ライフサイエンスコーパス: repopulation

1 ease paradoxically promotes neighbouring CSC repopulation.

2 ent of the stage of pathology at the time of repopulation.

3 itors throughout the CNS, resulting in rapid repopulation.

4 creas extracellular matrix to drive cellular repopulation.

5 and corresponded with the rate of host cell repopulation.

6 abiosis mouse model of tissue disruption and repopulation.

7 nsplanted cells and poses problems for liver repopulation.

8 st dual lineage contribution predominated in repopulation.

9 directly improves cell engraftment and liver repopulation.

10 particularly important for subsequent liver repopulation.

11 ived factor(s) impaired senescent host liver repopulation.

12 ng disease relapse or remission after B cell repopulation.

13 by adopting methods aimed at reducing tumor repopulation.

14 mia or inflammation, without improving liver repopulation.

15 through superior cell engraftment and liver repopulation.

16 cell engraftment and also kinetics of liver repopulation.

17 he potential to accelerate the rate of array repopulation.

18 ase in number, which may lead to accelerated repopulation.

19 apoptosis, alveolar regression and adipocyte repopulation.

20 programmed epithelial cell death and stromal repopulation.

21 a also cleared with central endothelial cell repopulation.

22 HSCs display reduced capability of long-term repopulation.

23 ansplantation into a syngenic model of liver repopulation.

24 ation, self-renewal, engraftment, or lineage repopulation.

25 g-term high level multilineage hematopoietic repopulation.

26 o the duration and variability of hepatocyte repopulation.

27 g with strong gammadelta T as well as B cell repopulation.

28 lung cancer cells were capable of tumor cell repopulation.

29 al hematopoietic progenitor/stem cell (HPSC) repopulation.

30 gptl3-null recipient mice exhibited impaired repopulation.

31 ss, possess the capacity for extensive liver repopulation.

32 that growth hormone might promote host liver repopulation.

33 loss enhanced hematopoietic stem cell (HSC) repopulation.

34 nfarct size, which is reversed by microglial repopulation.

35 subsequently needed to support cardiomyocyte repopulation.

36 ction to focus on detecting genes regulating repopulation.

37 antly increased proliferation and fibroblast repopulation.

38 proliferation resulting in incomplete T-cell repopulation.

39 helial carcinomas by abrogating early tumour repopulation.

40 tial drug targets for the promotion of liver repopulation.

41 ew liver mass with extensive long-term liver repopulation (40.8 +/- 10.3%).

42 alveolar regression and absence of adipocyte repopulation 7 days post-weaning.

43 ed vital ECM proteins and was liable to cell repopulation, a crucial first step towards the generatio

44 anges are accompanied by increased long-term repopulation ability and expression of CD44 and CXCR4.

45 generated from RUNX1a EBs possess >/=9-week repopulation ability and show multilineage hematopoietic

46 lly, elimination of Erf resulted in impaired repopulation ability, indicating that Erf is necessary f

47 -renewal capacity and long-term multilineage repopulation ability.

48 dly decreased with impaired bone marrow (BM) repopulation ability.

49 se unregulated overexpression diminishes the repopulation activity of HSCs.

50 oietic stem cell expansion and a competitive repopulation advantage, whereas homozygous deletion indu

51 ry B cell (P=0.02) and plasmablast (P<0.001) repopulation after 26 weeks was markedly faster in patie

52 SPCs engraft, and contribute to multilineage repopulation after autologous transplantation in a clini

53 cation, as well as the dynamics of phagocyte repopulation after full depletion.

54 butes to the frequently observed accelerated repopulation after therapeutic irradiation.

55 cities and show reduced but robust levels of repopulation after transfer.

56 f HSC quiescence, and failure of bone marrow repopulation after transplantation.

57 NFR1) was the most significant suppressor of repopulation among all of the genes tested.

58 Repopulation analysis after application of contact sensi

59 However, clonal repopulation analysis using the current methods is typic

60 zed cells preferentially supported long-term repopulation and exhibited lymphoid-biased differentiati

61 The loss of iNKT cells was followed by repopulation and expansion of phenotypically distinct ce

62 sia after vascular injury via accelerated EC repopulation and growth.

