ライフサイエンスコーパス: requirement for

1 energy-restricted diet (750 kcal/d below the requirement) for 16 wk while performing resistance train

2 rentiation and that aging is not an obligate requirement for a CD19(neg) state to be established.

3 Together this reveals a distinct requirement for a chromatin remodeller in promoting the

4 These data suggest requirement for a control of FKRP expression in muscles.

5 We illustrate a requirement for a critical mass of either Gea1 or Gea2 f

6 Ergodicity is a fundamental requirement for a dynamical system to reach a state of s

7 as social complexity increases, so does the requirement for a greater diversity of signals.

8 nd treatment, such as the perceived absolute requirement for a ketogenic diet, the assumed lack of st

9 's macrocyclic structure revealed a striking requirement for a low-entropy macrocycle for activity.

10 Previously, we demonstrated the requirement for a neutrophil (PMN) subset expressing CD4

11 concentrated in this structure, suggesting a requirement for a special set of genes for its function.

12 , poor localization of binding sites and the requirement for a total DNA input control which increase

13 ater channel isoforms, although the proposed requirement for a TRPV4-AQP4 macromolecular complex rema

14 This is the first example of a differential requirement for a viral protein across the four syn loci

15 that meets performance and power-dissipation requirements for a range of battery-powered smart-sensin

16 protein, this glycosylation is not a strict requirement for AAV2 binding or functional transduction.

17 ria, archaea, and eukaryotes in terms of the requirements for accessory factors and details of the mo

18 Free energy requirements for activation are defined with protein fra

19 Taken together, our results highlight the requirement for active transport in polarized growth and

20 mechanisms underlying transformation and the requirement for additional genetic hits remain unclear.

21 Loss of light perception, requirement for additional glaucoma surgery, hypotony ma

22 The requirements for additional noninvasive methods of data

23 uced paired-pulse facilitation, suggesting a requirement for adequate mitochondrial function to maint

24 ovide further insight into the pharmacophore requirements for allosteric inhibition.

25 lity and explicit representation a practical requirement for almost any rigorous systematic analysis.

26 and progenitor cells, and its indispensable requirement for AML development.

27 In this context, activation of PI3KKs is a requirement for amplification of the HBoV1 genome, and H

28 t classes of the enzyme exist based on their requirement for an additional subunit.

29 reconstructions do not sufficiently meet the requirements for an adequate model.

30 mized architecture to satisfy the electrical requirements for an organic-semiconductor-based logic ch

31 at high risk for HIV infection, sample size requirements for an RCT with HIV incidence as its outcom

32 Key requirements for any chemical filter molecule used in su

33 hor to the N-terminus of Sec17 bypasses this requirement for apolarity of the Sec17 loop, suggesting

34 ms, a detailed molecular stratification is a requirement for appropriate clinical management.

35 of introns from a target gene abolishes the requirement for Aquarius, but not HRDE-1, for small RNA-

36 terface and provide the first glimpse of the requirements for AT1R complex assembly.

37 ocking of GR binding is due to gene-specific requirements for ATP-dependent chromatin remodeling enzy

38 or axon morphology, demonstrating functional requirement for axonal SFPQ.

39 revailing paradigm, we found unique cellular requirements for B7 and CD40 expression in primary GC re

40 Entry requirements for becoming a shaman persist because the p

41 re necessary for life, as they are a crucial requirement for biological processes including reproduct

42 rization and Urgent Intervention Triage) and requirement for blood transfusions.

43 The requirement for both neurotransmitters in both the feedi

44 Our findings identify NDPK-C as an essential requirement for both the interaction between NDPK isofor

45 roup reveals insights into minimal enzymatic requirements for building a peptidoglycan-like sacculus

46 To assess current eligibility requirements for cancer clinical trials, we have conduct

47 o -12), we find that AAP is not an essential requirement for capsid assembly of AAV4, -5, and -11, an

48 anisms of action, which in part reflects the requirement for capsid function at both the efferent and

49 esolutions the authors verify the resolution requirements for capturing the observed variability in d

50 Independent monitoring should be a key requirement for carbon credit verification in future int

51 in the neonatal heart and to determine their requirement for cardiac development.

