ライフサイエンスコーパス: replicative

1 wed greater AUROCs for F2-4 diagnosis in low replicative (0.80, 0.62, 0.81 and 0.71, respectively) vs

2 In order to maintain genomic integrity, post-replicative 8-oxo-dG:dA mispairs are removed through DNA

3 s a significant determinant of overall viral replicative ability and an important target of the host

4 viruses transmitted to infants have a lower replicative ability as well as a higher similarity to th

5 ated that viral genetics may determine virus replicative ability within patients.

6 that transgenic miR-32 expression increases replicative activity in the prostate epithelium.

7 ression increased both the incidence and the replicative activity of prostatic intraepithelial neopla

8 these host mitochondrial functions to gain a replicative advantage and persist in chronically infecte

9 This response may have evolved to confer a replicative advantage, thus allowing HBoV1 to establish

10 t the stem-cell level generates a clone with replicative advantage.

11 d a small negative correlation between yeast replicative age and Idh1-GFP or Idh2-GFP but not Trx2-GF

12 c17Delta, vacuole scaling increases with the replicative age of the cell.

13 spectrum and genome distribution change with replicative age, chronological age, cell differentiation

14 so differ from each other depending on their replicative age.

15 ects in mitochondrial function and premature replicative ageing.

16 e use microfluidic technologies to track the replicative aging of single yeast cells and reveal that

17 o how the changes in genome structure during replicative aging result in an increased susceptibility

18 tion was also confirmed as an early event of replicative aging.

19 lations and how this diversity may shape the replicative and evolutionary dynamics of these viruses.

20 icative in origin but also when they are non-replicative and repaired efficiently.

21 ely 0.01-0.40%) that are in concordance with replicative and translational errors.

22 The replicative and translational machinery utilizes the uni

23 ganisms, including humans, that suggest both replicative and translesion DNA polymerases are involved

24 that in contrast to the toolbelt model, the replicative and translesion polymerases do not form a st

25 However, coronavirus replicative apparatus clearly has the plasticity to func

26 artial sacrifice of a mechanism that reduces replicative barriers, namely translating ribosomes that

27 cruitment is hypothesized to generate a safe replicative body to escape cellular immune responses in

28 Our study compares the intracellular replicative capacities of several different HIV isolates

29 eir cell-fate switch while maintaining their replicative capacity in a dose- and age-dependent manner

30 tures at chromosome ends, influence cellular replicative capacity in that critically short telomeres

31 The replicative capacity of drug-passaged populations was re

32 urthermore, we propose that the poorer viral replicative capacity of subtypes A and C may paradoxical

33 eproducible hierarchy of Gag-protease-driven replicative capacity, whereby recombinants exhibit the g

34 ission are decoupled from those that enhance replicative capacity.

35 eir detection requires measurements of their replicative capacity.

36 it accumulates distally from the parasite's replicative centre.

37 porated during DNA replication and mark post-replicative chromatin until the G2/M phase of the cell c

38 DNA replication provide a signature of post-replicative chromatin, read by the human TONSL-MMS22L ho

39 , CUL2(LRR2), that modifies a subunit of the replicative CMG (Cdc45, minichromosome maintenance [MCM]

40 Dissociation of the replicative CMG helicase (comprising CDC45, MCM2-7 and G

41 Evidence for post-replicative cohesion establishment mechanism exists, in

42 Generation of this replicative compartment requires effectors delivered int

43 quiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly.

44 itiate replication by recruitment of the pre-replicative complex (pre-RC).

45 A replication origins depends on the two pre-replicative complex components (origin recognition compl

46 apsids help to organize the viral genome and replicative complex(es).

47 LV nonstructural proteins to form functional replicative complexes.

48 cell cholesterol is important for the HSV-1 replicative cycle at a stage(s) beyond entry, after the

49 esses that are critical to the intracellular replicative cycle of T. gondii including secretion of ad

50 tcompeted weaker ones expressed later in the replicative cycle of the virus.

51 We describe herein its structure and replicative cycle, along with genomic analysis and genom

52 One approach to better understand the viral replicative cycle, and potential therapies to target it,

53 ant for understanding how HCMV regulates its replicative cycle.

