ライフサイエンスコーパス: replication factor

1 xic stress by inhibition of an essential DNA replication factor.

2 onfunctional and fails to interact with Cut5 replication factor.

3 a regulatory process targeting this key DNA replication factor.

4 y directly targeting expression of the Cdc45 replication factor.

5 k whether it also functions as a specialized replication factor.

6 hat converts the inhibitor into a beneficial replication factor.

7 e in levels and chromatin association of DNA replication factors.

8 bably involved in its interaction with other replication factors.

9 of BPDE on the chromatin association of DNA replication factors.

10 vely repressing mitotic, DNA repair, and DNA replication factors.

11 of the cytoskeleton, and, unexpectedly, DNA replication factors.

12 the promoters of other coordinately induced replication factors.

13 alphavirus-like superfamily, encodes two RNA replication factors.

14 poly(A) signal influence expression of viral replication factors.

15 ntrol by regulating the transcription of DNA replication factors.

16 mutant strains thermosensitive for essential replication factors.

17 sfection into cells expressing various viral replication factors.

18 NUCLEAR ANTIGEN, which encode essential DNA replication factors.

19 r foci that contain HPV genomes and cellular replication factors.

20 ases A and B and chromatin licensing and DNA replication factor 1 may explain the reduction in cellul

21 lization of gammaH2AX foci with the telomere replication factor 1 protein in untreated melanoma cells

22 anslation or translation of BMV RNA1-encoded replication factor 1a, and was independent of p20, a cel

23 evels and interactions of brome mosaic virus replication factors 1a and 2a polymerase (2apol) shifted

24 embrane-associated compartments, require BMV replication factors 1a and 2a, and use negative-strand R

25 BMV encodes RNA replication factors 1a, with domains implicated in RNA c

26 Brome mosaic virus (BMV) encodes two RNA replication factors: 1a has a C-terminal NTPase/helicase

27 aromyces cerevisiae) protein subunits of DNA REPLICATION FACTOR A (RFA) were produced.

28 on the heterotrimeric ssDNA-binding molecule replication factor A (RPA).

29 dition of Rta to Z(S186A) and the mixture of replication factors activated viral replication and late

30 serves the activity of several essential DNA replication factors, active processes may contribute to

31 bserved decline in the expression of ten DNA replication factors after the midblastula transition (MB

32 The geminivirus replication factor AL1 interacts with the plant retinobl

33 Earlier studies showed that the viral replication factor, AL1, is sufficient for host inductio

34 e findings, we propose that mutations in DNA replication factors alter acetylation of H3 K56.

35 cetylated proteins to include a critical DNA replication factor and provide an additional level of co

36 pathways for induction of this essential DNA replication factor and suggest a mechanism for oncogenic

37 ochondrial DNA (mtDNA) biosynthesis requires replication factors and adequate nucleotide pools from t

38 tool that may facilitate the study of other replication factors and aid in the discovery of novel in

39 We also show that both cellular DNA replication factors and DNA repair DNA polymerases coloc

40 ion by screening an RNAi library against DNA replication factors and identified multiple shRNAs again

41 Notably, key DNA replication factors and major DNA repair DNA polymerases

42 t BIR involves cross-talk between normal DNA replication factors and PRR.

43 heckpoint Rad complexes and the PCNA and RFC replication factors and thus provide further support for

44 ions between the viral genome, virus-encoded replication factors, and host factors.

45 stically to Ty3 cDNA synthesis but that host replication factors antagonize Ty3 replication.

46 omic RNA1 (gB1) and RNA2 (gB2), encoding the replication factors, are packaged into two separate viri

47 rotein 7 (MCM7), an E2F-induced cellular DNA replication factor, as a novel biomarker for cervical ca

48 ry subunits, mitochondrial transcription and replication factors, as well as certain heme biosyntheti

49 after pre-RC formation to promote loading of replication factors at origins, a previously unrecognize

50 t of many transcription factors, kinases and replication factors between the nucleus and cytoplasm is

51 d origin usage by evaluating the kinetics of replication factor binding in fission yeast and show tha

52 the EBV lytic cycle, is a transcription and replication factor, binding to Zta response elements (ZR

53 nscriptional regulator and mitochondrial DNA replication factor, both in P493-6 lymphocytes with high

54 CDKs are thought to activate one or more replication factors, but the identities of these protein

55 infection induces the accumulation of a host replication factor by activating transcription of its ge