52 y and motility in vitro and investigated the requirement for CCL7 in a murine model of IgE-mediated a

53 We further identified a requirement for CD4 T cells in the anti-glycan antibody

54 r, these data demonstrate CD28-costimulation requirement for CD8 T cell rescue and suggest an importa

55 The requirements for CDC are further impacted by factors suc

56 Further, we identified a requirement for CDK2 in the compensatory increases in be

57 reover, Ph(+) ALL cells exhibited a specific requirement for CDK6 but not CDK4 expression, most likel

58 y for basophil-bound IgE, substantiated by a requirement for cell-to-cell contact, aggregation, and F

59 Requirements for cell contact and specific cell type in

60 However, the requirements for cell-cycle progression in human cells r

61 cycle proteins and reveals insights into the requirements for cell-cycle progression.

62 Chdh(-/-) oocytes, directly demonstrating a requirement for CHDH for betaine accumulation in oocytes

63 a novel mechanism, exploiting gene-specific requirements for chromatin remodeling enzymes to selecti

64 Our work defines the minimum requirements for chromatin replication in vitro and show

65 The traditional requirement for clean rooms and specialized skills has i

66 OPS was carried out and completed before the requirement for clinical trial registration.

67 lonal CD8 T response, indicating the lack of requirement for clonal skewing.

68 in biotechnology, but is constrained by the requirements for colorimetric or tag-based detection met

69 flicting regarding dose, treatment duration, requirement for combinatorial agents, and extent of effi

70 tem with VirD4 bound, define the biochemical requirements for complex formation and describe the prot

71 The framework dramatically reduces storage requirements for connectome evaluation methods, with up

72 These results identify a general requirement for COPB2 in embryogenesis and a specific ro

73 t host tissues that have their own intrinsic requirements for copper homeostasis, have evolved mechan

74 biosynthesis in initiating and balancing the requirement for cortical cell activation without uncontr

75 two forelimb movements that differ in their requirement for cortical involvement.

76 ierarchy, and epitope-specific CD8(+) T cell requirements for costimulation, all of which influence t

77 of palladium(0) by O2, bypassing the typical requirement for Cu salts or related redox cocatalysts to

78 , and subsequent p65 silencing validated its requirement for CXCL8/IL-8 induction.

79 ality of CXCR4(-/-) mice, and stage-specific requirements for CXCR4 in thymus colonisation and pre-TC

80 nlike other available uricosuric agents, the requirement for Cys-32 is unique to verinurad.

81 The subunit requirements for DCUK-OEt actions distinguished DCUK-OEt

82 To investigate the requirement for de novo sphingolipid biosynthesis in adi

83 This requirement for degradation was independent of cytoskele

84 d CRMs in diverse insect species, a critical requirement for detailed GRN characterization, are also

85 sampling of more than 10(7) CD4+ T cells, a requirement for detecting exceedingly rare latently infe

86 and samples (multiplexing) is one of the key requirements for diagnostic tests in order to enable fas

87 telomeres also depends on this channel, Ku's requirements for DNA binding differ between DNA repair a

88 nd the fundamental thermodynamic and kinetic requirements for dynamic instability and its elimination

89 fferentiation, but the timing and respective requirement for each pathway vary depending on the milie

90 The structural and reaction requirements for each process are presented.

91 Moreover, the requirement for endogenous Muc4 for tumor growth progres

92 endothelial cells in this assay confirmed a requirement for endothelial cells in epithelial patterni

93 To test directly for a requirement for endothelial cells in instructive epithel

94 The requirements for engagement of the N-RNA template of VSV

95 re food, it met fewer of the US population's requirements for essential nutrients.

96 gation complex (TEC), detail the rate of and requirements for Eta-mediated transcription termination,

97 unknown complexity of telomerase structural requirements for expression and function in vivo.

98 targets at room temperature, eliminating the requirement for external temperature controllers and ove

99 e, such as a ubiquinone-binding site and the requirement for FAD as cofactor.

100 myloid growth that focuses on conformational requirements for fibril and nucleus elongation.

