ライフサイエンスコーパス: reposition

1 sed using alpha-FK2 antibodies are similarly repositioned.

2 accessibility that resulted from nucleosome repositioning.

3 e brains for at least 8 months without probe repositioning.

4 bstructure-domain interactions based on drug repositioning.

5 eling, and acts as a boundary for nucleosome repositioning.

6 nt in fragment-based drug discovery and drug repositioning.

7 r both novel disease gene discovery and drug repositioning.

8 tresses but were less likely to have planned repositioning.

9 ations in polypharmacology and rational drug repositioning.

10 ing pressure-reducing mattresses and planned repositioning.

11 and the corresponding dynamics of nucleosome repositioning.

12 illustrated to be a starting point for drug repositioning.

13 elationships among diseases that enable drug repositioning.

14 nderstanding of disease etiology and in drug repositioning.

15 ein translation are promising candidates for repositioning.

16 tential for systematic and fast-tracked drug repositioning.

17 des new opportunities for drug discovery and repositioning.

18 isassembly, histone exchange, and nucleosome repositioning.

19 raction (DTI) candidates is crucial for drug repositioning.

20 eractions are closely related to the nuclear repositioning.

21 g screening and in applications such as drug repositioning.

22 o use any data inputs for computational drug repositioning.

23 tain 31, 15, and 18 proteins and are used to reposition 15, 9, and 2 drug candidates for the brain, l

24 % of attempts resulting in success), patient repositioning (38%), rescue bougie use (19%), operator c

25 , we demonstrate that both 3q rearrangements reposition a distal GATA2 enhancer to ectopically activa

26 switch can adopt different conformations to reposition a universally conserved Asp (D) residue invol

27 a NET39 fragment to nucleoli correspondingly repositioned a target gene, indicating a direct tetherin

28 t mechanism that includes a form of ribosome repositioning after initial recruitment.

29 MTOC repositioning allows the release of proteases and the de

30 Although SSB binds ssDNA tightly, it can be repositioned along ssDNA to follow the advancement of th

31 Drug repositioning analysis identified several drug classes w

32 bly lines often feature robots that pick up, reposition and connect components in a programmed manner

33 modelers use a helicase-like ATPase motor to reposition and reorganize nucleosomes along genomic DNA.

34 hromatin remodelling proteins that assemble, reposition and space nucleosomes, and are robustly expre

35 requency was observed in fractures requiring reposition and subperiosteal fractures.

36 ing marked cells and find that, as cells are repositioned and alter their neighbours, their identitie

37 Box B, two homogenous domains of HMGB1, are repositioned and packed together by EGCG.

38 be applied to the defect and the flap can be repositioned and secured back in place.

39 tely removed from the pool, (b) the pool was repositioned and the cued platform remained in the same

40 ect to distal landmarks, or (c) the pool was repositioned and the cued platform remained in the same

41 n occurred in 2 patients and was resolved by repositioning and clipping of the proximal stent end.

42 -target direct interactions is vital to drug repositioning and discovery.

43 rovides a potential in silico model for drug repositioning and discovery.

44 screening with potential in lead discovery, repositioning and drug safety.

45 disrupting lamina interfered with hunchback repositioning and extended neuroblast competence.

46 a manoeuvre (done semi-recumbent with supine repositioning and passive leg raise immediately after th

47 g the free energy from ATP hydrolysis to the repositioning and restructuring of nucleosomes, but how

48 ibutors to cost were clinical nurse time for repositioning and skin inspection.

49 Snf2 plays a fundamental role in nucleosome repositioning and the expression of growth genes.

50 ATP-dependent chromatin remodeling, which repositions and restructures nucleosomes, is essential t

51 s an effective integrative strategy for drug repositioning, and identified new drugs against the VCP/

52 the orchestration of cell emergence, growth, repositioning, and loss under homeostatic conditions and

53 ovides new opportunities for diagnosis, drug repositioning, and rational drug design.

54 drug side effects and opportunities for drug repositioning, and show a remarkable coincidence with cl

55 ffectiveness of nutritional supplementation, repositioning, and skin care interventions versus usual

56 CAB repositioning appears to be a separate regulatory step o

57 ntial treatments for PD and 6 hold potential repositioning applications.

