ライフサイエンスコーパス: repression activity

1 vide evidence that methylation augments Scd6 repression activity.

2 with WT1 and mediates WT1's transcriptional repression activity.

3 lycine repeat domain of OsDrAp1 enhanced its repression activity.

4 red for both deacetylase and transcriptional repression activity.

5 s necessary and sufficient for its intrinsic repression activity.

6 ine- and proline-rich domain of OsDr1 had no repression activity.

7 he same surface of TBP that mediates the NC2 repression activity.

8 n3A interaction and thereby inhibits TIEG2's repression activity.

9 show that HERP has intrinsic transcriptional repression activity.

10 been shown to contain a Groucho-independent repression activity.

11 exhibit decreased or loss of transcriptional repression activity.

12 unchanged, reduced, or completely eliminated repression activity.

13 the cytoplasm and block its transcriptional repression activity.

14 P-1-like site in the TNF-RE is essential for repression activity.

15 viously described long-range transcriptional repression activity.

16 ain but not with KRAB mutants that have lost repression activity.

17 d mSin3 and inactivate Mad's transcriptional repression activity.

18 vivo promoter occupancy and transcriptional repression activity.

19 but strikingly, these mutations also cripple repression activity.

20 to the homeodomain confer activation versus repression activity.

21 as overexpression potentiates, SMRT-mediated repression activity.

22 ion of these sites altered its stability and repression activity.

23 istone deacetylases for full transcriptional repression activity.

24 TBX22 missense mutations result in impaired repression activity.

25 ad a negative impact on K-bZIP transcription repression activity.

26 clear protein that possesses transcriptional repression activity.

27 -motif could be a general modulator of their repression activity.

28 eins has both transcriptional activation and repression activity.

29 lated, exhibited the reduced transcriptional repression activity.

30 ain (aa 5-62), exhibits auto-transcriptional repression activity.

31 ined significant dephosphorylation-dependent repression activity.

32 moters, thereby exerting its transcriptional repression activity.

33 ity requires HCF-1 self-association and gene repression activity.

34 ne residues were required for efficient gene repression activity.

35 Knirps also possesses CtBP-independent repression activity.

36 e domains displays intrinsic transcriptional repression activity.

37 k together to phosphorylate PER and increase repression activity.

38 st significantly the ARMs, contribute to the repression activity.

39 titive inhibitor of RUNX2 and exhibited weak repression activity.

40 tive, rather than qualitative, deficiency in repression activity.

41 RX, however, it alleviates its transcription repression activity.

42 at sumoylation modulates its transcriptional repression activity.

43 that HoxA10 has Pbx1a-independent endogenous repression activity.

44 th transcriptional activators and endogenous repression activity.

45 t Ume1p binding to Rpd3p is required for its repression activity.

46 h a C-terminal domain, resulting in additive repression activity.

47 NIC-1 and NIC-1 mutants retaining activation/repression activities.

48 physical interaction enhances KNAT7 and BLH6 repression activities.

49 deficient in transcriptional activation and repression activities.

50 g its critical function in mediating the CAR repression activities.

51 anscriptional activation and transcriptional repression activities.

52 possible functional distinctions of the two repression activities.

53 , nonsteroidal GR ligand that possesses high repression activities against inflammatory mediator prod

54 rfering RNA inhibited BCL11B transcriptional repression activity and (3) MTA1 was specifically recrui

55 , although they possess comparable intrinsic repression activity and association with histone deacety

56 p-1 is required for its full transcriptional repression activity and function as an inhibitor of skel

57 (3) c-Abl inhibition reduces HDAC2-dependent repression activity and HDAC2 recruitment to the promote

58 onomeric state reduces Yan's transcriptional repression activity and impairs its function during embr

59 MO modification enhances p68 transcriptional repression activity and inhibits the ability of p68 to f

60 CDD component DET1 possesses transcriptional repression activity and physically interacts with two cl

61 GATA protein with intrinsic transcriptional repression activity and possibly a negative regulator of

62 hat GLI3 shows transcriptional activation or repression activity and subcellular localization similar

63 lex as a target for ataxin-1 transcriptional repression activity and suggest a novel pathogenic mecha

64 st that phosphorylation directly affects PER repression activity and that PER nuclear localization is

65 at AR possesses an intrinsic transcriptional repression activity, and AR interacts directly with SMRT

66 ation, DNA binding activity, transcriptional repression activity, and growth inhibitory effects of TI

67 dification, affecting both its stability and repression activity; and (5) treatment with Imatinib dec

68 (commonly found in human cancers) lost this repression activity; and (iii) this p53 repression activ

69 This result indicates that multiple repression activities are combined to exceed critical th

70 ctly binds to the Ssn6-Tup1 complex, and its repression activities are dependent upon Ssn6-Tup1 and h

71 nces between CtBP-dependent and -independent repression activities are poorly understood.

