ライフサイエンスコーパス: repurpose

1 t for 209,168 compound-disease pairs (het.io/repurpose).

2 yle to character data that can be reused and repurposed.

3 o which paralogous proteins are functionally repurposed.

4 e being evaluated, and older drugs are being repurposed.

5 gs, and providing new opportunities for drug repurposing.

6 e need for improved cancer treatment is drug repurposing.

7 net reveals as many as 18,145 candidates for repurposing.

8 oved drug, is a promising candidate for drug repurposing.

9 be targeted by specific therapies) and drug repurposing.

10 r both novel disease gene discovery and drug repurposing.

11 compound MoA and potential insights for drug repurposing.

12 Here we repurpose a high-throughput sequencing instrument to qua

13 ample of how a simple synaptic mechanism can repurpose a neural circuit to perform diverse computatio

14 om organisms that lack sequenced genomes, we repurposed a maximum likelihood-based Evolutionary Place

15 ature centrifuge force microscope (CFM) that repurposes a benchtop centrifuge for high-throughput sin

16 Repurposing already-approved drugs with well-characteriz

17 clinical study demonstrates the potential of repurposing amlexanox for the treatment of patients with

18 Here, we repurpose an endogenous protein degradation system to ra

19 Thus, we have successfully repurposed an agrochemical for a new application using r

20 demonstrates that two Asticcacaulis species repurposed an ancestral regulatory protein to rewire the

21 This change revealed and repurposed an ancient molecular surface that previously

22 One hypothesis is that the brain repurposed an available neurobiological mechanism when h

23 Bioinformatics drug repurposing analyses with the gene expression biosignatu

24 ature, which was used for computational drug repurposing analysis.

25 h content is usually not so easy to reuse or repurpose and does not capture all the information requi

26 nformatics-driven discovery roadmap for drug repurposing and development in overcoming resistance in

27 lated to polypharmacology of drugs including repurposing and explaining side effects of drugs.

28 t offer unprecedented opportunities for drug repurposing and the detection of adverse effects.

29 ne expressions with drugs/compounds for drug repurposing and translational research.

30 t ancestral mechanisms are often duplicated, repurposed, and differentially regulated to support soci

31 ing from off-target effects, comment on drug repurposing, and introduce approaches to the computation

32 t augur a new era of novel drug development, repurposing, and stratification in the management of hyp

33 tasks, including virtual screening, compound repurposing, and the detection of potential off-targets.

34 Here, we investigate the possibility of repurposing antibiotic monensin as an anti-ovarian cance

35 We also describe how repurposing anticoagulation clinics as broader medicatio

36 Several new or repurposed antimicrobial drugs are in advanced trial sta

37 drug-development pipeline (including new and repurposed antimicrobials and host-directed drugs) as th

38 Such a repurposing approach has also been pursued for dengue th

39 This in-silico drug repurposing approach suggested several compounds that re

40 By using an "in silico drug repurposing" approach and by validating our predictions

41 Following a "drug repurposing" approach, we tested anti-trypanosomal effec

42 Further cancer drug repurposing approaches reveal that NVP-AUY922 downregula

43 Delamanid has the potential to be repurposed as a much-needed oral therapy for VL.

44 that auranofin has significant promise to be repurposed as a novel antibacterial for treatment of inv

45 proved to treat renal hypertension, could be repurposed as a novel therapeutic agent for patients wit

46 ered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby

47 other conditions, it has the potential to be repurposed as a preventative agent for postsurgical lymp

48 at GlyT1 inhibitors have the potential to be repurposed as a treatment of both obesity and diabetes.

49 d a homologous but noncatalytic chain, Trm6, repurposed as a tRNA-binding subunit that acts in trans;

50 Our results suggest monensin may be repurposed as an anti-ovarian cancer agent although furt

51 trate that glipizide has the potential to be repurposed as an effective therapeutic for the treatment

52 treatments, also have great potential to be repurposed as antibiotics so that an old drug can learn

53 with decades of safe use - could be rapidly repurposed as cancer therapeutics.

