ライフサイエンスコーパス: reprogram

1 nclear whether AR signaling is significantly reprogrammed.

2 nce dependent in association with epigenetic reprogramming.

3 MYC that takes place during or shortly after reprogramming.

4 icant and did not require device revision or reprogramming.

5 PpCSP genes function redundantly in cellular reprogramming.

6 the chromatin changes underlying epigenetic reprogramming.

7 ssion of activation-induced T cell metabolic reprogramming.

8 actor that controls glycolysis and metabolic reprogramming.

9 omatin accessibility at the initial stage of reprogramming.

10 during temporal MeJA-induced transcriptional reprogramming.

11 -1alpha (HIF-1alpha) mediates such metabolic reprogramming.

12 at can be modulated to enhance cardiomyocyte reprogramming.

13 generation were related to in utero somatic reprogramming.

14 source for studying cell differentiation and reprogramming.

15 accumulation of PpCSP1 protein and enhances reprogramming.

16 ione (GSH), through HIF-1-mediated metabolic reprogramming.

17 ular plasticity and favor oncogenic cellular reprogramming.

18 pha and reversed TGF-beta1-induced metabolic reprogramming.

19 nistic target of rapamycin (mTOR) influences reprogramming.

20 nt of NOPE1 function for presymbiotic fungal reprogramming.

21 , that impede gene induction during cellular reprogramming.

22 implications on cancer-associated epigenetic reprogramming.

23 der growth conditions that enable epithelial reprogramming.

24 adversities induce sex-dependent epigenetic reprogramming.

25 or transitions in chromatin structure during reprogramming.

26 ortraits of mutant-IDH1-dependent epigenomic reprogramming.

27 entiation occurs concurrently with metabolic reprogramming.

28 he principal instructing signals for stromal reprogramming.

29 hances endocrine specification during ductal reprogramming.

30 networks throughout development and cellular reprogramming.

31 se epigenetic silencing during developmental reprogramming.

32 le regulators during the initiation stage of reprogramming.

33 s CBX4 and CBX6 by ubiquitination influences reprogramming.

34 arly distinct subpopulations of cells during reprogramming.

35 ith active transcription during somatic cell reprogramming.

36 to increase p53 levels and impair stem cell reprogramming.

37 aling activation, and evidence of epigenetic reprogramming.

38 onversely, acts as a barrier to somatic-cell reprogramming.

39 We reprogrammed 32 skin fibroblast cells from families of d

40 investigational immunotherapy that involves reprogramming a patient's own T cells with a transgene e

41 ecute a broad range of sensing and automated reprogramming actions for directed therapeutics.Protein-

42 In this context, FOXA1-dependent enhancer reprogramming activates a transcriptional program of emb

43 We conclude that Sox11 can reprogram adult RGCs to a growth-competent state, sugges

44 e demonstrate a tractable approach for fully reprogramming adult mouse endothelial cells to haematopo

45 ls, chromatin organization undergoes drastic reprogramming after fertilization.

46 Mutations in cancer reprogram amino acid metabolism to drive tumor growth, b

47 However, unexpectedly, without translation reprogramming an ATF4-high/MITF-low state is insufficien

48 scle-kidney crosstalk can suppress metabolic reprograming and fibrogenesis during kidney disease.

49 oves the first cleavage division, epigenetic reprogramming and apoptotic status of bovine preimplanta

50 Comparison of the promoter during reprogramming and differentiation showed tissue-independ

51 omes an early epigenetic barrier in cellular reprogramming and facilitates the generation of more rob

52 al important functions of DDX5 in regulating reprogramming and highlight the importance of a Ddx5-miR

53 antly bind active somatic enhancers early in reprogramming and immediately initiate their inactivatio

54 ce of Smarcb1-Myc-network-driven mesenchymal reprogramming and independence from MAPK signalling.

55 haracterized role for flow-induced metabolic reprogramming and inflammation in ECs.

56 investigate IDH1(R132H)-dependent metabolic reprogramming and its potential to induce biosynthetic l

57 ata highlighted the critical role of CX45 in reprogramming and may increase the cell division rate an

58 olate and infect primary fibroblasts; induce reprogramming and observe iCPC colonies; expand and char

59 45 expression significantly blocked cellular reprogramming and reduced the efficiency.

