ライフサイエンスコーパス: requisite

1 f oligosaccharides and glycoconjugates are a requisite.

2 e of otherwise essential pluripotency medium requisites.

3 em cyclization that directly establishes the requisite 1,3-trans stereochemical arrangement on one ri

4 Suzuki coupling/dimerization to generate the requisite 2,2'-biaryl linkage.

5 olated indole that could be coupled with the requisite 2-bromobenzoate to deliver the title natural p

6 (e.g. RecBCD, AddAB or AdnAB) generates the requisite 3' single-strand DNA substrate for RecA-mediat

7 by ribozymes and a trihelix-forming RNA with requisite 5' and 3' duplications, do not produce circles

8 loying trinuclear [In3(mu3-O)(O2C-)6] as the requisite 6-connected trigonal-prism and purposely made

9 s cofactor XRCC1 are widely considered to be requisite A-EJ factors, based on biochemical studies or

10 omplexity using a single catalyst, where the requisite activation modes are sequentially exploited as

11 remophyte offers a framework to identify the requisite adjustments of genomic architecture and expres

12 bination with controlled installation of the requisite alkene geometry.

13 The requisite alkenylaluminum reagents are synthesized with

14 methylsilyl)ethyl sulfoxides to liberate the requisite alkyl sulfenate anion intermediates.

15 into a ligand-binding domain, generating the requisite allosteric coupling, remains a rate-limiting s

16 The requisite allylic hydrazide precursors are readily prepa

17 nhanced CLIP (eCLIP) protocol that decreases requisite amplification by approximately 1,000-fold, dec

18 However, the activation requisites and regulatory cues governing T-bet and CD11c

19 when T-cell responses were high or when the requisite antibody titers had declined.

20 Subsequent conjugate addition of the requisite antipode of lithium N-benzyl-N-(alpha-methylbe

21 with EBV-related lymphocryptovirus (LCV) are requisite APCs for MHC-E-restricted autoaggressive effec

22 n to the matrin-3 network, bypassing the pre-requisite association with beta-catenin and Satb1 otherw

23 The requisite base and metal open site are masked in the res

24 d, role, and more robust prospective data is requisite before drawing overarching conclusions.

25 -initiated Grob fragmentation, furnishes the requisite bicyclo[4.3.1]decene.

26 eriments have suggested the existence of the requisite broken-symmetry phase in the high-T(c) cuprate

27 Both IL-10 and MCHII expression by DC10 are requisite, but not sufficient for tolerance induction, s

28 In addition, approaches to install the requisite butenolide moiety at the C17 position are disc

29 energy ring-protonated tautomer allowing the requisite C-C bond cleavage.

30 consequence of blocking the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous

31 owever, in B cells deficient for one or more requisite C-NHEJ factors, such as DNA ligase 4 (Lig4) or

32 er capable of operating at 100 Hz and allows requisite C-trap inject time during MSI to be reduced to

33 ermediate with formaldehyde to introduce the requisite C16 hydroxymethyl group.

34 -term plasticity, calcium transients and the requisite calcium-channel number for triggering release.

35 rearrangement of a vicinal diol to give the requisite carbonyl, followed by intramolecular Friedel-C

36 dily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been u

37 phoid-primed multipotent progenitors, as the requisite CD11a-dependent precursor for lymphocyte devel

38 tide backbones can intrinsically undergo the requisite chain expansion in aqueous solutions with high

39 tify ATR and Chk1 as molecular agents of the requisite checkpoint.

40 leading to a beta-lactone incorporating the requisite cis-fused 2-azadecalin moiety and also setting

41 be swayed by the fact that workers with the requisite clinical microbiology skills are becoming more

42 e (SLO), it has remained unclear whether the requisite close tunneling distance occurs through an unu

43 ically active surface area (ECSA), lower the requisite CO2 reduction overpotential by hundreds of mil

44 proteins and demonstrate that menin is not a requisite cofactor for MLL1 during normal hematopoiesis.

45 ts the location in the human brain where the requisite combination occurs.