101 through a single treatment, eliminating the requirement for FIX concentrate.

102 nical deformations, which is the fundamental requirement for flexible devices to work properly in com

103 ant mutation (Ku) that removed vernalization requirement for flowering.

104 suggesting that the two CLEs have different requirements for function.

105 oxidative stress, underscoring the cellular requirement for functional peroxisomes.

106 th-inducing cell populations is an essential requirement for further development of this approach.

107 There is a lack of strong evidence and a requirement for further research.

108 79g/kg) and residual sugar (164g/kg) content requirements for further use in the production of balsam

109 ass- and number-based) and low pressure drop requirements for gasoline particulate filters (GPFs), a

110 iciency, we also identified dosage-sensitive requirements for GATA6 and GATA4 in the formation of bot

111 We show that eIF5A can obviate the polyamine requirement for general translation elongation, and that

112 irus family of nonenveloped RNA viruses, the requirements for genome packaging remain poorly understo

113 ription factor Nrf2 and contributes to their requirement for glucose as a carbon source.

114 Studies to define the temporal requirements for Glut1 reveal that pre-symptomatic, AAV9

115 Thus the requirements for glutamine in cancer are overall highly

116 find that unlike other ETC components whose requirement for growth is inversely correlated with the

117 with nutrient uptake but greatly exceeds the requirement for growth.

118 t, CM degradation in culture RM had a strict requirement for H2 .

119 consensus and found that this suppressed the requirement for H2A.Z in splicing of that intron.

120 oduction using PS in an MPPC, and the energy requirement for H2O2 production was low ( approximately

121 nked glycosylation of the Fc is not a strict requirement for hFcgammaR engagement.

122 s study establishes a physiologic, selective requirement for HH/SMO signaling in taste homeostasis th

123 particles, are highly advantageous since the requirement for high carrier injection no longer holds.

124 been hampered by cellular rejection and the requirement for high levels of immunosuppression.

125 ed and reproducible sample handling is a key requirement for high-throughput compound screening and c

126 and identify unexpected differences in miRNA requirements for host gene suppression versus RNA virus

127 lation of PD-L1 is a correlate of, but not a requirement for, HSC maturation.

128 We identify that the requirement for HSF-1 in this phenotype was IL2 neuron-s

129 Mechanistic analyses revealed a requirement for IL-10 in LPS-mediated decrease in MC Fce

130 Although cereblon (CRBN) is an essential requirement for IMiD action, the complete molecular and

131 The requirement for immediate vascularization of engineered

132 We assessed the longitudinal requirement for immunosuppressive therapy in 339 patient

133 These studies demonstrate that the CCR2 requirement for iMO egress to the blood is not universal

134 he role of complement in disease, there is a requirement for inhibitors to control the initiating pro

135 vitro The neurophysiological and anatomical requirements for initiation and persistence of such acti

136 e components and slab waveguides is a common requirement for integrated optical devices, and is typic

137 iently than wild-type cells and bypassed the requirement for interleukin-2 administration to sustain

138 bility that genetic diversity is an absolute requirement for intraspecific chemical communication.

139 he receptor trafficking in addition to their requirement for its activation.

140 Here we show a conserved requirement for Jagged1-Notch2 signaling in patterning t

141 al muscle K(+) channel disease gene, but the requirement for KCNE3 in skeletal muscle has been questi

142 Our results indicate that the only requirement for L. monocytogenes invasion of epithelial

143 ntify the tile nick position as a structural requirement for lattice formation.

144 that define progenitor states and signalling requirements for long-term self-renewal.

145 gle-strand breaks (SSBs) as indicated by the requirement for loss of both proteins to greatly reduce

146 The results demonstrate a requirement for LPS in building arbor complexity and sug

147 e SVP transport, suggesting distinct subunit requirements for lysosomal and SVP trafficking.

148 aria diagnosis capabilities alongside policy requirements for mandatory testing before treatment moti

149 d with length of hospital stay (P = .04) and requirement for mechanical ventilation (P = .03).

