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1 ll potential that allows them to self-renew, repopulate a damaged tissue, and then undergo differenti
2 of larvae (e.g., the refugia hypothesis) to repopulate a select subset of the shallow water (<30 m)
3 atively younger' oral mucosal fibroblasts to repopulate a wound space and reorganize their surroundin
4 ertheless, the capacity of cultured cells to repopulate a wounded monolayer is markedly accelerated b
8 to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transp
9 on display decreased frequency and defective repopulating ability as well as decreased lymphoid but i
10 of its rich content of cells with sustained repopulating ability in spite of an apparent deficiency
13 ser extent HIF-1alpha, impedes the long-term repopulating ability of human CD34(+) umbilical cord blo
14 g dilution analysis, to assess the long-term repopulating ability of putative murine EpiSC population
16 ipients significantly impaired the long-term repopulating ability of transplanted mouse HSCs shortly
17 region, to maintain hematopoietic stem cell repopulating ability through a miR-675-Igf1r signaling c
19 ex differences were noted in HSC competitive repopulating ability, but not HPC numbers, in TIP110(TG)
20 stem cell (HSC) subtypes with self-renewable repopulating ability, but with different haematopoietic
23 ulating activity, as Foxa3(-/-) HSC fails to repopulate ablated hosts efficiently, implicating for th
24 al human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facili
25 otype ( approximately 10% HSCs with >6-month repopulating activity in immunodeficient mice) displayed
27 lantations showed no change in the long-term repopulating activity of HSCs from mice exposed to recom
29 -state in vivo hematopoiesis or on long-term repopulating activity of Wnt-deficient hematopoietic ste
30 mice to demonstrate that aged ECs impair the repopulating activity of young HSCs and impart a myeloid
31 creased endogenous competitive long-term HSC repopulating activity, and permitted efficient and durab
32 ar, HSC number, cell cycle status, long-term repopulating activity, and self-renewal capacity were no
33 We validated that Foxa3 is required for HSC repopulating activity, as Foxa3(-/-) HSC fails to repopu
34 t 1 in 65 000 zebrafish marrow cells contain repopulating activity, consistent with mammalian HSC fre
35 ciated with a marked loss of HSCs, long-term repopulating activity, HSC quiescence and common lymphoi
44 bset of horizontal basal cells (HBCs), which repopulate all microvillar cells and Bowman's glands dur
46 interactions and of microbial strategies to repopulate and survive in the soil are largely unexplore
47 of phenotypically corrected HSPCs capable of repopulating and developing proliferation advantage in i
48 -cohort study, we evaluated the phenotype of repopulating B cells and its correlation with donor-spec
52 of the allograft, fall as the graft becomes repopulated by hematopoietic cells of the NOD2 mutant re
53 nocyte-depleted interfollicular epidermis is repopulated by melanocyte precursors from hair follicle
57 er times, the ablated skin was progressively repopulated by non-recombined Chk1-expressing cells and
58 pool, and elevates short-term and long-term repopulating capabilities, leading to the development of
60 progenitors, and exhibited reduced long-term repopulating capacity as well as hyper granulocyte-colon
61 Psigma substantially increased long-term HSC-repopulating capacity compared with BM cells from contro
62 t derived xenografts we demonstrate that the repopulating capacity in normal mammary epithelial cells
65 TPsigma(-) cells substantially increased the repopulating capacity of human HSCs compared with CD34(+
66 ysical and chemical insults compromising the repopulating capacity of the epithelial stem cell compar
68 /-) LSK cells had an increased hematopoietic repopulating capacity with an altered cell differentiati
69 ant loss of quiescence and decline in serial repopulating capacity, but no substantial difference in
70 (-/-) HSCs exhibited decreased hematopoietic repopulating capacity, with skewed cell differentiation
75 eased severe combined immunodeficient (SCID)-repopulating cell counts in culture, compared to input a
79 both PMF HPCs, short-term and long-term SCID repopulating cells (SRCs), are JAK2V617F(+) and that JAK
80 reatment resulted in a dramatic loss of SCID-repopulating cells (SRCs), treatment with OKT3 or UCHT1
81 nhanced clonal outputs from human short-term repopulating cells (STRCs) without affecting their engra
