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   1   Galanin-1 receptor up-regulation therefore represents a novel mechanism accounting for the increase
  
     3 osslinking of alpha3alpha4alpha5NC1 hexamers represents a novel mechanism averting autoantibody bindi
     4 es cells to TMZ-induced cytotoxicity and may represent a novel, mechanism-based means of increasing T
  
     6 tial targeting of Kv channels to lipid rafts represents a novel mechanism both for the subcellular so
     7 ey host cell factor for T. gondii growth and represent a novel mechanism by which a microbial pathoge
     8 ne metabolites, GS-HNE and GS-DHN, which may represent a novel mechanism by which adipocyte dysfuncti
  
    10 d nuclear localization of MutLalpha may thus represent a novel mechanism by which cells fine-tune mis
    11 ity of high concentrations of CXCL12 and may represent a novel mechanism by which certain tumors evad
    12 d modulation of NFkappaB signaling by E2 may represent a novel mechanism by which E2 protects the vas
  
  
  
    16 SHV-mediated alterations in miRNA biogenesis represent a novel mechanism by which KSHV interacts with
  
  
    19 e and activation of PARs by serine proteases represent a novel mechanism by which such enzymes could 
    20 s2 is a primary TCDD-inducible gene that may represent a novel mechanism by which TCDD elicits its im
  
  
    23 ytic cleavage of beta-catenin by calpain may represent a novel mechanism by which the protein is acti
    24 te specification and morphogenesis, and they represent a novel mechanism by which Wnt signaling can r
    25  regulator of profibrotic potential of HSCs, representing a novel mechanism by which activated HSCs c
    26 es the number of CD86(high) DCs, potentially representing a novel mechanism by which IDO1 inhibition 
    27 king via caveolae/raft-mediated endocytosis, representing a novel mechanism by which the EGF receptor
    28 /CD21 complex in plasma membrane lipid rafts represents a novel mechanism by which a coreceptor enhan
    29 hosphorylation and function of Snail by Pak1 represents a novel mechanism by which a signaling kinase
    30 erful inhibitor of cytokine signaling, which represents a novel mechanism by which a virus usurps the
  
  
    33 ntion of Bax insertion into the mitochondria represents a novel mechanism by which Bcl-2 inhibits Fas
  
    35  Dephosphorylation of c-Abl by PEST-type PTP represents a novel mechanism by which c-Abl activity is 
    36  growth factors, and HSulf-1 down-regulation represents a novel mechanism by which cancer cells can e
  
    38 nhibition of small intestinal motor function represents a novel mechanism by which exenatide can atte
    39 ce replication and reactivation from latency represents a novel mechanism by which gammaherpesviruses
    40 rotein-dependent increase of eNOS expression represents a novel mechanism by which heterotrimeric G p
  
    42 opose that icIL-1Ra type I release from HAEC represents a novel mechanism by which IL-1 bioactivity i
  
  
    45 sTNFR1 from human bronchial epithelial cells represents a novel mechanism by which innate immune resp
  
  
    48  system that blocks phagolysosome biogenesis represents a novel mechanism by which NO mediates resist
  
  
    51 fold protein", as a propigmentation effector represents a novel mechanism by which propigmentary sign
    52 se that inhibition of protein palmitoylation represents a novel mechanism by which PUFAs exert their 
  
  
    55 omplex following its dissociation from Hsp90 represents a novel mechanism by which the activation of 
  
  
  
    59 ormation of a TNFR1-ARTS-1 molecular complex represents a novel mechanism by which TNFR1 shedding is 
    60 s occur with the iNOS gene, it seems that it represents a novel mechanism by which tumor-derived fact
    61 R mRNA 3'-UTR through phosphorylation of Y57 represents a novel mechanism by which uPA regulates post
  
    63 al STP and information processing, which may represent a novel mechanism contributing to cognitive im
  
    65 nscriptomic changes by RNA editing in cancer represent a novel mechanism contributing to sequence div
  
    67 PP5-dependent impairment of GRalpha function represents a novel mechanism driving GC insensitivity in
    68  that constitutive IGFBP2 downregulation may represent a novel mechanism for acquired resistance to I
    69 MuSK signaling cascade and NMJ formation and represent a novel mechanism for activation of receptor t
    70 gest that polypyrimidine tract variation may represent a novel mechanism for altered splicing and exo
    71  This differential receptor distribution may represent a novel mechanism for amplifying small differe
    72  of excitatory synapses onto raphe cells may represent a novel mechanism for autoregulation of seroto
  
  
  
  
    77 suggest that regulation of MMP-9 by EGFR may represent a novel mechanism for down-modulation of E-cad
  
  
  