54 multiple roles for cholesterol in the HSV-1 replicative cycle.IMPORTANCE HSV-1 infections are associ

55 both the host response to infection and the replicative cycles of several viruses.

56 vely with the DDR during the course of their replicative cycles.

57 lipids, and other molecules required for its replicative development and host survival.

58 g, as major contributors to subtype-specific replicative differences.

59 kers, particularly for APRI and FIB-4 in low-replicative disease.

60 Here, the G4 formation decreases the replicative DNA at each cell cycle, finally leading to a

61 ontrolling chromatin dynamics in response to replicative DNA damage.

62 Activation of the Mcm2-7 replicative DNA helicase is the committed step in eukary

63 ne that coordinates the Cdc45-MCM-GINS (CMG) replicative DNA helicase with DNA polymerases alpha, del

64 s revealed MCM3, an essential subunit of the replicative DNA helicase, as a new substrate.

65 ad53-1 cells stressed by dNTP depletion, the replicative DNA helicase, MCM, and the leading-strand DN

66 Replicative DNA helicases are loaded around origins of D

67 Although the enzymatic activities of the replicative DNA Pol III are well understood, its dynamic

68 The replicative DNA polymerase DnaE1 from the major pathogen

69 The replicative DNA polymerase epsilon (Pol epsilon) was sho

70 Thus, multi-subunit replicative DNA polymerase holoenzymes are present in al

71 oSMoS) to follow the exchange of the E. coli replicative DNA polymerase Pol IIIcore with the transles

72 To quantitatively image how the replicative DNA polymerase PolC functions in B. subtilis

73 The replicative DNA polymerase PolIIIalpha from Escherichia

74 DNA polymerase epsilon (Pol epsilon) is a replicative DNA polymerase with an associated 3'-5' exon

75 '-5' exonuclease that is associated with the replicative DNA polymerase.

76 Replicative DNA polymerases (DNAPs) require divalent met

77 inor groove and strongly blocks synthesis by replicative DNA polymerases (Pols).

78 ivated during S phase and associate with the replicative DNA polymerases and other accessory proteins

79 High fidelity replicative DNA polymerases are unable to synthesize pas

80 adducts formed by the 1-NP metabolites stall replicative DNA polymerases but are presumably bypassed

81 s chimeric RNA-DNA primers to be extended by replicative DNA polymerases delta and .

82 1-MeA presents a block to replicative DNA polymerases due to its inability to part

83 visiae mispair recognition proteins with the replicative DNA polymerases during DNA replication has s

84 PolC is one of two essential replicative DNA polymerases found in the Gram-positive b

85 Replicative DNA polymerases misincorporate ribonucleosid

86 of leading and lagging strands by the three replicative DNA polymerases Pol alpha, Pol delta, and Po

87 idelity of RNA synthesis resembling those of replicative DNA polymerases.

88 of the RNA primers that are elongated by the replicative DNA polymerases.

89 ve, less processive, and more mutagenic than replicative DNA synthesis.

90 g cell line increased viral mRNAs, proteins, replicative DNA, and covalently closed circular DNA.

91 , C241Y, A343T, and I573V) contribute to the replicative efficiency of H5N1 viruses in human lung cel

92 rom cells and, as such, is important for the replicative efficiency of influenza A virus.

93 t eukaryotic cells contain a multifunctional replicative enzyme called primase-polymerase (PrimPol) t

94 ent state in resting CD4+ T cells, where the replicative enzymes targeted by cART are not active.

