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2 vitro and show strikingly increased in vivo repopulating abilities after single or sequential bone m
4 6J (B6) and (BALB x B6) F1 hybrid (F1) mice, repopulating abilities increase with age; DR maintains t
7 rapy approaches aim to take advantage of the repopulating ability and plasticity of multipotent stem
8 to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transp
9 on display decreased frequency and defective repopulating ability as well as decreased lymphoid but i
10 matopoietic cells can be highly enriched for repopulating ability based upon the efflux of the fluore
12 of its rich content of cells with sustained repopulating ability in spite of an apparent deficiency
13 stem cells (HSCs) had decreased multilineage repopulating ability in vivo compared with WT controls i
16 empol treatment did not adversely affect the repopulating ability of FA hematopoietic stem cells.
17 ents that regulate engraftment and long-term repopulating ability of hematopoietic stem cells (HSCs)
20 ser extent HIF-1alpha, impedes the long-term repopulating ability of human CD34(+) umbilical cord blo
21 g dilution analysis, to assess the long-term repopulating ability of putative murine EpiSC population
23 ipients significantly impaired the long-term repopulating ability of transplanted mouse HSCs shortly
25 region, to maintain hematopoietic stem cell repopulating ability through a miR-675-Igf1r signaling c
27 , DR increases or maintains increased marrow repopulating ability with age in the 3 different genotyp
28 n 8-fold reduction in multilineage long-term repopulating ability, a defect not seen in marrow cells
29 olling the balance between proliferation and repopulating ability, a finding of importance in clinica
30 ex differences were noted in HSC competitive repopulating ability, but not HPC numbers, in TIP110(TG)
31 stem cell (HSC) subtypes with self-renewable repopulating ability, but with different haematopoietic
33 a p38 MAPK inhibitor significantly increased repopulating ability, supporting an integral role of p38
38 al human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facili
39 otype ( approximately 10% HSCs with >6-month repopulating activity in immunodeficient mice) displayed
43 ription-5 (STAT5) plays an important role in repopulating activity of hematopoietic stem cells (HSCs)
44 lantations showed no change in the long-term repopulating activity of HSCs from mice exposed to recom
47 -state in vivo hematopoiesis or on long-term repopulating activity of Wnt-deficient hematopoietic ste
48 mice to demonstrate that aged ECs impair the repopulating activity of young HSCs and impart a myeloid
49 old), and Ter119+ (17-fold) peripheral blood repopulating activity than c-Mpl(-/-) BM against wild-ty
50 eficient bone marrow had defective long-term repopulating activity that correlated with increased cel
51 creased endogenous competitive long-term HSC repopulating activity, and permitted efficient and durab
52 ar, HSC number, cell cycle status, long-term repopulating activity, and self-renewal capacity were no
53 We validated that Foxa3 is required for HSC repopulating activity, as Foxa3(-/-) HSC fails to repopu
54 t 1 in 65 000 zebrafish marrow cells contain repopulating activity, consistent with mammalian HSC fre
55 ciated with a marked loss of HSCs, long-term repopulating activity, HSC quiescence and common lymphoi
56 (HSCs) in older mice have decreased per-cell repopulating activity, self-renewal and homing abilities
66 of phenotypically corrected HSPCs capable of repopulating and developing proliferation advantage in i
69 -cohort study, we evaluated the phenotype of repopulating B cells and its correlation with donor-spec
72 pool, and elevates short-term and long-term repopulating capabilities, leading to the development of
74 progenitors, and exhibited reduced long-term repopulating capacity as well as hyper granulocyte-colon
75 Psigma substantially increased long-term HSC-repopulating capacity compared with BM cells from contro
76 t derived xenografts we demonstrate that the repopulating capacity in normal mammary epithelial cells
79 TPsigma(-) cells substantially increased the repopulating capacity of human HSCs compared with CD34(+
80 ysical and chemical insults compromising the repopulating capacity of the epithelial stem cell compar
81 -derived stem cells demonstrate a diminished repopulating capacity relative to that of purified bone
83 /-) LSK cells had an increased hematopoietic repopulating capacity with an altered cell differentiati
84 ant loss of quiescence and decline in serial repopulating capacity, but no substantial difference in
85 (-/-) HSCs exhibited decreased hematopoietic repopulating capacity, with skewed cell differentiation
92 Attenuation in the extent of acute damage by repopulating cardiomyocytes and vessels decreased signif
93 Extracardiac progenitor cells are capable of repopulating cardiomyocytes at very low levels in the hu
95 liferation, resulting in increased long-term repopulating cell (LTRC) and competitive repopulating un
96 human SCID (severe combined immunodeficient) repopulating cell (SRC) transduction 3- to 4-fold, resul
97 eased severe combined immunodeficient (SCID)-repopulating cell counts in culture, compared to input a
101 human severe combined immunodeficient (SCID)-repopulating cells (SRCs) by transplantation into the no
102 demonstrate that the absolute number of SCID-repopulating cells (SRCs) increased by 5.8-fold in hypox
103 both PMF HPCs, short-term and long-term SCID repopulating cells (SRCs), are JAK2V617F(+) and that JAK
104 reatment resulted in a dramatic loss of SCID-repopulating cells (SRCs), treatment with OKT3 or UCHT1
107 nhanced clonal outputs from human short-term repopulating cells (STRCs) without affecting their engra
111 , including a 17-fold increase in short-term repopulating cells and a net 23-fold ex vivo expansion o
112 D34+ cells produced a greater number of SCID-repopulating cells and established multilineage hematopo
113 al pitfall of antibody-mediated clearance of repopulating cells and is important for any groups worki
114 ene therapy since they efficiently transduce repopulating cells and may be safer than more commonly u
117 creasingly used to assay human hematopoietic repopulating cells as well as leukemia-initiating cells.
