ライフサイエンスコーパス: repression

1 er in epigenetics and in gene activation and repression.

2 oral patterns of translational activation or repression.

3 NA binding and transcriptional activation or repression.

4 s mRNA characteristics affect miRNA-mediated repression.

5 ), potentially affecting both activation and repression.

6 e-associated signature of IFN-gamma-mediated repression.

7 is triggered as a consequence of translation repression.

8 inactive or excess Ded1 leads to translation repression.

9 sufficient to mediate a strong translational repression.

10 , while essential, are not sufficient for de-repression.

11 rf2 levels by overcoming basal translational repression.

12 ng motifs, suggesting a novel mode of direct repression.

13 nd AHR2 activation, which suggests relief in repression.

14 oxa1 and Nanog through a mechanism of mutual repression.

15 he magnitude of miRNA-mediated translational repression.

16 antagonizing effect of RBP binding on miRNA repression.

17 abilization of the mRNA and by translational repression.

18 ation of the TFIID complex and transcription repression.

19 and demonstrate their roles in p53-mediated repression.

20 anscriptional activation and H2A.Z gain upon repression.

21 g the co-repressor CtBP1 and transcriptional repression.

22 ss granules is a mechanism for translational repression.

23 ted mRNA elements to modulate miRNA-mediated repression.

24 deacetylation occurred after transcriptional repression.

25 ate that loops are also associated with gene repression.

26 l of Cro to a concentration required for pRM repression.

27 cal coding sequence, can directly cause gene repression.

28 ructure controlled the extent of translation repression.

29 y expressed genes and magnitude of induction/repression.

30 rties including activation, maintenance, and repression.

31 epressed by CUX2 were enriched for early cGH repression.

32 tify mRNAs targeted for post-transcriptional repression.

33 activation for several generations following repression, a conserved phenomenon called epigenetic tra

34 synthesis, even under conditions of glucose repression, activated Hap1p and the Hap2/3/4/5p complex

35 ilence gene expression through translational repression and deadenylation but not cleavage.

36 ervations reveal the prognostic value of UBB repression and establish UBC as a promising therapeutic

37 tivity leads to growth promotion rather than repression and formation of the palate, lip, and charact

38 lex 2 (PRC2) mainly mediates transcriptional repression and has essential roles in various biological

39 gi, these effects are associated with growth repression and hence need sublethal to lethal NP doses,

40 However, mechanisms underlying ASS1 repression and HIF-1alpha turnover are not known.

41 , and reveals a link between transcriptional repression and mitophagy, which is also apparent in huma

42 ranslating mRNAs and the general translation repression and mRNA degradation machinery.

43 escribe the importance of mRNA translational repression and mRNA subcellular location for protein exp

44 were caused by PAX3-mediated transcriptional repression and overexpression of NNMT blocked tumor cell

45 ein, proteins that function in translational repression and stress granule regulation.

46 ially harmful requiring mechanisms for tight repression and substrate-specific activation.

47 exes: the ATRX-DAXX complex involved in gene repression and telomere chromatin structure, and a DAXX-

48 within the ISS-N1 are important for splicing repression and their contributions are cumulative rather

49 (PTEF) relieves upstream open reading frame repression and thereby facilitates VAR2CSA translation.

50 The AGO complex promotes translation repression and/or accelerated decay of this target mRNA

51 bcircuits encoding positive feedback, mutual repression, and coherent feedforward, as well as signali

52 sion was distinct in terms of activation and repression, and environmental condition.

53 llular p53 levels are reconstituted on E6/E7 repression, and that E6/E7 inhibition phenotypically res

54 However, the mechanisms that control their repression are not fully understood.

55 roteins escape cooling-induced translational repression are unknown.

56 Eleven sites showed miRNA-dependent repression, as confirmed in Dicer-null cells.

57 combination of AR binding and EZH2-mediated repression at the GR locus, but is restored in advanced

58 For its role in transcriptional repression, BCL11A was found to interact with several co

59 Nanog and Hoxa1 on shared targets and mutual repression between Hoxa1 and the core pluripotency netwo

60 iescent cells into senescence and preventing repression blocks progression into senescence.