  
    82 nist of LRP6, and blocking Wnt signaling may represent a novel mechanism for its protective effects a
  
    84 e abnormal methylation in Wilms' tumors, may represent a novel mechanism for loss of genomic imprinti
    85 f connexin-26 deafness in the USA, and could represent a novel mechanism for maintaining specific gen
  
    87 expansion and contraction of peptide repeats represent a novel mechanism for modulating adhesive capa
    88 nd changes in spinal dynorphin/KOR signaling represent a novel mechanism for modulating analgesic res
    89 ing transmitters with opposing functions may represent a novel mechanism for modulating synaptic acti
    90 d CD28 and serine/threonine phosphatases may represent a novel mechanism for modulating the intracell
    91 raction of G6 with adenylate cyclase and may represent a novel mechanism for modulation of neural act
    92 f the ON/LC complex to IOP elevation and may represent a novel mechanism for neuroprotection in glauc
  
    94 ttern of stimulation, and that switching may represent a novel mechanism for recruiting kinases invol
    95 hat this post-translational modification may represent a novel mechanism for regulating GSH biosynthe
    96 ectifying K+ channels; thus, these decreases represent a novel mechanism for regulating physiological
  
    98 trix by retinal pigment epithelial cells may represent a novel mechanism for remodeling of the provis
  
   100 diponectin and adipokine gene expression may represent a novel mechanism for the cardioprotective eff
  
   102 on results in D(5)R dysfunction and thus may represent a novel mechanism for the pathogenesis of esse
   103  between the cytosol and ER compartments may represent a novel mechanism for the post-transcriptional
   104 activation of Src family kinases by H2O2 may represent a novel mechanism for the protective effects o
  
   106 e possessing low affinity for phorbol esters represent a novel mechanism for the regulation of PKC ac
  
  
   109 along the vertebrate dorsal-ventral axis and represent a novel mechanism for Wnt gene regulation.    
   110 nflammatory response to bacterial infection, representing a novel mechanism for balancing inflammatio
   111 by IFN-gamma-induced up-regulation of Duox2, representing a novel mechanism for mucociliary dysfuncti
   112 ivator of transcription 5 (Stat5) and Stat3, representing a novel mechanism for the induction of FoxP
   113 ting in the affected tissue, cardiac muscle, representing a novel mechanism for variable penetrance o
   114  and gene expression by P. gingivalis lipids represents a novel mechanism for altering alveolar bone 
  
   116 is) will severely impair mucosal defense and represents a novel mechanism for bacterial colonization 
  
   118 neurons) from these sensory neurons and thus represents a novel mechanism for choosing between confli
   119  in the generation of CD8+ T cell memory and represents a novel mechanism for controlling adaptive im
   120 c ligands and further imply that RNA editing represents a novel mechanism for controlling physiologic
  
   122 ts suggest that microvillar vesicle shedding represents a novel mechanism for distributing host defen
   123 erential remodeling of cholinergic signaling represents a novel mechanism for enhancing sympathovagal
   124 ggest that the FOXO3-IRF7 regulatory circuit represents a novel mechanism for establishing the requis
   125 an antiphagocytic surface protein by GBS and represents a novel mechanism for evasion of immune recog
  
   127 l regulation of TSP1 activity by fibronectin represents a novel mechanism for extracellular signal tr
  
   129  expression in diabetic wound healing, which represents a novel mechanism for impaired re-epithelizat
  
   131 th attendant modulation of their association represents a novel mechanism for increasing G(beta gamma
   132 AM family disintegrin-like domain by HCMV gB represents a novel mechanism for integrin engagement by 
  
  
   135  Thus, the CRMP-2-Ca(2+) channel interaction represents a novel mechanism for modulation of Ca(2+) in
   136  suggest that the association of PML and Sp1 represents a novel mechanism for negative regulation of 
   137 ment of ubiquitylation in caspase activation represents a novel mechanism for non-apoptotic caspase-m
  
   139 sults show that Rad18 phosphorylation by JNK represents a novel mechanism for promoting TLS and DNA d
  
   141     Ang-induced alternative splicing of cGKI represents a novel mechanism for reducing sensitivity to
  
   143  intimately linked, and we propose that this represents a novel mechanism for regulating APP/APLP pro
  
   145 dependent modulation of nociceptive synapses represents a novel mechanism for regulating how injury-i
   146 els in photoreceptor cells are elevated, and represents a novel mechanism for regulating the activiti
   147 lication by virus-encoded temperance factors represents a novel mechanism for regulating the growth o
  
   149 lutamate receptors and gap junction proteins represents a novel mechanism for regulating the strength
   150 vage of a pre-existing transmembrane protein represents a novel mechanism for regulating vascular hom
   151 We propose a model for the DSF system, which represents a novel mechanism for regulating virulence fa
   152 ction between TstR and TstT described herein represents a novel mechanism for regulation of enzymatic
  