46 energy-storage materials do not provide the requisite combination of high energy density, high stabi

47 (2+) influx across the plasma membrane was a requisite component of egg activation signaling, and not

48 A requisite component of nervous system development is the

49 Two requisite components of timely access are (1) the abilit

50 are unique in experimentally confirming the requisite conditions of the antagonistic coevolution mod

51 These results support the notion that the requisite coupling between Cl(-) and proton transport oc

52 aPI-containing cell will lyse, releasing the requisite crop of SaPI particles as well as a greatly di

53 ry producers of type I interferons (T1-IFN), requisite cytokines for survival, following ECTV infecti

54 The MM cells produce requisite cytokines, but they require contact for optima

55 tions for analyses of contemporary data, for requisite data archiving (processed vs. non-processed da

56 work shows that sensory input can induce the requisite decrease in across-individual variability even

57 oth Huwe1 and USP10 appears to fine-tune the requisite degradation of TBP during myogenesis.

58 We establish the requisite design for aryleneethynylene polymers that giv

59 al research are cultured adherently, and the requisite detachment prior to biochemical analysis might

60 coupled to analysis techniques that lack the requisite detection power.

61 headache, photophobia, and phonophobia, is a requisite diagnostic criterion.

62 ct with regeneration of ruthenium(0) and the requisite dione.

63 Our model predicts that the requisite DMC and therefore necessary level of transferr

64 old hydrogen bond acceptor in templating the requisite double-eight rings (d8r) of the mer framework.

65 thelial IL-17 signaling axis is a potent and requisite driver of PanIN formation.

66 Retinoic acid (RA) is a requisite driver of spermatogonial differentiation and e

67 gested that interleukin (IL)-4 and IL-13 are requisite drivers of atopic dermatitis, evidenced by mar

68 ses, with a focus on mechanisms that provide requisite DSB target specificity and mechanisms that sup

69 Thus, the retrosplenial cortex has the requisite dynamics to serve as an intermediary between b

70 DA assembly and ciliary vesicle docking, two requisite early steps in cilia formation.

71 Following 80S assembly, the requisite eEF2-mediated translocation results in an unst

72 To achieve the requisite efficiency, we need a materials discovery and

73 er binds in contact with SAM and donates the requisite electron for the reductive cleavage of SAM to

74 sed in catalytic cross-coupling, possess the requisite electronic and steric attributes to allow them

75 system from Escherichia coli as a source of requisite electrons.

76 untries, with 78% of respondents reporting a requisite entrance examination.

77 Superoxide production by NADPH oxidase is a requisite event in the process leading from NMDA recepto

78 lity in patients with pancreatic cancer, the requisite events are currently unknown.

79 anon, however, such efficacy claims lack the requisite evidential basis from randomised controlled tr

80 dings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise

81 e the NuRD chromatin remodeling complex as a requisite factor in timely and stable peripheral nerve m

82 yte-macrophage colony-stimulating factor are requisite factors in the tumor that, working through the

83 Telomere length maintenance is a requisite feature of cellular immortalization and a hall

84 By ejecting PKA, PINK1 ensures the requisite fission of damaged mitochondria for organelle

85 A safe and sufficient blood supply is requisite for a functional surgical system.

86 3]dendralenes and deciphers their structural requisite for a successful diene transmissive Diels-Alde

87 major duplex deformations appear to be a pre-requisite for ActD binding.

88 Correlates of immunologic protection requisite for an efficacious herpes simplex virus 1 (HSV

89 Although myeloid cell activation is requisite for an optimal innate immune response, this pr

90 ation, and cell-cell adhesion, which are all requisite for angiogenesis.

91 Mechanistically, betaIV-spectrin is requisite for ankyrin-dependent targeting of calcium/cal

92 High quality DNA is the pre-requisite for any molecular biology study.

93 This report also suggests that trypsin is a requisite for AP only because it causes release of cathe

94 The artistic design stance, a requisite for artistic understanding, is an attitude whe

95 s studied, mTOR expression and activity were requisite for autophagy, a paradigm countering the curre

96 eneration of B-cell receptors, which are pre-requisite for B-cell progenitor survival.

97 A pre-requisite for both core alpha1,6-fucosylation and beta1,

98 Tumor vascularization is requisite for breast cancer progression, and high microv

99 Is inflammation the primary requisite for Breg cell differentiation?

100 hylated to 3-methylcytosine (m(3)C) as a pre-requisite for C-to-U deamination.