85 , including a 17-fold increase in short-term repopulating cells and a net 23-fold ex vivo expansion o
86 D34+ cells produced a greater number of SCID-repopulating cells and established multilineage hematopo
87 ene therapy since they efficiently transduce repopulating cells and may be safer than more commonly u
89 in lineage cells represent a major source of repopulating cells for reconstitution of the intraglomer
90 ng hematopoiesis by giving rise to long-term repopulating cells in recipient mice with an unexpected
91 fficiently transduce and/or expand long-term repopulating cells in vivo are needed for treatment of d
92 ly posttransplant, and 3% to 5% in long-term repopulating cells over 6 months following HSPC transpla
95 resence of DL yielded enhanced generation of repopulating cells with higher levels of engraftment of
96 to a pronounced increase in the frequency of repopulating cells, as assessed by extreme limiting dilu
97 g NOD.Cg-Prkdc(scid) IL2rg(tm1Wjl) /SzJ mice repopulating cells, induced by combination treatment.
104 in DNA-bound insulator proteins that rapidly repopulate chromatin as the bodies disassemble upon retu
110 ngineering of humanized intestinal grafts by repopulating decellularized rat intestinal matrix with h
113 nal stem/progenitor-like cells, were able to repopulate different nephron portions of renal extracell
114 d that Ly49G2(high) single-positive NK cells repopulated, displayed an activated phenotype, and were
116 proliferative Lgr5(-) cells that are able to repopulate entire glands, including the base, upon deple
117 tial (DPsim(hi)) were enriched for long-term repopulating EpiSCs versus unfractionated cells (3.9- an
118 ing dilution transplantation and competitive repopulating experiments demonstrated a dramatic reducti
120 ellularized human liver cubic scaffolds were repopulated for up to 21 days using human cell lines hep
123 ffect the homing and the number of long-term repopulating haematopoietic stem cells, haematopoietic s
129 scription factors that can amplify long-term repopulating hematopoietic stem cells in a controlled wa
130 en reported to identify functional long-term repopulating hematopoietic stem cells, and has been dete
131 tion of the edited CD34+ cells are long-term repopulating hematopoietic stem cells, demonstrating the
132 he maintenance of immunophenotypic long-term repopulating hematopoietic stem cells, suggesting that a
136 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD
137 In contrast, long-term, but not short-term, repopulating HSC engraftment was impaired significantly,
138 opic miR-193b expression restricts long-term repopulating HSC expansion and blood reconstitution.
140 IFN-gamma is sufficient to promote long-term repopulating HSC proliferation in vivo; furthermore, HSC
142 ined for a population enriched for long-term repopulating HSCs (LT-HSCs) versus their more differenti
144 rogeny, including closely related short-term repopulating HSCs (ST-HSCs) and fully differentiated lym
145 bient oxygen decreases recovery of long-term repopulating HSCs and increases progenitor cells, a phen
147 tro increased the recovery of both long-term repopulating HSCs and progenitor cells, and systemic adm
151 n, that an increased proportion of long-term repopulating HSCs proliferate during M. avium infection,
154 progenitor cells (MPPs) as well as long-term repopulating HSCs, while delaying myeloid differentiatio
158 entiation and myofilament formation from the repopulated human multipotential cardiovascular progenit
161 reases the ability of the cells to long-term repopulate immunodeficient mice compared with equivalent
162 of CML cells, as well as their efficiency in repopulating immunodeficient mice, both in the presence
163 ate that distinct stem/progenitor cell pools repopulate injured tissue depending on the extent of the
167 gesting a model wherein a parasite reservoir repopulates itself indefinitely, whereas some progeny ar
168 s exhibit growth and survival advantages and repopulate KO livers, eventually limiting hepatic injury
169 ensively after transplantation and therefore repopulate large parts of the recipient's hematopoietic
170 oligodendrocyte precursor cells efficiently repopulated lesions after demyelination, but showed dela
171 e fetal liver stem/progenitor cells (FLSPCs) repopulate livers of normal recipients by cell competiti
172 investigated the mechanisms by which FLSPCs repopulate livers of older compared with younger rats.