95 an fibroblasts rendered senescent by stress, replicative exhaustion, or oncogene activation, mTORC1 i

96 ese stem cells, coupled with their unlimited replicative expansion and maintained clonogenicity, sugg

97 Influenza virus' low replicative fidelity contributes to its capacity for rap

98 e to novel virus variants that enhance viral replicative fitness and respiratory droplet transmission

99 e of ClO2 resistance resulted in an enhanced replicative fitness compared to the less resistant start

100 Nonetheless, replicative fitness is restored by a compensatory mutati

101 ta highlight challenges in assessment of the replicative fitness of H7N9 NA variants that emerged in

102 a342 impaired the viral life cycle; however, replicative fitness was restored by an additional change

103 nts of budding efficiency, fusogenicity, and replicative fitness were dissociable: HeV-M budded more

104 re shown to have reduced growth rates (i.e., replicative fitness) in both TIP-treated and TIP-untreat

105 om VRC01 class antibodies can diminish viral replicative fitness, but compensatory changes may explai

106 This bNAb resistance mutation reduces replicative fitness, which may explain the persistence o

107 ng chimeras did not correlate with increased replicative fitness.

108 erturbing a metastable capsid can compromise replicative fitness.IMPORTANCE Capsids of nonenveloped v

109 GINS is a key component of eukaryotic replicative forks and is composed of four subunits (Sld5

110 By using the duplex replicative form of the HBoV1 genome in human embryonic

111 Increasing the levels of post-replicative H3K27me3 or preventing S phase entry inhibit

112 All 4 biomarkers in both, low and high-replicative HBV demonstrate modest accuracy for fibrosis

113 negative, low-replicative (n = 213) and high-replicative (HBV DNA >/=20,000 IU/mL, n = 153) patients

114 r significant fibrosis (Metavir F2-4) in low-replicative (HBV DNA <20,000 IU/mL) chronic hepatitis B

115 e antibody and 26 of 105 (25%) of those with replicative HCV infection.

116 his process involves displacement of the CMG replicative helicase (comprised of Cdc45, MCM2-7, and GI

117 NA replication by phosphorylating the Mcm2-7 replicative helicase [5-7].

118 Thus, imbalances in levels of the replicative helicase and helicase loader can inhibit rep

119 two mechanisms by which an imbalance in the replicative helicase and its associated loader protein c

120 s, indicative of extensive uncoupling of the replicative helicase and polymerase.

121 that Mcm10 plays a critical role in coupling replicative helicase assembly with helicase activation.

122 ATPase domain, allowing binding of the host replicative helicase but impeding loader self-assembly a

123 ntermediate step towards the assembly of two replicative helicase complexes at origins, moving in opp

124 The Escherichia coli replicative helicase DnaB and the helicase loader DnaC f

125 The Minichromosome Maintenance (MCM) replicative helicase is a crucial component of replisome

126 th the function of the Staphylococcus aureus replicative helicase loader, DnaI.

127 DNA unwinding by the replicative helicase may continue during such pauses, bu

128 The replicative helicase Mcm2-7 functions in both initiation

129 recognize DNA replication origins, load the replicative helicase on DNA, unwind DNA, synthesize new

130 the DnaC helicase loader, can load the DnaB replicative helicase onto DNA bound by the single-strand

131 Absence of the accessory replicative helicase Rep, resulting in increased replica

132 ichromosome maintenance (MCM) complex is the replicative helicase responsible for unwinding DNA durin

133 x in which a diverged Orc4 homologue and one replicative helicase subunit can also be found.

134 ng the Ctf4-interacting peptide (CIP) of the replicative helicase subunit Sld5.

135 on licensing factor CDC6 recruits the MCM2-7 replicative helicase to the replication origin, where MC

136 ngle-stranded DNA binding protein mtSSB, the replicative helicase Twinkle and the proposed mitochondr

137 f2 gene encoding the human mitochondrial DNA replicative helicase Twinkle are linked to several rare

138 Strikingly, the stoichiometries of the replicative helicase, DNA polymerase, and clamp loader c

139 d hexameric MCM, the motor of the eukaryotic replicative helicase, into double hexamers at replicatio

140 ge; however, we show that Twinkle, the mtDNA replicative helicase, is able to stimulate PrimPol DNA s

141 ssential for incorporation of Cdc45 into the replicative helicase, possesses a partner called MTBP (M

142 which the core enzyme of the eukaryotic DNA replicative helicase, the Mcm2-7 (minichromosome mainten

143 9 degrees N MCM3, the proposed replicative helicase, unwinds DNA at a faster rate compa

144 mal origin of replication, oriC, to load the replicative helicase.