101 The requisite for chromatin regulation in eukaryotic transcr

102 ion provides the precision and dynamic range requisite for closed-loop neuronal control, but no appro

103 est that persistent activity of PKMzeta is a requisite for cocaine-induced enhancement of synaptic pl

104 te that upregulation of lipogenesis is a pre-requisite for DCIS formation by endowing the ability of

105 c rates unequivocally shows that a necessary requisite for effective catalysis is the simultaneous pr

106 ation of attaching and effacing (AE) lesions requisite for EHEC colonization.

107 driven by ultra-short laser pulses is a pre-requisite for envisaged low-power spintronics combining

108 ional units) is achieved, representing a pre-requisite for exploring the underlying physics.

109 The combination with pDCs and rapamycin is requisite for Flt3L/antigen-induced Treg induction becau

110 ain array, proper cellular localization is a requisite for full activity and is mediated by a C-termi

111 ormation of large GAC oligomers is not a pre-requisite for full enzymatic activity.

112 , which is necessary for NO production, is a requisite for fungal clearance in the hypodermis.

113 traumatic brain injury (TBI) has emerged as requisite for further advancements in neurocombat casual

114 The data showed that endogenous VIP is not requisite for GF or GFR expression in the normal cornea

115 st time the existence of a developmental pre-requisite for highly efficient splicing during Drosophil

116 o DSBs, a marker of DSB processing that is a requisite for homologous recombination repair.

117 ith TANK-binding kinase 1 (TBK1), which is a requisite for IFN-1 induction in response to DNA.

118 Thus, IL-33 is requisite for IL-13 but not IL-4-driven Type 2 responses

119 cogenides provide further degrees of freedom requisite for information processing and spintronics.

120 emonstrate that mRNA docking per se is a pre-requisite for initiating Ire1's RNase activity and, henc

121 the complete evidence base that is now a pre-requisite for instituting screening.

122 study establishes that glycogen synthesis is requisite for LB formation and that LBs are pathogenic.

123 ations in environmental nutrient levels is a requisite for life.

124 ting the cytoskeletal reorganization that is requisite for lytic granule release.

125 establishment of viral persistence, which is requisite for malignant progression of HPV-infected lesi

126 The catalysis of electron transfer, requisite for metabolic activity, may have been attenuat

127 ects on the formation of lamellipodia, a pre-requisite for migration using human lung microvascular e

128 Accordingly, syntaxin 4 was a requisite for Munc18-1 potentiation of insulin release.

129 transients during development serve as a pre-requisite for normal adult behavior.

130 brane-bound ion channels and transporters is requisite for normal cardiac function.

131 ant for predator detection, as well as a pre-requisite for normal social functioning and more complex

132 that KLF4 binds to, cooperates with, and is requisite for optimal function of the estrogen-related r

133 st of the Wnt/beta-catenin signaling pathway requisite for osteoblast development and activity.

134 cient Dvl plasma membrane recruitment, a pre-requisite for PCP activation.

135 genesis as a suppressor for initiation but a requisite for progression (SIRP).

136 om a tumor-initiation suppressor to become a requisite for progression.

137 cute extinction of naive pluripotency, a pre-requisite for rapid progression from preimplantation epi

138 the action of biological molecules is a pre-requisite for rational advances in health sciences and r

139 that nuclear accumulation of SAPKs is a pre-requisite for SAPK-dependent gene expression, and reveal

140 gs, as compared to the CD8+ T effector cells requisite for skin graft rejection.

141 22, 23] exhibit periods of quiescence, a pre-requisite for sleep-like states, prompting us to ask whe

142 more, sight of the hands was a necessary pre-requisite for somatosensory remapping at 10 months.

143 and strength of synapses is an important pre-requisite for studying connectivity and plasticity in th

144 pful for insight into its function, but is a requisite for such insight.

145 on specifically in tumours, which is the key requisite for the acquisition of gain-of-functions activ

146 n of MRN/ATM signaling which appears to be a requisite for the activation of MDC1-dependent MRN compl

147 the severity of gas exchange impairment is a requisite for the characterization of the syndrome and t

148 damage or tissue injury may be an essential requisite for the development of allergic sensitization

149 release over extended time periods is a pre-requisite for the development of desired immune response

150 The inter-domain synergism was pre-requisite for the efficient degradation of cellulose in

151 of afferent growth cones is an essential pre-requisite for the identification of synaptic partner neu

152 f proteins that synthesize short RNA primers requisite for the initiation of DNA replication.

