ライフサイエンスコーパス: reprogramming

1 MYC that takes place during or shortly after reprogramming.

2 icant and did not require device revision or reprogramming.

3 PpCSP genes function redundantly in cellular reprogramming.

4 the chromatin changes underlying epigenetic reprogramming.

5 ssion of activation-induced T cell metabolic reprogramming.

6 actor that controls glycolysis and metabolic reprogramming.

7 omatin accessibility at the initial stage of reprogramming.

8 during temporal MeJA-induced transcriptional reprogramming.

9 -1alpha (HIF-1alpha) mediates such metabolic reprogramming.

10 at can be modulated to enhance cardiomyocyte reprogramming.

11 source for studying cell differentiation and reprogramming.

12 accumulation of PpCSP1 protein and enhances reprogramming.

13 ione (GSH), through HIF-1-mediated metabolic reprogramming.

14 ular plasticity and favor oncogenic cellular reprogramming.

15 pha and reversed TGF-beta1-induced metabolic reprogramming.

16 generation were related to in utero somatic reprogramming.

17 nistic target of rapamycin (mTOR) influences reprogramming.

18 nt of NOPE1 function for presymbiotic fungal reprogramming.

19 , that impede gene induction during cellular reprogramming.

20 implications on cancer-associated epigenetic reprogramming.

21 der growth conditions that enable epithelial reprogramming.

22 adversities induce sex-dependent epigenetic reprogramming.

23 or transitions in chromatin structure during reprogramming.

24 ortraits of mutant-IDH1-dependent epigenomic reprogramming.

25 entiation occurs concurrently with metabolic reprogramming.

26 he principal instructing signals for stromal reprogramming.

27 hances endocrine specification during ductal reprogramming.

28 and pluripotency-enhancer selection to drive reprogramming.

29 n infection requires extensive transcription reprogramming.

30 role of TH1 cells in vasculature and immune reprogramming.

31 networks throughout development and cellular reprogramming.

32 sion neutralized the effect of Nudt21 during reprogramming.

33 nduce G-quadruplex-dependent transcriptional reprogramming.

34 ntrol over transcript fate and developmental reprogramming.

35 cale atlas of mutant-IDH1-induced epigenomic reprogramming.

36 opposing influences on fibroblast to cardiac reprogramming.

37 se epigenetic silencing during developmental reprogramming.

38 le regulators during the initiation stage of reprogramming.

39 arly distinct subpopulations of cells during reprogramming.

40 ith active transcription during somatic cell reprogramming.

41 s CBX4 and CBX6 by ubiquitination influences reprogramming.

42 to increase p53 levels and impair stem cell reprogramming.

43 aling activation, and evidence of epigenetic reprogramming.

44 onversely, acts as a barrier to somatic-cell reprogramming.

45 nce dependent in association with epigenetic reprogramming.

46 investigational immunotherapy that involves reprogramming a patient's own T cells with a transgene e

47 ecute a broad range of sensing and automated reprogramming actions for directed therapeutics.Protein-

48 In this context, FOXA1-dependent enhancer reprogramming activates a transcriptional program of emb

49 e demonstrate a tractable approach for fully reprogramming adult mouse endothelial cells to haematopo

50 ls, chromatin organization undergoes drastic reprogramming after fertilization.

51 Clonal expansion via reprogramming also enables the discovery of somatic muta

52 However, unexpectedly, without translation reprogramming an ATF4-high/MITF-low state is insufficien

53 veness, our results suggest that translation reprogramming, an evolutionarily conserved starvation re

54 oves the first cleavage division, epigenetic reprogramming and apoptotic status of bovine preimplanta

55 Comparison of the promoter during reprogramming and differentiation showed tissue-independ

56 enetic roadblock that limits transcriptional reprogramming and efficient nuclear transfer (NT).

57 ferentiated features through transcriptional reprogramming and eventually invading the dermis.

58 omes an early epigenetic barrier in cellular reprogramming and facilitates the generation of more rob

59 al important functions of DDX5 in regulating reprogramming and highlight the importance of a Ddx5-miR

60 antly bind active somatic enhancers early in reprogramming and immediately initiate their inactivatio

61 ce of Smarcb1-Myc-network-driven mesenchymal reprogramming and independence from MAPK signalling.