150 Taken together, these data underscore the requirement for mechanistic studies to identify bacteria

151 S adapters exhibit some selectivity in their requirement for mediating FGF receptor (FGFR) signaling

152 ing blocked furrow progression, indicating a requirement for membrane trafficking to support furrow a

153 ments with system size: Periodicity is not a requirement for Mermin-Wagner fluctuations, which conser

154 adjacent residues, identifying the molecular requirements for methylphosphonate synthesis.

155 o determine whether there is a developmental requirement for microbial colonization, axenic embryos w

156 15 countries to assess the annual financial requirements for microbial water testing at both nationa

157 nventional DNase I sequencing because of the requirement for millions of starting cells.

158 We established the physiological requirements for miRNAs in ILC2 homeostasis and immune f

159 ic differentiation and reveal a differential requirement for mitochondrial Fh1 in normal hematopoiesi

160 is essential for heart repair, suggesting a requirement for mitochondrial quality control in regener

161 t the (p)ppGpp(0) strain has a strong growth requirement for Mn that is alleviated by Fe supplementat

162 This Mn(II) sensitivity results from the requirement for MntR to activate the transcription of tw

163 African-American race/Hispanic ethnicity and requirement for more than 1 antihypertensive medication

164 tochondrial MTOC defines a minimal molecular requirement for MTOC generation and implicates the poten

165 behavioral actions of GLYX-13, indicating a requirement for mTORC1 similar to ketamine.

166 in cell flattening from non-cell-autonomous requirements for MTs in regulating proliferation, differ

167 A requirement for Munc13-2 in MC exocytosis was revealed o

168 Previous studies on the sequence requirements for N-glycosylation have yielded the Asn-X-

169 of these residues revealed different surface requirements for Nap1 and Chz1 interaction with H2A.Z.

170 particles was prepared to satisfy regulatory requirements for nasal dosage forms and the polymer nano

171 and visceral pain pathways, we identify the requirement for NaV 1.7 in regulating somatic (noxious h

172 Here, we compared the PBR sequence requirements for NCAM, neuropilin-2 (NRP-2), and synapti

173 et the necessary cost targets and regulatory requirements for near-patient applications.

174 a paucity of muscle fibres demonstrating its requirement for normal muscle formation.

175 Together, these results demonstrate a requirement for normal recycling endosome function in AM

176 increase the flexibility of the DNA sequence requirements for origin licensing.

177 n vitro conditions, suggesting an additional requirement for other factors.

178 a precision better than 10 ppm, matching the requirements for paleo-environmental applications.

179 To determine the requirement for parvalbumin (PV) expressing GABAergic in

180 ssion construct identified a cell-autonomous requirement for paxillin in migrating neurons.

181 part explains why P450cam has such a strict requirement for Pdx.

182 There are age-based requirements for periodic testing and/or retirement for

183 als that the Arp2/3 complex is not a general requirement for phagocytosis or chemotaxis but is a crit

184 this result by defining additional molecular requirements for PhyR activation.

185 cide with the colonization of land, a likely requirement for plant adaptations to the more variable t

186 desired functionality is limited only by the requirement for polarity matching of the generated radic

187 drive large-scale cargo movement without the requirement for polymers and suggest a segregation mecha

188 es in autopolysialylation and found that the requirements for polyST autopolysialylation and substrat

189 n status as not detected or equivocal if the requirement for positive results from two assay targets

190 General requirements for PPI strategies, such as selecting the t

191 Our results thus define a specific requirement for primary cilia-mediated GPCR signaling in

192 State and local government requirements for private well water testing are rare and

193 To determine the metabolic requirements for productive KSHV infection, we induced l

194 -1.HLA-A2, probably due to either structural requirements for proper Valpha/Vbeta association or dire

195 ponses and the need to better understand the requirements for protective immunity against S. aureus.

196 These data show a requirement for PV+ interneurons of the NAc in behaviora

197 We review regulatory requirements for RA of FCMs in the United States and Eur

198 In order to diminish the requirements for rabies immunoglobulin (RIG) and multipl

199 ellular growth, but simultaneously unveils a requirement for Rac1-dependent macropinocytosis to provi

200 unity to identify mechanisms that bypass the requirement for Ras oncogene activity and drive leukemia

201 These findings discern fundamental molecular requirements for rationally designing porous molecular s

202 After characterizing the system's requirements for reaching equilibrium, the device was us

203 Legume mutants have shown the requirement for receptor-mediated cytokinin signaling in

204 etabolites in biological samples without the requirement for reference metabolite standards.