118 0-fold increase in the frequency of NOD/SCID repopulating cells compared with CD133+Lin- cells, sugge
120 in lineage cells represent a major source of repopulating cells for reconstitution of the intraglomer
121 id markers, are expressed on human long-term repopulating cells from cord blood and bone marrow.
122 red lentiviral transduction of hematopoietic repopulating cells from either stem cell factor (SCF)- a
123 the cell-surface phenotype of hematopoietic repopulating cells from murine yolk sac, aorta-gonad-mes
124 ay demonstrates that Bid-deficient long-term repopulating cells give rise to expanded myelomonocytic
125 ng hematopoiesis by giving rise to long-term repopulating cells in recipient mice with an unexpected
126 vectors to transduce long-term hematopoietic repopulating cells in the dog, a clinically relevant lar
127 fficiently transduce and/or expand long-term repopulating cells in vivo are needed for treatment of d
128 e find that the frequency of these long-term repopulating cells is 1 in 35,000 total epidermal cells,
129 ly posttransplant, and 3% to 5% in long-term repopulating cells over 6 months following HSPC transpla
133 transduction of canine CD34(+) hematopoietic repopulating cells using a very short, 18-hour transduct
134 efficient lentiviral transduction of canine repopulating cells using an overnight transduction proto
135 tailed macaque (Macaca nemestrina) long-term repopulating cells using VSV-G-pseudotyped HIV-based len
136 Furthermore, enhanced generation of NOD/SCID repopulating cells was seen following culture with lower
137 resence of DL yielded enhanced generation of repopulating cells with higher levels of engraftment of
138 in a multilineage increase in gene-modified repopulating cells with marking levels of greater than 9
139 ry, they efficiently transduce hematopoietic repopulating cells, and self-inactivating (SIN) designs
140 to a pronounced increase in the frequency of repopulating cells, as assessed by extreme limiting dilu
141 betic/severe combined immunodeficiency mouse repopulating cells, compared with day 0 CD34(+)CD38(-)li
142 g NOD.Cg-Prkdc(scid) IL2rg(tm1Wjl) /SzJ mice repopulating cells, induced by combination treatment.
143 an be overexpressed in bone marrow long-term repopulating cells, it is incapable of mediating their t
144 need for caution in genetic manipulation of repopulating cells, particularly when the transgene migh
146 to the expansion of CD34(+) cells and marrow-repopulating cells, treatment of IM CD34(+) cells result
147 f BIO5192 and plerixafor mobilized long-term repopulating cells, which successfully engraft and expan
165 ngineering of humanized intestinal grafts by repopulating decellularized rat intestinal matrix with h
169 Notably, in the absence of p16INK4a, HSC repopulating defects and apoptosis were mitigated, impro
171 an undergo reprogramming to become long-term repopulating epidermal progenitors following wounding.
172 spensable for the maintenance of established repopulating epidermal stem cells and for the differenti
173 tial (DPsim(hi)) were enriched for long-term repopulating EpiSCs versus unfractionated cells (3.9- an
174 ing dilution transplantation and competitive repopulating experiments demonstrated a dramatic reducti
176 a novel purification of HSCs with long-term repopulating function and may be considered an alternati
177 5ab(-/-) bone marrow (BM) cells showed equal repopulating function either competitively or noncompeti
178 types (CD34+CD38-) and demonstrated enhanced repopulating function in recipients of serial, secondary
182 ffect the homing and the number of long-term repopulating haematopoietic stem cells, haematopoietic s
184 support the ex vivo expansion of short-term repopulating hematopoietic stem cells (HSCs), the ex viv
191 scription factors that can amplify long-term repopulating hematopoietic stem cells in a controlled wa
192 en reported to identify functional long-term repopulating hematopoietic stem cells, and has been dete
193 tion of the edited CD34+ cells are long-term repopulating hematopoietic stem cells, demonstrating the
194 he maintenance of immunophenotypic long-term repopulating hematopoietic stem cells, suggesting that a
200 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD
201 In contrast, long-term, but not short-term, repopulating HSC engraftment was impaired significantly,
202 opic miR-193b expression restricts long-term repopulating HSC expansion and blood reconstitution.