62 haracterized role for flow-induced metabolic reprogramming and inflammation in ECs.

63 investigate IDH1(R132H)-dependent metabolic reprogramming and its potential to induce biosynthetic l

64 ata highlighted the critical role of CX45 in reprogramming and may increase the cell division rate an

65 gene networks triggering the HIF-1-mediated reprogramming and molecular mechanisms linking the repro

66 olate and infect primary fibroblasts; induce reprogramming and observe iCPC colonies; expand and char

67 mune function, perhaps through the metabolic reprogramming and polarization of macrophages.

68 at define cancer upon the LAM cell-metabolic reprogramming and proliferative signals that drive uncon

69 gatekeeper PDK1 has a critical role in BCSC reprogramming and provides a potential therapeutic strat

70 45 expression significantly blocked cellular reprogramming and reduced the efficiency.

71 to LAM pathology, and demonstrated that iPSC reprogramming and SMC lineage differentiation of somatic

72 matin remodeling occurring during epigenetic reprogramming and that they may be key players in the ac

73 cular organismal transition requires nuclear reprogramming and the initiation of RNAPII at thousands

74 ar plasticity in the context of somatic cell reprogramming and tumorigenesis.

75 ies a number of TFs previously validated for reprogramming and/or natural differentiation and predict

76 host immune responses, peripheral metabolic reprogramming, and different rates of mortality.

77 on, namely, neutrophil apoptosis, macrophage reprogramming, and efferocytosis, which have a major imp

78 , Rif1 acts as a barrier during somatic cell reprogramming, and its depletion significantly enhances

79 n of immune response, tumor microenvironment reprogramming, and metastasis.

80 ence of immune activation is transcriptional reprogramming, and some NLRs have been shown to act in t

81 t RICD susceptibility is linked to metabolic reprogramming, and that switching back to metabolic quie

82 c and metabolic transitions, i.e., metabolic reprogramming; and (4) inhibition of lipid biosynthetic

83 etabolism, the roles of RBPs in somatic cell reprogramming are poorly understood.

84 rstanding the molecular mechanism underlying reprogramming are still required.

85 or tissue regeneration, implicating cellular reprogramming as an essential element.

86 Using direct cardiac reprogramming as an example, we further determined the e

87 e of transcription factors (TFs) in cellular reprogramming, based on a device commonly used in optima

88 This reprogramming begins with a loss of SOX10-mediated diffe

89 nfluence of inflammatory pathways on cardiac reprogramming, blockade of these pathways with anti-infl

90 lyze cellular de-differentiation and nuclear reprogramming by acting at the cell surface.

91 iquitin-proteasome system regulates cellular reprogramming by degradation of key pluripotency factors

92 In vivo dopaminergic neuron reprogramming by EMF stimulation of AuNPs efficiently an

93 creatic cancer involves large-scale enhancer reprogramming by Foxa1, which activates transcriptional

94 tor 281 (ZNF281) potently stimulates cardiac reprogramming by genome-wide association with GATA4 on c

95 stem (ES) to trophoblast stem (TS)-like cell reprogramming by introducing individual TS cell-specific

96 e3 is essential for the induction of cardiac reprogramming by miR combo.

97 s for resistance of genes to transcriptional reprogramming by oocyte factors.

98 2b, a histone demethylase gene that promotes reprogramming by reactivating endogenous pluripotency ge

99 em cells (PSCs) can be generated via nuclear reprogramming by transcription factors (i.e., induced pl

100 sis, that captive rearing induces epigenetic reprogramming, by comparing genome-wide patterns of meth

101 CL cells and TME, leading to kinome adaptive reprogramming, bypassing the effect of ibrutinib and rec

102 Direct reprogramming can be achieved by forced expression of ma

103 ic to direct CPC reprogramming, whereas CASD reprogramming can generate various cell types depending

104 lated in quiescent cells and that epigenetic reprogramming can improve outcomes in glomerular disease

105 Building upon the unique chemical reprogramming capability of the Nafion shape memory poly

106 PpCSP1 accumulates in the reprogramming cells and is maintained throughout the rep

107 ate' could potentially provide insights into reprogramming cells to a state of totipotency.

