ライフサイエンスコーパス: require

1 of vegetative growth when sporulation is not required.

2 fin metathesis where Z-alkene substrates are required.

3 What data and epidemiological parameters are required?

4 are either biologically implausible, and/or require a continuous, real-time error signal to guide le

5 To carry out photosynthesis, plants require a large cohort of genes.

6 y assemblages in future climates, which will require a mechanistic understanding of the trade-offs th

7 cations such as heart-rate monitoring, which require a much lower pressure detection resolution.

8 The latter reaction pathway requires a C13=C14, C15=N double-isomerization of the re

9 The vortex-assisted lysis only requires a field strength of approximately 100 V/cm, yet

10 Understanding gene regulation and function requires a genome-wide method capable of capturing both

11 Elimination of filariasis requires a macrofilaricide treatment that can be deliver

12 Switching between these metabolic modes requires a rapid transcriptional response and this is or

13 hile ensuring that patients who are urgently requiring a liver transplant are prioritized.

14 fication of optimal risk thresholds, as this requires additional information on the long-term benefit

15 vivo gene transfer method, while efficient, requires additional operation for cell culture and there

16 ure crop production; however, this typically requires additional water inputs because of increased wa

17 DNA preconcentration technique that does not require an external field.

18 This process requires an adequate oxygen supply, typically delivered

19 m imaging with cellular resolution typically requires an animal to be tethered under a microscope, wh

20 Evolution of homochirality requires an initial enantiomeric excess (EE) between rig

21 nd larvae and that accurate denticle spacing requires an intact microtubule network and the microtubu

22 omplexes with sufficiently long values of T2 requires an understanding of precisely how the position

23 ladenosine (m(6)A) RNA modifications in mRNA requires an understanding of when and where in the life

24 CaMKI is required and serves as both a PINK1 and Parkin kinase.

25 Minimal sample treatment was required and the obtained results were in excellent agre

26 identification of fast-onset antidepressants requires animal models that can accurately predict the d

27 [PSI+] variants requiring Arg82p could propagate in ipk1Delta (IP5 kinas

28 However, bacterial lysis typically requires at least a 10-fold higher electric field ( appr

29 cleavage of DNA at sites of protein adducts requires ATP hydrolysis at both sites, as does the stimu

30 verwhelm attackers, creating an Allee effect requiring beetles to attack en masse to successfully rep

31 rannual variability, a 25% load reduction is required before there is 95% certainty of observing any

32 defines a novel mechanism of MAPK activation requiring binding of an activator and also shows that MA

33 he transcriptional cofactors YAP and TAZ are required both to maintain TA cell proliferation and to i

34 ind that analysis of large RNA-Seq data sets requires both careful quality control and the need to ac

35 Mitotic activation of Gwl requires both cyclin-dependent kinase 1 (CDK1)-dependent

36 ased on liquid phase (fusion) sintering that requires both oxide-free metal surfaces and high tempera

37 ta is the major topoisomerase for mRNAs, and requires both RNA binding and catalytic activity to prom

38 This problem requires changes to prescribing guidelines and patient c

39 More advanced disease may require chemotherapy, radiotherapy, and lymph node disse

40 erlying the regulation of MCU, in conditions requiring chronic increase in energy production, such as

41 The coronavirus (CoV) S protein requires cleavage by host cell proteases to mediate viru

42 ional medications, herbal medications do not require clinical studies before their marketing or forma

43 Stoichiometric binding requires conditions consistent with coalescence of the 5

44 n intermediate end point, such as MRD, would require confirmation using traditional efficacy end poin

45 ainable solid waste management (SWM) systems requires consideration of both economic and environmenta

46 extending those made in recent decades, will require continued research into mechanisms underlying di

47 hibited, indicating that network maintenance requires continuous membrane fusion and that Yop1p favou

48 RTN3-mediated ER-phagy requires conventional autophagy components, but is indep

49 Branching morphogenesis of developing organs requires coordinated but poorly understood changes in ep

50 Proper gp160 folding in the ER requires core glycosylation, disulfide-bond formation an

51 used as protein carriers, however they often require covalent fusion to the protein for efficient del

52 two different coupling regions, and does not require critical coupling at both or at any one of the t

53 diomyocyte and muscle contraction, but these require customized hardware, expensive apparatus, and ad

54 Tissue regeneration requires dynamic cellular adaptation to the wound enviro

55 retinoblastoma who developed severe PVR and required enucleation.