56 The human DNA damage sensors, Rad17-replication factor C (Rad17-RFC) and the Rad9-Rad1-Hus1

57 The five subunit replication factor C (RF-C) complex plays a critical rol

58 Replication factor C (RF-C) complex plays an important r

59 Eukaryotic replication factor C (RF-C) is a heteropentameric comple

60 Replication factor C (RF-C), a complex of five subunits,

61 ating cell nuclear antigen (PCNA) loading by replication factor C (RFC) acts as the initial sensor of

62 oliferating cell nuclear antigen (PCNA), and replication factor C (RFC) and a reconstituted Mlh1-Pms1

63 , proliferating cell nuclear antigen (PCNA), replication factor C (RFC) and DNA polymerase delta.

64 plication clamp PCNA is loaded around DNA by replication factor C (RFC) and functions in DNA replicat

65 Fractions that contained replication factor C (RFC) and proliferating cell nuclea

66 en (PCNA), and show that PCNA, together with replication factor C (RFC) and replication protein A (RP

67 Replication factor C (RFC) catalyzes assembly of circula

68 The eukaryotic equivalents are the replication factor C (RFC) clamp loader and the prolifer

69 The eukaryotic replication factor C (RFC) clamp loader is an AAA+ spira

70 We find that the replication factor C (RFC) clamp loader specifically inh

71 , and D subunits of Saccharomyces cerevisiae replication factor C (RFC) clamp loader, respectively, a

72 PCNA sliding clamps are loaded onto DNA by a replication factor C (RFC) clamp loader.

73 ell nuclear antigen (PCNA) sliding clamp and replication factor C (RFC) clamp-loading complex, using

74 ELG1 protein, which comprises an alternative replication factor C (RFC) complex and plays an importan

75 The multi-subunit replication factor C (RFC) complex loads circular prolif

76 visiae, this process involves an alternative replication factor C (RFC) complex that contains the fou

77 s, sliding clamps are loaded onto DNA by the replication factor C (RFC) complex, which consists of fi

78 igated the communication between subunits in replication factor C (RFC) from Archaeoglobus fulgidus.

79 e Methanosarcina acetivorans clamp loader or replication factor C (RFC) homolog.

80 s that are loaded onto DNA by clamp loaders [replication factor C (RFC) in eukaryotes].

81 Replication factor C (RFC) is a five-subunit complex tha

82 Replication factor C (RFC) is a five-subunit protein com

83 Replication factor C (RFC) is a heteropentameric AAA+ pr

84 ing cell nuclear antigen loading onto DNA by replication factor C (RFC) is a key step in eukaryotic D

85 Replication factor C (RFC) is an AAA+ heteropentamer tha

86 netic experiments reveal that ATP binding to replication factor C (RFC) is sufficient for loading the

87 Rad17 homologs have extensive homology with replication factor C (RFC) subunits (p36, p37, p38, p40,

88 tin by a complex of Rad17 and the four small replication factor C (RFC) subunits (Rad17-RFC) in respo

89 Pase, is the bacterial homolog of eukaryotic replication factor C (RFC) that loads the sliding clamp

90 24 interacts with the four small subunits of replication factor C (RFC) to form the RFC-Rad24 complex

91 ometry to contain Rfc2 and Rfc3, subunits of replication factor C (RFC), a five subunit protein that

92 In addition, DNA replication factor C (RFC), a protein complex that facil

93 and DNA binding by Saccharomyces cerevisiae replication factor C (RFC), and present the first kineti

94 l nuclear antigen (PCNA) and show that PCNA, replication factor C (RFC), and replication protein A (R

95 y the Saccharomyces cerevisiae clamp loader, replication factor C (RFC), and the DNA damage checkpoin

96 The clamp loader, replication factor C (RFC), can reverse this mark by unl

97 When loaded onto primed DNA templates by replication factor C (RFC), PCNA acts to tether the poly

98 tionation of these crude extracts identified replication factor C (RFC), proliferating cell nuclear a

99 several DNA replication proteins, including replication factor C (RFC), proliferating cell nuclear a

100 on, hLigI interacts with and is inhibited by replication factor C (RFC), the clamp loader complex tha

101 is study, we describe an association between replication factor C (RFC), the clamp loader, and DNA li

102 l nuclear antigen, a DNA sliding clamp, and, replication factor C (RFC), the clamp loader.