203 rophin caused a marked increase in long-term repopulating HSC numbers in culture, as measured in comp
205 IFN-gamma is sufficient to promote long-term repopulating HSC proliferation in vivo; furthermore, HSC
207 ined for a population enriched for long-term repopulating HSCs (LT-HSCs) versus their more differenti
210 rogeny, including closely related short-term repopulating HSCs (ST-HSCs) and fully differentiated lym
212 bient oxygen decreases recovery of long-term repopulating HSCs and increases progenitor cells, a phen
214 tro increased the recovery of both long-term repopulating HSCs and progenitor cells, and systemic adm
219 ant and increased the frequency of long-term repopulating HSCs present in murine bone marrow after li
220 n, that an increased proportion of long-term repopulating HSCs proliferate during M. avium infection,
224 t NPM promotes the self-renewal of long term repopulating HSCs while attenuated their commitment to m
225 self-renewal, the highest being on long-term repopulating HSCs, and decreases with differentiation, w
226 ls (HSCs), the ex vivo survival of long-term repopulating HSCs, and the prolonged in vivo expansion o
228 progenitor cells (MPPs) as well as long-term repopulating HSCs, while delaying myeloid differentiatio
235 ts an approximately 20-fold net expansion of repopulating human cord blood HSCs, a number potentially
237 of CML cells, as well as their efficiency in repopulating immunodeficient mice, both in the presence
241 staining revealed approximately 5% to 10% of repopulating liver cells expressing human alpha1-antitry
244 AMD3100 also mobilized murine long-term repopulating (LTR) cells that engrafted primary and seco
246 es expansion of multipotent cells capable of repopulating lymphoid and megakaryocyte lineages, which
249 Extracardiac progenitor cells are capable of repopulating most major cell types in the heart, but the
252 enhanced the rate of formation of short-term repopulating multipotential progenitor cells (MPPs) as w
253 port the expansion of human cells capable of repopulating non-obese diabetic/severe combined immunode
254 t stem cell that gives rise to the long-term repopulating of hematopoietic stem cells, mesenchymal st
255 C is influenced by both short- and long-term repopulating populations and that Flt3 expression may be
256 y less capable than more naive phenotypes of repopulating postdepletion, providing a potential mechan
257 1 regulation of HSC quiescence and long-term repopulating potential and hematopoietic lineage develop
259 enance of hematopoietic functions, including repopulating potential by up-regulating Notch-mediated s
260 g deficiency increases HSC proliferation and repopulating potential in vivo after myelosuppression an
264 r cell cycle greatly impaired the short-term repopulating potential of SKP2 null HSC and their abilit
265 d progressive depletion, defective long-term repopulating potential, and hematopoietic lineage develo
266 adult murine liver that possess potent blood-repopulating potential, approaching that of BM HSCs.
272 uivocally establish the ability of transient repopulating progenitors to initiate myeloid leukemias i
273 p a model system for ex vivo gene therapy by repopulating rat livers with hepatocytes and hepatoblast
274 tem cells as a therapeutic strategy aimed at repopulating regions of bowel, where enteric neurones ar
276 to efficiently mark rhesus macaque long-term repopulating stem and progenitor cells with retroviral v
277 dose, suggesting involvement of a short-term repopulating stem cell or an early myeloid progenitor.
278 erentiate into the less primitive short-term repopulating stem cells (ST-HSCs), which themselves prod
279 oietic progenitor cells (HPCs) and long-term repopulating stem cells from the bone marrow (BM) to the
280 veral months, suggesting that true long-term repopulating stem cells were not permanently deleted.
281 plexes preferentially expressed in long-term repopulating stem cells, is essential for adult hemopoie
286 gorously self-renew, expanding in number and repopulating the host muscle with new satellite cells.
288 Recently, it has been suggested that cells repopulating the ischemically injured tubule derive from
290 recently described a regulatable system for repopulating the liver of immunodeficient mice (specific
294 hlight an ERG-regulated mechanism capable of repopulating the parent tumor through the transient gene
295 ets displayed a specific growth advantage in repopulating the spleen in competitive replacement bone
296 ation of functional pulmonary vasculature by repopulating the vascular compartment of decellularized
298 nstrated a dramatic reduction of competitive repopulating units and progressive decline in hematopoie
299 erial transplantation of long-term epidermal repopulating units derived from CD133(+) and CD133(+)Del
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