56 ll angiogenic responses in vitro and in vivo require ETS1-mediated transduction of VEGF signaling to

57 ion of membrane discs in photoreceptor cells requires evagination of its ciliary plasma membrane by a

58 well suited for wearable applications which require excellent flexibility and durability.

59 ing haplotypes from generation to generation requires excessive scrolling back and forth.

60 nderstood and seemingly conflicting theories require experimental support which is difficult to obtai

61 tion is inhibited by a 3' to 5' pathway that requires extensive uridylation of mRNA decay intermediat

62 waves, but not individual endocytic events, requires feedback from downstream factors, including FBP

63 Since efficient leprosy diagnosis requires field-friendly test conditions, we evaluated tw

64 gricultural production but their prudent use requires firstly eliminating any fertilizer mismanagemen

65 A further course of rituximab was required for 4 patients as a result of FSGS relapse, wit

66 iple interdependent phosphorylation sites is required for a GC-A conformation capable of transmitting

67 pression of 3BP2, an adapter protein that is required for activation of SRC tyrosine kinase and simul

68 , and Sda inhibits histidine protein kinases required for activation of the transcription factor Spo0

69 clear whether endogenous KLF4 and Krox20 are required for adipogenesis in culture and in vivo Using c

70 BPTF is required for anterior-posterior axis formation of the mo

71 aPC, demonstrating that Nlrp3 suppression is required for aPC-mediated protection from IRI.

72 of SMARCA2 in response to EZH2 inhibition is required for apoptosis, but not for growth arrest, throu

73 on signals, and identify a biological factor required for appetite evoked by alcohol.

74 ted that Optn phosphorylation at Ser-177 was required for autophagosome formation but not for Optn re

75 t one of these adhesins has been shown to be required for binding of multiple glycan receptors.

76 ation between osteoblasts and osteoclasts is required for bone health and homeostasis.

77 ian SWI/SNF chromatin-remodeling enzymes, is required for both myoblast proliferation and differentia

78 multiple prostate cancer model systems, was required for cell proliferation, enhanced AR's transcrip

79 ound that VLVs contained viral glycoproteins required for cellular entry, as well as tegument protein

80 PRC2 is required for chromatin reprogramming in the germline, an

81 gesting STIM1 is the dominant calcium sensor required for classical short-term neutrophil responses.

82 neages arise as organogenesis begins and are required for construction of all major organ systems dur

83 DLL4 transcription and that this pathway is required for DLL4 expression.

84 r anchoring at parS, this interaction is not required for DNA condensation.

85 ample freezing at the cryogenic temperatures required for DNP.

86 This indicated that 2 copies of Zeb2 are required for EDN3 to prevent neuronal differentiation.

87 ly weak binding of tropomyosin to F-actin is required for effective thin filament function.

88 r H3-H4 tetrasome deposition in vitro, it is required for efficient DNA synthesis-coupled nucleosome

89 We found that the minimal domains required for efficient Ede1 localization at CME sites ar

90 gether, these data demonstrate that H2A.Z is required for efficient pre-mRNA splicing and indicate a

91 y Gpr124 as an endothelial GPCR specifically required for endothelial Wnt signaling and BBB integrity

92 ralizes by inhibiting conformational changes required for entry.

93 es is translated into the single-strand nick required for error-prone synthesis is an open question.

94 ts altogether suggest that MSRB8 function is required for ETI and containment of stress-induced cell

95 ollimated or polarised incident light, as is required for existing methods.

96 to-delay update session, the amygdala is now required for extinction of the updated memory but the re

97 ed NK-2 homeobox gene ceh-24 to be crucially required for flipping.

