ライフサイエンスコーパス: repression domain

1 nd repress transcription via small, portable repression 'domains'.

2 C-terminal-binding protein also bind the MLL repression domain.

3 neered as fusions with a KOX-1 transcription repression domain.

4 explored the mechanism of action of the MLL repression domain.

5 by using a synthetic, hormone-regulated KRAB repression domain.

6 inding and also functions as a transcription repression domain.

7 s and contains an N-terminal transcriptional repression domain.

8 this localization depends on the N-terminal repression domain.

9 GATA family with a separable transcriptional repression domain.

10 s of BRCA1 may function as a transcriptional repression domain.

11 3 C-terminus that can function as a portable repression domain.

12 BD) of the estrogen receptor and to the KRAB repression domain.

13 -terminal activation domain and a C-terminal repression domain.

14 served PLDLS motif within the amino-terminal repression domain.

15 sor of target gene expression and includes a repression domain.

16 l-CpG-binding domain or in the transcription repression domain.

17 PTIP to Pax2 is inhibited by the octapeptide repression domain.

18 teracts with HDACs via its carboxyl-terminal repression domain.

19 t the Giant effector domain is an autonomous repression domain.

20 ree transcription activation domains and one repression domain.

21 ressing the Ci zinc finger domain fused to a repression domain.

22 -terminal region also encoded a transferable repression domain.

23 Y1 have been identified as a transcriptional repression domain.

24 n coincides with the previously defined Tup1 repression domain.

25 sion, possibly by contributing an additional repression domain.

26 em zinc finger motifs and an N-terminal SNAG repression domain.

27 nd LSD1 associate with Gfi-1/1b via the SNAG repression domain.

28 ethyl DNA binding domain and transcriptional repression domain.

29 pped to Ser3486 and Thr3568 within the SHARP repression domain.

30 interaction with Brm and mSin3A through its repression domain.

31 The NID also acts as a transcriptional repression domain.

32 s contains both transcription activation and repression domains.

33 n be subdivided into distinct activation and repression domains.

34 Other PUF proteins lack these repression domains.

35 ted receptor interaction and transcriptional repression domains.

36 AP-1 silencing and the de novo design of new repression domains.

37 es, including two activation domains and two repression domains.

38 TN-2 were shown to function as transcription repression domains.

39 ressors which should therefore have specific repression domains.

40 , using regions of the ncRNAs referred to as repression domains.

41 reveal that MyoR contains two nonequivalent repression domains.

42 ein, acts as a repressor containing multiple repression domains.

43 erminal of ZIC2 contains both activation and repression domains.

44 opment and a central domain of RUNX1, termed repression domain 2 (RD2), was defined as being required

45 cho (Gro), in addition to possessing a third repression domain, 3R.

46 SAP180 has two repression domains: a C-terminal domain, which interacts

47 IC itself is targeted to the transcriptional repression domain (aa179 to 361) of CBF1.

48 Because the MLL repression domain activity was only partially relieved w

49 xpression of exogenous BMI-1 potentiates MLL repression domain activity.

50 f these proteins as fusions to activation or repression domains allows transcription to be specifical

51 eting with activators, but requires specific repression domains along with its DNA-binding domain.

52 proteins and implicated as a transcriptional repression domain, although few target genes for KRAB-co

53 However, deletion of the repression domain (amino acids 566-624) of TBX3 complete

54 al activation domain (amino acids 1-110) and repression domains (amino acids 111-188 and the homeodom

55 iating sequence-specific DNA binding and two repression domains: an N-terminal BTB/POZ domain and a c

56 factor bearing an ERF-associated amphiphilic repression domain and binding to the ACGTCAGTG sequence

57 n addition, SAFB1 contains a transcriptional repression domain and can bind certain hormone receptors

58 ABF-1 contains a transcriptional repression domain and is capable of inhibiting the trans

59 nt of histone deacetylases (HDAC) to the MLL repression domain and mediates HOX gene repression.