54 FDA-approved drugs that could potentially be repurposed as H7N9 influenza therapeutics.

55 e data suggest that fenamate NSAIDs could be repurposed as NLRP3 inflammasome inhibitors and Alzheime

56 edicted that seven FDA-approved drugs can be repurposed as novel anti-cancer therapies.

57 r, TE-derived proteins have been recurrently repurposed as part of defense systems that protect proka

58 rom viral infection and have been creatively repurposed as programmable molecular scalpels for surgic

59 sion inhibitors that merit consideration for repurposing as a cost-effective component of HCV combina

60 utputs help to develop hypotheses about drug repurposing as well as potential side effects.

61 Moreover, we repurposed AsCpf1 and LbCpf1 for efficient transcription

62 ngs demonstrate an unexpected opportunity to repurpose axitinib, an anti-angiogenic drug approved for

63 athways within living cells so as to realize repurposed, beneficial applications.

64 Drug repurposing bioinformatics analyses identified the relat

65 interactions driving multiple reactions are repurposed by a major E3 conformational change to promot

66 Our data identify GA as an attractive drug repurposing candidate to treat infections with Gram-nega

67 y, suggesting they will help prioritize drug repurposing candidates.

68 ally differentiated, non-cycling neutrophils repurpose cell-cycle proteins and pathways to form NETs.

69 Repurposing cell-based manufactured products to promote

70 des genetic signatures that may be useful in repurposing cIAP1-targeted therapies to correct NOD2-hyp

71 s in an AD transgenic model, suggesting that repurposing clinical alpha(2A)R antagonists would be an

72 This provides mechanistic groundwork for repurposing clinically approved JAK1/JAK2 inhibitors for

73 A repurposed compound has been advanced to human clinical

74 ranial convection-enhanced delivery and (ii) repurposed compounds, previously used in Food and Drug A

75 uidelines, many more could benefit from drug repurposing, considering compounds at various stages of

76 nd development of new drugs, a focus on drug repurposing could alleviate this problem by repositionin

77 Overall, drug repurposing could become increasingly important as a way

78 The repurposed CRISPR-Cas9 system has recently emerged as a

79 The repurposed device also successfully identified positive

80 Such SRPs have the potential to be repurposed directly without going through material dispo

81 Here we highlight the potential for repurposing disulfiram (also known by the trade name Ant

82 ethod termed "drug-protein interaction-based repurposing" (DPIR) that is potentially applicable to di

83 range of adjunct host-directed cellular and repurposed drug therapies.

84 th an existing drug, pyrazinamide (Z), and a repurposed drug, clofazimine (C), may assist treatment s

85 In an effort to repurpose drugs for RVFV treatment, our previous studies

86 d surgical management, the role of newer and repurposed drugs (including bedaquiline, delamanid, and

87 In this paper, we review both repurposed drugs and small-molecule compounds discovered

88 Advances in new and repurposed drugs for use in multidrug-resistant (MDR) or

89 therapeutic efforts have focused on testing repurposed drugs such as phenylbutyrate (2), valproic ac

90 Novel drug classes, repurposed drugs, and host-directed therapies are review

91 rates anti-metastatic activities of multiple repurposed drugs, blocking a self-reinforcing paracrine

92 targeted by Federal-Drug-Agency-approved but repurposed drugs, providing starting points for anti-onc

93 Repurposing drugs can lead to timely availability of new

94 pment in kidney transplantation necessitated repurposing drugs initially developed in oncology and au

95 ars as the first metal efflux pump regulator repurposed during infection to fine-tune lipoprotein pro

96 s, case reports, and clinical trials of drug repurposing efficacy in allergic disease are reviewed.

97 ses renewed opportunities to discover new or repurpose existing compounds and expedite treatment opti

98 drug actions, which can open up channels to repurpose existing drugs and identify rare adverse drug

99 The potential to repurpose existing drugs is a high-gain strategy for yie

100 to predict new drug-target interactions and repurpose existing drugs.Network-based data integration

101 ells is applicable to thousands of genes and repurposes existing IKMC Intermediate Vectors.