58 on of the obtained models, an in silico drug repositioning approach allowed for the identification of

59 edundant molecular pathways in AR and a drug repositioning approach to suppress these using FDA appro

60 affinity fingerprinting-based in silico drug repositioning approach.

61 Computation-based drug-repurposing/repositioning approaches can greatly speed up the tradit

62 allenges of the hindered gene target in drug repositioning approaches to date.

63 utperforms several recent computational drug repositioning approaches.

64 ligand simultaneous docking (MLSD) and drug repositioning approaches.

65 Repositioning approved drug and small molecules in novel

66 al ISR and suggest that the HIV-PIs could be repositioned as therapeutics in human diseases to modula

67 ween TADs and LADs was observed with the TAD repositioning as a unit.

68 thelmintics exhibit desirable properties for repositioning as anti-C. difficile agents.

69 ated electric microheaters, the traps can be repositioned at high speed ( approximately 30 kHz) with

70 was reintervention rate for band removal or repositioning at 3 years.

71 Nucleosome repositioning at gene promoters is a fundamental aspect

72 arget gene when it was coupled to nucleosome repositioning at or close to its binding site in most ca

73 We present evidence of extensive nucleosome repositioning at thousands of gene promoters as genes ar

74 First, chromatin is repositioned away from the nuclear periphery in response

75 It is possible that cannula repositioning based on the AS OCT depth may improve the

76 Novel drugs are also proposed for repositioning based on their mechanism of action to trea

77 ligand must be endocytosed to be modified or repositioned before it binds Notch and (2) pulling model

78 cible loci RBCS, PC and GUN5 undergo similar repositioning behaviour during their transcriptional act

79 The transition from zymogen to active C1s repositions both loops such that they would be able to i

80 , RSC depletion results in global nucleosome repositioning: Both upstream and downstream nucleosomal

81 et prediction is a promising avenue for drug repositioning, but performance is wanting.

82 Here we propose a framework for drug repositioning by comparing transcriptomes imputed from G

83 Computational approaches for drug repositioning by integrating information from multiple s

84 atients (eyes) were randomly assigned to IOL repositioning by scleral suturing (n = 54) or IOL exchan

85 signed 104 patients (104 eyes) either to IOL repositioning by scleral suturing (n = 54) or to IOL exc

86 twork model and applied the approach on drug repositioning by using existing omics data about disease

87 Nucleosome placement and repositioning can direct transcription of individual gen

88 he model on the whole phenome to narrow down repositioning candidates and suggest alternative indicat

89 k, PUDTI, is then designed to infer new drug repositioning candidates by integrating NDTISE, probabil

90 Repositioning candidates for a number of disorders were

91 sed approaches to identify and validate drug-repositioning candidates for epithelial ovarian cancer (

92 We found a number of repositioning candidates, many supported by preclinical

93 pplies cells to the endocardial cushions and repositions cardiac neural crest cells (NCCs) within the

94 Repositioning causes a significant decrease in the repro

95 Thus, dosage of Dyrk1a repositions cells within a p21-CycD1 signaling map, dire

96 her changes in differentiation revealed that repositioning contributes (1/3) to (2/3) of a gene's nor

97 The model enables us to reposition drugs based on available patient gene express

98 anisms, identify new disease biomarkers, and reposition drugs for diseases with unmet needs.

99 GWAS and gene expression microarray data to reposition drugs for PD.

100 tumor specimens to evaluate the targets and repositioned drugs.

101 that this modular approach is promising for repositioning drugs for use in polygenic diseases such a

102 This change repositions DSB hotspots and completely restores fertili

103 Four lenses (2.3%) were repositioned during the study.

104 ting approximately 50% of the genes that are repositioned during WT development.

105 These analyses demonstrate active nucleosome repositioning during Dictyostelium multicellular develop

106 ane proteins (NETs) that direct their normal repositioning during myogenesis.