60 t1 belongs, has a transcriptional activation/repression domain and RNA recognition motifs and has a s

61 ies suggest that phosphorylation of both the repression domain and the chromatin binding domain acts

62 uncated protein consisting of the N-terminal repression domain and the DNA-binding homeodomain repres

63 eins with a VP64 activation domain or a KRAB repression domain and the transcriptional control impose

64 mains of Crt1 and identified two independent repression domains and a region required for gene activa

65 culture assays revealed the presence of two repression domains and a single activation domain within

66 RNA, bind Pol II with high affinity but lack repression domains and hence do not inhibit transcriptio

67 This function is mediated through two repression domains and is dependent upon the promoter co

68 onservation of the N-terminal activation and repression domains (and not the RS/RNA recognition motif

69 2 ZNF that contains 9 finger domains, a KRAB repression domain, and a SCAN domain and identified more

70 binding proteins, where it may function as a repression domain, and less frequently in actin-binding

71 This complex binds via the CBF1 repression domain, and mutants defective in repression f

72 aining the AML1 DNA-binding domain, the KRAB repression domain, and the Estrogen receptor ligand bind

73 ossesses potent transcription activation and repression domains, and is necessary for c-myc expressio

74 egions of structural divergence; while their repression domains are structurally and functionally con

75 including most of the previously identified repression domain, are necessary and sufficient for coac

76 pression despite having the same C- terminal repression domain as IRF-2, suggesting that the relative

77 stitute region-specific but gene-nonspecific repression domains, as a number of heterologous genes tr

78 SAP130 has a repression domain at its C terminus that interacts with

79 criptional repressor that contains a modular repression domain at its carboxyl terminus.

80 to a putative Kruppel associated box (KRAB) repression domain at the N-terminus.

81 ethyl DNA binding domain and transcriptional repression domain both could function as nonspecific DNA

82 ylene response factor-associated amphiphilic repression domain but differ in the presence of an addit

83 tain both Groucho-dependent and -independent repression domains, but the extent to which this distinc

84 Brk possesses at least three repression domains, but these are not equivalent; one, 3

85 P1 cooperatively function as a transcription repression domain by recruiting the histone deacetylase

86 ption activation domain, and a transcription repression domain called the octapeptide.

87 n a context-dependent manner, the N-terminal repression domain can function in a heterologous context

88 nsistent with these findings, Ikaros and its repression domains can interact in vivo and in vitro wit

89 nducible deactivated Cas9 is fused to a KRAB repression domain, can specifically and reversibly inhib

90 inus of FIR contained an activator-selective repression domain capable of acting in cis or even in tr

91 NA encoding SOX3DeltaC-EnR, a SOX3-engrailed repression domain chimera.

92 assay, the relative activities of different repression domains closely parallel those seen in vivo,

93 The transcription repression domain comprises the C-terminal 154 amino aci

94 These results reveal a novel transcription repression domain, confirm the presence of a previously

95 D can function as an autonomous and portable repression domain, demonstrating that it is sufficient t

96 In these assays, the Hairy repression domain did not exhibit previously described l

97 pressor assay, indicating the existence of a repression domain distinct from SSX-KRAB.

98 A carboxy-terminal repression domain distinct from the well-characterized T

99 with one of these being an active, portable repression domain (domain I) and a second being an auxin

100 nal/functional analysis of the transcription-repression domain encoded in the N-terminal 80 amino aci

101 A conserved transcriptional repression domain exists in both PLAG1 and PLAGL2, whose

102 egulatory domains such as AT hooks (exon 3), repression domain (exon 6), zinc finger motifs (exon 8)

103 46 mice, in which Runx1 lacks the C-terminal repression domain, expression of MrgA/B/C genes is drama

104 n p66beta and the zinc finger/leucine zipper repression domain found in Foxp1/2/4.