61 Fbeta-induced pSMAD2 phosphorylation or CDK2 repression, but was required for upregulation of p21 and

62 NA-targeted reporter modulates translational repression by affecting the translation efficiency.

63 1 augmented the activity of Dex in NF-kappaB repression by attenuating GR down-regulation.

64 Initial Thpok repression by Bcl11b prior to the pre-selection stage is

65 results reveal modulation of miRNA-mediated repression by characteristics and features of the 5'UTR,

66 ding capacity of either RRM impairs splicing repression by hnRNP A1.

67 MCL cells were due to direct transcriptional repression by hypoxia-induced factor 1alpha (HIF-1alpha)

68 of Th2 immunity cannot be attributed to TCF1 repression by miR-24.

69 cription elongation factor, Spt6 counteracts repression by opposing H3K27me3 deposition at critical g

70 hymidylate synthase (TS) inhibition and DPYD repression by p53 is dependent on DNA-dependent protein

71 osphodiesterase inhibitor circumvents egress repression by PKAc1 or pH neutralisation.

72 Bypassing this repression by providing MHV68 RTA in trans rescued KLKI

73 se results demonstrate that the mode of slp1 repression by Runt is enhancer specific, whereas the mod

74 element (DESE) mediates both activation and repression by Runt.

75 ed gene expression, contradicting the "trans-repression by tethering" model.

76 To further examine NCoR1's role in repression by the unliganded TR, we deleted NCoR1 in the

77 factor) promoter region, and demonstrate LIF repression by ZEB1.

78 Furthermore, PAX7 target gene repression can explain oxidative stress sensitivity and

79 alysis of a frame-shifted uORF, in which the repression capability was lost, indicated that the uORF

80 c circuits with up to seven gRNAs, including repression cascades with up to seven layers.

81 This incomplete repression causes expression leak, which impedes the con

82 critical for Tbx3, Klf4 and Esrrb transcript repression, cell-cell contact abrogation, cell survival

83 afQ toxin is not a critical component of the repression complex in contrast to other toxin-antitoxin

84 tabolic activation independent of catabolite repression control.

85 As such, Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxi

86 This repression depended on class I HDACs and involved multip

87 emonstrated that miRNAs induce translational repression depending on their complementarity with targe

88 xist in a common PRC1 variant, their role in repression depends on the functional context.

89 In addition to gene repression, disrupting epigenetic process in the interpl

90 PcG-mediated repression does not play a significant role in regulatin

91 s the combination of multiple activation and repression epigenomics signals.

92 nactivating mutations in the transcriptional repression factor Capicua (CIC) occur in approximately 5

93 ibosome binding site sequestration increases repression from 85% to 98%, or activation from 10-fold t

94 Although their mechanism of transcriptional repression has been well studied for over a decade, the

95 By contrast, E2F3 repression has minimal impact on tissue proliferation or

96 That IHSF115 effectively countermanded repression in a significant fraction of heat-repressed g

97 pf1 and LbCpf1 for efficient transcriptional repression in Arabidopsis, and demonstrated a more than

98 he intrinsic heart rate, consistent with HCN repression in athletes.

99 ogical roles, ranging from carbon catabolite repression in bacteria to mediating the action of hormon

100 y PRMT5-MEP50 transcriptional activation and repression in cancer invasion pathways and in response t

101 ivision, thereby assuring stable target gene repression in differentiated cells.

102 Loss of ClpC repression in MD mutants causes constitutive activation

103 s (p.Arg252Trp) hyperactivates HUSH-mediated repression in neuronal cells.

104 This role rationalizes ccp repression in oxic environments.

105 oduction, supporting the involvement of AbrB repression in regulating C. perfringens sporulation.

106 VEGFR2 expression, lifting reproductive axis repression in response to shorter day lengths.

107 the effects of dCas9-KRAB-mediated enhancer repression in single cells.

108 etect and track nuclear RNAi transcriptional repression in single living human cells.