107 ng the clustering of lytic granules and MTOC repositioning during the development of NK cell-mediated

108 repurposing could alleviate this problem by repositioning effective and safe small-molecule drugs fr

109 Our findings may reposition EGFR-targeted agents for combination with DSB

110 Features of specific repositioning events were then tested by fluorescence in

111 nonical binding sites while Msn2 can promote reposition, expulsion and recruitment of nucleosomes to

112 ities is restored if these alpha-helices are repositioned extrinsically, suggesting that helper prote

113 onse and presents an economic methodology to reposition FDA approved drugs in organ transplantation.

114 The repositioning feature of the THV was applied in 25.8% of

115 ariants of the water task where the pool was repositioned for each training trial and a hidden platfo

116 macological properties that can lead to drug repositioning for the 15% drugs which seem to be inconsi

117 Computational drug repositioning framework via incorporating drug-gene sign

118 t in developing T cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior.

119 the domain of pathway and network-based drug repositioning from genetic associations.

120 RM3) and describe targets for potential drug repositioning from other clinical indications.

121 ctrical muscle stimulation increased p-AMPK, repositioned GLUT4, locally improved glucose metabolism,

122 anged by -1.2 +/- 5.8 mm Hg (P = .18) in the Repositioning group and -3.8 +/- 6.4 mm Hg (P < .001) in

123 ) units (range, -0.18 to 1.16 logMAR) in the repositioning group and 0.35+/-0.54 logMAR (range, -0.20

124 ior ischemic optic neuropathy (n = 1) in the repositioning group, and IOP increase (n = 9), pupillary

125 ystem included a cutting guide and a pair of repositioning guides.

126 Repositioning had a longer mean surgical time than excha

127 Many computational strategies for drug repositioning have been proposed, which are based on sim

128 the ACP binding pocket before dehydration by repositioning helix III.

129 ntemplated for optimizing current therapies, repositioning histaminergic ligands for new therapeutic

130 nal techniques have been developed to aid in repositioning, however, the majority of available method

131 ables designed to help researchers formulate repositioning hypotheses and identify potential biologic

132 In order to computationally generate repositioning hypotheses, we used the Web Ontology Langu

133 ue and prostate hyperplasia, whereas MMP2 is repositioned in both prostate cancer and hyperplasia.

134 the C-terminal alpha-helix, are dramatically repositioned in free CRM1 in comparison with the ternary

135 on, pressure-reducing mattresses and planned repositioning in bed.

136 pressure-reducing mattresses and (4) planned repositioning in bed.

137 target presentation, we show that centrosome repositioning in Jurkat T cells exhibited kinetically di

138 gether, our findings reveal a role for Golgi repositioning in regulating the initial integration of a

139 We conclude that dynein drives centrosome repositioning in T cells via microtubule end-on capture-

140 ere also compared pre- and post-IOL exchange/repositioning in the eye with IOL dislocation.

141 rite growth and maintenance, was dynamically repositioning in the soma of newborn cells during this i

142 to vaccine arrival resulting in a transnodal repositioning into specific antigen collection sites wit

143 Computer-aided drug repositioning is a cheaper and faster alternative to tra

144 Drug repositioning is considered to be a time- and cost-savin

145 ivocally demonstrates that NET-directed gene repositioning is critical for developmental gene regulat

146 The dramatic repositioning is influenced by a differential ability to

147 CAB repositioning is mediated by the red/far-red photorecept

148 One popular method of drug repositioning is network-based DTI prediction, which use

149 The mechanism of nucleosome repositioning is shown to be strongly linked to DNA sequ

150 Drug repositioning is the discovery of new indications for co

151 However, the extent to which nucleosome repositioning is used within eukaryotic genomes is poorl

152 cts were strongly frequency-dependent and we repositioned it for treatment of atrial fibrillation and

153 diffuse on ssDNA, which allows it to quickly reposition itself while remaining bound to ssDNA.

154 iated with a longer unattached flagellum and repositioned kinetoplast and basal body, reminiscent of

155 rch strategy to identify compounds in a drug-repositioning library (Prestwick library) that block lig

156 Such motif repositioning may serve as a conformational switch that

157 s, and achieved specificity similar to other repositioning methods.