105 scription, and this activity requires both a repression domain found in the N-terminal 137 amino acid

106 ll nuclear extract demonstrated that the Eve repression domain functions by preventing the assembly o

107 This C-terminal repression domain functions in a BRCA1-, histone deacety

108 A 65-amino-acid polypeptide containing the repression domain fused to the Ga14 DNA binding domain r

109 iofacial development, that a transcriptional repression domain fusion, MadFlagWdr68, failed to suppor

110 y responsible for this regulation to the H2A repression domain, HAR.

111 the ET protein reveals a novel transcription-repression domain highly conserved among ET, human TBX3,

112 ighly conserved domains of ETO interact with repression domains I and III of N-CoR.

113 In addition to a region containing an active repression domain identified in cell culture assays, we

114 otif that engages a conserved PPLXP motif in repression domain III of N-CoR.

115 omain (RHD) and a C-terminal transcriptional repression domain in AML1/ETO are required for transform

116 The repression domain in both Nrf1 and C/EBPbeta was determi

117 We have identified a transcriptional repression domain in Dnmt1 that functions, at least part

118 ipped C terminus acts as a Groucho-dependent repression domain in early Drosophila embryos.

119 identified a novel evolutionarily conserved repression domain in Elk-1, termed the R motif, which se

120 Analysis of the N-terminal repression domain in Foxp1, Foxp2, and Foxp4 shows that

121 the DNA-binding domain of GAL4, we mapped a repression domain in hEZF to amino acids 181-388.

122 We previously identified a transcriptional repression domain in MLL, which contains a region with h

123 Mutations in a putative repression domain in Mox4 caused constitutive expression

124 The R motif is related to the CRD1 repression domain in p300 and can functionally replace t

125 We also identified a minimal repression domain in PRDI-BF1 that is sufficient for tra

126 ous reporter assay, we identify a tripartite repression domain in SnoN.

127 tified a trichostatin A-sensitive autonomous repression domain in the amino terminus of Runx2.

128 We show that CBFbeta/SMMHC contains a repression domain in the C-terminal 163 amino acids of t

129 Here, we identify a transcriptional repression domain in the carboxy-terminal region of the

130 (amino acids 589-631) that has homology to a repression domain in the corepressor protein NCoR2/SMRTe

131 cation of a novel cis-acting transcriptional repression domain in the E protein family of bHLH transc

132 r protein genes, making it the most abundant repression domain in the human proteome.

133 urther shows the presence of a Wnt signaling repression domain in the SOX17 HMG box.

134 fy a novel, highly conserved transcriptional repression domain in these proteins.

135 lly distinguishable from the N-terminal KRAB repression domain in ZBRK1, which exhibits no BRCA1 depe

136 These findings show that EAR repression domains in a subgroup of JAZ proteins repress

137 Other repression domains in Gro may function in a histone deac

138 The presence of multiple repression domains in Nkx6 supports Nkx6's role as a rep

139 have characterized four distinct autonomous repression domains in RIP140, termed RD1-4, that are hig

140 nal co-repressors are known to contact other repression domains in RUNX1, the factors that bind to RD

141 confirmed previous findings of two separate repression domains in the N and C termini.

142 that there are two separate transcriptional repression domains in VIPR-RP, located between amino aci

143 Deletion of this repression domain increased gene transcription from a ne

144 While the MyoR C-terminal repression domain inhibits transcription in a context-de

145 nteracted in vivo with Hir2p, and both Hir1p repression domains interacted with full-length Hir1p.

146 Remarkably, this repression domain interacts specifically with hGrg, TLE1

147 sion protein containing the Drosophila Hairy repression domain interferes with notochord differentiat

148 e we test the hypothesis that the cis-acting repression domain is a conserved feature of PAX3 and PAX

149 The SNAG repression domain is comprised of a highly conserved 21-

150 that the interaction between TBP and the E1A repression domain is direct and specific.

