

172 associated with newly formed membranous RNA replication complexes in infected cells.

173 mini-chromosome maintenance complex onto pre-replication complexes in late S, G(2), and M phases.

174 both within the virus-induced membrane-bound replication complexes in the host cytoplasm and in the n

175 SL] RNA (37) and colocalized with flavivirus replication complexes in WNV- and dengue virus-infected

176 r (400 mg/day), and daclatasvir, an HCV NS5A replication complex inhibitor (60 mg/day), were co-admin

177 ity in HCV-infected subjects by the HCV NS5A replication complex inhibitor (RCI) daclatasvir (1) spaw

178 vided clinical proof-of-concept for the NS5A replication complex inhibitor class, and regulatory appr

179 aprevir (64), marketed as Sunvepra, the NS5A replication complex inhibitor daclatasvir (117), markete

180 the identification of the highly potent NS5A replication complex inhibitor daclatasvir (33) are descr

181 first-in-class hepatitis C virus (HCV) NS5A replication complex inhibitor daclatasvir (6) provides a

182 ndomly assigned patients to receive the NS5A replication complex inhibitor daclatasvir (60 mg once da

183 BMS-7590052 is the first NS5A replication complex inhibitor with multiple dose proof-o

184 ssed all-oral therapy with daclatasvir (NS5A replication complex inhibitor) plus asunaprevir (NS3 pro

185 We evaluated daclatasvir (an HCV NS5A replication complex inhibitor) plus sofosbuvir (a nucleo

186 antivirals, comprising daclatasvir (an NS5A replication complex inhibitor), asunaprevir (an NS3 prot

187 ial of the combination of ombitasvir (a NS5A replication complex inhibitor), paritaprevir, and ritona

188 The NS5A replication complex inhibitor, BMS-790052, inhibits hepa

189 y of the HCV nonstructural protein 5A (NS5A) replication complex inhibitor, BMS-790052, was investiga

190 MS-790052, a nonstructural protein 5A (NS5A) replication complex inhibitor, were evaluated in a doubl

191 HCV NS5A replication complex inhibitors are pan-genotypic in spec

192 nd 3 are prototypes of a novel class of NS5A replication complex inhibitors that demonstrate high inh

193 NS5A replication complex inhibitors, exemplified by daclatasv

194 ons elucidated a high-resolution view of the replication complexes inside vesicles and allowed us to

195 the most well-studied components of the HCV replication complex is a helicase known as nonstructural

196 ng the formation of the membrane-bound viral replication complex is a major frontier in current virol

197 ed during the S phase, is present in the DNA replication complex isolated from human cells, with enha

198 nsP2) is an essential component of the viral replication complex, it also has critical auxiliary func

199 that the level of recruitment of GBF1 to the replication complexes limits the establishment and expre

200 sDNA loop was frequently associated with the replication complex located at one end of the replicated

201 p16 and possibly other subunits of the viral replication complex may be a target for the development

202 Together with other components of the genome replication complex (NS3, double-stranded RNA, and cellu

203 us to construct high confidence models of a replication complex of the polymerase and of Acyclovir a

204 It has been shown previously that replication complexes of some other positive-strand RNA

205 Hepatitis C virus (HCV) assembles its replication complex on cytosolic membrane vesicles often

206 umulation leading to the assembly of the pre-replication complex on DNA.

207 tial for the formation and function of viral replication complexes on cellular membranes.

208 ruses is the necessity to assemble viral RNA replication complexes on host intracellular membranes, a

209 The assembly of RNA replication complexes on intracellular membranes is an e

210 sibly facilitating the assembly of viral RNA replication complexes on the cytoplasmic face of intrace

211 Flock House virus (FHV), which assembles its replication complexes on the mitochondrial outer membran

212 hase, presumably to prevent reloading of pre-replication complexes once S-phase has begun.

213 utations disrupted the formation of putative replication complexes, one mutation altered the stabilit

214 r the RNA is packaged as it emerges from the replication complex, or the RNA undergoes extensive refo

215 D40 repeat domain, interacts with the origin replication complex (ORC), a protein complex involved in

216 Previous studies of coronavirus replication complex organization and protein interaction

217 d to maintain genomic stability and may help replication complexes overcome sites of damaged DNA and

218 that MMR may have a "special relation to the replication complex", perhaps one that allows 5' or 3' D

219 %) that is replicated by the nuclear-encoded replication complex Pfprex.

220 In this study, we used preinitiation RNA replication complexes (PIRCs) to determine when CRE-depe

221 These results argue that the replication complex plays a role in modulating the SOS r

222 ng single-molecule experiments, we show that replication complexes pre-assembled on DNA support synth

223 yclin E has been shown to have a role in pre-replication complex (Pre-RC) assembly in cells re-enteri

224 y promotes cdc6 and cdt1 expression, and pre-replication complex (pre-RC) assembly in cycling cells.

225 to investigate the link between zones of pre-replication complex (pre-RC) assembly, replication initi

226 Cyclin E supports pre-replication complex (pre-RC) assembly, while cyclin A-as

227 ole in orchestrating the assembly of the pre-replication complex (pre-RC) by ORC-Cdc6 and Cdt1.

228 Since the assembly of pre-replication complex (pre-RC) in G(1) is required for the

229 data revealed asymmetric localization of pre-replication complex (pre-RC) proteins within large NDRs-

230 hromatin together with components of the pre-replication complex (pre-RC), such as the minichromosome

231 on requires the assembly of multiprotein pre-replication complexes (pre-RCs) at chromosomal origins o

232 o humans and is required for assembly of pre-replication complexes (pre-RCs) to initiate DNA replicat

233 on is due to a defect in the assembly of pre-replication complexes (pre-RCs).