63 SALL4 expanded HSCs/HPCs retain multilineage repopulation and long-term engraftment activities, which

64 ese factors as important regulators of liver repopulation and potential drug targets for the promotio

65 e animals, a preferential skewing toward CD4 repopulation and proliferation was observed, particularl

66 o enhanced hematopoiesis because competitive repopulation and recovery from myelosuppression were the

67 ult HSC function, negatively affecting their repopulation and self-renewal ability, partly through th

68 dHSCs to exit quiescence and abrogated their repopulation and self-renewal potential.

69 -negative cells, exhibit robust multilineage repopulation and serial reconstitution ability in immuno

70 able long-term reconstitution in competitive repopulation and serial transplantation experiments.

71 dvantage over wild-type cells in competitive repopulation and serial transplantation experiments.

72 )Lineage(-) (KSL) pool and reduced stem cell repopulation and spleen colony-forming capacity.

73 Remarkably, MLK3 expression induces luminal repopulation and suppresses the expression of the pro-ap

74 ntiation, while compromising their long-term repopulation and survival.

75 The mechanisms of T-cell repopulation and their posttransplantation kinetics are

76 loss, with rare clonal victors driving gland repopulation and tumor growth.

77 ion of GSIs with TMZ treatment could inhibit repopulation and tumor recurrence.

78 These findings suggest T-cell repopulation and/or immune reconstitution as putative me

79 e reversal with ART may be related to T-cell repopulation and/or immune reconstitution.

80 pletely rescued the impaired HSC quiescence, repopulation, and BM hematopoietic niche occupancy capac

81 erely defective in self-renewal, competitive repopulation, and bone marrow (BM) hematopoietic niche o

82 rporating effects of radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis of

83 NG2(+) glial cell early proliferative, late repopulation, and distribution response after ablation i

84 ol size, impaired radioprotection, defective repopulation, and loss of quiescence.

85 In vivo functionality, host cell repopulation, and matrix remodeling of homologous transc

86 e long-term in vivo functionality, host cell repopulation, and remodeling of "off-the-shelf" tissue e

87 ural stem cells differ in their capacity for repopulation, and that adult-born neurons are not requir

88 exposed to radiotherapy promoted rapid tumor repopulation, and this effect was suppressed by Hh inhib

89 We identified 17 regulators of HSPC repopulation: Arhgef5, Armcx1, Cadps2, Crispld1, Emcn, F

90 within their own attractor, thus driving the repopulation, as shown by fluorescent dye tracing.

91 Using this competitive repopulation assay, we compared the effects of INC424 (r

92 d directly to wild-type HSC in a competitive repopulation assay.

93 d repopulation potentials in the competitive repopulation assay.

94 ngraftment in competitive and noncompetitive repopulation assays (<1.5% chimerism of Vav1(-/-) cells

95 s were significantly impaired in competitive repopulation assays and defective in generating common m

96 In vivo competitive repopulation assays demonstrated a sevenfold difference

97 Competitive repopulation assays demonstrated disease appearance and

98 In competitive repopulation assays in vivo, they reconstituted the inna

99 When challenged in competitive BM repopulation assays, primary human leukemia-initiating c

100 scence reporter mice in lineage tracking and repopulation assays, we show that CM expression cell aut

101 solated from nonleukemic mice in competitive repopulation assays.

102 ed mice as measured in long-term competitive repopulation assays.

103 logical effects in multi-lineage competitive repopulation assays.

104 rated successful in vivo detection of T cell repopulation at 2, 4, and 8 wk after HSC transplantation

105 Following BCDT and subsequent B cell repopulation, BAFF levels were significantly higher duri

106 of the sub-basal nerve plexus and keratocyte repopulation by 12 months postoperatively.