108 ng constitutive and inducible regulators, to reprogramming cellular phenotypes and controlling multig

109 ocesses: sensory initiation, transcriptional reprogramming, cellular protein component change, and ce

110 edly enhances three other TF-mediated direct reprogramming conversions, from B cells to macrophages,

111 This protocol describes conditional reprogramming (CR), which involves coculture of irradiat

112 o establish tumor cell cultures, conditional reprogramming (CR), with a rapid, reproducible and robus

113 e nucleus initiate a massive transcriptional reprogramming critical to mount an appropriate host defe

114 gy field clearly demonstrates that metabolic reprogramming defines immune cell functionality.

115 th mitotic chromatin in ESCs and during iPSC reprogramming, demonstrating the importance of mitotic b

116 r findings show how LSD1-mediated epigenetic reprogramming drives CRPC, and they offer a mechanistic

117 cription factor target gene in transcriptome reprogramming during Heterodera cyst nematode parasitism

118 unexpected role in metabolic integration and reprogramming during inflammatory T cell responses.

119 olecular mechanism, for global translational reprogramming during pattern-triggered immunity in plant

120 g indicates that genome-wide DNA methylation reprogramming during preimplantation development is a dy

121 However, whether developmental methylation reprogramming during the sporophytic life cycle of flowe

122 While metabolic reprogramming during Treg cell differentiation has been

123 31542 and the WNT inhibitor XAV939 increased reprogramming efficiency 8-fold when added to GMT-overex

124 Reprogramming efficiency in vitro is improved by small m

125 The reprogramming efficiency of human astrocytes reaches up

126 xpression of CX45 significantly enhanced the reprogramming efficiency together with the Yamanaka fact

127 Somatic and pluripotency TFs modulate reprogramming efficiency when overexpressed by altering

128 ng, and its depletion significantly enhances reprogramming efficiency.

129 While these genomic reprogramming events depend on a specialized network of

130 f-care combination therapy, suggesting these reprogramming events were not specific to MEKi alone.

131 l for understanding important topics such as reprogramming, evolution, and disease.

132 Metabolic energy reprogramming facilitates adaptations to a variety of st

133 verall, we demonstrate that FOSL1 is a novel reprogramming factor for melanocytes with potent tumor t

134 endai virus (SeV) vectors expressing cardiac reprogramming factors efficiently and rapidly reprogram

135 ation of binding motifs for the Sertoli cell reprogramming factors SOX9, GATA4 and DMRT1.

136 s exhibit increased expression of epigenetic reprogramming factors such as Ezh2 and Sox2.

137 Collectively, our study implicates enhancer reprogramming, FOXA1 upregulation, and a retrograde deve

138 ic infections and cancer trigger a metabolic reprogramming from the preferential use of glucose to th

139 To test the role of nuclear surveillance in reprogramming gene expression, we identified transcripto

140 ctive ER protein-folding environment through reprogramming gene transcription and mRNA translation.

141 ave revealed an oncogenic function of YAP in reprogramming glucose metabolism, while the underlying m

142 Although this reprogramming has been associated with the antioxidant a

143 ntroduced nonmuscle nuclei undergoes nuclear reprogramming has not been investigated.

144 In vivo cell reprogramming has the potential to enable more-effective

145 potent stem cells (iPSCs) and direct somatic reprogramming, have shown enormous potential for cell-ba

146 Direct cardiac reprogramming holds great promise for regenerative medic

147 sponses in leukemic and host CD4(+) T cells, reprogramming host T cells toward normalcy.

148 Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechan

149 ferentiation but can undergo transcriptional reprogramming in a bidirectional manner between protecti

150 Metabolic reprogramming in brain tumors is also influenced by the

151 Metabolic reprogramming in breast tumors is linked to increases in

152 However, epigenetic reprogramming in cancer often involves gene body hypomet

153 MYC promotes metabolic reprogramming in cancer, but targeting MYC has proven no

154 anscriptional activity, undergoes epigenetic reprogramming in CRPC.

155 contributes to resistance to transcriptional reprogramming in mouse nuclear transfer embryos.

