ライフサイエンスコーパス: requirement of @2 for

1 These data demonstrate the specific requirement of a pathogen for a tick salivary protein to

2 The requirement of Cap1 for a cellular apical constriction s

3 directed siRNA approach, we substantiate the requirement of FoxO6 for a correct radial migration in t

4 This variability indicates the requirement of multiple markers for a comprehensive TAI

5 hese data and double mutant assays showing a requirement of LAR for actions of both HSPGs lead to a m

6 its downstream targets and bypass the normal requirement of altered tonicity for activation of these

7 t that by CCS gene silencing, indicating the requirement of copper for activation of HIF-1, which is

8 P, such a circuit would fulfill the absolute requirement of cytohesins for activation by Arf-GTP befo

9 vating mu-calpain, implying that the calcium requirement of mu-calpain for activation is attained dur

10 er both in their primary sequence and in the requirement of the latter for activation via enhancer-bo

11 the intermediate domain (ID), we confirm the requirement of this domain for activation of these signa

12 two features shared by these enzymes: their requirement of Golgi localization for activity on cellul

13 Our results suggest that the requirement of E3-ADP for Ad spread could be readily com

14 Thus, we demonstrate an early requirement of Wnt1 for all MbDA neurons.

15 ons enabled an exploration of the structural requirements of the anticodon for aminoacylation by meth

16 catalytic activity of the APC/C, whereas the requirement of Mnd2p for APC/C function appears to be ne

17 To determine the requirement of Par-4 for apoptosis, we treated primary f

18 terations, in studied males, demonstrating a requirement of C5aR1 signaling for appropriate brain dev

19 d AR activity, thus demonstrating a specific requirement of BAF57 for AR activity.

20 Collectively, these data support a requirement of gamma1 laminins for assembly of the colle

21 Although the requirement of ScoI for assembly of the Cu(A)-CoxB compl

22 Therefore, the requirements of technical developments for automated ass

23 to their germline sequences to determine the requirement of mutations for autoreactivity.

24 The requirement of ultraviolet light for azobenzene isomeriz

25 le for protection, indicating a differential requirement of this cytokine for bacterial and viral inf

26 The requirements of A2AR expression for better A2BR cell sur

27 July 30, 2013) the Ohio Board of Pharmacy's requirement of PSPs for bevacizumab.

28 with respect to ATP is also confirmed by the requirement of nucleotide for binding of the compounds.

29 erformed to identify the amino acid sequence requirements of BLIP for binding the TEM-1, SME-1, SHV-1

30 extended to examine the amino acid sequence requirements of BLIP for binding to the SHV-1 beta-lacta

31 Here, we have identified a requirement of Brg1 for both Xenopus primary neurogenesi

32 We demonstrate a strict requirement of Six5 for both spermatogenic cell survival

33 The length requirements of the hinge for both transcriptional regul

34 isolated from Bim(-/-) mice corroborated the requirement of Bim expression for cAMP-promoted apoptosi

35 GRK5 gene deletion to determine the absolute requirement of endogenous GRK5 for cardiac hypertrophy a

36 The structural requirements of flavaglines for cardio- and neuroprotect

37 rradiation-induced apoptosis and negated the requirement of PETCM for caspase activation.

38 Strikingly, the requirement of SARM for CCL5 induction was not restricte

39 itro evolution, we eliminated the functional requirement of IL-2 for CD25 expression by engineering a

40 tional gene deletion showed a cell-intrinsic requirement of CD28 for CD8 T cell proliferation after P

41 In this study, we demonstrate a general requirement of receptor internalization for CD95 ligand-

42 The requirement of Akt for cell proliferation and oncogenesi

43 The absolute requirement of c-Myc for cell cycle progression in human

44 s and/or extracellular signals bypassing the requirement of EGF for cell proliferation and survival.

45 rference (RNAi) was used to characterize the requirement of protein glycosylation for cell membrane s

46 pidly die in RBPjkappa mutants, suggesting a requirement of RBPjkappa for cell survival in this tissu

47 The universal requirement of (+)RNA viruses for cellular membranes for

48 pe (NCS) mutants provide models to study the requirement of mitochondrial function for chloroplast bi

49 Requirement of VHL for ciliogenesis was independent of H

50 The requirement of lipopolysaccharide for colN cytotoxicity

51 iled to efficiently colonize cattle, and the requirement of flhC for colonization was not dependent o

52 We illustrate the requirement of dCAP-G for condensation during prophase a

53 To better understand the structural requirements of specific residues for conversion initiat

54 es demonstrate specific temporal and spatial requirements of NFAT signaling for coronary vessel angio

55 ult of the polyploid nature of cpDNA and the requirement of P for cpRNA degradation by PNPase.