107 a Notch2-dependent role in assuring orderly repopulation by HSCs, MPPs, myeloid cells, and lymphoid

108 nervous system (CNS), neuron/oligodendrocyte repopulation by transplanted cells, and enhanced endogen

109 In LEC rats with liver repopulation by transplanted healthy hepatocytes, excret

110 Yet, efficient liver repopulation by transplanted hepatocytes is low in liver

111 wth hormone substitution might improve liver repopulation by transplanted hepatocytes, thus augmentin

112 The age-dependent liver repopulation by transplanted wild-type hepatocytes was i

113 This repopulation can be abrogated by a PGE2-neutralizing ant

114 recipient mice show maintenance of efficient repopulation capacities of Kit(int) but not of Kit(hi) L

115 increase in HSC numbers that show increased repopulation capacity and competitive advantage after tr

116 The impaired repopulation capacity extends to BCR-ABL(p210+) LSCs.

117 enhanced stem cell engraftment and long-term repopulation capacity in vivo.

118 one ERDJ4 (also called DNAJB9) increases HSC repopulation capacity in xenograft assays, linking the U

119 cktail, the STFIA cocktail maintains in vivo repopulation capacity of cultured CD34+ cells.

120 iescence and improved the maintenance of the repopulation capacity of HSCs during aging.

121 or complex, severely impairs the competitive repopulation capacity of HSCs.

122 Moreover, loss of Ezh2 enhanced the repopulation capacity of Jak2V617F-expressing hematopoie

123 g antibodies, CD41+ HSCs possessed long-term repopulation capacity on serial transplantations and sho

124 ents showed that cadaveric liver cells had a repopulation capacity similar to freshly isolated hepato

125 colony forming HSCs, but also enhanced their repopulation capacity upon transplantation.

126 ber of HSCs and a complete loss of long-term repopulation capacity, whereas the stem cell compartment

127 apoptosis and exhibited defective long-term repopulation capacity.

128 nfection, and excessive exposure reduces HSC repopulation capacity.

129 stem cells (HSCs) has revealed variations in repopulation characteristics.

130 pretreatment significantly accelerated liver repopulation, compared to control rats.

131 l engraftment led to greater extent of liver repopulation, compared to drug-untreated controls.

132 s (hESCs) lack HOXA expression compared with repopulation-competent human cord blood CD34(+) cells, i

133 ditioned with ischemia decreased under liver repopulation conditions.

134 Surprisingly, complete and therapeutic liver repopulation could be achieved with hepatocytes derived

135 mechanism by which lymphocyte depletion and repopulation could reduce the risk of CoBRR.

136 we sought to examine whether G-CSF-mediated repopulation defects are a result of increased prolifera

137 to a similar PB phenotype and HSC-intrinsic repopulation defects.

138 result in significant long-term competitive repopulation deficiency.

139 Repopulation depends on the presence of hair cells and c

140 To account for repopulation during treatment, we considered two indepen

141 on produced profound lymphopenia followed by repopulation, during which naive IL-7Ralpha(+) CD57(-) P

142 cell ablation model in mice, we examined the repopulation dynamics of NG2(+) glial cells in the matur

143 ice, leading to at least a doubling of liver repopulation efficiencies.

144 Repopulation efficiency by LPC and/or biliary cells incr

145 rituximab administered prior to total B cell repopulation enhances B cell depletion and clinical resp

146 Using clonal repopulation experiments and computational-mathematical

147 Competitive repopulation experiments showed that cadaveric liver cel

148 In in vivo competitive repopulation experiments with two rhesus macaques, the c

149 competitive than control cells in long-term repopulation experiments, and overexpression of the self

150 pic as well as in vivo long-term competitive repopulation experiments.

151 ental data is provided by a model, where the repopulation failure kinetics of each HSC are largely an

152 ubsets and selectively delayed CD4(+) T cell repopulation following alemtuzumab-induced lymphopenia m

153 bone microenvironment associated with T-cell repopulation following ART initiation may explain ART-in

154 f BAFF in driving disease flare after B cell repopulation following BCDT.

155 hematopoietic niche by promoting competitive repopulation following lethal irradiation.

156 Strikingly, however, monocyte repopulation for up to 6 mo did not modify amyloid load

157 rgeting of TSLP may interfere with tissue LC repopulation from circulating precursors.