156 uring the initiation and maturation stage of reprogramming in partially and fully reprogrammed cells

157 However, the extent of DNA methylation reprogramming in plants remains unclear.

158 e-dimensional structure of chromatin and its reprogramming in preimplantation development remain poor

159 te initial inhibitor response and subsequent reprogramming in resistance.

160 PRC2 is required for chromatin reprogramming in the germline, and the transcriptome of

161 acute transposon activity during epigenetic reprogramming in the mammalian germline.

162 The addition of drug then induces epigenetic reprogramming in these cells, converting the transient t

163 in differentiated SMCs is essential for SMC reprogramming in vivo, whereas in vitro approaches demon

164 ssion, suggesting that DF leads to metabolic reprogramming in vivo.

165 a sequential, two-step mechanism of cellular reprogramming in which repression of pre-existing ES cel

166 types through UCHL1-HIF-1-mediated metabolic reprogramming including the activation of PPP and provid

167 sely related PpCSP genes exhibits attenuated reprogramming indicating that the PpCSP genes function r

168 ere is limited knowledge about the metabolic reprogramming induced by cancer therapies and how this c

169 the underlying mechanism for gene expression reprogramming induced by persistent DNA damage remains p

170 To identify modulators of reprogramming-induced senescence, we performed a genome-

171 ic variations detected in iPSCs-whether iPSC reprogramming induces such variations.

172 Mitochondrial activity and metabolic reprogramming influence the phenotype of cancer cells an

173 bute to reinforce antibacterial responses by reprogramming innate and adaptive immune mechanisms.

174 ial transition is requisite to initiate SMCs reprogramming into vascular progenitors and that members

175 Metabolic reprogramming is a hallmark of cancer.

176 Reprogramming is a slow and inefficient process, suggest

177 Reprogramming is a stepwise process with well-defined st

178 Metabolic reprogramming is an emerging hallmark of pancreatic aden

179 Metabolic reprogramming is central to tumorigenesis, but whether c

180 Transcriptional reprogramming is essential for TB pathogenesis.

181 One potential mediator of long-term cellular reprogramming is heritable (epigenetic) regulation of tr

182 imprinting control regions escape from this reprogramming is largely unknown.

183 Transcriptional reprogramming leading to higher TAG content is balanced

184 in stemness, direct differentiation, promote reprogramming, manipulate the genome, or select function

185 nsion of the complex process of somatic cell reprogramming, many questions regarding the molecular me

186 to the genetic compositions rather than the reprogramming mechanisms (SCNT vs. iPSCs).

187 differentiated cells generated by different reprogramming mechanisms have yet to be evaluated.

188 n in the four chemical inhibitors (4i)-naive reprogramming medium and showed transcriptional consiste

189 Existing reprogramming methodologies, however, are fraught with c

190 eed for safer and more deterministic in vivo reprogramming methods.

191 and validated models of these mechanisms by reprogramming microglia-like cells from peripheral blood

192 Translation reprogramming mitigates stress by activating pathways th

193 egatively regulates macrophage activation by reprogramming mitochondrial pyruvate metabolism.

194 ed with well-established and newly developed reprogramming models of induced neurons and endothelium,

195 This metabolic reprogramming not only promotes cancer cell plasticity,

196 UCHL1 overexpression induced the reprogramming of carbohydrate metabolism and increased N

197 Reprogramming of cardiac fibroblasts into induced cardio

198 s a SIRT1 target involved in transcriptional reprogramming of CD8(+)CD28(-) T cells.

199 Reprogramming of cellular identity using exogenous expre

200 Here we report large-scale reprogramming of chromatin modifications during the natu

201 The reprogramming of differentiated cells into induced pluri

202 marks in sperm, with a primary focus on the reprogramming of DNA methylation, histone posttranslatio

203 KSHV lytic replication induces dynamic reprogramming of epitranscriptome, regulating pathways t

204 d that TOR not only dictates transcriptional reprogramming of extensive gene sets involved in central

205 Direct reprogramming of fibroblasts to cardiomyocytes represent

206 tically, and demonstrate its application for reprogramming of fibroblasts to prostate tissue.