145 ly and activation of Cdc45-Mcm2-7-GINS (CMG) replicative helicase.

146 bandoned replication forks and reloading the replicative helicase.

147 is key to activating the eukaryotic MCM(2-7) replicative helicase.

148 ates with the regulatory MCM5 subunit of the replicative helicase.

149 , forms the catalytic core of the eukaryotic replicative helicase.

150 Replicative helicases are loaded onto DNA by dedicated i

151 Replicative helicases are ring-shaped hexamers that enci

152 Replicative helicases in all cell types are hexameric ri

153 ifferences in the strategies used to deposit replicative helicases onto DNA and to melt the DNA helix

154 Replicative helicases play central roles in chromosome d

155 eplication origins direct the recruitment of replicative helicases via the action of initiator protei

156 Unlike other replicative helicases, eukaryotic CMG helicase partially

157 lance and DNA replication, including the Mcm replicative helicases.

158 Replicative hexameric helicases are thought to unwind du

159 Replisome assembly requires the loading of replicative hexameric helicases onto origins by AAA+ ATP

160 ionally related subpopulations that included replicative histones, ribosomal biogenesis and cell moti

161 Moreover, in replicative human senescent fibroblasts, DDR precluded M

162 subgroup of the inherited form is caused by replicative impairment of hematopoietic stem and progeni

163 k cell divisions not only when mutations are replicative in origin but also when they are non-replica

164 stablish a nonreactivating, latent-like or a replicative infection in CD34(+) hematopoietic progenito

165 were expressed similarly in both latent and replicative infection.

166 Asn/Gln residues may act in concert along a replicative interface to promote prion conversion.

167 to a previously identified structure in the replicative intermediate (RI) RNA and a panhandle domain

168 uch intrahepatic markers of WHV infection as replicative intermediate DNA, covalently closed circular

169 s essential for the accumulation of the cRNA replicative intermediate in infected cells.

170 acilitates HBV infection in vitro, where all replicative intermediates including covalently closed ci

171 ting two quantitative, continuous variables, replicative labeling and DAPI staining.

172 ei, flow-sorted on the basis of DNA content, replicative labeling was widely distributed across euchr

173 Although the replicative life cycle of HIV within CD4 T cells is unde

174 Understanding the mechanisms of the replicative life cycle of the virus may bring to light d

175 iological transactions, including control of replicative life span (RLS), prevention of collision bet

176 control intrachromatid recombination and the replicative life span (RLS).

177 hondrial quantity causes a severe decline of replicative life span of daughter cells.

178 at DLX2 expression led to increased cellular replicative life span.

179 tion-depend nucleosome assembly and advanced replicative life span.

180 Budding yeast cells have a finite replicative life span; that is, a mother cell produces o

181 The replicative lifespan (RLS) of a cell-defined as the numb

182 less-fit mitochondria by buds and decreased replicative lifespan and healthspan.

183 ast does not age and that cellular aging and replicative lifespan can be uncoupled in a eukaryotic ce

184 Previous studies indicate that replicative lifespan in daughter cells of Sacchraromyces

185 ed the proteome and transcriptome during the replicative lifespan of budding yeast.

186 ghters are born rejuvenated and enjoy a full replicative lifespan.

187 promotes mitochondrial function and extends replicative lifespan.

188 this framework to that of LIG1, the nuclear replicative ligase.

189 ssion, reduces cell size, and suppresses the replicative longevity of cells lacking the Sch9p protein

190 to survive later generations, we developed a replicative longevity paradigm in which mother cells are

191 metic effect of extracellular H2O2 stress on replicative longevity.

192 ements are fundamentally linked to the viral replicative machinery.

193 e breakpoint junctions, suggesting potential replicative mechanisms for rearrangement formation.

194 ociated CNVs further support the role of DNA replicative mechanisms in CNV mutagenesis, and facilitat

195 Different autocatalytic and 'self-replicative' molecular species have been extensively inv

196 ening of telomeres (ALT) pathway to overcome replicative mortality.