205 gether, our data implicate Irk channels as a requirement for regulated release of Dpp, highlighting t

206 ave uncovered one of the first physiological requirements for regulated replication time and demonstr

207 Immunological requirements for rejection and tolerance induction diffe

208 We found that there was no cell-intrinsic requirement for RelB for development of most cDC subsets

209 s, population substructure, and ultimately a requirement for replication.

210 including virus-host interactions, host cell requirements for replication, and how virus-host interac

211 Enhanced and standardized regulatory requirements for reporting spills could improve the accu

212 to target outer hair cells at high rates, a requirement for restoration of complex auditory function

213 tic nephropathy), eye events (a composite of requirement for retinal photocoagulation therapy or vitr

214 mechanisms of seed vigor and reveal distinct requirement for RFOs in modulating seed vigor in a monoc

215 se two subsets of components differ in their requirements for ribosomal DNA; the two actively assembl

216 icity of these disorders with the ubiquitous requirement for ribosomes in all cells.

217 experiments in vitro to determine the ligand requirements for RNA binding by SMAD3.

218 nto the cellular, biochemical, and molecular requirements for robust and long-lasting immunity agains

219 s when fed a diet supplying the minimum I(-) requirement for rodents.

220 arly DENV protein accumulation, suggesting a requirement for RPLP1/2 in viral translation.

221 The requirement for Runx1 in the normal hematopoietic develo

222 gnals through S1P1R on T cells, and that the requirement for S1P1R is independent of the established

223 Our findings thus reveal a novel motif requirement for SAM binding by TlyA and set the stage fo

224 riving force for Cl(-) secretion is the main requirement for secreting 140 mm HCO3(-) .

225 teria inhabit a static environment where the requirement for sensory functions is expected to be rela

226 cell whole-genome sequencing, with a minimal requirement for sequencing depth (>0.5X).

227 urs) cold storage, as well as to analyze the requirement for SIRT1 in autophagy regulation by HO-1.

228 Previous reports demonstrated a requirement for SOCE in neurons that regulate Drosophila

229 Here, we review the requirements for spatial transcriptomic methods toward t

230 rferences, limited multiplexability, and the requirement for specialized instrumentation are among th

231 We also identify research requirements for specific communities to address the rem

232 tly, emerging molecular diagnostics have met requirements for speed, low cost, and ease of use for PO

233 ision and resumes vegetative growth, but the requirements for spore germination are incompletely unde

234 However, many aspects of the requirement for Spt5 in transcription are poorly underst

235 Our results reveal a global requirement for Spt5 in transcription elongation.

236 mes, modest predictive value of ST, resource requirements for ST, and the benefits of early treatment

237 f SAv with biotinylated surfaces is a strict requirement for stable immobilization, while monovalent

238 whereas PKA activation bypassed the c-di-GMP requirement for stalk gene expression.

239 CFs is important, particularly given the new requirement for stewardship programs by the Centers for

240 this suppressive mechanism is a fundamental requirement for subsequent initiation of erythroid diffe

241 and often tedious composition rules, and the requirements for substantial resources for encoding and

242 that are consistent with the notion that the requirements for successful coreference resolution in th

243 Consistent with genetic data showing the requirement for SUMO and PCNA binding for the SDSA role

244 membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being

245 The requirement for talin in maintaining high IL-2Ralpha exp

246 se of their relatively relaxed base sequence requirements for target recognition, indirect readout me

247 To understand the pharmacologic requirements for TASK-3 activation, we studied the conce

248 tiple mitogenic inputs may alter the minimal requirement for TCR signaling in CD8 T cells.