234 mutations in multiple components of the pre-replication complex (preRC; ORC1, ORC4, ORC6, CDT1, or C

235 dc6 protein is an essential component of pre-replication complexes (preRCs), which assemble at origin

236 The pre-replication complex protein, origin recognition complex-

237 Genome-scale mapping of pre-replication complex proteins has not been reported in ma

238 mutations in one of five genes encoding pre-replication complex proteins: ORC1, ORC4, ORC6, CDT1, an

239 Interestingly, FAPP2 is redistributed to the replication complex (RC) characterized by HCV NS5A, NS4B

240 A occurs on intracellular membranes, and the replication complex (RC) contains viral RNA, nonstructur

241 toichiometrically participates in flavivirus replication complex (RC) formation is unknown; both redu

242 argeted to sites of yellow fever virus (YFV) replication complex (RC) formation, where it interacts w

243 ith other viral and host proteins within the replication complex (RC), and regulatory elements within

244 in the organization and function of the HCV replication complex (RC).

245 plicates its genome in a membrane-associated replication complex (RC).

246 eEF1A colocalized with viral replication complexes (RC) in infected cells and antibod

247 he host cell's secretory pathway to generate replication complexes (RCs) for viral RNA synthesis.

248 Here we show that NoV establishes RNA replication complexes (RCs) in association with mitochon

249 eplicates its RNA within membrane-associated replication complexes (RCs) in the cytoplasm of infected

250 , the complex of P123+nsP4 forms the primary replication complexes (RCs) that function in negative-st

251 embranous structures in the cytoplasm called replication complexes (RCs).

252 , and yet its biological function within the replication complex remains unknown.

253 yclin E leads to inefficient assembly of pre-replication complexes, replication stress, and chromosom

254 Collisions between DNA replication complexes (replisomes) and barriers such as

255 Frequent collisions between cellular DNA replication complexes (replisomes) and obstacles such as

256 th detergent-resistant membranes where viral replication complexes reside.

257 ther replicase proteins to assemble a larger replication complex specifically formed to transcribe po

258 reviously undescribed aspect of picornavirus replication complex structure-function and an important

259 suggest that the coordinated action of these replication complexes supports leading strand synthesis.

260 activation of the simian virus 40 (SV40) pre-replication complex, SV40 T antigen (Tag) helicase activ

261 n the nature of the minicircle template, the replication complex synthesized leading and lagging stra

262 ure products, P150 and P90, that compose the replication complex that mediates viral RNA replication;

263 ge is a central integrating component of the replication complex that must continuously bind to and u

264 tion of the virus occurs in association with replication complexes that are formed by host cell membr

265 pothesis that Nodamura virus establishes RNA replication complexes that associate with mitochondria i

266 man cells, SFTSV sequesters STAT proteins in replication complexes, thereby inhibiting type I interfe

267 ex loads the beta clamp onto DNA to link the replication complex to DNA during processive synthesis a

268 elements that function as a part of the pre-replication complex to initiate DNA replication in eukar

269 ymerase, functions in TLS and allows for DNA replication complexes to bypass lesions in DNA.

270 these, DnaJB11 relocalizes to virus-induced replication complexes to promote RNA synthesis, while Dn

271 lts imply that recombination occurred in RNA replication complexes to which parental RNAs were indepe

272 Here we probe the composition of this replication complex using nanoscale DNA biopointers to s

273 of HCV proteins because viral particles and replication complex vesicles cannot form or egress.

274 embranous web structures and, ultimately, of replication complex vesicles, but also inhibits an early

275 aracteristic inclusion bodies known as viral replication complexes (VRCs), with a second population o

276 e the formation of host membrane-bound viral replication complexes (VRCs), yet the underlying mechani

277 and play critical roles in assembly of viral replication complexes (vRCs).

278 ns in infected cells in order to build viral replication complexes (VRCs).

279 ost factors and various lipids to form viral replication complexes (VRCs).

280 ining replication-associated proteins (virus replication complexes [VRCs]) upon infection.

281 eplication when the viral RNA polymerase and replication complexes were retargeted from the mitochond

282 formation of the membranous cytoplasmic MNV replication complex, where Atg16L1 localized.

283 how that ORC1--a component of ORC (origin of replication complex), which mediates pre-DNA replication

284 endoplasmic reticulum (ER) membranes to form replication complexes, which are believed to be sites of

285 acilitates the formation of virus-associated replication complexes, which are required for the amplif

286 by strictly controlling the activity of pre-replication complexes, which assemble at specific sites

287 sites of single strand lesions in the DNA of replication complexes, which has a more open structure c

288 olocalized at the actively replicating MCPyV replication complexes, which were absent when a replicat

289 ed both the formation and functioning of the replication complexes, while E5(1) and E7(2) were most e

290 eplication occurs in membrane-associated RNA replication complexes, whose assembly remains poorly und

291 tural 5A protein (NS5A) and enriches the HCV replication complex with its product, phosphoinositol 4-

292 ded DNA binding protein (gp32) of the T4 DNA replication complex with longer ssDNA (and dsDNA) lattic

293 The association of the HCV RNA replication complex with the autophagosomal membranes wa

294 a antigen, suggesting the association of HDV replication complex with the Pol I and Pol II transcript

295 biophysical measurements on T4 bacteriophage replication complexes with detailed structural informati

296 nteraction of HCV NS5B polymerase-containing replication complexes with HCV minus-strand RNA over HCV

297 aps of the subcellular localization of viral replication complexes with the RNAi machinery, and the r

298 The coupling of membrane-associated replication complexes with virus intra- and intercellula

299 C to direct staged assembly of bacterial pre-replication complexes, with DnaA contacting low affinity

300 nd RNA replication, and scaffolding of viral replication complexes within host cell substructures.