72 The finding that both repression activities are simultaneously deployed sugges

73 n genetic switches, suggesting that multiple repression activities are utilized to provide quantitati

74 ub-complexes that are required for Ssn6-Tup1 repression activity, are found to be required for Sfl1 r

75 e p130 pocket domain, which is important for repression activity, as well as an LXCXE sequence within

76 ivation but deficient in the transcriptional repression activity associated with c-Fos, did not induc

77 We further demonstrate DNA-binding and repression activities by the mammalian neural BEN-solo p

78 II sites potentiates VIPR-RP transcriptional repression activity by enhancing its nuclear translocati

79 lish that arginine methylation augments Scd6 repression activity by promoting eIF4G1-binding.

80 f life and exhibited reduced transcriptional repression activity compared to wild-type TBX18.

81 2 proteins all exhibited transactivation and repression activities, depending on the sequence context

82 One repression activity depends on dCtBP binding, and this f

83 aneously deployed suggests that the multiple repression activities do not function as cryptic 'backup

84 ent studies investigate modulation of HoxA10 repression activity during myelopoiesis.

85 the full-length mSin3A, exhibited a level of repression activity equivalent to, or greater than, the

86 tational analysis of CHF2 indicated that the repression activity for both transcription and myogenic

87 os-CtBP interactions do not abolish Ikaros's repression activity, implicating the involvement of addi

88 ibited compromised trans-activation or trans-repression activities in reporter gene assays.

89 We studied giant repression activity in a CtBP mutant and find that this

90 n, nuclear localization, and transcriptional repression activity in cultured S2 cells.

91 importance of this putative transcriptional repression activity in neural cytotoxicity nor the trans

92 the native Giant protein does not impair its repression activity in transgenic embryos.

93 We have titrated out AmiC repression activity in vivo by increased AmiR production

94 o sites in vitro abolish Nanos translational repression activity in vivo.

95 not flank the HD is particularly crucial to repression activity in vivo.

96 , indicating that Rpd3 contributes to Knirps repression activity in vivo.

97 taining both CtBP-dependent and -independent repression activities is higher than that of the CtBP-in

98 The functional importance of multiple repression activities is not well understood, but the fi

99 We find that this transcriptional repression activity is abrogated by histone deacetylase

100 The translational repression activity is found throughout the oocyte and a

101 general transcriptional repressor, and that repression activity is in the pseudoreceiver domain of t

102 This intrinsic repression activity is masked by the AF-2 helix, which a

103 ressing E2F-regulated transcription, and its repression activity is not affected by trichostatin A, a

104 temperatures (30 degrees C and below), MogR repression activity is specifically inhibited by an anti

105 GmaR anti-repression activity is temperature dependent due to DegU

106 a central region, which harbours autonomous repression activity, is mainly responsible for this inte

107 ex is required for the known transcriptional repression activities mediated by UBC9 and SUMO1.

108 tween target mRNA cleavage and translational repression activities of Ago2.

109 Neither the apoptosis nor the repression activities of CtBP required histidine-315, su

110 required for both self-association and gene repression activities of HCF-1 were also required for ef

111 n experiments to examine the transcriptional-repression activities of the Hunchback (Hb) protein grad

112 nvolved only in the induction or only in the repression activities of the protein.

113 e region responsible for the transcriptional repression activity of ataxin-1 and participates in prot

114 The transcriptional repression activity of AtERF7 is enhanced by HDA19 and A

115 tic environment promotes the transcriptional repression activity of c-Myc for gene-specific co-regula

116 We also provide details for testing the repression activity of CRISPRi using quantitative fluore

117 uents, HDACs contribute predominantly to the repression activity of CtBP1.