60 to LAM pathology, and demonstrated that iPSC reprogramming and SMC lineage differentiation of somatic

61 matin remodeling occurring during epigenetic reprogramming and that they may be key players in the ac

62 cular organismal transition requires nuclear reprogramming and the initiation of RNAPII at thousands

63 ar plasticity in the context of somatic cell reprogramming and tumorigenesis.

64 ies a number of TFs previously validated for reprogramming and/or natural differentiation and predict

65 host immune responses, peripheral metabolic reprogramming, and different rates of mortality.

66 on, namely, neutrophil apoptosis, macrophage reprogramming, and efferocytosis, which have a major imp

67 , Rif1 acts as a barrier during somatic cell reprogramming, and its depletion significantly enhances

68 n of immune response, tumor microenvironment reprogramming, and metastasis.

69 ence of immune activation is transcriptional reprogramming, and some NLRs have been shown to act in t

70 t RICD susceptibility is linked to metabolic reprogramming, and that switching back to metabolic quie

71 c and metabolic transitions, i.e., metabolic reprogramming; and (4) inhibition of lipid biosynthetic

72 etabolism, the roles of RBPs in somatic cell reprogramming are poorly understood.

73 or tissue regeneration, implicating cellular reprogramming as an essential element.

74 Using direct cardiac reprogramming as an example, we further determined the e

75 , we adapted a recently described epithelial reprograming assay for short-term propagation of epithel

76 e of transcription factors (TFs) in cellular reprogramming, based on a device commonly used in optima

77 standardized protocol and were appropriately reprogrammed before the scanning.

78 nfluence of inflammatory pathways on cardiac reprogramming, blockade of these pathways with anti-infl

79 studies to determine epigenetic changes that reprogram brain development and metabolic changes in ear

80 ine does not increase Xi expression ahead of reprograming, but instead reveals a second cadre of gene

81 lyze cellular de-differentiation and nuclear reprogramming by acting at the cell surface.

82 iquitin-proteasome system regulates cellular reprogramming by degradation of key pluripotency factors

83 creatic cancer involves large-scale enhancer reprogramming by Foxa1, which activates transcriptional

84 tor 281 (ZNF281) potently stimulates cardiac reprogramming by genome-wide association with GATA4 on c

85 stem (ES) to trophoblast stem (TS)-like cell reprogramming by introducing individual TS cell-specific

86 2b, a histone demethylase gene that promotes reprogramming by reactivating endogenous pluripotency ge

87 em cells (PSCs) can be generated via nuclear reprogramming by transcription factors (i.e., induced pl

88 sis, that captive rearing induces epigenetic reprogramming, by comparing genome-wide patterns of meth

89 Direct reprogramming can be achieved by forced expression of ma

90 ic to direct CPC reprogramming, whereas CASD reprogramming can generate various cell types depending

91 lated in quiescent cells and that epigenetic reprogramming can improve outcomes in glomerular disease

92 Building upon the unique chemical reprogramming capability of the Nafion shape memory poly

93 ures, resulting in populations of completely reprogrammed cells and bihormonal cells that displayed h

94 tage of reprogramming in partially and fully reprogrammed cells respectively.

95 rentiation markers and presence of partially reprogrammed cells which retained a typical gene express

96 PpCSP1 accumulates in the reprogramming cells and is maintained throughout the rep

97 in cancer biology is that oncogenes actively reprogram cellular metabolism to enable tumors to surviv

98 ng constitutive and inducible regulators, to reprogramming cellular phenotypes and controlling multig

99 ocesses: sensory initiation, transcriptional reprogramming, cellular protein component change, and ce

100 At week 1 post-transduction, we found that reprogrammed CMs expressed neuronal markers such as Tuj1

101 neuron-like electrophysiological profile of reprogrammed CMs.

102 edly enhances three other TF-mediated direct reprogramming conversions, from B cells to macrophages,

103 e nucleus initiate a massive transcriptional reprogramming critical to mount an appropriate host defe

104 th mitotic chromatin in ESCs and during iPSC reprogramming, demonstrating the importance of mitotic b

105 r findings show how LSD1-mediated epigenetic reprogramming drives CRPC, and they offer a mechanistic

106 ukaryotic gene expression and is extensively reprogrammed during animal development.