153 nd demonstrate that WASH-mediated F-actin is requisite for the integrity of both endosomal and lysoso

154 membrane domain, not necessarily its own, is requisite for the lumenal domain of B5 to interact with

155 This is a pre-requisite for the second phase, in which the Par complex

156 The combination of these activities appears requisite for the utilization of WTA as a phosphate rese

157 terestingly, NMDA receptor function is not a requisite for these short-term spatiotemporal memory pro

158 Requisite for this activity was a TOG5-specific N-termin

159 making subtle postural adaptations that are requisite for this task.

160 erentiation of the malaria parasite is a pre-requisite for transmission from humans to the mosquito v

161 A functional cell is requisite for TSWV infection and cell-to-cell movement;

162 infection of monocytes by HTLV-1 is likely a requisite for viral persistence in humans.

163 the large ribosomal subunit protein rpL40 as requisite for VSV cap-dependent translation but not bulk

164 This is a pre-requisite for widespread use of mice to examine mechanis

165 tion of treatment effect (PTE) explained are requisites for a suitable surrogate end point.

166 advantages and disadvantages in terms of pre-requisites for applicability, throughput, and accuracy.

167 an be chemically engineered to fit the above requisites for conditional gates with no need of local c

168 Requisites for development of this highly mineralized ti

169 teaching or proto-language may have been pre-requisites for the appearance of Acheulean technology.

170 tide synthesis was employed to elaborate the requisite fragments, with full peptide construction via

171 eir metabolic heterogeneity, and provide the requisite framework for strategies designed to target me

172 However, despite their requisite function in building bone and decades of obser

173 It has since been found to have a requisite function in differentiation initiation in many

174 to a transient nitrosoalkene to install the requisite functionality and configuration at the C7 posi

175 terizing myocardial infarction (MI), but the requisite gadolinium infusion is estimated to be contrai

176 repressing expression of the T-cell-lineage-requisite Gata3 gene.

177 e the stages of carboxysome assembly and the requisite gene products necessary for progression throug

178 similar in their ability to accommodate the requisite geometric constraints during protein binding.

179 Yet the synthesis of the requisite geometrically defined enamides remains problem

180 developing "heuristics" to define structural requisites governing activity at TLR7 and/or TLR8.

181 or progression, cancer cells can produce the requisite growth- and invasion-promoting factors and can

182 Providing clinicians with the requisite health status data on which to base treatment

183 nanophase precipitates, which maintains the requisite high carrier conductivity and the associated p

184 the use of UV-active photocatalysts for the requisite high-energy hydrogen atom abstraction event.

185 In the C-O bond-forming step, requisite hydrogen bonding biases the tethered nucleophi

186 to be unsuitable for the introduction of the requisite hydroxyl groups at carbons 4a and 12a.

187 rates without extended pi-systems, a typical requisite in many C-O bond-cleavage reactions.

188 sure to commensal glycoantigens provides the requisite information to responding T cells for proper t

189 These findings suggest that the lOFC sends requisite input to the BLA, via monosynaptic connections

190 according to the standards, establishing the requisite internal compliance bureaucracies has markedly

191 The requisite intersystem crossing in the open-shell structu

192 nem-3-carboxylate ("simple" carbapenem), the requisite inversion at C5 and formation of the character

193 ted due to the relatively slow nature of the requisite ion-molecule reactions that result in long ion

194 As antibodies with loops of requisite length are created through uncommon recombinat

195 neutrophils (PMNs) and epithelial cells are requisite lines of communication during mucosal inflamma

196 Drosophila wings, but hard evidence for the requisite long-range action has only now come from two n

197 ons have been able to form galaxies with the requisite luminosities, but have otherwise been unable t

198 raft fate after transplantation, and to take requisite measures to prevent immune rejection.

199 eading depolarizations are hypothesized as a requisite mechanism and clinical marker of infarct devel

200 The requisite microcanonical dissociation rates are obtained

201 ng from the methyl cholate core provided the requisite modification in the block copolymer interfacia

202 N or C terminus of proteins of interest the requisite modifications to execute a strain-promoted cop

203 uch antibodies are generated and acquire the requisite molecular characteristics for neutralization.