173 FLSPCs, resistant to activin A signaling, repopulate livers of older rats; hepatocytes in older ra
174 ution returned to normal in 2 weeks, but the repopulated livers were unable to fully respond to drug-
176 es expansion of multipotent cells capable of repopulating lymphoid and megakaryocyte lineages, which
177 py is demonstrating how TCR transgenic cells repopulate lymphopenic hosts and target tumors in an ant
178 the GFP sorted cells failed to give rise to repopulated mammary glands in de-epithelialized recipien
181 enhanced the rate of formation of short-term repopulating multipotential progenitor cells (MPPs) as w
182 are thus able to proliferate to efficiently repopulate mutant livers and cure the underlying metabol
184 through recycling endosomal compartments to repopulate newly formed focal adhesions on the ventral s
185 served numbers of long-term HSCs, yet cannot repopulate nor sustain itself after transplantation agai
187 ith intact subunits in sucrose gradients and repopulate polysomes after a short starvation-induced tr
188 y less capable than more naive phenotypes of repopulating postdepletion, providing a potential mechan
189 enance of hematopoietic functions, including repopulating potential by up-regulating Notch-mediated s
193 r cell cycle greatly impaired the short-term repopulating potential of SKP2 null HSC and their abilit
197 f-2alpha-deficient HSCs and their ability to repopulate primary recipients, indicating that Hif-1alph
198 ain large numbers of mouse mitochondria that repopulate recipient mouse cells along with the injected
199 via an unexpected proliferative response to repopulate residual tumours between chemotherapy cycles,
201 However, Apc(min) bone marrow was unable to repopulate secondary recipients because of loss of the q
203 rsor cells proliferate and mature adipocytes repopulate skin wounds following inflammation and in par
204 t allow lingering immunosuppressive cells to repopulate small pockets of residual disease quickly.
206 erentiate into the less primitive short-term repopulating stem cells (ST-HSCs), which themselves prod
207 plexes preferentially expressed in long-term repopulating stem cells, is essential for adult hemopoie
208 y is associated with long-lasting effects on repopulated T cells and subsequent increased rates of in
209 veral studies have analyzed the phenotype of repopulated T-lymphocytes following alemtuzumab inductio
210 tor-transduced progenitor cells were able to repopulate the B-cell compartment with a normal distribu
212 plant, HSPCs need to expand substantially to repopulate the BM and replenish the peripheral blood cel
213 se progenitors can migrate out of the lungs, repopulate the bone marrow, completely reconstitute bloo
214 ed depletion rapidly enter the cell cycle to repopulate the cortex with altered spatial distribution.
216 buffering it to a level such that Zn(2+) can repopulate the defective binding site, but how it accomp
220 estigated whether cells of renin lineage can repopulate the glomerulus after podocyte injury and serv
224 receptors PD-1 and Lag3, whereas those that repopulate the liver following IL-18 plus IL-12 had incr
225 epatic stem/progenitor cells can effectively repopulate the liver with advanced fibrosis/cirrhosis.