102 This has prompted studies in repurposing existing drugs for use against diseases with

103 Repurposing existing drugs presents an alternative strat

104 The feasibility of repurposing existing drugs to face novel threats is demo

105 translation, we explored the feasibility of repurposing existing optical imaging devices for fluores

106 These adaptations include repurposing existing proteins to diversify endocytosis a

107 s (TB) and multi-drug resistant TB (MDR-TB), repurposing FDA (U.S. Food and Drug Administration) -app

108 ministration-approved small-molecule drug to repurpose for CLL treatment.

109 une system, CRISPR-Cas9 has been coopted and repurposed for a variety of new functions, including the

110 triggered by a hot, dry environment and was repurposed for aposematism by high-elevation crown-group

111 cal defenses, too toxic to sequester, can be repurposed for defensive functions through respiration a

112 Here we show that human APC's RING domain is repurposed for dual functions in polyubiquitination.

113 eptococcus pyogenes (SpCas9) has been widely repurposed for genome editing.

114 The bacterial CRISPR-Cas9 system has been repurposed for genome engineering, transcription modulat

115 s9 and Cas12a (Cpf1), have been successfully repurposed for genome engineering.

116 code chemokines, copied from their hosts and repurposed for multiple functions, including immune evas

117 nd flexibility for genome editing and can be repurposed for numerous DNA targeting applications inclu

118 broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellula

119 t such a photosensitiser, chlorin e6, can be repurposed for PCI by conjugating the chlorin to a cell

120 modules, suggesting this structure has been repurposed for RNA interactions.

121 Finally, we speculate that, if repurposed for the problem of neural systems identificat

122 therapeutic strategy that can potentially be repurposed for the treatment of FA.

123 drugs approved for other indications may be repurposed for the treatment of RA.

124 conditions, such as cancer, may possibly be repurposed for treating heterotopic ossification and oth

125 ablished safety records could potentially be repurposed for treatment of this lethal disease.

126 SR, or other angiogenesis inhibitors, can be repurposed for TSP1 replacement therapy for CCMs.

127 mic repeats (CRISPR) loci have recently been repurposed for use in mammalian cells.

128 , and this autophagy-enhancing action may be repurposed for use in novel clinical indications.

129 ith a diversity of Cas nucleases that can be repurposed for various applications.

130 em; its biological characterization; and its repurposing for genome engineering--remains little known

131 g that PPS is a promising candidate for drug repurposing for the treatment of alphavirus-induced arth

132 clinical indications, they are now ready for repurposing for tuberculosis in phase 2 clinical trials.

133 Genomics-based drug repurposing (GBR) offers the potential of savings in the

134 his assay could readily be incorporated into repurposed glucose meters to rapidly detect glycosidases

135 Tacrolimus repurposing has therefore therapeutic potential in HHT.

136 ons and establish a proof of principle for a repurposed, host-targeted approach to combat emerging vi

137 classification can be used to generate drug repurposing hypotheses, using Alzheimers disease as a us

138 st that homologs of bacterial MscS have been repurposed in eukaryotes to function as mechanosensors i

139 ilin, showing once again how proteins can be repurposed in evolution for different functions.

140 ami receptor (the T1R1-T1R3 heterodimer) was repurposed in hummingbirds to function as a carbohydrate

141 d illustrate how the cell cycle regulator is repurposed in post-mitotic cells.

142 We find that OSTN has been repurposed in primates through the evolutionary acquisit

143 aterial commonly called "bubble wrap" can be repurposed in resource-limited regions as containers to

144 ring of well-characterized materials for the repurposing in applications of flexible and stretchable

145 tidiabetic drug currently being explored for repurposing in cancer treatment based on recent evidence

146 indings suggest that NRTIs are ripe for drug repurposing in P2X7-driven diseases.

147 quencing has been extensively and creatively repurposed, including as a 'counter' for a vast range of

148 e association results in psychiatry for drug repurposing is an ongoing challenge.

149 that has been relatively neglected for drug repurposing is animal model phenotype.