107 cription factor target gene in transcriptome reprogramming during Heterodera cyst nematode parasitism

108 olecular mechanism, for global translational reprogramming during pattern-triggered immunity in plant

109 g indicates that genome-wide DNA methylation reprogramming during preimplantation development is a dy

110 However, whether developmental methylation reprogramming during the sporophytic life cycle of flowe

111 While metabolic reprogramming during Treg cell differentiation has been

112 ted the ability of RB loss to differentially reprogram E2F1 in human cancers.

113 31542 and the WNT inhibitor XAV939 increased reprogramming efficiency 8-fold when added to GMT-overex

114 The reprogramming efficiency of human astrocytes reaches up

115 xpression of CX45 significantly enhanced the reprogramming efficiency together with the Yamanaka fact

116 Somatic and pluripotency TFs modulate reprogramming efficiency when overexpressed by altering

117 ng, and its depletion significantly enhances reprogramming efficiency.

118 bcutaneous white fat (iWAT) involves several reprograming events, but the underlying mechanisms are i

119 While these genomic reprogramming events depend on a specialized network of

120 f-care combination therapy, suggesting these reprogramming events were not specific to MEKi alone.

121 l for understanding important topics such as reprogramming, evolution, and disease.

122 Metabolic energy reprogramming facilitates adaptations to a variety of st

123 verall, we demonstrate that FOSL1 is a novel reprogramming factor for melanocytes with potent tumor t

124 s exhibit increased expression of epigenetic reprogramming factors such as Ezh2 and Sox2.

125 Here, we reprogrammed fibroblasts to generate induced pluripotent

126 Collectively, our study implicates enhancer reprogramming, FOXA1 upregulation, and a retrograde deve

127 Whether the cell types are directly reprogrammed from human somatic cells or differentiated

128 tic and epigenetic features that distinguish reprogrammed from non-reprogrammed sites, and suggested

129 ic infections and cancer trigger a metabolic reprogramming from the preferential use of glucose to th

130 To test the role of nuclear surveillance in reprogramming gene expression, we identified transcripto

131 ctive ER protein-folding environment through reprogramming gene transcription and mRNA translation.

132 le during somatic growth, DNA methylation is reprogrammed genome-wide during mammalian reproduction.

133 le many of the early muscle marker genes are reprogrammed, global gene expression and accessibility c

134 not only reveals the mechanism by which YAP reprograms glucose metabolism, but also highlights the t

135 e exogenous glutamine for growth and exhibit reprogrammed glutamine metabolism, at least in part due

136 ntroduced nonmuscle nuclei undergoes nuclear reprogramming has not been investigated.

137 In vivo cell reprogramming has the potential to enable more-effective

138 potent stem cells (iPSCs) and direct somatic reprogramming, have shown enormous potential for cell-ba

139 Direct cardiac reprogramming holds great promise for regenerative medic

140 sponses in leukemic and host CD4(+) T cells, reprogramming host T cells toward normalcy.

141 Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechan

142 serve iCPC colonies; expand and characterize reprogrammed iCPCs by immunostaining, flow cytometry and

143 CARs are synthetic receptors that reprogram immune cells for therapeutic purposes.

144 is, and how O2 deficiency leads to metabolic reprograming in cancer.

145 the oscillating transcriptome is extensively reprogrammed in aged stem cells, switching from genes in

146 ferentiation but can undergo transcriptional reprogramming in a bidirectional manner between protecti

147 Metabolic reprogramming in brain tumors is also influenced by the

148 Metabolic reprogramming in breast tumors is linked to increases in

149 However, epigenetic reprogramming in cancer often involves gene body hypomet

150 anscriptional activity, undergoes epigenetic reprogramming in CRPC.

151 uring the initiation and maturation stage of reprogramming in partially and fully reprogrammed cells

152 However, the extent of DNA methylation reprogramming in plants remains unclear.

153 e-dimensional structure of chromatin and its reprogramming in preimplantation development remain poor

154 te initial inhibitor response and subsequent reprogramming in resistance.