158 be sustained solely by short-lived PCs with repopulation from clonally related memory B cells.

159 The liver regenerated through activation and repopulation from progenitors due to lineage-dependent d

160 quency was increased (as measured by in vivo repopulation, growth fraction, and colony formation).

161 revealed subtle differences in CD4(+) T-cell repopulation in an AIDS-sensitive versus an AIDS-resista

162 in this study will facilitate hematopoietic repopulation in FA patients with gene corrected HSPCs, o

163 tion and tracking of subclinical bone-marrow repopulation in human beings and revealed new insights i

164 possessed the capacity to achieve long-term repopulation in lethally irradiated animals and the abil

165 ells may limit MS, rapid CD19+ B-cell subset repopulation in the absence of effective T-cell regulati

166 c or pharmacological microglial ablation and repopulation in the adult, indicating that local cues pl

167 est the impact of 43 selected genes on liver repopulation in the Fah(-/-) mouse model of hereditary t

168 r cells, including those capable of enhanced repopulation in the marrow of immunodeficient nonobese d

169 he efficacy of cell engraftment and on liver repopulation in the mdr2-knockout mouse, a model for pro

170 eft eye, with probable host endothelial cell repopulation in the right eye.

171 We show, using long-term repopulation in vivo and colony formation in vitro, that

172 engrafted poorly when tested by competitive repopulation in vivo.

173 We created a model for tumor cell repopulation in which a small number of luciferase-label

174 Interestingly, early after repopulation, infiltrating monocytes neither clustered a

175 rowth hormone augmented senescent host liver repopulation involving the growth hormone-mediated relea

176 ink that recipient BM-HSC-derived hepatocyte repopulation is a very rare event at best and is not of

177 nd hence the understanding of melanoma tumor repopulation is crucial for improving our current therap

178 s designed to take advantage of the distinct repopulation kinetics of langerin(+) dDC and LC revealed

179 cts of HSC exposure to PGE2, we followed the repopulation kinetics of PGE2-treated hematopoietic graf

180 During repopulation, microglia formed clusters of highly prolif

181 n within peripheral tissues in a competitive repopulation model.

182 nt animals, stem cells were rapidly lost and repopulation occurred by non-mutant cells that had escap

183 pletion of lung macrophages, the majority of repopulation occurred by stochastic cellular proliferati

184 Repopulation occurs in a coordinated pattern, first thro

185 Consequently, their repopulation occurs rapidly from irradiated progenitors

186 enic after chemotherapy, contributing to the repopulation of anti-CMV immunity.

187 ducing cytokines that directly enhance their repopulation of areas of demyelination and hence their a

188 This coincided with extensive repopulation of beta-catenin null livers with beta-caten

189 While the coordinated repopulation of both hepatocyte and cholangiocyte compar

190 eostatic proliferation is involved in T-cell repopulation of both naive and memory T cells.

191 tion of gastric emptying was associated with repopulation of CD206(+)/HO1(+) M2 macrophages.

192 eased plasma viremia in all animals and that repopulation of CD8(+) T cells was associated with promp

193 y the bud sequence, is a major mechanism for repopulation of cirrhotic livers.

194 AOSLO imaging showed repopulation of cone outer segments, although their dens

195 zation efficiency of TM segments and lead to repopulation of conformational ensemble for the dimer.

196 a predominantly Near Eastern source for the repopulation of Europe after the Last Glacial Maximum.

197 donor-derived survival and recipient-derived repopulation of GCH transgenic ECs, revealed by tracking

198 transposon vector allowed for the selective repopulation of genetically corrected hepatocytes in Fah

199 poiesis and that CB/CB agonist axis mediates repopulation of hematopoiesis and mobilization of HSPCs.

200 r inflammation, and the subsequent selective repopulation of hepatocytes carrying the transgene(s) co

201 type I receptor did not rescue the decreased repopulation of HSCs in IGFBP2-null recipients, suggesti

202 on HSC function, we found decreased in vivo repopulation of HSCs in primary and secondary transplant

203 The gradual repopulation of KO livers with beta-catenin-positive hep

204 Repopulation of LC-deficient mice using fetal liver LC-p

205 Whereas inflammation-induced repopulation of LCs appears to be dependent on Csf-1, on

206 cytokines, and dexamethasone accelerated the repopulation of liver phagocytes.