109 cell cycle suggests that the release of Kdm8 repression in the absence of a functional Miz1 is a cent

110 Strikingly, BldO has one target for repression in the entire genome, whiB.

111 ver, these regulators suffer from incomplete repression in their OFF state, making their dynamic rang

112 Here, we exemplify the novel 'Transgene Repression In vector Production' (TRiP) system for the p

113 G context is associated with transcriptional repression, including at genes silenced on the inactive

114 ing complex proteins displayed a significant repression indicating an exclusive retrograde impact on

115 te in Sabin-1 IRES relieved miR-134-mediated repression indicating that these regulatory molecules ha

116 Gene repression induced by the formation of transcriptional t

117 onvergently impacted Wnt signaling, Polycomb repression, innate immune cell interactions and a cluste

118 ttractive hypothesis to explain some of this repression involves inhibition of the expression of ICP0

119 y Even-skipped (Eve), but, of interest, this repression involves regulation of P-TEFb recruitment and

120 ay-length-specific removal of CDF1-dependent repression is a critical mechanism in photoperiodic flow

121 Thus, PAX7 target gene repression is a hallmark of FSHD that should be consider

122 Here, we show that FLO1 de-repression is accompanied by Swi-Snf recruitment, promot

123 subunit further indicate that this relief of repression is achieved through expending energy via ATP

124 TP53 repression is dependent on ZBTB11 cys116, which is a fun

125 It has been assumed that SaPI de-repression is effected by specific phage proteins that b

126 Epigenetic maintenance of gene repression is essential for development.

127 We show that U2AF35b repression is facilitated by weak, closely spaced BPs ne

128 We find that PIM3 repression is mediated by miR-33, an intronic microRNA e

129 -DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PAH.

130 ICP0 expression in transfection assays, such repression is weak.

131 tor of the Wnt/beta-catenin pathway, and its repression leads to CRC cell proliferation, EMT, and tum

132 gene promoter levels of the transcriptional repression mark H3K27me3 (histone 3 lysine 27 trimethyla

133 e revealed that histone activation marks and repression marks are associated with activated and repre

134 d functional contribution of transcriptional repression mechanisms at high temporal resolution.

135 nscriptome-wide scale, how microRNA-mediated repression modulates the associations of the core mRNP c

136 one deacetylase 4 (HDAC4) to the nucleus for repression of 15-hydroxy prostaglandin dehydrogenase (15

137 n stromal cells by signaling transcriptional repression of 15-PGDH elucidates long sought-after molec

138 Mechanistically, we noticed transcriptional repression of 5-LO by proto-oncogene c-Myb and conclude

139 Myb in TAMs induced a stable transcriptional repression of 5-LO.

140 PRC2, necessary for the LINC-PINT-dependent repression of a pro-invasion signature of genes regulate

141 ion of the methylated EloA residue decreased repression of a subset of PRC2 target genes as measured

142 eased MAF1 nuclear localization and enhanced repression of ACC1 and FASN, but with impaired repressio

143 l role of chromatin state changes during the repression of active genes.

144 Our findings support a model in which repression of activin signaling by FST enables uterine r

145 ased reporter we found that LuxR can mediate repression of ainS, providing a negative feedback mechan

146 Seed-specific repression of AtCGS in RNAi seeds triggered the inductio

147 down-regulated and induces a transcriptional repression of ATZ expression.

148 evelop SNH spontaneously, which is linked to repression of both liver and intestinal UGT1A1.

149 siRNA led to an increase in p53 protein and repression of Cdc25C gene expression.

150 how that the key driver of this phenotype is repression of CDKN2A transcript p16 where myoepithelial

151 suppressors, most likely via transcriptional repression of cell cycle genes in response to stress.

152 Tests of FM4-64 internalization and repression of ClaH corroborated the observation that cla

153 One of the key mechanisms includes repression of class-II transactivator (CIITA) and MHC-II

154 e promotes barrier through IL-10RA-dependent repression of claudin-2.

155 CRY repression of CLOCK-BMAL1 and regulation of circadian pe

156 ed in beta cell function, but also continual repression of closely related endocrine gene programs.