207 karyotes, S. cerevisiae undergoes a dramatic reprogramming of gene expression during meiosis, includi

208 to engage in DNA binding, triggering a major reprogramming of gene expression that includes component

209 N (NLP) transcription factors to specify the reprogramming of gene sets for downstream transcription

210 ive and exclusively phosphorylation-mediated reprogramming of glycolytic activity, supported addition

211 The reprogramming of hemoglobin expression was achieved at t

212 on by macrophages, thereby indicating global reprogramming of host kinase signaling.

213 ular monosaccharides through transcriptional reprogramming of host sugar transporter genes and activa

214 inst PDA and was associated with immunogenic reprogramming of innate and adaptive immunity within the

215 changes in Egr1, and sex-specific epigenetic reprogramming of its effector gene, Npy1r, represents th

216 We demonstrate that partial direct reprogramming of mesoderm-derived cardiomyocytes into ne

217 velopmental events and leading to sequential reprogramming of metabolic and developmental genes.

218 n in lipid contents of human hepatocytes and reprogramming of metabolic signatures, which are mediate

219 e either Sox2 and Myc (c-Myc) or Oct4 during reprogramming of mouse embryonic fibroblasts into iPSCs.

220 scriptome changes at early stages during the reprogramming of mouse fibroblasts into induced cardiomy

221 Here, by studying the reprogramming of mouse fibroblasts to neurons, we found

222 Although regeneration through the reprogramming of one cell lineage to another occurs in f

223 level vancomycin resistance mediated by the reprogramming of peptidoglycan biosynthesis to use precu

224 ould otherwise interfere with PRC2-dependent reprogramming of PGC chromatin.

225 r-infiltrating myeloid cells and, therefore, reprogramming of PGE2 metabolism in tumor microenvironme

226 of various reported gene knockdowns, and the reprogramming of pre-B cells into macrophages induced by

227 n the cerebellum and speculate that adaptive reprogramming of progenitors in other brain regions play

228 fibrosis, suggesting that direct mechanical reprogramming of PSCs may be a viable alternative in the

229 Direct reprogramming of somatic cells has been demonstrated, ho

230 Vertebrate eggs can induce the nuclear reprogramming of somatic cells to enable production of c

231 Reprogramming of somatic cells to induced pluripotent st

232 It synergizes with metabolic reprogramming of T cells to achieve superior antitumor e

233 e performed a RNA-Seq study of transcriptome reprogramming of the basidiomycete Hebeloma cylindrospor

234 Germ cell development involves major reprogramming of the epigenome to prime the zygote for t

235 However, intracellular drivers of global reprogramming of the inflammatory gene networks in the i

236 2 and suggest a process of adaptive cellular reprogramming of the intestinal epithelium that occurs t

237 on was not detected in vivo although nuclear reprogramming of the muscle-specific myosin light chain

238 r-supportive environment by inducing a novel reprogramming of the stroma.

239 This translational control culminates in reprogramming of the transcriptome to facilitate parasit

240 etastasis, while switching off the metabolic reprogramming of tumor cells.

241 , maintenance of G-CIMP, and DNA methylation reprogramming outside CGI.

242 broad and general roles for SMAD2/3 as cell-reprogramming potentiators.

243 ination of transcriptional and translational reprogramming prevents ER dysfunction and inhibits "foam

244 in medical research is hampered by laborious reprogramming procedures that yield low numbers of induc

245 mming cells and is maintained throughout the reprogramming process and in the resultant stem cells.

246 Moreover, after determining the reprogramming process and iPSC colony formation quantita

247 rotease 26 negatively regulates somatic cell-reprogramming process by stabilizing chromobox (CBX)-con

248 CX45 was dramatically upregulated during the reprogramming process.

249 factors can drive lineage-specific neuronal reprogramming, providing a general platform for high-eff

250 iated depletion of MDSCs promoted macrophage reprogramming, reactivation of T cells, apoptosis of Kra

251 Normal differentiation and induced reprogramming require the activation of target cell prog

252 DF-induced metabolic reprogramming required hypoxia inducible factor-1alpha (

253 Myofibroblast reprogramming required neogenic hair follicles, which tr

254 cell to a pluripotent state during cellular reprogramming requires DNA methylation to silence somati