158 n by cisplatin or genetically can rescue and reposition MGL, arresting NGF-induced growth responses.

159 Schizophrenia working group to build a drug repositioning model for schizophrenia.

160 ork analysis, novel drug methods (e.g., drug repositioning, multi-target drug and combination therapy

161 All repositioning (n = 26) and retrieval (n = 6) attempts we

162 tated version of KAHRP, with the PEXEL motif repositioned near the signal sequence, prevented PMV cle

163 d treating pressure ulcers: wound cleansers, repositioning, negative pressure therapy, debridement, e

164 zymes that are critical for reorganizing and repositioning nucleosomes in concert with many basic cel

165 While nucleosome repositioning occurs pervasively, we found that a class

166 5a resulted in the conformational change and reposition of the activation loop, alphaC-helix, and jux

167 required for BRCA1 function in promoting the repositioning of 53BP1 during HR.

168 be identified with eRepo-ORP, we discuss the repositioning of a kinase inhibitor for Ras-associated a

169 Our finding that the chromosomal repositioning of a regulatory gene can determine the cel

170 ral rearrangements involving the chromosomal repositioning of a single enhancer can cause deregulatio

171 However, repositioning of AD2-adjoining degrons (i.e. DSGLS-conta

172 Importantly, the repositioning of AEPs in this way better recognizes thei

173 Repositioning of all these components requires BRCA1's B

174 failed to demonstrate the benefit of routine repositioning of at-risk patients for the prevention of

175 roliferation but rather to cytokine-mediated repositioning of B cells to the lymph nodes, as shown wi

176 Supercontraction was accompanied by the repositioning of centromeres, pericentromeres, and long

177 Importantly, we found significant repositioning of chromosomes X and Y towards the nuclear

178 f recombination in male meiosis only, with a repositioning of Class I crossovers determined by cytolo

179 ne drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential

180 Tisseel fibrin glue for the repositioning of conjunctival autografts in pterygium su

181 A103V affect the protein-DNA interaction by repositioning of DNA recognition helices.

182 we employed an integrative strategy for the repositioning of drugs as novel inhibitors of the VCP/p9

183 Repositioning of drugs towards new indications is an att

184 ld inspire novel strategies on the effective repositioning of existing drugs and therapies.

185 PVR might be treated by rational repositioning of existing drugs that target mTOR and IL-

186 ensive resource constructed by a large-scale repositioning of existing drugs to orphan diseases with

187 Loss of EZH2 expression leads to repositioning of EZH1 to EZH2 targets.

188 developed genomics-based tools are allowing repositioning of Food and Drug Administration (FDA)-appr

189 offer a preclinical rationale to explore the repositioning of GSK3 inhibitors to enhance differentiat

190 timulation of hDot1L activity and leads to a repositioning of hDot1L on the nucleosomal surface, whic

191 at branches into a pathway that leads to the repositioning of His-54 and another pathway that leads t

192 g efficacy, avoidance of adverse effects, or repositioning of histaminergic ligands.

193 n by bound TFs and TF regulation via dynamic repositioning of nucleosomes.

194 Repositioning of residue 78 modifies the intraprotein hy

195 X-ray data at pHs of 4.5-6 reveal the repositioning of side chains along one side of the FeMo-

196 opic versus isotropic substrates resulted in repositioning of specific chromosomes, which contained g

197 lled by neuronal activity and suggest mutual repositioning of synaptic components as a potential nove

198 cription factor IRX-1/Iroquois, allowing the repositioning of synaptic inputs to the ventral side.