207 l lungs in vitro, these results suggest that repopulation of lung matrix is a viable strategy for lun

208 Finally, repopulation of lymphocyte-free Rag1(-/-) mice with CD40

209 tablish the feasibility of significant liver repopulation of mice with human hepatocytes generated in

210 -AR treatment, whereas Rituximab resulted in repopulation of mostly naive B cells.

211 ic live cell imaging of muscle regeneration, repopulation of muscle stem cells within their endogenou

212 are capable of multi-lineage haematopoietic repopulation of myeloablated adult mice similarly to bon

213 Interestingly, SMs showed a faster repopulation of naive CD4(+) T cells than RMs.

214 l strategy for accelerating endothelial cell repopulation of stented blood vessels after angioplasty.

215 The lack of effective repopulation of Th17 cells has been associated with chro

216 1 and 3 months, but by 6 months, keratocyte repopulation of the anterior stroma was apparent.

217 row ablation, mutant animals exhibit delayed repopulation of the B-lymphoid compartment after the ear

218 cyte proliferation may be key to promote the repopulation of the biliary epithelium when large bile d

219 spensable for B-cell development, B-lymphoid repopulation of the BM, and humoral immune function.

220 CD11b-HSVTK (TK) mice is followed by a rapid repopulation of the brain by peripherally derived myeloi

221 In conclusion, repopulation of the glomerular tuft by parietal cells ma

222 All charge-separated states lead to the repopulation of the ground state with dynamics that are

223 g nonradiative decay mechanism that promotes repopulation of the ground state.

224 CD4(+) T cell repopulation of the gut is rarely achieved in HIV-1-infe

225 ary approaches that prevent replenishment or repopulation of the HIV reservoir.

226 CA-FOXO3a and for maintaining hematopoietic repopulation of the HSCs.

227 interventions that prevent expansion and/or repopulation of the latent HIV reservoir.

228 Recent data in mice also show long-term repopulation of the LC compartment with alternative myel

229 suggesting that a Langerin(+) cell regulates repopulation of the LC compartment.

230 neration was completely unaffected, although repopulation of the lesion site by astrocytes was delaye

231 provide for defect fill and/or selected cell repopulation of the lesion.

232 Repopulation of the liver with oval cells that expressed

233 systemic loss requiring an intact thymus for repopulation of the liver.

234 ed lymphodepletion modulates the homeostatic repopulation of the lymphocyte compartment and influence

235 Their repopulation of the matrix could promote the repair of c

236 However, although the repopulation of the optic nerve lesion site by astrocyte

237 cline to induce Zap70 expression resulted in repopulation of the peripheral naive compartment.

238 glet nitrene, either directly or via thermal repopulation of the singlet from the lower-energy triple

239 modeling to estimate rates of microfilarial repopulation of the skin in a cohort of 217 participants

240 ntation into the extraction sockets to allow repopulation of the surgically treated root canal with p

241 ignal to protect their stem cells for future repopulation of the tissue.

242 vely from the donor, despite nearly complete repopulation of the transplanted lipogranulomas by host

243 of the Notch pathway in chemoprotection and repopulation of TMZ-treated gliomas.

244 tion in human HSCs by long-term multilineage repopulation of transplanted mice.

245 ibited normal properties in either long-term repopulation or cell cycling.

246 e JAK2V617F mutation and show no decrease in repopulation or self-renewal and no increase in DNA dama

247 Crypt repopulation originates from CBCs that survive irradiati

248 the clones analyzed contributed to long-term repopulation (over 3-10 years), arising in sequential gr

249 NS cells seem to be a good tool for scaffold repopulation, paving the way for experimental investigat

250 reatment with an IL-1R antagonist during the repopulation phase impaired microglia proliferation.