118 Moreover, the full repression activity of CtIP requires a PLDLS domain that

119 The repression activity of CWH-3 was mapped to the region of

120 iate with and inactivate the transcriptional repression activity of E2F6, thereby subverting a critic

121 ction of FoxD3 and Grg4, the transcriptional repression activity of FoxD3 is enhanced by Grg4, and re

122 talytic residue, were important for the gene repression activity of HD2A.

123 on with 14-3-3 and dramatically enhanced the repression activity of HDAC7 in NIH3T3 cells, but not in

124 ic protease 1 attenuated the transcriptional repression activity of K-bZIP.

125 ays an important part in the transcriptional repression activity of K-bZIP.

126 action is important for the CtBP-independent repression activity of Knirps and is required for regula

127 hich is essential for the transactivation or repression activity of Miz1, resulted in hyperinflammati

128 Endogenous repression activity of other Hox-Pbx1a complexes require

129 dition to the inhibition of DNA binding, the repression activity of P3 on TR may also be mediated by

130 Surprisingly, the repression activity of Pbx1 did not require homeodomain-

131 placing PML from PODs, failed to inhibit the repression activity of PML1, whereas the sumoylation-neg

132 e embryonic development and much of the gene repression activity of PRC1.

133 We localized the repression activity of PU.1 to a small acidic N-terminal

134 leads to spatial and temporal regulation of repression activity of RGG-motif proteins remains unknow

135 domain of RUNX2 may contribute to the strong repression activity of RUNX2 for some target gene promot

136 Here we show that the repression activity of RXR correlates with its binding t

137 ole of arginine methylation in regulation of repression activity of Scd6, a conserved RGG-motif prote

138 The importance of Arg-57 methylation for the repression activity of SHP provides a molecular basis fo

139 first time that Pak1 promotes transcription repression activity of Snail from E-cadherin, occludin,

140 a N-terminal motif that is essential for the repression activity of some regulators in ethylene signa

141 nding domains of StBEL5 or POTH1 blocked the repression activity of StBEL5 or POTH1, respectively.

142 StBEL5-POTH1 heterodimer also abolished the repression activity of StBEL5, POTH1, and the StBEL5-POT

143 evidence for the gene-specific transcription repression activity of Tet2 via histone deacetylation an

144 e leaves, whereas the E2F1 site counters the repression activity of the E2F2 element in young leaves.

145 is of IRE binding affinity and translational repression activity of the resulting IRP1 mutants showed

146 This motif is essential for the repression activity of these proteins in transgenic embr

147 nucleotide sequence and does not affect the repression activity of WT1.

148 sphatases, the control of ScoC transcription repression activity plays a crucial role in the initiati

149 ng E2A-mediated gene transcription, but full repression activity required the presence of two conserv

150 function also lost most of its transcription repression activity suggesting that interaction with the

151 HD fingers or bromodomains failed to restore repression activity, suggesting high specificity in thei

152 A treatment reduced Dermo-1 transcriptional repression activity, suggesting that histone deacetylati

153 greater DNA binding activity and a stronger repression activity than do the respective homodimers.

154 ong form of Atrophin-2 has a transcriptional repression activity that is not found in the other Atrop

155 main protein had independent transcriptional repression activity that mapped to the C-terminal region

156 BRCA1 exerts its transcriptional repression activity through interaction with the transcr

157 ing deletion constructs of SSX1 we localized repression activity to 33 amino acids at the C-terminus.

158 Knirps synergizes with the CtBP-independent repression activity to potently repress promoter element

159 DR4 promoter and Hh requires an intact GLI3-repression activity to silence DR4 expression.

160 tro mapping studies define the transcription repression activity to the PHD finger domain of the chic

161 ted SSX-KRAB domains to specifically measure repression activity, using a previously characterized KO

162 this repression activity; and (iii) this p53 repression activity was mediated at least in part by the

163 TRP transcriptional repression activity was specifically reduced by mutation

164 separately analyze the components of Knirps repression activity, we elucidated the specific repressi

165 To initiate mechanistic studies of the giant repression activity, we have identified a minimal repres

166 ers showed that Meq/Meq homodimers exhibited repression activity, whereas Meq/Jun heterodimers showed

167 rated that SQU possesses both activation and repression activities, while KEW acts only as an activat