199 a kinked and untwisted conformation to allow repositioning of the 'activated' SRP-SR complex on the r

200 Binding to the B domain was associated with repositioning of the A domain of E2 that enabled cross-l

201 , we demonstrate that light triggers a rapid repositioning of the Arabidopsis light-inducible chlorop

202 Surprisingly, this is due to repositioning of the Arg254 side chain in the Glu256 enz

203 e flagella and a shorter FAZ, accompanied by repositioning of the basal body, the kinetoplast, Golgi,

204 Conversely, experimental repositioning of the bulbous arteriosus by tissue recomb

205 Fashioning and repositioning of the conjunctival autograft (flap time)

206 includes the relocation of a beta-strand and repositioning of the functionally important "BB-loop" re

207 extracellular matrix interactions as well as repositioning of the Golgi apparatus, both of which can

208 Repositioning of the intertropical convergence zone is t

209 e MIT domain in linker-deleted Vps4 mimics a repositioning of the MIT domain normally caused by bindi

210 opensity for Na2 release, which leads to the repositioning of the N terminus and transition to an inw

211 layers along the dorso-ventral axis and the repositioning of the neuroectodermal borders.

212 rapid pacing used during valvuloplasty, and repositioning of the prosthesis.

213 ional activation in MCL cells relates to the repositioning of the rearranged IgH-Ccnd1-carrying chrom

214 ing of large-scale chromatin structure and a repositioning of the region within the nucleus.

215 This interaction caused repositioning of the RNAP sigmaA subunit from a -35-like

216 art sites, in a way that can be described by repositioning of the single-stranded transcription bubbl

217 omophores is switched on and off by a simple repositioning of the substituents, which alters the noda

218 Repositioning of the templating nucleotide residue and t

219 ) loss due to Sirt1 S-nitrosation results in repositioning of the tetrathiolate subdomain away from t

220 irus homolog pM50 but reveals a considerable repositioning of the very C-terminal alpha-helix of pUL5

221 mutants, in spite of a dramatic rostrocaudal repositioning of these neurons in hindbrain.

222 Repositioning of these vessels to lie in contact with th

223 This regulation is achieved by the azimuthal repositioning of Tm along the actin (Ac):Tm:troponin (Tn

224 Importantly, we found that restructuring and repositioning of two C-terminal helices enable MapZ to d

225 plexed with the portal, which is achieved by repositioning of two consecutive repeats of a conserved

226 His-54 and another pathway that leads to the repositioning of Tyr-84.

227 inates from the C-terminal domain of VipD is repositioned on Rab5 binding, thereby exposing the catal

228 The impact of nucleosome repositioning on the three-dimensional chromatin structu

229 DrugPredict exploited unique repositioning opportunities rendered by a vast amount of

230 ies of active compounds and can provide drug repositioning opportunities.

231 y unpredictable, clinically significant drug-repositioning opportunities.

232 modelers use the energy of ATP hydrolysis to reposition or evict nucleosomes or to replace canonical

233 The repositioning or ejection of nucleosomes is therefore cr

234 the rate of catheter misplacement requiring repositioning or replacement was 1.0% (95% CI, 0.6-1.7%)

235 plications of the procedures (TCOs), such as repositioning or retrieval of the valve prosthesis and e

236 hich could serve as start point for CNS drug repositioning research.

237 ently, imaging of microtubules during normal repositioning revealed a microtubule end-on capture-shri

238 Differentiating neutrophils also repositioned ribosomal DNA and mininucleoli to the lamin

239 A drug-repositioning screen identified the HIV1-protease inhibi

240 cardiovascular Doppler, and lower extremity repositioning should be performed as soon as feasible.

241 g loop to an even greater degree, as well as reposition specific CBL-binding residues, bringing them

242 uman cells, we found that slow transcription repositioned specific co-transcriptionally deposited chr

243 his study, we provide a rationale for a drug repositioning strategy to blunt integrin activation in A

244 novel drug therapies, taking advantage of a repositioning strategy, the small teleost zebrafish (Dan

245 ur findings offer a mechanistic rationale to reposition SYK kinase inhibitors for evaluation in patie

246 ia within a single theoretical framework and repositions synaesthesia not as some quirk of aberrant c

247 strategy that combines a computational drug-repositioning system (DrugPredict) with biological testi

248 This appears to be coupled to subdomain repositioning that is required for catalytic activation/

249 We propose a method for drug repositioning that uses the clinical signatures extracte

250 e hTR RNA using circular permutations, which reposition the 5' and 3' ends.