56 ce supporting the notion that the functional requirements of SUV3 for degradosome activity and mainte

57 vercome the lethality, indicating the unique requirement of PXR for detoxification.

58 not identified, consistent with the absolute requirement of cytosolic translation for development of

59 Given the requirement of tumors for different cytokine and growth

60 This study provides new insights into the requirement of genotoxicity for DMBA-induced immunosuppr

61 The requirement of a nucleotide for DNA binding and the stim

62 ng pre-RC formation has been hampered by the requirement of most subunits for DNA binding.

63 These results highlight dissociated circuit requirements of D1R for dopamine-dependent behaviors.

64 induction alone was sufficient to bypass the requirement of Grhl2 for E-cadherin, Cldn4, and Rab25 ex

65 However, the requirement of SRF for early neuronal development includ

66 portance of specific sequence and structural requirements of pre-miRNA for editing along with a sugge

67 gamma' peptide (410-427) and to evaluate the requirement of sulfonation for effective thrombin intera

68 Our data demonstrate that the requirement of Kindlin-3 for effector T cells to induce

69 Consistent with a requirement of ATP for elevated PINK1 levels and Parkin

70 pression of GFP-AtSAUR19 bypasses the normal requirement of auxin for elongation growth by increasing

71 l regimens may not fully address some unique requirements of the heart for energy.

72 we have further elucidated the differential requirement of Ca2+/CaM for enzyme activation between eN

73 ficantly reduced F77 antigen, confirming the requirement of these enzymes for epitope synthesis.

74 The simultaneous requirement of beta-catenin for ERK activation and of ER

75 It is expected that the analytical requirements of legal frameworks, for example, the EU Dr

76 Thus, the requirement of Akt for exiting contact inhibition is med

77 e, these studies are the first demonstrating requirement of SPDEF for expression of E-cadherin, an es

78 In this report, we sought to determine the requirement of Vpr for facilitating HIV-1 infection of m

79 SMG epithelia to investigate the structural requirements of HS for FGF10-mediated epithelial morphog

80 e of RPT in the melanosome filaments and the requirement of this domain for filament formation, we pr

81 ession in certain contexts, we show a direct requirement of NuRD also for FOG-1-dependent transcripti

82 These data identify the requirement of RIAM for formation of immunological synap

83 The distribution, phenotype, and requirement of macrophages for fracture-associated infla

84 If true, it would explain the CcO requirement of bound cardiolipin for full electron trans

85 the inhibitor trichostatin A, indicating the requirement of histone deacetylase for full TPL activity

86 and coimmunoprecipitation to investigate the requirement of associated kinases for functioning and li

87 additional indications about the structural requirement of pharmacophores for further increasing pot

88 To determine the requirement of Cyclin D1 for genesis of rhabdoid tumors

89 axin 4LE expressed with Munc18c bypasses the requirement of insulin for GLUT4 vesicle plasma membrane

90 lack of reaction under nitrogen atmosphere, requirement of oxygen for good conversion yields, inhibi

91 reduce resident variability and address the requirements of Accreditation Council for Graduate Medic

92 However, the spatial-temporal requirement of dpp for growth and patterning remained la

93 The requirement of peptidoglycan synthesis for growth compli

94 The requirement of cholesterol for H-Ras activation was prob

95 H3/H4 tetramers, recapitulating the in vivo requirement of Asf1 for H3-K56 acetylation using recombi

96 Finally, we show the requirement of the mesenchyme for hair regeneration thro

97 ur findings reveal a cardial cell-autonomous requirement of Ggamma1 geranylgeranylation for heart for

98 tial goal of this study was to reexamine the requirement of UL21 for herpes simplex virus 1 (HSV-1) r

99 Our findings explain the requirement of RbC for high-affinity E2F binding and gro

100 RNAi attenuation experiments confirmed the requirement of STAT3 for HO-3867-mediated apoptosis in o

101 under inflammatory conditions, the intrinsic requirement of Blimp1 for homeostatic maintenance of the

102 d range of exposure doses and determined the requirement of T cells for host defense.