157 Functionally, repression of CPT1A is critical for tumor formation, as

158 plify p53 levels further induced significant repression of DDR genes in Bi-Tg thyrocytes (P=2.4 x 10(

159 tivation, and deletion of pab1 overcomes the repression of differentiation genes in cells overexpress

160 3 appears to mediate both the activation and repression of distinct classes of inflammatory genes in

161 tional categories, through the activation or repression of distinct transcriptional networks.

162 The repression of E-cadherin transcription by the EMT induce

163 of HCMV also rescues p107- and p130-mediated repression of E2F-responsive gene expression, but it doe

164 In the absence of E2F1 and E2F2, however, repression of E2F3 elicits profound reduction of prolife

165 In addition, we present evidence that repression of egl-1 is dependent on binding sites for mi

166 mediates invasion and metastasis through de-repression of ELMO1, a RAC-activating guanine exchange f

167 The repression of EMT genes was dependent on early viral gen

168 serves as a proatherogenic mediator through repression of eNOS-dependent pathways.

169 o favors growth in stress conditions through repression of ER stress-induced bZIP28/IRE1-bZIP60 arms.

170 n of the ShcD SH2 domain results in enhanced repression of Erk.

171 nate a mechanism in which androgen-dependent repression of ERRgamma reprograms prostate cancer cell m

172 patients with neuroblastoma exhibited strong repression of EZH2-regulated genes.

173 x1 to Sf1 to further enhance transcriptional repression of FAdE.

174 Our findings suggest that repression of FBP1 by HDACs has important implications f

175 Among the IL-4-induced changes, repression of fibronectin critically impaired the human

176 Cold-induced epigenetic repression of FLOWERING LOCUS C (FLC) in the plant Arabi

177 rrent view, our data suggest that reciprocal repression of GATA6 and NANOG is not fundamental for the

178 ethionine-sufficiency response, resulting in repression of gene expression related to purine cataboli

179 with a more direct mechanism of AFP-mediated repression of gene expression.

180 (shRNAs) are effective in generating stable repression of gene expression.

181 evels: (1) directly, via posttranscriptional repression of gene expression; (2) indirectly, via suppr

182 n of Lys-5 and Lys-12 on histone H4, causing repression of gene transcription.

183 iation factor-2alpha (eIF2alpha), leading to repression of general translation and latency induction.

184 ic bile acid levels, despite the coordinated repression of genes involved in cholesterol and primary

185 may act to facilitate the expression and/or repression of genes that are necessary for the initiatio

186 novel B-lymphoid program for transcriptional repression of glucose and energy supply.

187 ells lacking Msn2 and Msn4 exhibit prevalent repression of glycolytic genes and a significant delay o

188 estigate the role of microRNAs (miRs) in the repression of HCN4.

189 rtner (SHP) mediates postprandial epigenetic repression of hepatic autophagy by recruiting histone de

190 Cas9-mediated knockout of C3G failed to show repression of histone marks and did not show up-regulati

191 d suppresses expression from the HRAS locus; repression of HRAS is sufficient to promote the transiti

192 These results demonstrated that the repression of hTERT gene was dictated by distal elements

193 n source of microorganisms, which causes the repression of hydrolytic enzyme secretion by industriall

194 volves a multitarget mechanism that includes repression of IFN signaling.

195 ancer activity in a manner greatly exceeding repression of individual constituents.

196 Central to these processes is the repression of initiation of mRNA translation through GCN

197 ci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with de

198 Inactivation of CIC relieves repression of its effector ETV4, driving ETV4-mediated u

199 Ezh2 maintains the repression of key cell senescence inducer genes through

200 De-repression of key erythroid genes in Thra1 (PV/+) Ncor1

201 ng postnatal development leads to epigenetic repression of Kv1.1-type potassium channels, increased e

202 Furthermore, EAF2 knockdown blocked androgen repression of LNCaP or C4-2 cells from doxorubicin induc

203 r mechanisms for miR-H2 activity and for the repression of lytic gene expression during latency deser

204 been a major hypothesis to help explain the repression of lytic gene expression during latency.

205 and maintenance of latency and suggest that repression of lytic replication by kLANA, as previously

206 ) exerts its pro-neuronal function by direct repression of many different somatic lineage programs ex

207 ycomb-deposited H3K27me3 and is required for repression of many Polycomb target genes in Arabidopsis

208 3, suggesting that robust fertility requires repression of MET-1 activity at nuclear RNAi targets.