155 PRC2 is required for chromatin reprogramming in the germline, and the transcriptome of

156 The addition of drug then induces epigenetic reprogramming in these cells, converting the transient t

157 in differentiated SMCs is essential for SMC reprogramming in vivo, whereas in vitro approaches demon

158 ssion, suggesting that DF leads to metabolic reprogramming in vivo.

159 a sequential, two-step mechanism of cellular reprogramming in which repression of pre-existing ES cel

160 sely related PpCSP genes exhibits attenuated reprogramming indicating that the PpCSP genes function r

161 We previously generated directly reprogrammed induced cardiomyocyte-like cells (iCMs) by

162 the underlying mechanism for gene expression reprogramming induced by persistent DNA damage remains p

163 To identify modulators of reprogramming-induced senescence, we performed a genome-

164 F is integrated at the level of chromatin to reprogram inflammatory responses, and identify previousl

165 bute to reinforce antibacterial responses by reprogramming innate and adaptive immune mechanisms.

166 monstrate that the epithelium is transiently reprogrammed into a primitive state.

167 nce that differentiated somatic cells can be reprogrammed into cancer initiating cells.

168 ells can partially dedifferentiate or become reprogrammed into other islet endocrine cells.

169 ial transition is requisite to initiate SMCs reprogramming into vascular progenitors and that members

170 i, together with a tryptophan-rich diet, can reprogram intraepithelial CD4(+) T cells into immunoregu

171 Metabolic reprogramming is a hallmark of cancer.

172 Reprogramming is a slow and inefficient process, suggest

173 Reprogramming is a stepwise process with well-defined st

174 Metabolic reprogramming is an emerging hallmark of pancreatic aden

175 Metabolic reprogramming is central to tumorigenesis, but whether c

176 imprinting control regions escape from this reprogramming is largely unknown.

177 Transcriptional reprogramming leading to higher TAG content is balanced

178 and economically important species of fish, reprograms liver metabolism in the offspring and alters

179 and STING agonists (a) for their ability to reprogram macrophages to a state optimal for mAb immunot

180 We conclude that preconditioning reprograms macrophages and tubules to generate a protect

181 in stemness, direct differentiation, promote reprogramming, manipulate the genome, or select function

182 nsion of the complex process of somatic cell reprogramming, many questions regarding the molecular me

183 of concept for the use of anti-Jagged1/2 to reprogram MDSC-mediated T-cell suppression in tumors, wi

184 to the genetic compositions rather than the reprogramming mechanisms (SCNT vs. iPSCs).

185 n in the four chemical inhibitors (4i)-naive reprogramming medium and showed transcriptional consiste

186 Pancreatic cancer cells have extensively reprogrammed metabolism, which is driven by oncogene-med

187 been illuminated by numerous studies, with "reprogrammed" metabolism being one of the most important

188 Existing reprogramming methodologies, however, are fraught with c

189 and validated models of these mechanisms by reprogramming microglia-like cells from peripheral blood

190 egatively regulates macrophage activation by reprogramming mitochondrial pyruvate metabolism.

191 ed with well-established and newly developed reprogramming models of induced neurons and endothelium,

192 s in response to IL-7 signalling in order to reprogram naive T cells for proliferation and differenti

193 AML exosomes reprogram NK-92 cells, interfering with their anti-leuke

194 MSX1-reprogrammed normal human melanocytes express the neural

195 This metabolic reprogramming not only promotes cancer cell plasticity,

196 weight loss intervention without persistent reprograming of the liver transcriptome.

197 Reprogramming of cardiac fibroblasts into induced cardio

198 s a SIRT1 target involved in transcriptional reprogramming of CD8(+)CD28(-) T cells.

199 Here we report large-scale reprogramming of chromatin modifications during the natu

200 The reprogramming of differentiated cells into induced pluri

201 marks in sperm, with a primary focus on the reprogramming of DNA methylation, histone posttranslatio

202 KSHV lytic replication induces dynamic reprogramming of epitranscriptome, regulating pathways t

203 d that TOR not only dictates transcriptional reprogramming of extensive gene sets involved in central

204 Direct reprogramming of fibroblasts to cardiomyocytes represent

205 tically, and demonstrate its application for reprogramming of fibroblasts to prostate tissue.