103 lts provide a mechanistic explanation of the requirement of p30 for HTLV-1 infectivity in vivo, sugge

104 ic chondrocyte removal of Sox9 confirmed the requirement of Sox9 for hypertrophic chondrocyte develop

105 Although genetic studies have indicated the requirement of HIF-1alpha for hypoxia-induced growth arr

106 ding domain in TAK1 and further examined the requirement of this interaction for IL-1, TNF, and RANKL

107 Our results demonstrate the requirement of accounting for Illite decollapse especial

108 7(Kip1) and p21(WAF1) expression, suggesting requirement of STAT3 for importation or retention of Fox

109 These results suggest a requirement of T cells for improved radiation tumor resp

110 erformed to identify the amino acid sequence requirements of BLIP for inhibiting TEM-1 beta-lactamase

111 ins we were able to dissociate the molecular requirements of vesicle exocytosis for initial membrane

112 s deficient in innate signaling question the requirement of these receptors for initiation of autoimm

113 o define the relative and unified structural requirements of nucleoside analogs for interaction with

114 caveolae is increasingly well described, the requirement of cholesterol for internalization of eukary

115 Requirement of FcgammaR engagement for internalization o

116 The requirement of CDK9 activity for ISG expression was show

117 brane-targeted centaurin-alpha1 bypasses the requirement of PIP3 for its involvement in ARF6 inactiva

118 1 mutant plants to examine the extent of the requirement of COI1 for JA-induced and wound-induced gen

119 ives to promote organ donation must meet the requirements of society for justice, equity of access, a

120 data provide in vivo evidence supporting the requirement of dynamic MTs for kinesin-1-dependent axona

121 efficiently packaged, implying the possible requirement of RNA compaction for L RNA packaging.

122 The requirement of Car for late endosome-to-lysosome fusion

123 onal cells, consistent with the demonstrated requirement of FtsA for late stages of cell division.

124 f LC-derived TGF-beta1 is complicated by the requirement of TGF-beta1 for LC development and by the a

125 and clarifies the controversy regarding the requirement of beta-catenin for limb initiation.

126 Here we determine the sequence requirements of the PAM for LMG18311 Cas9.

127 xchange mass spectrometry suggested that the requirement of PDZ4 for localization and SR-BI regulatio

128 , 95% CI: 1.03-1.25; P = 0.01) and increased requirement of inhaled corticosteroid for long-term asth

129 We investigate the requirement of cholesterol for LOX-1-mediated lipid part

130 We also demonstrate the requirement of hNatB activity for maintaining the struct

131 Using DKO mice we demonstrated a requirement of L-PGDS for maintenance of subcutaneous WA

132 nduced inactivation of Sox2 demonstrates the requirement of Sox2 for maintenance of the DESCs in adul

133 aoxane-based molecule, E209, which meets key requirements of the Medicines for Malaria Venture drug c

134 development has been limited because of the requirement of this pathway for many essential cellular

135 lysis of GANAB-null cells showed an absolute requirement of GIIalpha for maturation and surface and c

136 ity in their (S,S) isomer indicating similar requirement of regiospecificity for maximum interaction.

137 f XCR1(+) DCs, we demonstrate a differential requirement of these cells for mCTL recall during second

138 of p53 protein, which can be attributed to a requirement of DCAF1 for MDM2-mediated p53 poly-ubiquiti

139 The requirement of obligatory catecholamines for melanizatio

140 The fundamental requirement of phosphorylation for membrane translocatio

141 Our results clarify the in vivo requirements of acidification for membrane fusion.

142 Lee et al. previously revealed the requirement of autophagic machinery for MHC II presentat

143 tro and in vivo models explaining an unusual requirement of CooA for millimolar levels of divalent ca

144 d individuals and zebrafish demonstrated the requirement of SFXN4 for mitochondrial respiratory homeo

145 transcription with heterochromatin, but the requirement of heterochromatin proteins for most telomer

146 The requirement of myristic acid for multimerization was rep

147 Although the requirement of IE1 for multiplication of Autographa cali

148 To determine the requirement of nsp4 for murine hepatitis virus (MHV) inf

149 sites are not saturated in CSF, and that the requirement of kainate receptors for Na(+) occurs simply

150 The requirement of proper avidity for nanoparticles to reach

151 on) solid phase extraction (SPE) without the requirement of pre-methylation for NAs.