151 ression domain, supporting the idea that the repression domain is implicated in interactions between

152 e IL-10 expression, but a C-terminal minimal repression domain is necessary.

153 The KRAB repression domain is one of the most widely distributed

154 transgenes that the widely conserved in vivo repression domain is required for the normal function of

155 primary embryo fibroblasts and that the RD1 repression domain is required for this activity.

156 In chromosomal translocations, the MLL repression domain is retained in the leukemogenic fusion

157 Although the N-terminal repression domain is sufficient for partial repression,

158 This minimal repression domain is sufficient for the association of C

159 he protein separate from the DNA binding and repression domains is necessary and sufficient for gluco

160 A large region of Ubx, including the repression domain, is required for interaction with DIP1

161 The N terminus of Crt1 is the major repression domain, it directly binds to the Ssn6-Tup1 co

162 othelial cell lines or, when combined with a repression domain, knocked down expression.

163 n independent and homologous transcriptional repression domain lies within the N-terminal end of the

164 DNA-binding zinc fingers and on a separable repression domain located in the N terminus.

165 cumulative data suggest that the C-terminal repression domain, located near the first WD repeat, pla

166 ntly represses basal transcription, with the repression domain mapped to the N-terminal silencing med

167 ufficient to repress transcription, and this repression domain mediates a two-hybrid and physical int

168 ptapeptide repeat, suggesting that the PIE-1 repression domain might target a protein complex that ca

169 AL4-COUP-TF2(117-414), but not by a COUP-TF2 repression domain mutant.

170 and the Drosophila engrailed transcriptional repression domain (NFIen) was conditionally expressed in

171 Expression vectors containing the repression domain of C/EBPepsilon strongly inhibited gen

172 r Notch1, Notch2 interacted with the minimal repression domain of CBF1 and was targeted to CBF1 throu

173 r studies show that TFIID interacts with the repression domain of Crt1, suggesting that the derepress

174 by fusing the SpOtx homeodomain to an active repression domain of Drosophila Engrailed.

175 e Siamois homeodomain was fused to an active repression domain of Drosophila engrailed.

176 motif which can be negatively regulated by a repression domain of FBP.

177 The repression domain of FIR targeted only TFIIH's p89/XPB h

178 We also show that the repression domain of hTR alpha maps to the C-terminal li

179 re L is leucine and x is another amino acid) repression domain of IAA3, IAA6, or IAA19 confers enhanc

180 at interact specifically with the C-terminal repression domain of Interferon Regulatory Factor-2 (IRF

181 The transcriptional repression domain of JMJ is critical for the interaction

182 of the C-terminal binding protein-dependent repression domain of Knirps.

183 sferase homology domain, and transcriptional repression domain of MLL fused to the CREB binding domai

184 directly demonstrate that the amino-terminal repression domain of Mxi1-SR functions solely to recruit

185 repression involved the CRD1 transcriptional repression domain of p300.

186 11, a domain that is homologous to the major repression domain of Qin.

187 e effects of amino acid substitutions in the repression domain of selected Aux/IAA proteins.

188 nd USF that is dependent upon the C-terminal repression domain of Stra13 and the DNA-binding domain o

189 s bind to the pointed domain and the central repression domain of TEL, respectively.

190 ividuals with HPE affect the transcriptional repression domain of TGIF, the DNA-binding domain or the

191 ctivation domain of Xcad3 is replaced by the repression domain of the Drosophila Engrailed protein.

192 An interaction screen with the repression domain of the orphan receptor RevErb identifi

193 The zinc finger and repression domains of KLF3 plus the MADS box and transcr

194 We assayed CtBP-dependent and -independent repression domains of Knirps in Drosophila embryos, and

195 Two characterized repression domains of MeCP2 are involved in tethering th

196 n the methyl-CpG-binding and transcriptional-repression domains of MeCP2.

197 ons of the DNA binding or C-terminal minimal repression domains of p53 abolished its ability to repre

198 tion analysis was used to define the minimal repression domains of TEL.