197 eristic curve (AUROC) of HBeAg-negative, low-replicative (n = 213) and high-replicative (HBV DNA >/=2

198 The parasitophorous vacuole is a unique replicative niche for apicomplexan parasites, including

199 pid translocation of L. monocytogenes to its replicative niche in the cytosol.

200 ve identified a likely paradigm by which the replicative niche of many intracellular bacterial pathog

201 thogens form an intracellular membrane-bound replicative niche termed the inclusion, which is enriche

202 eath is critical for Chlamydia to maintain a replicative niche, but the underlying mechanisms are unk

203 es, to maintain the parasite's intracellular replicative niche.

204 To establish these replicative niches, intracellular pathogens secrete vari

205 r bacterial pathogens establish a variety of replicative niches.

206 els of nucleotide substitution, indicating a replicative origin for such mutations.

207 date have been interpreted as pointing to a replicative origin of most mutations could instead refle

208 0.62, 0.81 and 0.71, respectively) vs. high-replicative patients (0.73, 0.52, 0.67 and 0.69, respect

209 and AAR identified it more frequently in low-replicative patients (37.5% vs. 19.4%, P = 0.037).

210 tly identified F2-4 fibrosis in low vs. high-replicative patients (48.7% vs. 69.6%, P = 0.032) and AA

211 Of the low and high-replicative patients, 40 (18.8%) and 73 (47.7%) had F2-4

212 or identifying F2-4 fibrosis in low and high-replicative patients.

213 ed, cells treated with NeoB showed decreased replicative permissiveness for poliovirus, which also re

214 Meanwhile, no replicative PGCs or prophase I meiocytes could be found.

215 ons, serine is mainly metabolized during the replicative phase for the biosynthesis of some amino aci

216 e cellular response to DNA damage during the replicative phase of the cell cycle has been extensively

217 During the replicative phase, the bacteria grow within host cells i

218 Using purified proteins, we show that the replicative polymerase DnaE is mutagenic within the sequ

219 port a stable ternary complex of Pol II, the replicative polymerase Pol III core complex and the dime

220 d DNA, allowing stringent DNA synthesis by a replicative polymerase to resume beyond the offending da

221 ther suggest that approach is performed by a replicative polymerase, while extension involves a compl

222 amage where they may also displace a blocked replicative polymerase.

223 ity when ribonucleotides incorporated by the replicative polymerases are not removed by RNase H2.

224 is contrasts with the multi-subunit B-family replicative polymerases of eukaryotes.

225 DNA lesions encountered by replicative polymerases threaten genome stability and ce

226 riately activated inflammasomes and enhanced replicative potential.

227 tocyte epithelial differentiation to sustain replicative precursor phenotype.

228 Here, we report that archaeal replicative primases (Pri S, primase small subunit) can

229 Here we describe an alternate replicative process, termed nonadaptive prion amplificat

230 t autophagy is essential for maintaining the replicative quiescence of hematopoietic stem cells throu

231 -, and liver-cancer-associated mutations and replicative ("R-class") asymmetry dominating POLE-, APOB

232 breakpoint junction features reminiscent of replicative repair, and show increased de novo point mut

233 s of active telomerase to sustain their high replicative requirements.

234 from the loss of T cells that have attained replicative senescence (i.e., the Hayflick limit).

235 corneal epithelial stem/progenitor cells to replicative senescence and apoptosis.

236 roperties may underlie its ability to thwart replicative senescence and, not surprisingly, have been

237 were remarkably similar to those induced by replicative senescence but occurred in only 13 days vers

238 n-induced genome instability and accelerated replicative senescence in HGPS.

239 Replicative senescence may result from chronic, low-dose

240 Raman and infrared spectroscopy can identify replicative senescence on the single cell level, suggest

241 Insofar as telomere shortening and replicative senescence prevent genomic instability and c

242 ith activation of stress-induced rather than replicative senescence programs.

243 of the T cells, and also imprints them with replicative senescence signatures.

244 However, p19(Arf) is required for replicative senescence, a condition associated with an a

245 We show that, in a mouse model of replicative senescence, decline in muscle satellite cell

246 seen in several cancer cell lines and during replicative senescence.