103 dogenous and transfected Brd4 interacts with replication factor C (RFC), the conserved five-subunit c

104 utation in RFC4, encoding a small subunit of replication factor C (RFC), was found to display allele-

105 Unlike replication factor C (RFC), which uses the 3' primer/tem

106 proliferating cell nuclear antigen (PCNA) in replication factor C (RFC)-catalyzed loading of the clam

107 e-molecule analysis, we demonstrate that the replication factor C (RFC)-CTF18 clamp loader (RFC(CTF18

108 hat Ctf18, Ctf8, and Dcc1, the subunits of a Replication Factor C (RFC)-like complex, are essential f

109 tf18, a homologue of the p140 subunit of the replication factor C (RFC).

110 interact with their associated clamp loader, replication factor C (RFC).

111 r antigen (PCNA), and hRad17 has homology to replication factor C (RFC).

112 with proliferating cell nuclear antigen and replication factor C (RFC).

113 nctions by a clamp loader molecular machine, replication factor C (RFC).

114 DNA requires the activity of a clamp-loader [replication factor C (RFC)] complex and the energy deriv

115 a nucleotide-bound eukaryotic clamp loader [replication factor C (RFC)] revealed a different and mor

116 Replication factor C (RFC, also called activator 1), in

117 ating cell nuclear antigen (PCNA, clamp) and replication factor C (RFC, clamp loader), we have examin

118 The DNA damage clamp loader replication factor C (RFC-Rad24) consists of the Rad24 p

119 the structural gene for the large subunit of replication factor C (rfc1), which loads PCNA onto DNA,

120 ding proteins have been reported previously: replication factor C (the PCNA clamp loader), family B D

121 Our results demonstrate that S. cerevisiae Replication Factor C (yRFC) can load yPCNA onto 5'-ssDNA

122 CTF7/ECO1, POL30 (PCNA), and CHL12/CTF18 (a replication factor C [RFC] homolog) genetically interact

123 pha, proliferating cell nuclear antigen, and replication factor C activate MutLalpha endonuclease to

124 The identification of both replication factor C and DNA helicases as critical for s

125 h three- and four-subunit complexes required replication factor C and proliferating cell nuclear anti

126 dition of M. thermoautotrophicum homologs of replication factor C and proliferating cell nuclear anti

127 rms a replication complex in the presence of replication factor C and proliferating cell nuclear anti

128 PCNA, together with replication factor C and replication protein A, stimulat

129 n A, proliferating cell nuclear antigen, and replication factor C and was active in the SV40 DNA repl

130 Three distinct forms of replication factor C are known to play vital roles in ge

131 repair protein (248kDa) and the five-subunit replication factor C clamp loader (250 kDa).

132 and essential DNA polymerase, and a modified Replication Factor C clamp--loader complex.

133 esis, and the localization and activation of replication factor C complex (RFC) subunits.

134 tion in the large subunit of the replicative replication factor C complex (rfc1-1) increased the expa

135 ase delta/proliferating cell nuclear antigen/replication factor C complex on telomeric templates that

136 FC3 encode three of the five subunits of the replication factor C complex, which is required to load

137 rotein family, which include subunits of the Replication factor C complex.

138 rase epsilon, replication protein A, and two replication factor C complexes on chromatin.

139 ng cell nuclear antigen and the clamp loader replication factor C facilitated DNA synthesis with Dpo3

140 ticipation that the discovery of this unique replication factor C homolog will lead to critical insig

141 a its non-conserved C-terminal domain (CTD); replication factor C interaction results in approximatel

142 Replication factor C is required to load proliferating c

143 Eukaryotic replication factor C is the heteropentameric complex tha

144 Then replication factor C loads a proliferating cell nuclear

145 subunits of the origin recognition complex, replication factor C proteins, MCM DNA-licensing factors

146 s two similar small subunits (M. acetivorans replication factor C small subunit (MacRFCS)) and one la

147 The ATPase activity of replication factor C was characterized and found to be s

148 Complexes of replication factor C with a N-terminal truncation (Delta

149 gammaS), a nonhydrolyzable analog of ATP, to replication factor C with a N-terminal truncation (Delta

150 ohesion establishment factor, the Ctf18-RFC (replication factor C) complex.

151 ation factors, and the clamp loader complex (replication factor C) remained tethered to chromatin.