199 p-Leu-Ser-X-Lys (P-DLS-K), is present in the repression domains of two unrelated short-range represso

200 a presented indicate that the activation and repression domains of Vnd are complex, and whether Vnd f

201 s indicate that RYBP binds within the known "repression domain" of E2F6.

202 domain acted as an independent transcription repression domain on a heterologous activation domain.

203 ind that the BRCA1-dependent transcriptional repression domain on ZBRK1 includes elements that modula

204 n analysis of HIR1 has revealed two separate repression domains: one in its N terminus, where seven c

205 ET, which has been demonstrated to contain a repression domain, only minimally diminishes the ability

206 The dominance of Aux/IAA repression domains over activation domains in ARF transc

207 we have named this region the p53 N-terminal Repression Domain (p53-NRD).

208 Histone deacetylase 1 interacts with the MLL repression domain, partially mediating its activity; bin

209 A conserved SNAG repression domain present in all vertebrate Snail protei

210 ression motif (alpha-HRM) located within the repression domain (R1) of TIEG2.

211 is a potent transcriptional repressor whose repression domain (RD) interacts directly with SMRT and

212 A number of short repression domain (RD) sequences have previously been id

213 In a yeast 2-hybrid screen with GRIP1 repression domain (RD)-containing fragment, we repeatedl

214 via an intrinsic and transferable C-terminal repression domain (RD).

215 We show that a key repression domain (RD1) resides in the Tbx3 C-terminus t

216 PIASy contains two transcriptional repression domains, RD1 and RD2.

217 The second repression domain (RD2) of PLZF, not the POZ/BTB domain,

218 Each corepressor contains multiple repression domains (RDs), the significance of which is u

219 Further analyses mapped a novel repression domain (RepD1) to a small region at the N-ter

220 s localized to amino acids 1-35, whereas the repression domain resides in amino acids 67-168.

221 cing complex through MeCP2's transcriptional repression domain results in histone deacetylation and c

222 no acid substitutions in the transcriptional repression domain revealed that activation of gene expre

223 udy is to further define and distinguish the repression domain(s) in human GW182/TNGW1.

224 esults point to intrinsic differences in the repression domain(s) of IAA proteins and suggest that so

225 levels, a Tbx3 mutant lacking its C-terminal repression domain shows no anti-apoptotic activity and f

226 rovide a DNA-binding module fused to the EAR-repression domain (SRDX) to generate a chimeric represso

227 RPW motif to be a functional transcriptional repression domain sufficient to confer active repression

228 ion of the inv(16) fusion protein contains a repression domain, suggesting a molecular mechanism for

229 but distinct from the Ssn6-Tup1 binding and repression domain, suggesting that Crt1 may have activat

230 ity of HESX1(R160C) is mediated by the Hesx1 repression domain, supporting the idea that the repressi

231 SpEts4 DNA binding and Drosophila engrailed repression domains, suppresses its transcription.

232 e IAA proteins have stronger or more complex repression domains than others.

233 A-binding domain, we have identified a PIE-1 repression domain that appears to inhibit the transcript

234 chromoshadow domain (CSD) of HP1 is a potent repression domain that binds directly to all four previo

235 rminal domain of Vnd contains a putative eh1 repression domain that binds Groucho in vitro.

236 pa, one of which is identical to the central repression domain that binds the Notch effector fragment

237 4-Giant fusion proteins identified a minimal repression domain that contains a sequence motif, VLDLS,

238 t the hypothesis that Eve contains an active repression domain that functions specifically to prevent

239 ltransferase-mediated pathways, as well as a repression domain that interacts with the histone deacet

240 oprotein encodes an N-terminal transcription repression domain that is essential for early viral func

241 at domain I in Aux/IAA proteins is an active repression domain that is transferable and dominant over

242 identical to a previously identified HoxA10 repression domain that mediates interaction with transcr