204 , the bulk plastic deformation triggered the requisite molecular mobility of the polymer chains, caus

205 receives an input beyond that boundary, the requisite mRNAs for local translation and plasticity may

206 on pathways do not require transit through a requisite multipotent or bipotent megakaryocyte-erythroc

207 The process consists of formation of the requisite N-(2-nitrobenzyl)(tritylthio)alkylamine, subse

208 although the precise role for NOTCH and the requisite nature of BMSCs following fracture is unknown.

209 BLs respectively, as a pathway to access the requisite net-cBUs.

210 Despite this requisite NF1 loss of heterozygosity in the tumor cell o

211 rylation strategy for the elaboration of the requisite nine-membered lactam ring as the key step are

212 The development of the requisite nitrogen- and oxygen-based ligand libraries la

213 interactions facilitate the transduction of requisite Notch signals from the somite to the precursor

214 The requisite nucleotide fluorosugars could be produced from

215 ls and to establish curricular standards and requisite nutrition and physical activity competencies i

216 uently purine acquisition from the host is a requisite nutritional function for the parasite.

217 itions required for the rearrangement of the requisite O-aryl carbamothioates often leads to decompos

218 which work is done on the environment - the requisite of a molecular machine - is more likely than c

219 Accurate genotype calling is a pre-requisite of a successful Genome-Wide Association Study

220 y 4 days), immunity protein release is a pre-requisite of colicin intoxication, which occurs on a tim

221 udy in the quantum regime is hindered by the requisite of ground state cooling.

222 Understanding the structural and energetic requisites of ligand binding toward its molecular target

223 irst to identify microRNA 486 (miR-486) as a requisite oncomiR and credible therapeutic target in mye

224 e as yet to provide such an implant with the requisite optical quality or ability to change the focus

225 ic acid can easily be coupled to prepare the requisite organic strut with four metal-binding sites in

226 eprotection/oxidation sequence to access the requisite oxidation state at C(11) of the tetrahydropyra

227 ignaling, which was recently identified as a requisite PDGF-gradient-sensing pathway, with the goal o

228 The requisite peptides with heterogeneous backbones were pre

229 gender excellent patient compliance but lack requisite performance underscoring the need for better p

230 the E1 glycoprotein and therefore block the requisite pH-dependent fusion of viral and host membrane

231 ol lactone-based C-ring, which possessed the requisite pharmacophores for binding to protein kinase C

232 thesis of 2a is amenable to formation of the requisite phosphoramidite for solid-phase oligonucleotid

233 s is an emerging strategy for achieving this requisite physical parameter.

234 ormational changes, and possibly providing a requisite post-translational modification.

235 This suggests that the requisite practice for durable perceptual learning is in

236 thod reduces analysis time while maintaining requisite precision and detection limit.

237 lungs are reservoirs for megakaryocytes, the requisite precursor cell in thrombopoiesis, which is the

238 Given the requisite presence of CPSs in all land plants for gibber

239 ified L can copy synthetic RNA that contains requisite promoter sequences.

240 c pi-conjugated molecular materials with the requisite properties for all-optical switching applicati

241 hat gamma-actinorhodin possesses many of the requisite properties of an antibacterial drug, displayin

242 may impair memory consolidation by impairing requisite protein translation in the VHIPP.

243 zyme activity, although the mechanism of the requisite pyridine/dehydropiperidine synthase remains to

244 ts and elevated temperatures to generate the requisite radical species.

245 cells transfected with cDNAs encoding three requisite receptor subtypes: alpha7-nAChR, alpha4beta2-n

246 orresponding 1,2,3-derivative 7 prior to the requisite reductive coupling step leading to 8a.

247 ent eosinophilic dermatitis to demonstrate a requisite role for basophils.

248 velopmental Cell, Arraf et al. (2016) find a requisite role for bilaterally symmetrical BMP signaling

249 n reduced PPARalpha activation, confirming a requisite role for FABPs in this process.