152 quirements for DNA polymerase alpha-primase, replication factor C, and PCNA.

153 ntenance (MCM) 3' --> 5' DNA helicase, PolB, replication factor C, and proliferating cell nuclear ant

154 sence of proliferating cell nuclear antigen, replication factor C, and single-stranded binding protei

155 ly loaded around effector DNA by its loader, replication factor C, are ubiquitinated.

156 These functions include loading onto DNA by replication factor C, as well as Okazaki fragment synthe

157 PCNA is loaded onto DNA by replication factor C, but it has been unknown how PCNA i

158 liferating cell nuclear antigen clamp loader replication factor C, DNA polymerase delta, and DNA liga

159 re assembled around DNA by the clamp loader, replication factor C, efficiently.

160 conformations matching the helical pitch of Replication Factor C, it is not biased toward a right-ha

161 ix purified human proteins: AP endonuclease, replication factor C, PCNA, flap endonuclease 1 (FEN1),

162 S. pombe Uve1p, Rad2p, DNA polymerase delta, replication factor C, proliferating cell nuclear antigen

163 system comprised of MutS alpha, MutL alpha, replication factor C, proliferating cell nuclear antigen

164 ating cell nuclear antigen (PCNA) loading by replication factor C, providing a potential mechanism fo

165 loader gamma complex (homolog of eukaryotic Replication Factor C, RFC).

166 loaded onto the template-primer junction by replication factor C, the C-terminal domain of PCNA medi

167 this process through a pathway that includes replication factor C, the chromatin assembly factor Asf1

168 a circular substrate without the addition of replication factor C, which is the protein responsible f

169 nterfaces by the ATP-dependent clamp loader, Replication Factor C, whose clamp-interacting sites form

170 loaded onto DNA by a dedicated complex, the replication factor C, whose mechanism has been studied i

171 d circular DNA do in fact support MutSbeta-, replication factor C-, and PCNA-dependent activation of

172 log 6, Exonuclease 1, replication protein A, replication factor C-Delta1N, proliferating cell nuclear

173 Here we show that the Elg1 replication factor C-like complex (Elg1-RLC) functions i

174 factor is loaded onto DNA by the Rad24-RFC (replication factor C-like complex with Rad24) clamp load

175 es now present data strongly implicating the replication factor C-like complex, Elg1/ATAD5-RLC, in th

176 lity of PCNA to be loaded onto primed DNA by replication factor C.

177 egions of homology with the five subunits of Replication factor C.

178 yeast CHL12 and has similarity to mammalian replication factor C.

179 teracts with multiple subunits of Drosophila replication factor C.

180 al DNA template was dependent on PCNA and on replication factor C.

181 provides a binding site for the clamp-loader Replication Factor C.

182 th the 9-1-1 heterotrimer reminiscent of the replication factor C/proliferating cell nuclear antigen

183 ucturally homologous proteins, including the replication factor-C small subunit (RFCS).

184 re of the five-protein clamp loader complex (replication factor-C, RFC) of the yeast Saccharomyces ce

185 on factors: replication protein A70 (RPA70), replication factor C1 (RFC1), and DNA polymerase delta.

186 BRCA1/2), Poly-ADP ribose polymerase (PARP), replication factor c2-5 (Rfc2-5), ataxia telangiectasia

187 The top hits based on the combined data-replication factor C3 (RFC3), FAM111A, and interferon re

188 origin firing and concurrent binding of the replication factor Cdc45p to origins.

189 Exogenous expression of replication factors Cdc6 or Cdt1 in RB-proficient cells

190 hat has previously been shown to degrade the replication factor Cdt1 during S phase.

191 Here we show that stabilization of the DNA replication factor Cdt1, a substrate of cullins 1 and 4,

192 -G2-M phases produces high levels of the DNA replication factor Cdt1, and this leads to efficient Mcm

193 DNA replication by inhibiting the essential replication factor Cdt1.

194 The replication factors Cdt1 and Cdc6 are essential for orig

195 of S phase entry in cells overproducing the replication factor, Cdt1.

196 nt form of the nuclear matrix-associated DNA replication factor Ciz1 is present in 34/35 lung tumors

197 Further, lethal insertions in replication factor complex 4 (rfc4) and GTPase-activatin

198 ors, proliferating cell nuclear antigen, and replication factor complex, was disrupted by DeltaNLA.