251 Our results provide a rationale to reposition the approved drug auranofin for clinical eval

252 s and activated cohesin-dependent looping to reposition the Bcl11b enhancer from the lamina to the nu

253 plana vitrectomy may be required in order to reposition the dislocated IOL-CB complex in the presence

254 findings provide a mechanistic rationale to reposition the experimental clinical agent, AS101, to de

255 nd, stairs, and ramps--and of the ability to reposition the leg while the patient was seated.

256 emodeling factors but does not significantly reposition the nucleosome.

257 pervasive cross-environmental tradeoffs that reposition the peaks in such a way that trapped genotype

258 These changes reposition the remaining sarcomeres back into their opti

259 A structural rearrangement in AAV2-R432A repositioned the betaA strand region under the icosahedr

260 A mechanical registration system repositioned the head to within a few microns, allowing

261 template system provides greater accuracy in repositioning the chin than traditional intraoperative m

262 l enzymes primes HA for fusion competence by repositioning the fusion peptide to the newly created N

263 cing a beta1 mutation implicated in epilepsy repositions the (58)Cys-containing loop and disrupts bet

264 n with Asp or phosphorylation) "undocks" and repositions the cofilin N terminus away from the filamen

265 ggesting a second slow conformational change repositions the RNA:DNA hybrid into the telomerase activ

266 Of 373 muscles repositioned, the lateral rectus muscle (n = 115/373; 30

267 In the context of drug discovery or drug repositioning, the methods presented here could help ass

268 I) prediction plays an integral role in drug repositioning: the discovery of new uses for existing dr

269 T cells rapidly reposition their centrosome to the center of the immunol

270 l novel drug-target pairs that may result in repositioning these drugs.

271 to oncogenic activation of GFI1B and GFI1 by repositioning these genes next to super-enhancers.

272 l treatment, with a mechanistic rationale to reposition this drug to improve the management of colore

273 ) to Eallo or an S121P substitution in Eallo repositions this region to increase Ecat activity; and (

274 acetylated after the duplicated centrosomes reposition to the apical side.

275 hile bound to ssDNA enables it to be readily repositioned to allow other proteins access to ssDNA.

276 as ciclopirox or deferiprone, which might be repositioned to control cancer cell growth.

277 est that PKC and NF-kappaB inhibitors may be repositioned to suppress cancer mutagenesis, dampen tumo

278 system in cancer immunotherapy, is now being repositioned to treat inflammatory and autoimmune disord

279 heir trapping, retrieving, transporting, and repositioning to a desired microwell on the array.

280 Whether gene repositioning to the nuclear periphery during differenti

281 that are necessary and sufficient to induce repositioning to the nuclear periphery.

282 BRCA1 promotes 53BP1 repositioning to the periphery of enlarged foci and form

283 ring differentiation, thousands of genes are repositioned toward or away from the nuclear envelope.

284 trans-activator is sufficient to induce gene repositioning toward the nuclear interior in embryonic s

285 iation between TMJ remodeling and mandibular repositioning under orthopedic loading.

286 nd, once created, that they can be moved and repositioned using applied electric fields.

287 Drug repositioning, using known drugs for treating conditions

288 f three successive measurements without head repositioning was 1.5 +/- 0.7 mum.

289 In agreement with this mechanism, centrosome repositioning was impaired by inhibiting microtubule dep

290 On the other hand, planned repositioning was more likely to be used at the general

291 within 3 degrees in both eyes, therefore IOL repositioning was not necessary.

292 rotubule dynamics, confirmed that centrosome repositioning was responsible for further cell disengage

293 he reintervention rate for band retrieval or repositioning was significantly higher in the absence of

294 Drug repositioning, which aims to identify new indications fo

295 It is distinct from drug repositioning, which identifies new uses for existing dr

296 target genes provide an opportunity for drug repositioning, while for 36 genes CpG methylation was fo

297 The phenome has been also explored for drug repositioning with efforts focusing on the search space

298 position (intraimage reproducibility), after repositioning (within-day reproducibility), and 1-4 week

299 ar incisions with minimal flap elevation and repositioning without advancement.

300 ir neighbors, thereby allowing confined cell repositioning without jeopardizing global architecture.