206 karyotes, S. cerevisiae undergoes a dramatic reprogramming of gene expression during meiosis, includi

207 to engage in DNA binding, triggering a major reprogramming of gene expression that includes component

208 The reprogramming of hemoglobin expression was achieved at t

209 on by macrophages, thereby indicating global reprogramming of host kinase signaling.

210 ular monosaccharides through transcriptional reprogramming of host sugar transporter genes and activa

211 inst PDA and was associated with immunogenic reprogramming of innate and adaptive immunity within the

212 changes in Egr1, and sex-specific epigenetic reprogramming of its effector gene, Npy1r, represents th

213 We demonstrate that partial direct reprogramming of mesoderm-derived cardiomyocytes into ne

214 velopmental events and leading to sequential reprogramming of metabolic and developmental genes.

215 e either Sox2 and Myc (c-Myc) or Oct4 during reprogramming of mouse embryonic fibroblasts into iPSCs.

216 level vancomycin resistance mediated by the reprogramming of peptidoglycan biosynthesis to use precu

217 ould otherwise interfere with PRC2-dependent reprogramming of PGC chromatin.

218 r-infiltrating myeloid cells and, therefore, reprogramming of PGE2 metabolism in tumor microenvironme

219 of various reported gene knockdowns, and the reprogramming of pre-B cells into macrophages induced by

220 n the cerebellum and speculate that adaptive reprogramming of progenitors in other brain regions play

221 fibrosis, suggesting that direct mechanical reprogramming of PSCs may be a viable alternative in the

222 Direct reprogramming of somatic cells has been demonstrated, ho

223 Reprogramming of somatic cells to induced pluripotent st

224 It synergizes with metabolic reprogramming of T cells to achieve superior antitumor e

225 e performed a RNA-Seq study of transcriptome reprogramming of the basidiomycete Hebeloma cylindrospor

226 Germ cell development involves major reprogramming of the epigenome to prime the zygote for t

227 However, intracellular drivers of global reprogramming of the inflammatory gene networks in the i

228 on was not detected in vivo although nuclear reprogramming of the muscle-specific myosin light chain

229 r-supportive environment by inducing a novel reprogramming of the stroma.

230 This translational control culminates in reprogramming of the transcriptome to facilitate parasit

231 etastasis, while switching off the metabolic reprogramming of tumor cells.

232 , maintenance of G-CIMP, and DNA methylation reprogramming outside CGI.

233 l cells and were unable to progress to fully reprogrammed phenotype.

234 broad and general roles for SMAD2/3 as cell-reprogramming potentiators.

235 mming cells and is maintained throughout the reprogramming process and in the resultant stem cells.

236 ch androgen-dependent repression of ERRgamma reprograms prostate cancer cell metabolism to favor mito

237 factors can drive lineage-specific neuronal reprogramming, providing a general platform for high-eff

238 iated depletion of MDSCs promoted macrophage reprogramming, reactivation of T cells, apoptosis of Kra

239 ike particles from endosomal origin that can reprogram recipient cells.

240 proteins, lipids, and nucleic acids that can reprogram recipient cells.

241 emingly minor changes to its variable region reprogram recognition outcomes.

242 Normal differentiation and induced reprogramming require the activation of target cell prog

243 DF-induced metabolic reprogramming required hypoxia inducible factor-1alpha (

244 Myofibroblast reprogramming required neogenic hair follicles, which tr

245 cell to a pluripotent state during cellular reprogramming requires DNA methylation to silence somati

246 MT was more efficient than retroviral-GMT in reprogramming resident cardiac fibroblasts into iCMs in

247 des that altered chromatin states to broadly reprogram responses induced by TLR4.

248 ven though different methods of somatic cell reprogramming result in stem cell lines that are molecul

249 Our results indicate that metabolic reprogramming resulting from LAL deficiency enhances the

250 Tumor suppressor helps reprogram Schwann cells to promote peripheral nerve rege

251 The nanobubbles can also reprogram several hypoxia associated and tumor suppresso

252 tures that distinguish reprogrammed from non-reprogrammed sites, and suggested ways to potentially im

253 Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency.