199 97-dependent turnover and disassembly of DNA replication factor complexes.

200 We show that four DNA replication factors--Cut5, RecQ4, Treslin, and Drf1--are

201 While several transcription/replication factors directly regulate mitochondrial gene

202 of interactions between the Escherichia coli replication factor DnaC protein and the DnaB helicase ha

203 e report that MAT switching requires the DNA replication factor Dpb11, although it does not require t

204 dDP eliminates G(1)-S transcription of known replication factors during embryogenesis and compromises

205 nding model to decipher the roles of various replication factors during metazoan DNA replication.

206 n by interacting with and recruiting the HPV replication factor E1 to the viral origin.

207 The viral replication factors E1 and E2 of papillomaviruses are ne

208 butable to their efficient expression of the replication factors E1 and E2.

209 s bound by a virus-encoded transcription and replication factor E2, which binds to a 12 bp recognitio

210 probably due to a stabilization of the viral replication factor E2.

211 papillomavirus 16 (HPV16) transcription and replication factor E2.

212 Using purified replication factors encoded by herpes simplex virus type

213 ed by competition among origins for limiting replication factors establishes the timing and efficienc

214 These findings make CDC45 the only putative replication factor experimentally proven to be essential

215 been well established, its effects on viral replication factor expression and plasmid replication of

216 re we investigate the role of one of the DNA replication factors, flap endonuclease I (FEN1), in regu

217 DNA replication and to recruit cellular DNA replication factors for viral DNA replication.

218 The E2 proteins are transcription/replication factors from papillomaviruses.

219 Rbf1-dependent repression of E2f1-regulated replication factor genes, which are expressed continuous

220 Saccharomyces cerevisiae, but not other DNA replication factors, greatly reduced PFA at replication

221 e through S phase and implicated several DNA replication factors in silencing, later works showed tha

222 ion defect is due to dosage insufficiency of replication factors in the nucleus, which stems from two

223 te in vitro plasmid DNA replication, whereas replication factors in the polymerase fractions are stri

224 Vpr indirectly binds MCM10, a eukaryotic DNA replication factor, in a Vpr-binding protein (VprBP) (Vp

225 o a regulator of viral gene expression and a replication factor, in association with the viral E1 pro

226 ve restart was inhibited along with numerous replication factors, including MCM6 and RPA, the latter

227 mutations and the genes encoding several DNA replication factors, including POL1, CTF4, DNA2, and CHL

228 How core replication factors integrate into this phosphorylation

229 The coordinated activity of DNA replication factors is a highly dynamic process that inv

230 identity and order of assembly of eukaryotic replication factors is highly conserved across all speci

231 This motif, named RRF (for repression of replication factors), is conserved in the promoters of o

232 tes polymerase translation relative to other replication factors, just as many single-component RNA v

233 irects cell-specific expression of the viral replication factor large T antigen, and thus transcripti

234 The baculovirus replication factors LEF-1 and LEF-2 of the Autographa ca

235 for optimal replication, encode a conserved replication factor, LEF-7, that manipulates the DDR via

236 DNA replication initiation with 16 purified replication factors, made from 42 polypeptides.

237 Another replication factor, Mcm10, mediates the interaction betw

238 that the G1 phase-specific expression of the replication factor Mcm2 is a useful marker for detecting

239 We have applied this method to the DNA replication factor mcm4/cdc21, and find that chromatin a

240 s revealed significantly lower levels of the replication factors Mcm4, Mcm7, and Cdc45 at replication

241 icing factors Rbmx, Sfrs5 and Sfrs7, the DNA replication factors Mcm5 and Brd4, phosphoinositide-3-ki

242 sion, and prevented chromatin recruitment of replication factor Mcm7, demonstrating that JADE1 is req

243 nt cells also retain high levels of tethered replication factors, MCM7 and PCNA, indicating that DNA

244 tions of the DnaB-primase complex with other replication factors might be critical for determining th

245 MDI-Larp's targets include mtDNA replication factors, mitochondrial ribosomal proteins, a

246 proteins, transcription regulation proteins, replication factors, modifying enzymes, and a number of

247 racts with DNA as both a transcription and a replication factor, modulates both intracellular signal

248 lisome) by yet unidentified host factors [Mu replication factors (MRF alpha 2)], which displace the t

249 ation regulates the interaction with another replication factor, MUS-101.