98 Thus, mTORC1 activation is required for fueling B cells prior to DZ proliferation r

99 st a structural basis for several activities required for fusion, including a C2B surface implicated

100 NV through the MAVS signaling pathway is not required for generation of effective immunity.

101 ontrolled but not constitutive activation is required for gonococcal infection in mice.

102 the HIV co-receptors CD4 and CCR5, that are required for HIV infection yet are dispensable for cellu

103 ugh Ska complex recruitment and that this is required for improved load-bearing capacity and silencin

104 r homeostatic Th17 cell development, JunB is required for induction and maintenance of Th17 effector

105 F2alphaP and demonstrated that eIF2alphaP is required for induction of ATF4 protein synthesis in vivo

106 to remain at the base of mature cilia and is required for intraflagellar transport trafficking.

107 ults suggest that phosphorylation of EMS1 is required for its function in anther development.

108 acement of colonized water reservoirs may be required for long-term clearance.

109 rease; this led to the concept that glia are required for maintenance of the gastrointestinal epithel

110 ould examine the minimum treatment intensity required for meaningful treatment effects, and determine

111 Mechanistically, CD2AP is required for mechanosensitive ICAM-1 downstream signalin

112 ent reductions in tyrosinase and other genes required for melanogenesis.

113 elopment, while maternally deposited gdf3 is required for mesendoderm formation and dorsal-ventral pa

114 t condensin II function at the centromere is required for new CENP-A deposition in human cells.

115 HSPGs are required for Nogo-A-Delta20-induced inhibition of adhesi

116 rupt the epithelial-mesenchymal interactions required for normal development.

117 stream of the SNARE heptad-repeat domain, is required for normal fusion activity with HOPS.

118 ne such nuclear receptor is DAF-12, which is required for normal nematode development, including the

119 ta suggested that protein O-mannosylation is required for normal sensory feedback to control coordina

120 found that ST8Sia-IV autopolysialylation is required for NRP-2 polysialylation and that ST8Sia-II au

121 DNA occupancy of YY1, a transcription factor required for OL maturation.

122 at the INO80 chromatin remodeling complex is required for oncogenic transcription and tumor growth in

123 hereas an acidic region at the N-terminus is required for optimal SWR function.

124 PDZ-binding motif (TAZ) expression, which is required for osteoblast proliferation and differentiatio

125 First, after DSB formation, Mer2 is required for pairing by mediating homolog spatial juxtap

126 to determine if intrinsic MAVS signaling is required for participation of Tregs in anti-WNV immunity

127 CMTM6 is not required for PD-L1 maturation but co-localizes with PD-L

128 photoreaction due to the orbital approaches required for photochemical reactivity.

129 ignalling through the TrpA1 thermo-sensor is required for PMW, and that TrpA1 specifically impacts si

130 levating extracellular [K(+)], and KCNQ2 was required for potentiation of SMIT activity by myo-inosit

131 that Sema-1a-dependent R axon lamination is required for preventing the spread of synaptic inhibitio

132 d by its ATPase domain, that this binding is required for processing protein substrates in nucleoprot

133 spensable for myocarditis induction but were required for progression to DCMi.

134 ted that T-cell intrinsic MyD88 signaling is required for proliferation, protection from apoptosis an

135 cific EZH2 deficiency we found that EZH2 was required for proper development of adaptive, but not inn

136 To test for cis genetic elements required for Pxr function, we deleted the entire pxr gen

137 mmary, we show here that Rap1 contains an AD required for Rap1-dependent gene transcription.

138 licated in SNARE complex interaction that is required for rapid synchronization and Ca(2+) cooperativ

139 te (peroxide and anisidine value, PV and AV) required for refined oils.

140 llular organelles to access host machineries required for replication and spread.

141 ry but the retrosplenial cortex is no longer required for retrieval.

142 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC.