152 These findings indicate novel and essential requirements of EIF4A3 for NCC migration and osteochondr

153 erentiation promoted by NeuroD2, showing the requirement of Brg1 for neuronal differentiation is cons

154 oth H3K4me1 and NF-Y occupancy, suggesting a requirement of H3K4me1 for NF-Y binding.

155 This indicated a requirement of BMP-2 for NFATc1 expression in OBs.

156 and mutant dvCcmE' demonstrate the absolute requirement of residue C127 for noncovalent heme binding

157 While the data supporting the requirement of ubiquitination/deubiquitination for norma

158 Our findings demonstrated the requirement of Cx29 for normal cochlear functions and su

159 is rescued by exogenous ECD, demonstrating a requirement of ECD for normal mammalian cell cycle progr

160 se model allowed us to establish the minimal requirement of functional Runx2 for normal bone developm

161 Since the requirement of Lmx1b function for normal isthmic organiz

162 The requirement of PAH1 for normal droplet formation can be

163 have yielded conflicting data regarding the requirements of hedgehog signaling for normal ductal bud

164 This study investigates the requirement of p22phox for Nox enzyme activity and explo

165 Using this approach, we bypassed the requirement of Nup2 for NPC segregation.

166 The requirement of this domain for nuclear receptor repressi

167 mplexan parasites and emphasize the distinct requirements of these parasites for nutrients and growth

168 nt in MMTV-Wnt1 mice, further underscoring a requirement of TGIF for oncogenic Wnt signaling.

169 decrease in proliferation, in line with the requirement of dcSAM production for oncogenicity.

170 universal MSP is inherently aerobic due to a requirement of molecular oxygen for one of the key enzym

171 These results underscore the prevalent requirement of active CRMP2 for optic nerve regeneration

172 Furthermore, the requirement of ExsB for optimal T3SS assembly and activi

173 The requirement of PrfA for optimal biofilm formation may pr

174 Plants with RCS had reduced nutrient requirement of root tissue for optimal plant growth, red

175 This requirement of SCD2 for optimal protein synthesis in ful

176 This novel report demonstrates the requirement of SPAG6 for optimal synapse formation and f

177 cell imaging methodologies, we demonstrate a requirement of VASP for optimal development of FAs and c

178 Together, these studies support the requirement of c-Myb for p210(BCR/ABL)-dependent leukemo

179 enetic and biochemical data that confirm the requirement of MurJ for peptidoglycan biosynthesis and t

180 over contamination, false positive results, requirement of technical expertise for performance and d

181 These results indicate that the requirement of CycB for PGC and GSC divisions unlikely r

182 These results, together with the known requirement of core phosphorylation for pgRNA packaging

183 New data question the requirement of chloride for pH regulation of various org

184 ved Leu-X-X-Leu-Ala-Pro motif, the molecular requirement of HIF-1alpha for PHDs/HPHs binding remains

185 These data also help define minimal requirements of chromophore for photoreceptor survival i

186 ing that commitment to NB fate nullified the requirement of Egfr activity for placode cell survival.

187 The requirement of Gcn5/PCAF for PPARgamma expression was un

188 iated with signalling function, suggesting a requirement of NOPE1 function for presymbiotic fungal re

189 n in the spleen and demonstrate differential requirement of CCR7 for primary and secondary CD8 T cell

190 ous virus could be recovered, indicating the requirement of ETIF for productive virus infection.

191 The requirement of TbMCU for proline and pyruvate metabolism

192 These data suggest a requirement of beta1 for proper kidney AE1 membrane resi

193 ransgene, demonstrating a myocyte-autonomous requirement of alpha1G for protection.

194 The requirement of functional Slr1270 for protein secretion

195 Despite the broad requirement of GlyRS for protein biosynthesis in all cel

196 ing Axl and Mer, but not Tyro3, suggesting a requirement of Tyro3 for PS-mediated protection.