150 Moreover, as drug repurposing is becoming an attractive drug discovery app

151 Their repurposing is currently being proposed to treat certain

152 Drug repurposing is the application of approved drugs to trea

153 in prokaryotes for docking tRNA and instead repurposes it to form a dimer interface presenting a DNA

154 We applied this model to repurpose known or shelved drugs for brain, lung, and bo

155 th their toxicity and safety profiles, while repurposing known drugs for new anticancer indications h

156 l ATP synthase disorders, we screened a drug repurposing library, and applied genomic and biochemical

157 e of the new (delamanid and bedaquiline) and repurposed (linezolid and clofazimine) MDR-TB drugs and

158 olescents have limited access to the new and repurposed MDR-TB drugs.

159 I will also discuss some future direction on repurposing mechanosensitive channel for mechanical actu

160 key mechanistic insights that may facilitate repurposing meclizine for disorders of energy metabolism

161 reatments for vitiligo, and first considered repurposed medications because of the availability of sa

162 To repurpose metformin as a precision anti-cancer therapy,

163 This study will shed new light into repurposing metformin for safe, effective, personalized

164 d provide a preclinical proof of concept for repurposing mibefradil as a mechanism-based treatment st

165 cur upon activation of macrophages therefore repurpose mitochondria from ATP synthesis to ROS product

166 We have repurposed (N)-methanocarba adenosine derivatives (A3 ad

167 ed association-mapping platform (CHAMP) that repurposes next-generation sequencing chips to simultane

168 used G protein-coupled receptor modeling to repurpose nucleoside scaffolds in favor of binding at no

169 Finally, through repurposing of a clinically used drug, we illustrate the

170 at the tRNA import pathway resulted from the repurposing of a preexisting protein import apparatus.

171 Herein we report the repurposing of a thiazole/oxazole-modified microcin (TOM

172 In addition to the remarkable functional repurposing of adenosylcobalamin from an enzyme cofactor

173 ent need for ZIKV prophylaxis and treatment, repurposing of approved drugs appears to be a viable and

174 is type of study is an important step in the repurposing of approved drugs for treatment of emerging

175 rdiac magnetic resonance imaging and cardiac repurposing of bone scintigraphy tracers.

176 We document a repurposing of cellular ubiquitin during infection to sw

177 We conclude that the repurposing of chemotherapeutics in osteosarcoma by usin

178 Our findings demonstrate a functional repurposing of components of TRRs and NFkappaB signaling

179 utionary innovation and loss with widespread repurposing of conserved DHSs to alternative cell fates,

180 offer a mechanistic rationale to explore the repurposing of drugs that target angiotensin action to i

181 ovide a mechanistic rationale to explore the repurposing of drugs that target angiotensin II-dependen

182 with the development of novel drug targets, repurposing of drugs with known and validated targets ma

183 rolled by VprBP and highlight the functional repurposing of E3 ligase substrate receptors independent

184 ell protein kinase profiling will facilitate repurposing of existing anti-cancer drugs and identifica

185 lcitonin, and teriparatide) or opportunistic repurposing of existing compounds (eg, bisphosphonates)

186 Therefore, repurposing of existing drugs with EPI activity could be

187 The repurposing of existing non-cancer drugs is a potential

188 Finally, we discuss targeted repurposing of existing therapies and review promising n

189 Recoding--the repurposing of genetic codons--is a powerful strategy fo

190 eptors in mucocyst biogenesis, suggests that repurposing of lysosomal enzymes was an important step i

191 Drug repurposing of non-cancer drugs represents an attractive

192 ed on the above observations we believe that repurposing of NTZ for PD may offer therapeutic benefit.

193 Repurposing of old drugs for new clinical applications i

194 a promising pipeline is emerging through the repurposing of old drugs, re-engineering of existing ant

195 We describe the successful clinical repurposing of PDE4 inhibitors in B-cell malignancies, a

196 , but also provide guidance on the potential repurposing of pharmacological agents that may improve L

197 ower reference value combined with increased repurposing of postindustrial lands are heightening conc

198 The repurposing of the bacterial CRISPR/Cas9 system provides

199 (ALK) catalytic domains led to the clinical repurposing of the Food and Drug Administration (FDA)-ap

200 s are not typically recycled, a need for the repurposing of the PC waste has arisen.