  
   155 work suggests that Ser 105 dephosphorylation represents a novel mechanism for reorienting helix alpha
  
  
  
   159 mponent of the timekeeper for this cycle and represents a novel mechanism for the control of behavior
   160  variations in the phase of Ca(2+) alternans represents a novel mechanism for the development of atri
   161 pleiotrophic nature of noggin and sclerostin represents a novel mechanism for the fine-tuning of BMP 
  
   163 naptic miRNA levels by postsynaptic activity represents a novel mechanism for the modulation of synap
   164 lective RNA editing to invertebrate taxa and represents a novel mechanism for the posttranscriptional
  
   166 of Jak2 on Ser523 inhibits Jak2 activity and represents a novel mechanism for the regulation of Jak2-
   167 tive regulation of CCR7 and MMP-9 expression represents a novel mechanism for the therapeutic effect 
  
   169 ndogenously produced fusion protein epitopes represents a novel mechanism for tolerance induced by pe
   170 metabolically regulated transcription factor represents a novel mechanism for transcriptional integra
   171 onvergent transcription through a CAG repeat represents a novel mechanism for triggering a cellular s
  
  
  
   175 y genes encoding HECT domain ligases and may represent a novel mechanism in regulating intracellular 
   176 due to local changes in morphogen diffusion, representing a novel mechanism in this tissue context, a
  
   178 e results suggest that compromised autophagy represents a novel mechanism in the development of OA.  
   179 f the epsilon-sarcoglycan-containing complex represents a novel mechanism in the pathogenesis of LGMD
  
   181 CAT-mediated reactivity with pre-beta(1)-HDL represents a novel mechanism increasing the efficiency o
  
  
  
   185 ment of A20 to the C-terminal domain of NEMO represents a novel mechanism limiting NF-kappaB activati
  
   187 Therefore, the Pnn/CtBP functional interplay represents a novel mechanism linking the corepressor CtB
   188 ndings suggest that telomere attrition might represent a novel mechanism mediating the detrimental ef
   189 ng through the TLR4-MyD88 and TLR4-TRIF axes represents a novel mechanism mediating C. jejuni-induced
  
  
  
   193 erentiation followed by rapid cell death may represent a novel mechanism of altered peptide ligand-in
  
   195  These results suggest that shadow enhancers represent a novel mechanism of canalization whereby comp
   196 unction, their targeted disruption by RI may represent a novel mechanism of damage in periodontal dis
   197 ment of these alternative upstream exons may represent a novel mechanism of developmental regulation 
  
  
   200    UA-induced shedding of endothelial TM may represent a novel mechanism of malaria pathogenesis, in 
   201 in of membrane-spanning leptin receptors may represent a novel mechanism of modulating leptin's biolo
   202  channel-cytoskeleton interactions and might represent a novel mechanism of presynaptic inhibition.  
   203 nclude that cTnI phosphorylation by AMPK may represent a novel mechanism of regulation of cardiac fun
   204 DD45beta induction by SAMe via NF-kappaB may represent a novel mechanism of SAMe-mediated hepatoprote
   205 Ralpha and ERbeta in breast cancer cells may represent a novel mechanism of selenium action and provi
   206 s, this mode of beta-arrestin activation may represent a novel mechanism of signal transduction and r
  
  
  
   210 opriate retention of p53-deficient cells may represent a novel mechanism of tumour predisposition.   
   211 vely regulates LDL receptor expression, thus representing a novel mechanism of fine tuning cellular l
   212 NF-kappaB p65 to the IL-1beta promoter, thus representing a novel mechanism of IL-1beta inhibition by
   213 ight junctions caused by the toxin, possibly representing a novel mechanism of intestinal secretion. 
   214 n directly down-regulates the MDM2 oncogene, representing a novel mechanism of its action that may ha
   215 -induced ODD and mammary cell tumorigenesis, representing a novel mechanism of prevention against bre
   216 n phosphorylate the condensing enzymes, thus representing a novel mechanism of regulating mycolic aci
   217 scription independently of Ets-related TCFs, representing a novel mechanism of SRF-dependent transcri
  
   219 te that blockade of IGF1R-mediated signaling represents a novel mechanism of action for sorafenib in 
   220     The coactivation of GIRK and SK channels represents a novel mechanism of adenosine-mediated neuro
  