243 is an HMG-domain, DNA binding protein with a repression domain that recruits the Tup1/Ssn6 general re

244 We determine that HoxA10 has endogenous repression domains that are not functionally altered by

245 the p300 CRD1 motif represent a new class of repression domains that are regulated in a context-depen

246 A 107 amino acid stretch of the SnoN repression domain, that contains two of the subdomains,

247 lization and acts together with the adjacent repression domains (the transcription repression domain

248 3) was also fused to a human transcriptional repression domain, the mSIN3 interaction domain, and int

249 In contrast to these two repression domains, the T-box was capable of weakly acti

250 udies also identify a new function for ncRNA repression domains: they stabilize interactions of ncRNA

251 hat p300 can serve as a scaffold for the E1A repression domain to access specific cellular gene promo

252 Importantly, fusing a repression domain to B1 RNA stabilizes its interaction w

253 The ability of the E1A repression domain to block TBP interaction with the TATA

254 ZFM1 comes from the ability of its specific repression domain to function when fused to Gal4 and tet

255 roposed mechanisms include tethering the E1B repression domain to p53-responsive promoters via direct

256 ssor approach that directs a transcriptional repression domain to target genes deregulated by the PAX

257 Fusion of this repression domain to the VP16 activation domain inhibite

258 truncate all or some of the transcriptional repression domain (TRD) affect the ability to repress tr

259 The transcription repression domain (TRD) of MeCP2 will repress transcript

260 It contains a transcriptional-repression domain (TRD) that can function at a distance

261 binding domain (MBD) or the transcriptional repression domain (TRD).

262 its MBD and also contains a transcriptional repression domain (TRD).

263 ion, both of which disrupt the transcription repression domain (TRD).

264 jacent repression domains (the transcription repression domain [TRD] and the corepressor-interacting

265 This novel repression domain was active on two target genes that ar

266 This repression domain was also found to functionally and dir

267 and SRC1 corepressed, and the GRIP1-specific repression domain was dispensable.

268 on causing a V288X stop in the transcription-repression domain was identified in a woman with motor-c

269 A repression domain was identified near the N terminus of

270 The EAR repression domain was required for MYBH-regulated leaf s

271 ped protein, outside the Groucho-independent repression domain, we have identified a conserved C-term

272 The major determinants of the repression domain were shown to be amino acid residues F

273 Activation and repression domains were detected in their common amino e

274 Two repression domains were identified in H2A.

275 tem, distinct transcriptional activation and repression domains were identified.

276 ARF MRs alone function as activation or repression domains when targeted to reporter genes via a

277 ional repressor with a minimal 36 amino acid repression domain which can mediate promoter-specific re

278 10 amino acids 224-249 as a Pbx1-independent repression domain, which interacts with histone deacetyl

279 The second domain of Dr1 is the repression domain, which is glutamine-alanine rich.

280 In addition, we identified a C-terminal repression domain, which is independent of Ssn6-Tup1 and

281 ion containing the SID represents a dominant repression domain whose activity can be transferred to a

282 d the interaction of the fused activation or repression domain with endogenous proteins.

283 ssion activity, we have identified a minimal repression domain within giant that encompasses residues

284 ng domain assay, we mapped a transcriptional repression domain within the N-terminal region of HBO1.

285 n within a common region and a counteracting repression domain within the OVO-A-specific region.

286 f a portable BRCA1-dependent transcriptional repression domain within ZBRK1 composed of zinc fingers

287 at EGR activity is modulated by at least two repression domains within NAB2, one of which uniquely re

288 Two complementary cis-regulatory repression domains within pri-miR-17 approximately 92 ar

289 ealed the presence of at least two separable repression domains within TGIF.

290 Distinct activation and repression domains within the RFX1 protein were further

291 sed transcriptional assays to identify three repression domains within TIEG1 and TIEG2 that we call R

292 zinc finger proteins fused to activation or repression domains, zinc finger transcription factors (T