209 lly regulates the expression of PHF8 via the repression of microRNAs.

210 cessed mitochondrial transcripts, and modest repression of mitochondrial translation in Drosophila Sc

211 e downstream pathway for the transcriptional repression of MMP-3 in CAFs.

212 bsence of NCoR1 function, we observed strong repression of more than 43% of positive T3 (3,3',5-triio

213 ar processes through the posttranscriptional repression of multiple transcripts.

214 ial interrogation, we find that simultaneous repression of multiple weak constituents can alter super

215 In vivo repression of MYC and BCL2 in combination with cyclophos

216 Thus, epigenetic repression of naive-associated genes in effector CD8 T c

217 of HO-1, TGF-beta, and IL-10, as well as the repression of NF-kappaB, EDN-1 and pro-inflammatory cyto

218 ermination pathway of Caenorhabditis elegans Repression of nhl-2 by the mir-35 family is required for

219 mechanism of cellular reprogramming in which repression of pre-existing ES cell-associated gene expre

220 tylates forkhead box o3 (FOXO3a), leading to repression of proapoptotic gene expression, because the

221 simplex virus 1 (HSV-1) latency entails the repression of productive ("lytic") gene expression.

222 te model, Skp2 depletion leads to a profound repression of prostate tumor growth and distal metastasi

223 which c-Myb achieved precise spatiotemporal repression of Rag expression remained obscure.

224 nds, for a large part, on the activation and repression of regulatory sequences, including transcript

225 r results indicate that the glucose-mediated repression of respiration in budding yeast is at least p

226 receptor co-repressor (NCoR1), resulting in repression of Rev-erbbeta target genes.

227 pression of ACC1 and FASN, but with impaired repression of RNA pol III targets.

228 validating the mechanism of miR-134-mediated repression of Sabin-1.

229 tial immunological process by which feedback repression of sequential DNA rearrangements ensures that

230 on of SGK1 expression by hypoxia includes de-repression of SGK1 transcription because of hypoxia-trig

231 t MTA1 translocation to the cytoplasm and de-repression of SGK1 transcription.

232 of a subset of these regions and alleviates repression of some polycomb telomeric genes.

233 We find that the repression of specific murine endogenous retroviruses is

234 on, macrophages upregulate Ch25h to maintain repression of SREBP2 activation and cholesterol synthesi

235 Repression of TGD1 (BdTGD1) in Brachypodium affected gro

236 AA-induced PPARalpha up-regulation leads to repression of TGF-beta signaling, specifically by inhibi

237 epidermis is maintained by estrogen-induced repression of TGFbeta signaling in the local fibroblasts

238 has been ascribed to KLF2- and KLF4-mediated repression of Thbs1 In vitro reconstitution of TSP1 with

239 s based primarily on the oxacillin-dependent repression of the accessory gene regulator quorum-sensin

240 ins, and this appears to be mediated through repression of the Agr quorum sensing system.

241 with Pten loss, circumventing PI3K-mediated repression of the androgen axis.

242 Thus, the repression of the Cdc25C promoter by p53, together with

243 receptors, dexamethasone (Dex)-induced trans-repression of the estrogen E2 program appears to depend

244 gi compaction and relieved microRNA-mediated repression of the Golgi scaffolding protein PAQR11.

245 rentiated CRC cell lines as a consequence of repression of the KCNQ1 promoter by beta-catenin:T-cell

246 l line that produces rhEPO in the context of repression of the key GSL biosynthetic enzyme UDP-glucos

247 he system in a stable state that ensures the repression of the meiotic program by Mmi1.

248 The down-regulation of TET1 relieves its repression of the methylated Lhb gene promoter, which is

249 sis-impaired strain was aborted upon induced repression of the mitochondrial isoform, demonstrating i

250 the Nus factor complex in Escherichia coli: repression of the Nus factor-encoding gene, suhB.