250 The results showed that the replication factors of PCV1 and PCV2 are fully exchangea

251 in determining the function of the different replication factors once they have been assembled at the

252 ested that the direct interaction of RB with replication factors or sites of DNA synthesis may contri

253 is for negative-strand RNA3 templates, viral replication factors, or common host components.

254 Our data indicate that Cdc2 phosphorylates replication factor Orp2, a subunit of the origin recogni

255 In eukaryotes, the DNA replication factor PCNA is loaded onto primer-template j

256 eckpoint components with limited homology to replication factors PCNA and RF-C, respectively, suggest

257 l, Dzantiev et al. present evidence that the replication factors PCNA and RFC modulate the directiona

258 1 may play a role in inactivation of the DNA replication factor proliferating cell nuclear antigen du

259 Here, we find that the replication factors proliferating cell nuclear antigen (

260 ding potential by supplying the RNA1-encoded replication factor protein A in trans.

261 n S phase and replicates via accumulation of replication factors, rather than recruitment of DNA to p

262 h HPV16 E1, E2, and a number of the cellular replication factors: replication protein A70 (RPA70), re

263 been shown to be structurally similar to the replication factors, RFC clamp loader and proliferating

264 re11/NBS1 complex and Rad51/Rad52 along with replication factors (RPA) and telomere binding proteins

265 NA replication through modulation of crucial replication factor(s) (trans-acting mechanism).

266 ecreased levels or inactivation of essential replication factor(s).

267 xRTS, which bears homology to the yeast replication factors Sld2/DRC1, is essential for DNA repl

268 es a subset of Cdk1 substrates including the replication factors, Sld2 and Dpb2.

269 The loading of essential DNA replication factors such as Cdc45 and proliferating cell

270 ays a direct role in recruiting cellular DNA replication factors, such as replication protein A or po

271 Mcm10 is a DNA replication factor that interacts with multiple subunits

272 Moreover, the viral E2 transcription and replication factor that is expressed at high levels in d

273 the yeast Sld3 protein, is an essential DNA replication factor that is regulated by cyclin-dependent

274 Mcm10 is an essential replication factor that is required for DNA replication

275 Mcm10 is a conserved eukaryotic DNA replication factor that is required for S phase progress

276 ntigen (PCNA) is an essential eukaryotic DNA replication factor that is transcriptionally regulated b

277 drug targets because they are essential DNA replication factors that are highly expressed in cancer

278 proteins MCM2-MCM7 are conserved eukaryotic replication factors that assemble in a heterohexameric c

279 some maintenance) proteins are essential DNA replication factors that each contain a putative ATP bin

280 protein family are essential eukaryotic DNA replication factors that form a six-member protein compl

281 ycle progression, here we identify three DNA replication factors that interact with each other and th

282 herichia coli DnaB helicase complex with the replication factor, the DnaC protein, have been examined

283 RB, we observed the attenuation of multiple replication factors, the complete cessation of DNA synth

284 rongly attenuated the RNA levels of multiple replication factors, their protein expression was not di

285 cation machinery and contribute few, if any, replication factors themselves.

286 cm10) is an essential eukaryotic DNA-binding replication factor thought to serve as a scaffold to coo

287 CDK phosphorylation of the replication factor TICRR (TopBP1-interacting checkpoint

288 d (Dup), the Drosophila homologue of Cdt1, a replication factor to which geminin binds.

289 of dsRNA from host defenses and concentrate replication factors to enhance RNA production.

290 cts in part to facilitate the recruitment of replication factors to oriLyt.

291 wn to recruit many of the necessary cellular replication factors to the viral origin of replication.

292 show that the binding of cellular and viral replication factors to viral RNA is conserved despite ge

293 In particular, expression of the viral DNA replication factor UL84 is affected by the deletion of I

294 alization of the human cytomegalovirus viral replication factor UL84 relative to other proteins invol

295 us DNA polymerase subunit UL44 and the viral replication factor UL84.

296 y, several proteins, including the viral DNA replication factors UL84 and UL57, were identified by ma

297 IE2 40 affect the expression of a viral DNA replication factor, UL84.

298 stein-Barr virus (EBV) encodes a set of core replication factors used during lytic infection in human

299 Mcm10 is a conserved eukaryotic DNA replication factor whose function has remained elusive.

300 n is likely due to suboptimal association of replication factors with the abnormal origins found in t