247 because naive T cells collectively approach replicative senescence.

248 e genes whose enhanced expression can bypass replicative senescence.

249 netic screens to identify genes required for replicative senescence.

250 pectroscopy, following their transition into replicative senescence.

251 ctin-dependent coalescence of multiple early replicative sites.

252 compartments during both the latent and the replicative stages of the KSHV life cycle.IMPORTANCE Kap

253 ersist within memory CD4(+) T cells in a non-replicative state and activate when ART is discontinued.

254 der-based mechanism for recognizing the post-replicative state, offering a new angle to understand DN

255 switch as a research tool to examine in vivo replicative states in a mouse model of chronic infection

256 lly, mechanisms to distinguish pre- and post-replicative states locally remain unknown.

257 t are differentially regulated in latent vs. replicative states of infection.

258 elicase in ICL resolution, influenced by the replicative-status of the cell/tissue.

259 Like other types of DNA damage, replicative stress activates the DNA damage response, a

260 uggest that decreased SRF expression induces replicative stress and chromosomal condensation defects

261 Here, we analyzed PhIP-triggered replicative stress and elucidated the role of the apical

262 sed cancer cell resistance to DNA damage and replicative stress and increased tumor cell killing and

263 sts or mouse liver tissue is associated with replicative stress and mitochondrial dysfunction.

264 ze from the nucleolus into the nucleus after replicative stress and significantly associate with each

265 ression of the DNA replication fork, causing replicative stress and/or cell cycle arrest.

266 understanding of how mitochondria cope with replicative stress but can also explain some controversi

267 u complex mutants are primarily sensitive to replicative stress caused by MMS and not to more direct

268 l ATM signaling in response to oxidative and replicative stress conditions.

269 Persistent R-loops lead to replicative stress due to RNA polymerase stalling and DN

270 Replicative stress during embryonic development influenc

271 RC1/CDC6 binding site that is detected after replicative stress induced by hydroxyurea treatment, sug

272 dent cell cycle inhibition, and tolerance to replicative stress induced by hydroxyurea, but result in

273 The lack of deoxynucleotides causes replicative stress leading to activation of the ataxia t

274 demonstrate that the role of Pol epsilon in replicative stress sensing is conserved in plants, and p

275 idence for the direct role of Pol epsilon in replicative stress sensing.

276 roteins involved in the cellular response to replicative stress significantly abrogates NER uniquely

277 liferation and survival in vivo by resolving replicative stress to maintain genomic stability.

278 of DNA replication in response to UV-induced replicative stress) are characterized by profound inhibi

279 e S-phase checkpoint in yeast in response to replicative stress, but whether this mechanism functions

280 n of NER capacity during periods of enhanced replicative stress, ostensibly caused by inordinate sequ

281 ding to replication fork arrest and minimize replicative stress.

282 on of a replication fork is hampered causing replicative stress.

283 egions that are unstable under conditions of replicative stress.

284 capacity of individual mutants to respond to replicative stress.

285 ions at a high frequency under conditions of replicative stress.

286 CFS replication, in the absence of exogenous replicative stress.

287 be a dormant origin activated in response to replicative stress.

288 regulate DNA replication in the presence of replicative stress.

289 leading-strand synthesis under conditions of replicative stress.

290 and active, particularly in tumors with high replicative stress.

291 to be driven by immune pressures as well as replicative success in PBMCs and potentially other repli

292 TL in skeletal muscle represents a minimally replicative tissue.

293 iently than NiV-M, accounting for the higher replicative titers of HeV-M-bearing chimeras at early ti

294 s a biphasic life cycle with a switch from a replicative to a transmissive phenotype.

295 Here we tested this hypothesis, using highly replicative transgenic mouse models.

296 osed circular intermediates, suggestive of a replicative transposition mechanism, which provides a po

297 The Tn3 family is a widespread group of replicative transposons that are notorious for their con

298 in for the absolute quantification of single replicative units, propagons.

299 novel form of ubiquitylation to generate its replicative vacuole.

300 uole into an endoplasmic reticulum (ER)-like replicative vacuole.