251 In mice, transcriptional repression of the paternal X-chromosome (Xp) and enrichm

252 ter system we validate an Hfq-dependent mRNA repression of the putative colonization factor PrpB by t

253 In turn, this impaired SUFU-mediated repression of the SHH pathway, as shown by altered expre

254 nt is enhancer specific, whereas the mode of repression of the slp1 PESE enhancer is transcription fa

255 pment of induced Treg cells (iTreg cells) by repression of the T helper type 2 (TH2) transcriptional

256 ntroduced methylation causes transcriptional repression of the targeted genes.

257 e but devastating myopathy caused by loss of repression of the transcription factor DUX4; however, DU

258 genic commitment and differentiation, timely repression of their activity is necessary for the self-r

259 engagement of Smc1-Smc3 heads prompted by de-repression of their ATPase activity.

260 action of heat-repressed genes suggests that repression of these genes is mediated by transcriptional

261 This was mediated by the de-repression of thioredoxin-interacting protein, a major r

262 We show that repression of this pathway by sugar starvation occurs do

263 nxiety and suggest that increased epigenetic repression of transcription through H3K9 during cocaine

264 and H4R3me2s marks, which correlate with the repression of transcription.

265 cation site (5'UTR or 3'UTR), LIN41 triggers repression of translation or mRNA decay, suggesting that

266 bal reduction in heavy polysomes and overall repression of translation.

267 rio, allowing them to relieve intramolecular repression of Trio GEF activity by the Trio N-terminal d

268 k to those events that control developmental repression of UGT1A1 and hyperbilirubinemia.

269 nteraction is required for the translational repression of Zfp36's target mRNAs in resolving inflamma

270 riptional regulator RsmA imposes a concerted repression on all three T6SS clusters.

271 epressor activities alleviates Rpd3-mediated repression on the erm enhancer, enabling acetylation of

272 Repression or activation correlates with the distance of

273 RISPR activation (CRISPRa) - that enable the repression or overexpression, respectively, of target ge

274 fic messenger RNA degradation, translational repression, or transcriptional inhibition.

275 al. (2017), suggest that gene activation and repression play fundamentally important roles in structu

276 e both in vivo and in vitro that translation repression plays a major role (3-7) .

277 The most persistent gene repression required the action of several effector domai

278 Furthermore, mutational analysis shows p21 repression requires interaction of TRF2 with a p21 promo

279 e alleviation of upstream open reading frame repression requires the proteolytic processing of PTEF b

280 , high resolution mapping of transcriptional repression reveals complex and interdependent mechanisms

281 leasing Pdcd1 expression from Satb1-mediated repression, Satb1-deficient tumor-reactive T cells lost

282 sistent with blood-to-hepatocyte transporter repression (Slco1a1, Slc10a1, Slco2b1, Slco1b2, Slco1a4)

283 s been linked to pathogenesis, translational repression, starvation responses, and ribosome turnover.

284 We show that both activation and repression target genes can be bound by Bcl11b in vivo,

285 ment, suggesting that resistance can require repression through multiple epigenetic mechanisms.

286 n important role controlling the switch from repression to activation each day.

287 iator, then acts to relieve Mediator-induced repression to generate an active form of the PIC.

288 eously tuning transcriptional activation and repression, using a novel strategy that relies on the pr

289 n which, at least in metazoans, the observed repression vastly exceeds that typically observed for en

290 on histone tails, promoting transcriptional repression via condensation of chromatin.

291 However, repression was noted in both wildtype and Ppp1r15a delet

292 Potent repression was observed in primary human blood mononucle

293 Interestingly, p21 repression was through engagement of the REST-coREST-LSD

294 sures Dexamethasone (Dex)-mediated NF-kappaB repression, we have screened 8,000 compounds and identi

295 etic modification that marks transcriptional repression, were changed in miR combo-treated fibroblast

296 predominantly associated with translational repression, while more actively initiating mRNAs become

297 We observed maximal repression with intermediate codon optimality and weak r

298 with intermediate codon optimality and weak repression with very high or low codon optimality.

299 s an effective biological strategy for trans-repression, with clear implications for breast cancer an

300 ted with both transcriptional activation and repression, with Wnt-repressed genes often lacking canon