249 Here we define the minimal requirements for TCR antigen specificity, through an ana

250 nation defect results from a cell-autonomous requirement for THAP1 in the OL lineage and is recapitul

251 Here we demonstrate a direct requirement for the androgen receptor (AR) to maintain H

252 Here, our data indicate a post-mitotic requirement for the APC/C(Fzr/Cdh1) in epithelial cell p

253 a DeltasdhE E. coli strain, we show that the requirement for the assembly factor depends on the cellu

254 geted screen of autophagy genes identified a requirement for the conserved sorting nexin Snx4 in the

255 for a secreted staphylococcal protease as a requirement for the development of a biofilm.

256 Binding selectivity is a requirement for the development of a safe drug, and it i

257 and low-cost platform which can fulfill the requirement for the development of point-of-care (POC) d

258 ponents that fail to meet the stretchability requirement for the entire device.

259 mation of GSG: the loss of p53 function is a requirement for the formation of GSG whereas DNA damage

260 Ch is not only a potent modulator but also a requirement for the full expression of sensory-evoked ne

261 As oxygen is a key requirement for the generation of ROS in PDT and given t

262 ieduszynski find that early replication is a requirement for the highest expression levels of certain

263 of direct, causal evidence demonstrating its requirement for the maintenance of arousal during wakefu

264 We also identify a requirement for the mitotic kinesin KIF23, a key target

265 Our data reveal an unanticipated requirement for the NSD pathway during oxidative stress

266 ing this mouse line, we establish a specific requirement for the P1-RUNX1C isoform in megakaryopoiesi

267 ing lipid bilayers in a controlled manner, a requirement for the realization of a functional protocel

268 haeological human skeletons is a fundamental requirement for the reconstruction of the human past.

269 arcoded DNA; its specificity arises from the requirement for the same mutation to be identified in bo

270 To define the requirement for the Smarca4 -encoded BRG1 subunit of the

271 Here, we demonstrate a key requirement for the steroid hormone 20-hydroxyecdysone (

272 hic silicon technology struggles to meet the requirements for the 7-nm technology node, there has bee

273 A better understanding of the molecular requirements for the design of potent and specific inhib

274 adult, indicates a maturational shift in the requirements for the development of multisensory integra

275 Our recent work highlights unique requirements for the induction of Th17 cells at the oral

276 owever, the localization pattern and genetic requirements for the SMC5/6 complex during mammalian oog

277 There are no generally accepted requirements for the training of subspecialists availabl

278 nactivation studies have revealed a critical requirement for THEMIS during thymocyte positive selecti

279 aling and product melting and eliminates the requirement for thermal calibrations and cycling program

280 er; however, probes that can satisfy all the requirements for these two advanced technologies are lim

281 hese findings reveal a surprisingly specific requirement for this ATR activator in adult mice restric

282 ent mice deficient in STAT6 to demonstrate a requirement for this critical component of M2 polarizati

283 ly resected human GBM samples also reveals a requirement for this integrin in tumorigenesis in vivo.

284 For many nonenveloped RNA viruses the requirements for this critical part of the viral life cy

285 provide valuable insight into the metabolic requirements for this developmental process in Bacillus

286 These findings extend the notion that requirements for tolerance induction after lung transpla

287 ACI Specialty Committee proposes the minimal requirements for training and certification of subspecia

288 conservation of aaRS proofreading pathways, requirements for translation quality control vary depend

289 the Fluc pore and characterize its chemical requirements for transport.

290 with disease outcome parameters, such as the requirement for treatment with biologic agents.

291 Although the requirement for tumor-expressed CXCR3 in metastatic engr

292 nthesize primary and secondary cell walls, a requirement for two or more functionally distinct CESA i

293 telomere re-synthesis, but with a diminished requirement for Ubc13.

294 and quiescent yeast in response to cellular requirements for ubiquitin-dependent degradation.

295 ups except serogroup E which has a synthetic requirement for UDP-GalNAc.

296 tritium in 18 drug molecules, which meet the requirements for use in ligand-binding assays and absorp

297 on, access to unique polymer designs, and no requirement for using excess NaN3.

298 enhance sustainable agriculture by reducing requirements for water and N.

299 Conflicting data exist on the requirement for wild-type MLL1 in MLL-rearranged leukemi

300 at graded activity of Dpp is not an absolute requirement for wing growth.