197 Mysm1 in a subset of CMPs and the different requirement of Mysm1 for PU.1 recruitment to the Flt3 lo

198 These data demonstrate in the mouse that the requirement of TLR4 for pulmonary inflammation depends o

199 l exogenous pyrimidines that can satisfy the requirement of the parasite for pyrimidine nucleotides a

200 set of genes, thereby demonstrating that the requirement of HDACs for RB-mediated transcriptional rep

201 s transcriptional role is mediated through a requirement of Cdc28/Cks1 for recruiting proteasomes to

202 To assess the requirement of the heterotrimer for regulated Thr-210 ph

203 The specific requirement of Coa6 for respiratory complex IV biogenesi

204 in the LGE, our results demonstrate a novel requirement of this gene for retinoid production within

205 training in repeated switches did remove the requirement of OFC for reversal retention.

206 To study the possible requirement of VPg release for RNA translation, we devel

207 To further validate the requirement of rquA for RQ biosynthesis, we generated a

208 The requirement of TNF-alpha for RV1B-induced airway respons

209 roduced by dermal fibroblasts; and (iii) the requirement of the propeptide for secretion is linked to

210 cells to PD-0332991, further demonstrating a requirement of Rb for sensitivity to cdk4/6 inhibition.

211 yonic tissue organizations and the conserved requirement of zen for serosa development suggest that t

212 croscopy experiments further demonstrate the requirement of TssK for sheath assembly.

213 Despite the requirement of joint CSPGs for skeletal flexibility and

214 These findings provide evidence for the requirement of miR-26a for skeletal muscle differentiati

215 The requirement of rho for sleep localized to the pars inter

216 Meanwhile, it is estimated that the minimum requirements of soil elements for soil microbes are 0.8

217 anslesion DNA synthesis despite the absolute requirement of RecA for SOS mutagenesis.

218 in encounter has suggested that the frequent requirement of protein folding for specific IDP recognit

219 poptose, except for the IPC NB, indicating a requirement of Egfr signaling for specification of alter

220 lts are unique in demonstrating the absolute requirement of alpha4 for sperm fertility.

221 et these results to demonstrate an intrinsic requirement of GCs for stability and/or transport of a s

222 umor metastases in nude mice, indicating the requirement of PTTG for STAT3-promoted metastasis.

223 elective activation of Ste5 and the distinct requirements of the MAPKs for Ste5 scaffolding.

224 Here, we examined the structural requirements of NBD1 for sterol transport.

225 Moreover, based on the requirement of dimerization for strong fluorogen activat

226 sts, with TLR4 and TLR5 agonists sharing the requirement of DCs for subsequent lymph node recruitment

227 e formation has not been established and the requirement of placode formation for subsequent invagina

228 We demonstrate a cell-autonomous requirement of AFG3L2 for survival of PCs.

229 ing in repeated reversals did not remove the requirement of PL-IL for switch retention, training in r

230 major impact on plant growth because of the requirement of inorganic phosphate for synthesis of orga

231 This study thus reveals a requirement of Smad4 for T-cell-mediated autoimmunity an

232 Classical genetic approaches to examine the requirements of genes for T cell differentiation during

233 r its S-palmitoylation are consistent with a requirement of palmitoylation for targeting and function

234 This circumvents a requirement of previous approaches for technically diffi

235 We found a functional requirement of PEG3 for TFEB transcriptional induction a

236 This study indicates the requirement of STAT3 activity for TGFbeta-induced invasi

237 forced targeting of Crn7 to TGN bypasses the requirement of K33-ubiquitination for TGN-pool F-actin a

238 These data define, for the first time, the requirement of AFAP1 for the spatial and temporal regula

239 Together, these data demonstrate the requirement of AhR for the maintenance of CD49a(+)TRAIL(

240 Although deletion analysis supported the requirement of binding sites for the U3 snoRNA, it showe

241 p53-MDM2 interaction to assess the relative requirement of both proteins for the viability of normal

242 kinase inhibitor imatinib, demonstrated the requirement of c-Abl for the TGFbeta-induced phosphoryla

243 le release may partly result from an earlier requirement of Ca(2+) for the assembly of soluble N-ethy

244 The requirement of center asymmetry for the creation of seco

245 This finding provides new insight into the requirement of chemokines for the generation, survival,

246 Thus, the requirement of dFMRP for the retention of transitory pep

247 l and cell-based readouts to demonstrate the requirement of DGCR8 for the maturation of miRNA primary

248 its endogenous stripe domain, we confirm the requirement of Dpp for the activation of a downstream ph

249 This reduction may be related to the requirement of endothelin signalling for the proliferati

250 However, the requirement of ERKs for the effector functions of periph

251 The requirement of FcR engagement for the agonistic and anti

252 results show there is a critical gene dosage requirement of functional Runx2 for the formation of int

253 The unique requirement of HSP1 for the TFAM tail may enable its reg

254 ese results suggest a possible basis for the requirement of isoprenoid biosynthesis for the activity

255 and TNF-induced cell death by the selective requirement of JNK signaling for the latter.