143 group of MYB transcription factors that are required for sperm release from the pollen tube to the f

144 filling any other of the additional criteria required for spontaneous acute myocardial infarction (28

145 stimulated polymerization of F-actin is not required for Syk recruitment but is progressively involv

146 where low-frequency Ca(2+) oscillations are required for synaptic refinement and the response to the

147 TDPs are required for tardigrade desiccation tolerance, and these

148 Wild-type cells are required for the active elimination of mutant cells from

149 Copper is required for the activity of cytochrome c oxidase (COX),

150 -associated replication complexes, which are required for the amplification and subsequent spread of

151 e complex to provide the symmetry adaptation required for the assembly of the entire secretion machin

152 ls supply the hepatocyte growth factor (HGF) required for the chemotactic gradient responsible for su

153 c interactions between Gag and viral RNA are required for the enhancement of particle production.

154 component of axon-glial communication and is required for the function and maturation of OLs to promo

155 This is required for the induction of lipophagy, but not basal a

156 uclear-encoded proteins, whereas the Oxa1 is required for the insertion of mitochondria-encoded membr

157 lncRNA expressed across all progenitors was required for the myeloid lineage, whereas the other leuk

158 alysis of the expected number of comparisons required for the proposed Lexicographic search that comp

159 ectronics with very low power consumption is required for the reading of the optical responses and da

160 that the extracellular domain of IL1RAPL1 is required for this effect, independently of the interacti

161 Positive transmural pressure is required for this suction, providing the energy required

162 ings uncover a mechanism of SAC inactivation required for timely mitotic exit.

163 ighly conserved in metazoans, where they are required for various processes in development, and misre

164 approach has the advantage that it does not require formation of double-stranded DNA breaks or provi

165 oration of new biomarkers to help manage CHB require further exploration.

166 o the interindividual variability in the MFO requires further clarification.We sought to identify whe

167 ation can prevent and/or treat calciphylaxis requires further study.

168 systemic vascular risk in patients with OSA requiring further comprehensive investigation.

169 rnative programs, comparison of results will require general agreement on definitions of response, re

170 in individual infants following a clinically required heel lance.

171 The formation of the ER requires homotypic membrane fusion, which is mediated by

172 r hydroisomerization of n-hexane, a reaction requiring hydrogenation/dehydrogenation and moderate to

173 sk of DCGF; however, later-onset dysfunction requiring IBx had far greater impact (HR = 13.8, P < .00

174 role of this mechanism in specific circuits requires identifying the protein composition and mRNA ca

175 least 1 lower respiratory tract symptom not requiring immediate antibiotic treatment and with no his

176 iac, allergic, or neurological complications requiring immediate intervention and that led (or could

177 y other viral pathogens of significance that require IMPalpha/beta1 in their infectious cycle.

178 yzed, as is the role of additives, which are required in many systems.

179 Swift action is often required in the face of indeterminate sensory evidence.

180 e Arabidopsis (Arabidopsis thaliana) ADF3 is required in the phloem for controlling infestation by My

181 hing or grasping, respectively, and both are required in the transitional pronation step.

182 The biomass increase requires increased trophic efficiency, which could arise

183 arrays, demonstrating that different arrays require individual characterization and that global pept

184 t memory-efficient classical algorithm known requires infinite memory, while a quantum simulator requ

185 Researchers require information synthesized across multiple biologic

186 e cardiovascular health of African Americans require input from a broad set of stakeholders, includin

187 s with AF, the sole presence of diabetes not requiring insulin did not imply an increased thromboembo

188 t such as readers and imaging systems, which require intensive and time-consuming procedures.

189 This reduction required intracellular signaling via second messengers-c

190 Among patients in the ICU requiring intubation, video laryngoscopy compared with d

191 nalize lumped parameter models have thus far required invasive measurements or fall short of being su

192 The effects of PGE2-G required its hydrolysis into PGE2, were not observed wit

193 sue that deep probabilistic graphical models requires large number of labeled training samples, we pr

194 than catabolic pathways are more stringently required, likely due to functional redundancy in the lat

195 ationally intensive workspace-based analysis require login/password access to its expert review (ER)

196 al DNA-alkylating agent against glioma, 6OTD required lower concentrations to exert anti-cancer effec

197 erived cells such as circulating tumor cells requires manipulating small sample volumes without loss

198 Joint morphogenesis requires mechanical activity during development.

199 ody to at least $2.97 PPP would increase the required mitigation rate by 27%.