254 vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripoten

255 patic macrophage infiltration, and metabolic reprogramming, suggesting increased hepatic lipid metabo

256 ggest a therapeutic target in GADD45beta for reprogramming TAM to overcome immunosuppression and T-ce

257 PSCs and will inform clinical development of reprogramming technology.

258 TPE2A constructs resulted in more efficient reprogramming than 3P2A or PTE2A constructs.

259 tablished as key regulators of transcriptome reprogramming that define cell function and identity.

260 , the histone landscape, and transcriptional reprogramming that occur following IDH1 mutation.

261 ritical component of myofibroblast metabolic reprogramming that regulates myofibroblast differentiati

262 models and cell lines reveal transcriptional reprogramming that supports metastasis in response to mT

263 tion, and protein engineering can be used to reprogram the cyclization cascade to generate alternativ

264 How effectors reprogram the cytoskeleton network remains unclear.

265 ISPR-Cas9 systems to successfully modify and reprogram the genome of single live cells, providing the

266 in mutualistic associations, host cells also reprogram the membrane trafficking system to accommodate

267 rate that high-risk HPV oncogenes profoundly reprogram the tumor microenvironment independently of an

268 small molecule, (aminooxy)acetic acid, that reprograms the differentiation of T helper 17 (TH17) cel

269 Improved perfusion alleviates hypoxia, which reprograms the immunosuppressive tumor microenvironment

270 In the most extreme case of functional reprogramming, the S84D mutant displays a dramatic rever

271 entricular inhibited pacing and could not be reprogrammed; the device was subsequently replaced.

272 n either peripheral macrophages or microglia reprograms their phenotype and their pathogenic roles in

273 a stepwise process that also begins early in reprogramming through collaborative binding of OSK at si

274 r ubiquitin-specific protease 26 in cellular reprogramming through polycomb-repressive complex 1.The

275 to-implement non-viral approach to topically reprogram tissues through a nanochannelled device valida

276 onset of heat stress, translation is rapidly reprogrammed to enhance the synthesis of stress mitigato

277 Cs were not changed, they were metabolically reprogrammed to skew allergic inflammation from eosinoph

278 ell activation and signaling-directed (CASD) reprogramming to cardiac progenitors.

279 tions facilitate an efficient direct lineage reprogramming to induced dopamine neurons in vitro and i

280 resulting in increased H4S1ph and epigenetic reprogramming to suppress Slug transcription to inhibit

281 immune cell infiltrate in the tumor could be reprogrammed toward a higher ratio of effector T cells t

282 Metabolic reprogramming toward aerobic glycolysis unavoidably favo

283 ialized immune cells, the need for plants to reprogram transcription to transition from growth-relate

284 Genetic alterations and genomic reprogramming underlie the innate and adaptive resistanc

285 nsight into signaling recovery and molecular reprogramming upon resistance.

286 and plays a key role in the transcriptional reprogramming upon shifts between exponential and statio

287 Moreover, mTORC1 promoted metabolic reprogramming via CDK4 toward increased glycolysis while

288 moved towards the end of the construct while reprogramming was most efficient with the fluorophore at

289 Human cardiac reprogramming was similarly enhanced on transforming gro

290 Epigenetic reprogramming was therefore not sufficient to eliminate

291 jor role in cardiac morphogenesis and direct reprogramming, was dispensable for this process.

292 ection of inducers and repressors of cardiac reprogramming, we discovered that the zinc finger transc

293 Using conditional cell reprogramming, we generated a stable cell culture of an

294 ntify additional regulators of adult cardiac reprogramming, we performed an unbiased screen of transc

295 e epigenome changes during tumorigenesis and reprogramming, we performed integrated epigenetic analys

296 Our method is specific to direct CPC reprogramming, whereas CASD reprogramming can generate v

297 ata demonstrate a positive role of PpCSP1 in reprogramming, which is similar to the function of mamma

298 A translation and concurrent gene expression reprogramming, which permits simultaneous stress sensing

299 t its direct antitumor effects due to kinome reprogramming, which resulted in suppression of proapopt

300 Moreover, ADHFE1 promoted metabolic reprogramming with increased formation of D-2HG and reac