256 data from previous mammalian studies and the requirement of light for the activation of LJ001, we hyp

257 This function is mediated by the requirement of NFIA for the expression of HES5, a Notch

258 pment of pharmacological tools to bypass the requirement of NGF for the activation of the TrkA tyrosi

259 , these observations could be explained by a requirement of Notch for the expression of the trunk det

260 The shared requirement of Notch signaling for the development of bo

261 o monocyte tracking further demonstrated the requirement of NOTCH1 for the migration of blood monocyt

262 SPR/Cas9 technology further corroborates the requirement of OsSWEET13 expression for the state of Pth

263 Using this methodology, we analyzed the requirement of ovarian hormones for the maintenance of t

264 new molecular mechanism for HSP based on the requirement of paraplegin for the proteolysis of a speci

265 Our results demonstrate the requirement of plasmalogens for the correct and timely d

266 this genomic region in vivo, and the in vivo requirement of Ptf1a for the activity of the regulatory

267 This mechanism rationalizes the in vivo requirement of Rad54 protein for the turnover of Rad51 f

268 Deletion mutant analysis suggested a requirement of RopGEF activity for the function of RopGE

269 PCR experiments verified the transcriptional requirement of Sig1 for the heat shock induction of the

270 The requirement of Tfp for the production of EPS was verifie

271 ponent of the HPA axis, and demonstrates the requirement of TrkB for the transmission of glucocortico

272 Thus, our findings underscore the requirement of ubiquitylation for the coactivator functi

273 ortance of normal neuronal migration and the requirement of Wg signaling for the process are indicate

274 ogether our results demonstrate differential requirements of distinct MRFs for the induction of micro

275 successfully operated for 100 h with minimal requirements of laccase for the transformation of estron

276 ether inactivation of pRb might overcome the requirement of UL97 for these roles, as pRb inactivation

277 A better understanding of the structural requirements of inhibitors for these transporters will a

278 here is a significant overlap in the genetic requirements of Photorhabdus for these contrasting inter

279 cts in the ark2-1/pub9-1 lines, indicating a requirement of auxin accumulation for this process.

280 These results suggest that the requirement of Cat-1 for this hallmark of cellular trans

281 To study the structural requirements of the substrate for this catalytic coopera

282 Therefore, we delineated the requirement of SWI/SNF for three critical facets of Plk1

283 ctivation thereby demonstrating the specific requirement of MADD for TNF receptor-mediated MAPK activ

284 s in vesicular trafficking and demonstrate a requirement of AP-1 for Toll-like receptor homeostasis.

285 xin subtypes, perhaps reflecting the special requirements of these synapses for tonic release.

286 t their +1 nucleosome, which exemplifies the requirement of this histone for transcription.

287 The requirement of CD28 for Treg differentiation was mediate

288 ethal immune pathology, revealing an ongoing requirement of LUBAC activity for Treg cell homeostasis.

289 ed PKA activities could partially bypass the requirement of TRI10 for TRI gene-expression and DON pro

290 To investigate the requirements of these enzymes for tRNASer recognition, s

291 A differential requirement of HIF-1alpha for tumor growth was also obse

292 in a nonmotile phenotype, demonstrating the requirement of this gene for V. cholerae motility.

293 aken together, these studies demonstrate the requirement of caveolae for VEGF-triggered multiple myel

294 s protein is not sufficient to alleviate the requirement of sigma(E) for viability, suggesting that t

295 n analysis has been hampered by the cellular requirement of TAF1 for viability.

296 of nsp1 and nsp2 in order to investigate the requirements of nsp3 domains for viral RNA synthesis.

297 The requirement of FTR1 for virulence in a systemic infectio

298 ence of the water and energy sectors, global requirements of energy for water (E4W) are still poorly

299 multiple signalling pathways, we establish a requirement of Pent for Wg signalling.

300 In addition, our results demonstrate a requirement of vitamin B2 for worm health and fertility,