255 MT was more efficient than retroviral-GMT in reprogramming resident cardiac fibroblasts into iCMs in

256 ven though different methods of somatic cell reprogramming result in stem cell lines that are molecul

257 Our results indicate that metabolic reprogramming resulting from LAL deficiency enhances the

258 vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripoten

259 To date, reprogramming strategies for generating cell types of in

260 patic macrophage infiltration, and metabolic reprogramming, suggesting increased hepatic lipid metabo

261 ggest a therapeutic target in GADD45beta for reprogramming TAM to overcome immunosuppression and T-ce

262 PSCs and will inform clinical development of reprogramming technology.

263 TPE2A constructs resulted in more efficient reprogramming than 3P2A or PTE2A constructs.

264 tablished as key regulators of transcriptome reprogramming that define cell function and identity.

265 ress described in PE, as well as endothelial reprogramming that may underlay the increased risk of ca

266 , the histone landscape, and transcriptional reprogramming that occur following IDH1 mutation.

267 ritical component of myofibroblast metabolic reprogramming that regulates myofibroblast differentiati

268 models and cell lines reveal transcriptional reprogramming that supports metastasis in response to mT

269 In the most extreme case of functional reprogramming, the S84D mutant displays a dramatic rever

270 rs and present a domain swapping approach to reprogramming these enzymes for peptides with altered le

271 a stepwise process that also begins early in reprogramming through collaborative binding of OSK at si

272 r ubiquitin-specific protease 26 in cellular reprogramming through polycomb-repressive complex 1.The

273 iven by advances in genome editing, cellular reprogramming, tissue engineering, and information techn

274 ell activation and signaling-directed (CASD) reprogramming to cardiac progenitors.

275 tions facilitate an efficient direct lineage reprogramming to induced dopamine neurons in vitro and i

276 ain novel insights in two complex processes: reprogramming to induced pluripotent stem cells (iPSCs)

277 We show that during reprogramming to induced pluripotent stem cells (iPSCs),

278 resulting in increased H4S1ph and epigenetic reprogramming to suppress Slug transcription to inhibit

279 Metabolic reprogramming toward aerobic glycolysis unavoidably favo

280 enerated a robust human cell model of LAM by reprogramming TSC2 mutation-bearing fibroblasts from a p

281 Genetic alterations and genomic reprogramming underlie the innate and adaptive resistanc

282 rplay between mTORC1 signaling and metabolic reprogramming underlies M-CSF-induced myelopoiesis.

283 ents did not reproduce the hallmarks of this reprogramming, underscoring that rewiring, rather than a

284 nsight into signaling recovery and molecular reprogramming upon resistance.

285 and plays a key role in the transcriptional reprogramming upon shifts between exponential and statio

286 Moreover, mTORC1 promoted metabolic reprogramming via CDK4 toward increased glycolysis while

287 moved towards the end of the construct while reprogramming was most efficient with the fluorophore at

288 Human cardiac reprogramming was similarly enhanced on transforming gro

289 Epigenetic reprogramming was therefore not sufficient to eliminate

290 jor role in cardiac morphogenesis and direct reprogramming, was dispensable for this process.

291 ection of inducers and repressors of cardiac reprogramming, we discovered that the zinc finger transc

292 Using conditional cell reprogramming, we generated a stable cell culture of an

293 ntify additional regulators of adult cardiac reprogramming, we performed an unbiased screen of transc

294 e epigenome changes during tumorigenesis and reprogramming, we performed integrated epigenetic analys

295 Our method is specific to direct CPC reprogramming, whereas CASD reprogramming can generate v

296 ata demonstrate a positive role of PpCSP1 in reprogramming, which is similar to the function of mamma

297 A translation and concurrent gene expression reprogramming, which permits simultaneous stress sensing

298 t its direct antitumor effects due to kinome reprogramming, which resulted in suppression of proapopt

299 Moreover, ADHFE1 promoted metabolic reprogramming with increased formation of D-2HG and reac

300 ramming and molecular mechanisms linking the reprogramming with radioresistance remain to be determin