   222 ry via voltage-sensitive Ca(2+) channels and represents a novel mechanism of arterial relaxation.    
   223     We suggest that cell-matrix entanglement represents a novel mechanism of cell anchorage that uniq
   224 se that the inhibition of chromatin assembly represents a novel mechanism of cell transformation indu
   225 t in changes in ion channel expression; this represents a novel mechanism of crosstalk between change
   226 from the endocytic pathway (termed exosomes) represents a novel mechanism of DC-to-DC communication. 
   227      The movement of the iron sulfur protein represents a novel mechanism of electron transfer, in wh
   228 ecifically in amygdala pyramidal neurons and represents a novel mechanism of endocannabinoid-CRH inte
   229 a-THP levels by acute ethanol administration represents a novel mechanism of ethanol action as well a
   230 malian LD function by a pathogenic bacterium represents a novel mechanism of eukaryotic organelle sub
  
   232 -mediated repression of PPAR-alpha signaling represents a novel mechanism of HCV-induced hepatic stea
  
   234 ial amyloid fibrils in the intestinal mucosa represents a novel mechanism of immunoregulation, which 
   235 eduction in liver-specific MAT protein level represents a novel mechanism of inactivation of liver-sp
   236  of TFPI expression and activity by androgen represents a novel mechanism of increasing the anticoagu
   237 COX-2 attenuates TRAIL-induced apoptosis and represents a novel mechanism of intrinsic drug resistanc
   238 odulation of I(AHV) fast inactivation by PKC represents a novel mechanism of neural plasticity with p
   239 ative means of stimulation of VP release and represents a novel mechanism of neuronal control by loca
   240 erence of IER3 with the PI3K/Akt-Fyn pathway represents a novel mechanism of Nrf2 regulation that may
   241 hat is critical for leukemia maintenance and represents a novel mechanism of oncogene addiction.     
  
  
  
   245 bacteria and several nonvertebrate organisms represents a novel mechanism of pathogen recognition.   
  
  
  
  
  
  
   252 cetylase activity into complexes with E2 and represents a novel mechanism of transcriptional activati
  
  
   255 -Hc-beta(2)-microglobulin complex, by p12(I) represents a novel mechanism of viral interference and d
   256 the bradykinin-dependent endothelial repair, representing a novel mechanism promoting endothelial inj
   257 cient vWf-cleaving protease activity and may represent a novel mechanism regulating primary platelet-
  
  
   260 t that atypical processing of laughter could represent a novel mechanism that impoverishes social rel
  
   262 ronized bursts of inhibitory synaptic inputs represent a novel mechanism that may contribute to the a
  
   264 iferation and survival of CaP cells, thereby representing a novel mechanism that contributes to CaP p
   265  of Tid-1S in Th2 cells following activation represents a novel mechanism that may contribute to the 
   266      Thus, heterodimerization of these GPCRs represents a novel mechanism that modulates their functi
   267  inhibition of porins by excreted cadaverine represents a novel mechanism that provides bacterial cel
   268 nation of Wnt and SHH signaling through GLI3 represents a novel mechanism that regulates ventral-dors
  
  
   271  of lymphoma cells to HIV-infected MVECs and represent a novel mechanism through which viruses may in
  
  
   274 DNA-dependent cooperative dimerization could represent a novel mechanism to achieve tissue-specific r
  
   276 hat HAVCR/KIM-1 upregulation in tumors might represent a novel mechanism to activate tumor growth and
  
   278 rmination level for local Ca(2+) release may represent a novel mechanism to increase SR Ca(2+) releas
   279 discovery efforts targeting RGS proteins may represent a novel mechanism to manipulate 5-HT(1A)-media
   280 scriptional regulation of hERG1 pre-mRNA may represent a novel mechanism to modulate the expression a
  
   282 ic modulation of PMCA-mediated Ca(2+) efflux represents a novel mechanism to control excitability in 
   283 calization phenomenon that we have described represents a novel mechanism to coordinate the functions
  
   285 rphosphorylated in several cancers, and this represents a novel mechanism to maintain high Ubc9 prote
   286 1-mediated downregulation of Gab1 expression represents a novel mechanism to promote vascular inflamm
   287      Overall, the secreted activity of HHIP1 represents a novel mechanism to regulate HH ligand local
  
  
   290 d to BAT activity, suggesting that FGF21 may represent a novel mechanism via which BAT activity in hu
   291 ignaling required for UB development and may represent a novel mechanism whereby integrins regulate s
   292 endocytosis and release of neurotrophins may represent a novel mechanism whereby neuroglia can regula
   293 n through phosphorylation of spinophilin may represent a novel mechanism whereby PKA regulates G prot
  
   295      Also, alternative splicing of TRAFs may represent a novel mechanism whereby TNF family receptors
  
   297 rease in mitochondrial PLC-delta1 expression represents a novel mechanism whereby mCa uptake can incr
  
  
  
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