251 ith FL and adult HSCs, AGM HSCs have reduced repopulation potential in irradiated adult transplant re

252 that dormant HSCs contain all the long-term repopulation potential in the bone marrow (BM), and that

253 omeostasis, preserving HSC self-renewal, and repopulation potential in vivo and proliferation in vitr

254 ilure that correlated with reduced long-term repopulation potential of irradiated Parp-2-/- HSPC unde

255 notypic HSCs, we found reduced HSC long-term repopulation potential that could be rescued completely

256 w derived from Apc(min) mice showed enhanced repopulation potential, indicating a cell intrinsic gain

257 and increasing durable short- and long-term repopulation potential.

258 e in the long-term-HSC pool, and a decreased repopulation potential.

259 or initiation capacity, and clonal long-term repopulation potential.

260 scid BM cells showed severely impaired repopulation potentials in the competitive repopulation

261 retrorsine (RS)-based model of massive liver repopulation, preexposure to this naturally occurring al

262 Administration of 1-MT prior to B cell repopulation prevented the production of autoantibodies

263 any clear association between microfilarial repopulation rate and the number of years of prior inter

264 We also increased the in vivo repopulation rate of hematopoietic stem cell grafts with

265 atistically significantly high microfilarial repopulation rates.

266 The sequence of repopulation recapitulated the order of maturation in he

267 Microglia repopulation relied on CNS-resident cells, independent f

268 older animals failed to stimulate a similar repopulation response, possibly because of a decrease in

269 transcription factor that confers definitive repopulation status on primitive hematopoietic progenito

270 Cs, B cells, and T cells under hematopoietic repopulation stress in vivo.

271 n controlling LT-HSC integrity in vivo under repopulation stress.

272 partial hepatectomy model was used for liver repopulation studies.

273 n by rituximab, they show earlier and higher repopulation than CD20(+) B cells.

274 oved cell engraftment, and accelerated liver repopulation, this pharmacological approach to control h

275 Microglial repopulation throughout the CNS occurs through prolifera

276 t prostheses because of their rapid cellular repopulation, tissue remodeling, and therewith self-repa

277 C function, we performed serial, competitive repopulation transplant experiments using FLVCR-deleted

278 isting in patients with low-level CD4 T-cell repopulation under suppressive high active antiretrovira

279 y depletes B cells, but is followed by rapid repopulation up to levels exceeding base line.

280 effect of ECM niche preservation on cellular repopulation using different scaffold generation methods

281 nt, we considered two independent 1) kickoff-repopulation using exponential growth with a decreased v

282 creased volume doubling time, or 2) Gompertz-repopulation using the gradually accelerating growth rat

283 aced 20%-98% of mutant host hepatocytes, and repopulation was accelerated by injection of an adenovec

284 Remarkably, more than 20% liver repopulation was achieved in the absence of PH, associat

285 Liver repopulation was assessed by immunohistochemistry, and t

286 cornea cleared, and central endothelial cell repopulation was documented by confocal microscopy.

287 In addition, in both species CD8(+) T-cell repopulation was faster than that of CD4(+) T cells, wit

288 Repopulation was quantified by flow cytometry and histoc

289 To discover novel regulators of HSPC repopulation, we transplanted >1,300 mice with shRNA-tra

290 B cell depletion and repopulation were variable and were predictive of these

291 We observed 4- to 5-fold increases in liver repopulation when FLSPCs were transplanted into older co

292 phil-depleted WT recipients was sustained by repopulation with bone marrow neutrophils from WT mice b

293 occur, resulting from host endothelial cell repopulation with corneal clearing and improved visual a

294 nstrate decellularization of human liver and repopulation with derived human liver cells.

295 irrhotic hosts whose livers permit extensive repopulation with donor cells.

296 Spontaneous hepatic repopulation with engrafted hepatocytes occurred in the

297 pair of cirrhotic livers occurs, in part, by repopulation with hepatocytes through the stem/progenito

298 Intestinal allograft mucosa undergoes repopulation with host immunocytes.

299 uman cytochrome metabolism is used following repopulation with human hepatocytes.

300 one or in combination enhanced hematopoietic repopulation without impairing myeloid-lymphoid differen