250 Taken together our studies demonstrate a requisite role for mesodermal integrin alpha5beta1 in si

251 ion that the ITSN1-PI3K-C2beta pathway has a requisite role in human cancer, specifically neuroblasto

252 While phagocytic cells have a requisite role in the response to ECTV, the requirement

253 lymphoid irradiation, host CD8(+) DCs play a requisite role in tolerance induction through interactio

254 Timing of expression dictates the in vivo requisite role of each ligand, and concurrent expression

255 sents a novel mechanism for establishing the requisite set points in the interferon pathway that bala

256 In providing cancer aftercare there is a requisite shift to proactive care, supported self-manage

257 vivo, nanoparticles can be targeted to their requisite site of action.

258 ion to ensure that future graduates have the requisite skills necessary to manage these critically il

259 fcu-MOF pores permits the achievement of the requisite sorbate cutoff, ideal for selective adsorption

260 gas, we explicitly introduce and measure the requisite spin-dependent Lorentz forces, finding them to

261 well as the increasing accessibility of the requisite starting materials is giving birth to the hybr

262 of two-dimensional solids in many cases is a requisite step for exploiting their unique properties.

263 ed modulation of WNT signaling by MEF2A is a requisite step for proper muscle regeneration, and repre

264 xes on the surface of professional APCs is a requisite step in an effective immune response following

265 tering of presynaptic molecules as part of a requisite step in the coordinated assembly of a chemical

266 moiety of rhodopsin is an extremely slow but requisite step in the restoration of the visual pigment

267 calcium-dependent calpain, CAPN1, which were requisite steps for induction of apoptosis in MDS cells

268 ressor of cancer migration and invasion, two requisite steps of metastasis in vivo, and knockdown of

269 Our measurements confirm the requisite strong spin-orbit coupling and low-temperature

270 ge rigid-body motion almost certainly impede requisite structural rearrangements during the fusion pr

271 neuronal glycolysis was sufficient to supply requisite substrate.

272 The requisite substrates were readily prepared from tert-but

273 The requisite substrates were readily prepared using the con

274 e GluA1 subunit has been suggested to be the requisite subunit for HSP-induced AMPAR insertion and ac

275 ing mechanisms governing polar growth or the requisite suite of factors that direct polar growth.

276 ral networks and the TKO measure provide the requisite targets for the search for effective predictiv

277 Single-photon detection is a requisite technique in quantum-optics experiments in bot

278 can propagate across neural systems without requisite templated misfolding, but the absence of endog

279 ation of many neurons in a network, with the requisite temporal precision to simulate accurate neural

280 undergoes a cascade reaction to install the requisite tetracyclic ring system.

281 SOX4 and SOX13 directly regulated the two requisite Tgammadelta17 cell-specific genes, Rorc and Bl

282 and CBP, demonstrating a previously unknown requisite TGF-beta1/beta-catenin/CBP-mediated pro-EMT si

283 tain multiple [4Fe-4S] clusters, to form the requisite thioether bridge between a cysteine and the al

284 from other signals, including speech, a pre-requisite to avoid false alarms in normal vocal communic

285 at the density-functional theory level is a requisite to form the mixed disulfide intermediate.

286 that mesenchymal-to-epithelial transition is requisite to initiate SMCs reprogramming into vascular p

287 A pre-requisite to medicinal chemistry optimisation programmes

288 etween DNA loops of different centromeres is requisite to recapitulate experimentally determined corr

289 atients signed written informed consent as a requisite to undergo PET/CT examination.

290 Mg solvation structure in the electrolyte is requisite to understand the transport behavior of Mg ion

291 s interactions and a network approach may be requisite to understanding demographic responses to envi

292 f ribosome assembly in vivo and provides the requisite tools to characterize additional assembly path

293 Forkhead box (FOX)P3 is a requisite transcription factor for the development and m

294 ction of nitrogen (N2) to ammonia (NH3) is a requisite transformation for life.

295 ate reagent to expedite the synthesis of the requisite trifluoromethyl-substituted alkene starting ma

296 from Phaeodactylum tricornutum, imports the requisite unnatural triphosphates from its medium and th

297 icant impediment to improvement has been the requisite use of conventional destructive mechanical tes

298 Similarly, these structural requisites were found in store-operated Orai channels.

299 en both genotyped and phenotyped are the key requisite when aiming for high prediction accuracy.

300 The requisite (Z)-substituted potassium allyltrifluoroborate