226 planted in vivo into wild-type stroma, fully repopulate the mammary gland fat pad, undergo unperturbe
227 urther, we demonstrate that the B cells that repopulate the MZ in aged bumble mice were distinct from
228 In chronic infection, HIV-1 escape mutants repopulate the plasma, and V3 and CD4bs nAbs emerge that
229 tic cell transplantation (HCT) is applied to repopulate the recipient myeloid compartment, including
231 endothelial cell progenitor cells (BM SPCs) repopulate the sinusoid as liver sinusoidal endothelial
232 ce during symbiosis using host resources; to repopulate the soil; to survive in the soil between host
233 ith reduced capacity to repair myofibers and repopulate the stem cell reservoir in vivo following tra
235 bone marrow progenitors that can efficiently repopulate the thymus are poorly reconstituted for at le
236 n may allow them to survive chemotherapy and repopulate the tumor after exposure to chemotherapeutics
237 with the exclusive ability to self-renew and repopulate the tumor and have been reported to be less s
239 eration, including defects in the cells that repopulate the wound and the RPE at the wound site.
241 rescued as newly generated immature neurons repopulated the granule cell layer upon termination of t
244 rred in a hematopoietic stem cell (HSC) that repopulated the myeloid but not the lymphoid lineage.
245 oke patients without tPA treatment gradually repopulated the numbers of circulating regulatory T cell
246 ctive B cells that had escaped depletion and repopulated the periphery through homeostatic expansion.
248 ours after injection of dimethylnitrosamine, repopulated the sinusoid as LSECs and reduced liver inju
251 othelial cells, and these T-cell progenitors repopulated the thymus and differentiated into mature T-
253 pulation selected from a population of cells repopulated the whole original basin of attraction withi
254 A very limited number of HSC clones (<10) repopulated the xenografted thymus, with further restric
256 lar triplet-state 'reservoir' that thermally repopulates the photoluminescent state of CdSe through e
257 an asymmetrically dividing adult neuroblast repopulates the pool of neuronal progenitor cells in the
260 recently described a regulatable system for repopulating the liver of immunodeficient mice (specific
262 hlight an ERG-regulated mechanism capable of repopulating the parent tumor through the transient gene
263 ation of functional pulmonary vasculature by repopulating the vascular compartment of decellularized
264 st for extremely long periods of time and to repopulate their own pool size through homeostatic self-
268 -) mice in which the peripheral T cells were repopulated to a normal level by syngeneic bone marrow t
271 arbon flow direction in stem-like cells that repopulate tumors (tumor-repopulating cells (TRCs)).
272 expression enabled prostate cancer cells to repopulate tumors in orthotopic and heterotopic tissues.
274 ble for maintaining the capacity of HSPCs to repopulate under steady-state conditions, by activating
275 nstrated a dramatic reduction of competitive repopulating units and progressive decline in hematopoie
276 erial transplantation of long-term epidermal repopulating units derived from CD133(+) and CD133(+)Del
277 he potential of hematopoietic progenitors to repopulate upon adoptive transfer or after 5-fluorouraci
278 onditions, Cdk6(-/-) HSCs do not efficiently repopulate upon competitive transplantation, and Cdk6-de
280 ng of a decellularized lung scaffold that is repopulated with a patient's own cells could provide des
281 T(1a) receptor(-/-) mice were irradiated and repopulated with bone marrow-derived cells isolated from
282 nt phenomenon allows for the construct to be repopulated with cells and to be connected to the blood
284 G mice backcrossed to the NOD background and repopulated with huHeps and human red blood cells suppor
287 re combined immunodeficient mice with livers repopulated with human hepatocytes (humanized livers).
288 plicating and in mice whose livers have been repopulated with human hepatocytes and infected with HBV
289 hat homozygous PIRF mouse livers are readily repopulated with human hepatocytes, and when the murine
293 n regions of CD11b-HSVTK transgenic mice are repopulated with new Iba-1-positive cells within 2 wk.
295 Once in the body, these biomaterials are repopulated with somatic cells of various phenotypes who
296 sing a decellularized deceased donor trachea repopulated with the recipient's respiratory epithelium
298 that the microglia-depleted brain completely repopulates with new microglia within 1 week of inhibito
299 as in cartilage injured by blunt impact were repopulated within 7-14 days by cells that appeared to m
300 eveals that re-epithelializing keratinocytes repopulate wounds by TGF-beta- and integrin-dependent la
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