201 rglycemic injury and raises the potential of repurposing of this drug for the experimental therapy of

202 an pathogenic fungi establish NSC319726 as a repurposed, off-patent compound that has potential antif

203 libraries of clinical molecules in order to repurpose old drugs for new applications (as antimicrobi

204 t the power of MoA-profiling technologies in repurposing old drugs for new targets.

205 Repurposing "old" drugs can facilitate rapid clinical tr

206 ics and calcium channel blockers may provide repurposing opportunities.

207 he potential side effects of drugs and their repurposing options.

208 nome of S. haematobium and should assist the repurposing or discovery of drugs against schistosomiasi

209 rompt further preclinical investigation into repurposing penfluridol for the treatment of metastatic

210 toolbox for drug target identification, drug repurposing, phenotypic screening, and side effect predi

211 C. crescentus thus repurposes pilus retraction, typically used for surface

212 These findings together suggest that repurposing pioglitazone could potentially enhance the p

213 We envision repurposing poly(BPA carbonate) for the production of va

214 ach for prioritizing FDA-approved drugs with repurposing potential, which could aid the development o

215 res for prioritizing FDA-approved drugs with repurposing potential.

216 first step, anodic oxidation in MeOH using a repurposed power source provides a convenient route to l

217 ts of this study highlight the potential for repurposing probiotics for the therapy of osteoporosis.

218 se observations, we propose a mechanism that repurposes protein channel architecture for active trans

219 Nature repurposes proteins via evolutionary processes.

220 Drug repurposing provides a potentially efficient solution to

221 perties of enzyme function, promiscuity, and repurposing provides lessons for engineering new enzymes

222 Computation-based drug-repurposing/repositioning approaches can greatly speed u

223 Our results show that the retinal circuitry repurposes rods, when they are not directly sensing ligh

224 neurological conditions, we performed a drug repurposing screen of approximately 6,000 compounds that

225 In a drug repurposing screen targeting CYP2J2, the human ortholog

226 In this study, we performed a novel drug-repurposing screening to identify Food and Drug Administ

227 Two recent drug repurposing screens identified ITZ as a promising antica

228 the foundation for further investigation of repurposing simvastatin as a topical antibacterial agent

229 important potential to help identify new and repurposed small molecules that alter p53 sumoylation, a

230 Components of neural circuits are often repurposed so that the same biological hardware can be u

231 In light of these findings, we propose that repurposing statin drugs for topical treatment of DFUs m

232 drug repurposing, the implementation of drug repurposing still faces important financial and regulato

233 e context of clinical trials to develop drug repurposing strategies for patients with urgent medical

234 By using a "drug repurposing" strategy, histone deacetylase inhibitors (H

235 n attractive drug discovery approach, recent repurposing studies of chromone-based drugs are also rep

236 izes the constraint of overlapping genes and repurposes that constraint to its own advantage.

237 HCMV is known to repurpose the interferon-stimulated genes (ISGs) viperin

238 we propose it as the first protein known to repurpose the nitroreductase fold solely for protein-pro

239 To do this, the virus must alter and repurpose the normal cellular balance of membrane and pr

240 Here, we develop CRISPR-X, a strategy to repurpose the somatic hypermutation machinery for protei

241 Here, we sought to repurpose the Src family kinase inhibitor oncology compo

242 We repurposed the approximately 650 boronic acid reagents i

243 Evolution has often copied and repurposed the mitogen-activated protein kinase (MAPK) s

244 ysis indicates that TgISPs have functionally repurposed the phospholipid-binding site likely to coord

245 We suggest a new conceptual framework that repurposes the 21st-century transition underway in toxic

246 phylococcus aureus unexpectedly secretes and repurposes the lipoylated E2 subunit of PDH to suppress

247 n capture dissociation (AP-ECD) experiments; repurposing the AP-ECD ion source for AP-CS requires onl

248 we demonstrate such an imaging technique by repurposing the bacterial CRISPR/Cas system.