200 sed susceptibility of phoQ Salmonella to RNS requires molecular O2 and coincides with the nitrotyrosi

201 that an effective VAR2CSA-based vaccine may require multivalent activity.

202 genome, an early developmental process that requires Nanos activity.

203 n of the brain's vast synaptic networks will require new tools for high-throughput structural and mol

204 hey can provide high temporal resolution and require no sample preparation.

205 d sustaining beta cell identity and function requires not only active maintaining of the expression o

206 Assembly of this cofactor requires O2, Fe(II), and a reducing equivalent.

207 Some aspects of JH function apparently require one receptor or the other.

208 with identical stimuli but two contexts: one required only routine responses and the other with occas

209 ssay is highly sensitive and specific and it requires only 50 mug of leukocyte DNA isolated from 2-3

210 s infinite memory, while a quantum simulator requires only finite memory.

211 tions where a small fluorescence reporter is required or desirable, the choice of fluorophores is rat

212 f V. velutina, we conclude that vigilance is required over a large area to prevent the establishment

213 TLR2 agonists required pannexin-1 and P2X7 receptor activation to stim

214 The intervention required people to attend clinic for treatment and did n

215 Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention [PCI] [CHAMPI

216 epithelial cell division and cell extrusion require Piezo1 at the steady state, the type of mechanic

217 -six patients with PDR-related complications requiring PPV were prospectively randomized into 1 of 2

218 Regulation of blood glucose requires precise coordination between different endocrin

219 Skin sensitization did not require prior skin damage or enzymatic activity within H

220 groups also differed in the number of draws required prior to committing to a decision, but not in d

221 ies of MCC are disassembled by different ATP-requiring processes.

222 Sensory processing requires proper alignment of neural maps throughout the

223 uggests that the folding path of twister RNA requires proper orientation of the substrate prior to T1

224 could not be rejected in any population, but required rates much higher than those recorded.

225 st mode of diagnosis (68%), although 7 cases required repeat testing.

226 il onset of pain and the time until patients required rescue medication, both showing statistical sig

227 n is a rhythmic activity as well as one that requires responsiveness to internal and external circums

228 application of precision oncology approaches require robust elucidation of the genomic landscape of a

229 conditions BMP4 acts as a morphogen but this requires secondary signals and particular cell densities

230 geted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal

231 two semi-independent populations that could require separate management consideration for their cons

232 antimicrobial susceptibility, but they often require several days of turnaround time, which leads to

233 cumulation of AGO4-dependent het-siRNAs also requires several factors known to participate in the eff

234 is and treatment for all people with TB will require simpler, more sensitive diagnostics and broader

235 fied cells in intact neural circuits, but it requires skill to perform.

236 This requires socio-pragmatic competence, much of which is no

237 are based on morphological characteristics, requiring specialists and being very time-consuming.

238 mputational resources, the handling of which requires specific programing skills.

239 nd query-able, but fulfilling this potential requires standardized formal patterns for structuring on

240 y relations is crucial to optimize gamma but requires state of the art measurement techniques which a

241 However, neutrophil cytokine production required STIM2, but not STIM1, at least in part as a res

242 The nonlinear input-output transfer function requires strong optical nonlinearity, e.g. self-phase mo

243 stallography as a pipeline for obtaining the required structures.

244 Characterizing this inherent complexity requires studies at single-cell resolution.

245 This task requires subjects to discriminate highly similar scenes,

246 ough biosynthesis of these complex molecules requires substrate flux from the isoprenoid pathway, enz

247 yposis receiving topical corticosteroids who required surgery, mepolizumab treatment led to a greater

248 of prosthetic joint infection (PJI) usually requires surgical replacement of the infected joint and

249 CD8(+) T cells require sustained Ca(2+) signaling for inflammatory cyto

250 rvation of average post-transplant eGFR will require sustained improvement in immunosuppression and o

251 vivo, and the stability maintenance of Rad51 requires TCTP in MCF-7 cells under normal cell culture c

252 thin 30 days, defined as completion of three required tests and their post-test counselling.