249 Thus, repurposing the FDA-approved DECA may be a pharmacologic

250 ew enzymatic activities has mainly relied on repurposing the interiors of preexisting protein folds b

251 an important strategy for counteracting and repurposing the posttranslational modification machineri

252 improving the energy efficiency of WWTPs by repurposing the stream of carbon substrates across syste

253 is progressing rapidly in the field of drug repurposing, the implementation of drug repurposing stil

254 ic elements capture host defense systems and repurpose them for different stages in the life cycle of

255 e minimal systems has enabled researchers to repurpose them into a versatile technology that is broad

256 enables the identification of compounds for repurposing therapeutic potentials.

257 There is an opportunity to repurpose therapeutics used to treat other diseases to t

258 focus on mechanistic pathways, could lead to repurposed therapeutics.

259 We conclude that mutant K-Ras repurposes these signaling and regulatory proteins to su

260 Repurposing these GABAA-R PAMs to help treat diabetes is

261 and metastasis, and present a case report of repurposing thioridazine for treating a human patient.

262 In an effort to repurpose this drug, structure-activity relationship stu

263 To repurpose this technology for visualizing cellular netwo

264 These findings support repurposing this analgesic for the treatment of LID.

265 ow amyloid burden, providing a rationale for repurposing this anticancer agent as an Alzheimer's dise

266 form unlocks an opportunity to catalytically repurpose three abundant, orthogonal feedstocks under mi

267 the existing clinical agent auranofin may be repurposed to aid in the treatment of several important

268 ains, vertebrate Itsn1 has been functionally repurposed to also facilitate interhemispheric connectiv

269 Current user-friendly glucose meters can be repurposed to detect influenza viruses.

270 e open-field imaging device was successfully repurposed to distinguish cancer from normal tissue in t

271 nd CRISPR-based molecular machines have been repurposed to enable a genome editing revolution.

272 CRISPR/Cas9 system has recently been repurposed to enable target gene activation, allowing re

273 rate cytoplasmic proteins and DNA, which are repurposed to form the extracellular matrix that binds t

274 20E, ETH, and JH during juvenile stages are repurposed to function as an endocrine network essential

275 Mechanisms that may seem detrimental can be repurposed to generate diversity.

276 ecent years, the Waddington diagram has been repurposed to illustrate how cellular identity changes i

277 covering GR-modulating compounds that may be repurposed to improve current GC-based therapies.

278 treatment of pulmonary hypertension, can be repurposed to improve hematopoietic stem cell transplant

279 Cs to identify drugs that can potentially be repurposed to lower serum LDL-C.

280 d drug used to treat biliary spasm, could be repurposed to prevent, and possibly treat, T1D in at-ris

281 ate how a single transcription factor can be repurposed to program different cell types.

282 Thus, COMPASS and Mediator are repurposed to promote epigenetic transcriptional poising

283 e, myogenin mRNA is stabilized while KSRP is repurposed to promote maturation of myogenic microRNAs,

284 s suggest that Cu-chelation therapy could be repurposed to treat cancers containing the BRAF(V600E) m

285 e for the first time, that fingolimod may be repurposed to treat cutaneous inflammation.

286 ical use to treat multiple sclerosis, may be repurposed to treat cutaneous inflammation.

287 FDA-approved drugs that could potentially be repurposed to treat H7N9 and other pathogenic influenza

288 spasm in humans, we propose that it could be repurposed to treat MS.

289 on of tamoxifen as a drug suitable for being repurposed to treat photoreceptor degenerative disease.S

290 humans, our results suggest that it could be repurposed to treat TBI.

291 ratimod as a valuable new candidate for drug repurposing to MIF-relevant diseases, including multiple

292 ay be further investigated as candidates for repurposing to treat diseases.

293 cells, representing promising candidates for repurposing to treat TSC-related tumors.

294 Here we repurpose tolcapone, an FDA-approved molecule for Parkin

295 lts reveal that signals from viral infection repurpose TRAMP components to a cytoplasmic surveillance

296 to a light sensor, we find that nature also repurposed two independent protein modules in assembling

297 We present an amine synthesis that repurposes two simple feedstock building blocks: olefins

298 m of CSF secretion that could be targeted by repurposed US Food and Drug Administration (FDA)-approve

299 Therefore, repurposing US9 to track/modify these molecular events r

300 des a workflow for pathway analysis and drug repurposing using GWAS results.