253 Novel models are required that maintain physiological levels of FUS expre

254 The goal of universal health coverage (UHC) requires that families who get needed health care do not

255 to eliminate pediatric HIV-1 infection will require the characterization of maternal immune response

256 lications and their high-computational needs require the development of pipelines orchestrating the e

257 years, but are generally time consuming and require the use of advanced instrumentation.

258 All other division proteins are thought to require the Z-ring for recruitment to the future divisio

259 The resolution of this paradox required the insight that an intimate relationship exist

260 This premature stabilization requires the conserved microtubule-binding Ska complex,

261 To fully dissect this data requires the development of stochastic models that can b

262 Thus, understanding how sex impacts immunity requires the elucidation of complex interactions among s

263 Proper neural circuit formation requires the precise regulation of neuronal migration, a

264 saturable in vitro Sterol binding by MpPR-1 requires the presence of a flexible loop region containi

265 The normal function of the human myocardium requires the proper generation and utilization of energy

266 istance of soybean (Glycine max), which also requires the rhg1 gene.

267 cofactor-containing extracytoplasmic domains requiring the dual action of the co-translational Sec an

268 Because no library preparation is required, the technology permits very efficient use of t

269 ions supported by these diverse polypeptides require them to have an amphipathic nature, and this is

270 onkeys performed a visual matching task that required them to detect target stimuli composed of conju

271 gation, lowers the sugar content in the leaf required to achieve a given export rate and accelerates

272 MUS81 nucleolytic activity is required to activate compensatory DNA synthesis during m

273 pre-existing disulfide links are absolutely required to allow protein folding and, conversely, that

274 y is the first demonstration that an SRRP is required to bind beta-1,4-linked galactose and the first

275 can account for the emission source that is required to close the Amazon CH4 budget.

276 Randomized controlled trials are required to confirm these results.

277 fferences both at baseline and in disease is required to effectively consider and treat all patients

278 tenuation of beta-catenin, both of which are required to execute the osteoclast developmental program

279 ed and determine the minimal antibody titers required to halt transmission in different settings.

280 Further, the interventions required to interrupt tuberculosis transmission must be

281 as a monomer, additional flanking bases were required to invoke sequential dimerization of the bound

282 n cleavage, in the sensory neuron and L7 are required to maintain each form of LTF.

283 MEK1 was required to make Xenopus pluripotent cells competent to

284 ng decreases in greenhouse gas emissions are required to meet the reduction trajectory resolved withi

285 DCIR), a key component in DC homeostasis, is required to modulate lung inflammation and bacterial bur

286 The high cognitive load required to navigate such a workflow is detrimental to h

287 International collaboration will be required to perform clinical studies to inform the treat

288 expressed in murine thymic epithelium and is required to prime thymic epithelial cells (TEC) for effe

289 A borane (e.g., pinacolborane) is required to promote CAH.

290 uired for this suction, providing the energy required to reopen the vessel.

291 gs indicate that a combination of factors is required to sensitize these regions.

292 etween the two groups, although more work is required to show this definitively.

293 Further study is required to test effects of agents that target the NO pa

294 Additional studies are required to test the prognostic significance of CNA pres

295 compounds (EDCs) affect population dynamics requires tracking males and females (and sex-reversed in

296 quantifying these processes is a challenge, requiring tracking of rapidly moving, sub-diffraction ob

297 ion reduces the rate of asthma exacerbations requiring treatment with systemic corticosteroids.

298 f UV dosage over the United States in summer require understanding the response of this dynamical and

299 of severe IgE-mediated hypovolemia and shock required VE-restricted ABL1 expression.

300 nsity, low-power neuromorphic computing will require very large numbers of nanoscale nonlinear oscill